JP2010518822A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010518822A5 JP2010518822A5 JP2009549719A JP2009549719A JP2010518822A5 JP 2010518822 A5 JP2010518822 A5 JP 2010518822A5 JP 2009549719 A JP2009549719 A JP 2009549719A JP 2009549719 A JP2009549719 A JP 2009549719A JP 2010518822 A5 JP2010518822 A5 JP 2010518822A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- multivitamin
- composition
- mineral
- oxidizable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 137
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 104
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 100
- 239000011707 mineral Substances 0.000 claims description 100
- 229940088594 vitamin Drugs 0.000 claims description 81
- 239000011782 vitamin Substances 0.000 claims description 81
- 229930003231 vitamin Natural products 0.000 claims description 79
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 77
- 235000013343 vitamin Nutrition 0.000 claims description 76
- 239000003826 tablet Substances 0.000 claims description 75
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 62
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 43
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 39
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 36
- 229930003268 Vitamin C Natural products 0.000 claims description 36
- 235000019154 vitamin C Nutrition 0.000 claims description 36
- 239000011718 vitamin C Substances 0.000 claims description 36
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 32
- 229910052751 metal Inorganic materials 0.000 claims description 32
- 239000002184 metal Substances 0.000 claims description 32
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 31
- 229930003427 Vitamin E Natural products 0.000 claims description 31
- 239000001506 calcium phosphate Substances 0.000 claims description 31
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 31
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 31
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 31
- 235000019165 vitamin E Nutrition 0.000 claims description 31
- 229940046009 vitamin E Drugs 0.000 claims description 31
- 239000011709 vitamin E Substances 0.000 claims description 31
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 30
- 238000007254 oxidation reaction Methods 0.000 claims description 30
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 29
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 29
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 29
- 235000019155 vitamin A Nutrition 0.000 claims description 29
- 239000011719 vitamin A Substances 0.000 claims description 29
- 229940045997 vitamin a Drugs 0.000 claims description 29
- 229910052742 iron Inorganic materials 0.000 claims description 21
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 20
- 230000003647 oxidation Effects 0.000 claims description 20
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 19
- 229910052802 copper Inorganic materials 0.000 claims description 19
- 239000010949 copper Substances 0.000 claims description 19
- -1 dicalcium phosphate anhydride Chemical class 0.000 claims description 19
- 229910021645 metal ion Inorganic materials 0.000 claims description 18
- 229940029985 mineral supplement Drugs 0.000 claims description 18
- 235000020786 mineral supplement Nutrition 0.000 claims description 18
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 17
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 17
- 229910052804 chromium Inorganic materials 0.000 claims description 17
- 239000011651 chromium Substances 0.000 claims description 17
- 239000011777 magnesium Substances 0.000 claims description 17
- 229910052749 magnesium Inorganic materials 0.000 claims description 17
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 16
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 16
- 230000015572 biosynthetic process Effects 0.000 claims description 16
- 229960000304 folic acid Drugs 0.000 claims description 16
- 235000019152 folic acid Nutrition 0.000 claims description 16
- 239000011724 folic acid Substances 0.000 claims description 16
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 16
- 239000007909 solid dosage form Substances 0.000 claims description 16
- 239000011701 zinc Substances 0.000 claims description 16
- 229910052725 zinc Inorganic materials 0.000 claims description 16
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 claims description 15
- 229910052759 nickel Inorganic materials 0.000 claims description 15
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 14
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 14
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 14
- 229910017052 cobalt Inorganic materials 0.000 claims description 14
- 239000010941 cobalt Substances 0.000 claims description 14
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 14
- 229910052750 molybdenum Inorganic materials 0.000 claims description 14
- 239000011733 molybdenum Substances 0.000 claims description 14
- 239000002243 precursor Substances 0.000 claims description 14
- 239000011669 selenium Substances 0.000 claims description 14
- 229910052711 selenium Inorganic materials 0.000 claims description 14
- 239000011135 tin Substances 0.000 claims description 14
- 229910052718 tin Inorganic materials 0.000 claims description 14
- 229910052720 vanadium Inorganic materials 0.000 claims description 14
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 14
- 235000020772 multivitamin supplement Nutrition 0.000 claims description 13
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 12
- 229930003448 Vitamin K Natural products 0.000 claims description 11
- 239000002552 dosage form Substances 0.000 claims description 11
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 11
- 235000019168 vitamin K Nutrition 0.000 claims description 11
- 239000011712 vitamin K Substances 0.000 claims description 11
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 11
- 229940046010 vitamin k Drugs 0.000 claims description 11
- 239000013589 supplement Substances 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 7
- 150000002500 ions Chemical class 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 239000007894 caplet Substances 0.000 claims description 5
- 235000016709 nutrition Nutrition 0.000 claims description 5
- 159000000007 calcium salts Chemical class 0.000 claims description 4
- 235000021466 carotenoid Nutrition 0.000 claims description 4
- 150000001747 carotenoids Chemical class 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- 238000007907 direct compression Methods 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- 235000005282 vitamin D3 Nutrition 0.000 claims description 2
- 239000011647 vitamin D3 Substances 0.000 claims description 2
- 229940021056 vitamin d3 Drugs 0.000 claims description 2
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 5
- 235000010755 mineral Nutrition 0.000 description 73
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 20
- 235000010323 ascorbic acid Nutrition 0.000 description 16
- 239000011668 ascorbic acid Substances 0.000 description 16
- 229960005070 ascorbic acid Drugs 0.000 description 16
- 235000015872 dietary supplement Nutrition 0.000 description 16
- 150000003839 salts Chemical group 0.000 description 13
- 239000000126 substance Substances 0.000 description 13
- 239000000546 pharmaceutical excipient Substances 0.000 description 11
- 235000015097 nutrients Nutrition 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 9
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 9
- 238000006731 degradation reaction Methods 0.000 description 8
- 230000036571 hydration Effects 0.000 description 7
- 238000006703 hydration reaction Methods 0.000 description 7
- 230000015556 catabolic process Effects 0.000 description 6
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 5
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000002274 desiccant Substances 0.000 description 5
- 239000011574 phosphorus Substances 0.000 description 5
- 229910052698 phosphorus Inorganic materials 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 150000001768 cations Chemical class 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 3
- 239000006057 Non-nutritive feed additive Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000002144 chemical decomposition reaction Methods 0.000 description 3
- 239000013626 chemical specie Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 235000019195 vitamin supplement Nutrition 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 229960000344 thiamine hydrochloride Drugs 0.000 description 2
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 2
- 239000011747 thiamine hydrochloride Substances 0.000 description 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 2
- 230000001228 trophic effect Effects 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229910021555 Chromium Chloride Inorganic materials 0.000 description 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 1
- 239000005751 Copper oxide Substances 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 description 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 239000003911 antiadherent Substances 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 description 1
- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 229940117373 dl-alpha tocopheryl acetate Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- LGQLOGILCSXPEA-UHFFFAOYSA-L nickel sulfate Chemical compound [Ni+2].[O-]S([O-])(=O)=O LGQLOGILCSXPEA-UHFFFAOYSA-L 0.000 description 1
- 229910000363 nickel(II) sulfate Inorganic materials 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000002897 polymer film coating Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical compound [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/706,923 US8491937B2 (en) | 2007-02-15 | 2007-02-15 | Stability in vitamin and mineral supplements |
| US11/706,923 | 2007-02-15 | ||
| PCT/US2008/053960 WO2008101076A1 (en) | 2007-02-15 | 2008-02-14 | Improved stability in vitamin and mineral supplements |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013047661A Division JP2013106619A (ja) | 2007-02-15 | 2013-03-11 | ビタミンおよびミネラル補助食品における改善された安定性 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518822A JP2010518822A (ja) | 2010-06-03 |
| JP2010518822A5 true JP2010518822A5 (enExample) | 2012-03-22 |
| JP5554069B2 JP5554069B2 (ja) | 2014-07-23 |
Family
ID=39361442
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549719A Active JP5554069B2 (ja) | 2007-02-15 | 2008-02-14 | ビタミンおよびミネラル補助食品における改善された安定性 |
| JP2013047661A Pending JP2013106619A (ja) | 2007-02-15 | 2013-03-11 | ビタミンおよびミネラル補助食品における改善された安定性 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013047661A Pending JP2013106619A (ja) | 2007-02-15 | 2013-03-11 | ビタミンおよびミネラル補助食品における改善された安定性 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8491937B2 (enExample) |
| EP (2) | EP2491800A1 (enExample) |
| JP (2) | JP5554069B2 (enExample) |
| KR (1) | KR101535310B1 (enExample) |
| CN (2) | CN105029442A (enExample) |
| AU (1) | AU2008216234C1 (enExample) |
| BR (1) | BRPI0807742A2 (enExample) |
| CA (1) | CA2676607C (enExample) |
| DK (1) | DK2111126T3 (enExample) |
| EC (1) | ECSP099575A (enExample) |
| ES (1) | ES2438600T3 (enExample) |
| HK (1) | HK1211440A1 (enExample) |
| IL (2) | IL200339A (enExample) |
| MX (1) | MX2009008768A (enExample) |
| MY (1) | MY154534A (enExample) |
| NZ (1) | NZ578781A (enExample) |
| PL (1) | PL2111126T3 (enExample) |
| PT (1) | PT2111126E (enExample) |
| RU (1) | RU2460340C2 (enExample) |
| SA (1) | SA08290068B1 (enExample) |
| TW (1) | TWI410258B (enExample) |
| WO (1) | WO2008101076A1 (enExample) |
| ZA (1) | ZA200905679B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101573316B1 (ko) * | 2004-03-29 | 2015-12-01 | 와이어쓰 엘엘씨 | 종합비타민 및 무기물 영양 보충제 |
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| DK3357496T3 (da) | 2006-06-21 | 2020-05-11 | Opko Ireland Global Holdings Ltd | Terapi ved brug af vitamin d-repletteringsmiddel og vitamin d-hormonsubstitutionsmiddel |
| US8491937B2 (en) * | 2007-02-15 | 2013-07-23 | Wyeth Llc | Stability in vitamin and mineral supplements |
| PT2148684E (pt) | 2007-04-25 | 2013-04-19 | Cytochroma Inc | Método de tratamento para a insuficiência e deficiência de vitamina d |
| PT2148661E (pt) | 2007-04-25 | 2013-03-06 | Proventiv Therapeutics Llc | Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso |
| MX351356B (es) * | 2008-11-13 | 2017-10-04 | Com S Car Borr S A De C V | Kit de formulaciones farmaceuticas caracterizado por la presencia de oxigeno molecular. |
| MY160706A (en) * | 2009-01-23 | 2017-03-15 | Wyeth Llc | A multivitamin/mineral formulation to combat the effects of environmental stress; improve immunity and improve energy while addressing vitamin and mineral deficiencies without the negative side effects of a mega dose nutritional supplement |
| NZ593506A (en) * | 2009-01-23 | 2013-09-27 | Wyeth Llc | Nutritional supplements for 50+ individuals for improving vitality, immunity, eye and bone health |
| ES2337758B1 (es) * | 2010-01-25 | 2011-02-10 | Laboratorios Q Pharma, S.L. | Composicion farmaceutica para el tratamiento de la andropenia/andropausia. |
| US20110195158A1 (en) * | 2010-02-10 | 2011-08-11 | Fuhr David R | Wildlife nutritional supplementation and methods for making the same |
| US11672809B2 (en) | 2010-03-29 | 2023-06-13 | Eirgen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| JP2013094525A (ja) * | 2011-11-04 | 2013-05-20 | Toyobo Co Ltd | 生体適合性に優れた血液浄化用中空糸膜の製造方法 |
| JP2013133322A (ja) * | 2011-12-27 | 2013-07-08 | Uha Mikakuto Co Ltd | 酸化ｌｄｌ結合阻害剤組成物 |
| JP5948089B2 (ja) * | 2012-03-02 | 2016-07-06 | アサヒフードアンドヘルスケア株式会社 | ビタミンミネラル含有錠剤及びその製造方法 |
| US20150017266A1 (en) * | 2012-09-05 | 2015-01-15 | Lucille Townsend | Compositions and Methods for Relieving Symptoms of Rheumatoid Arthritis and Related Illnesses |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US9629846B1 (en) | 2013-11-14 | 2017-04-25 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
| US9492421B1 (en) | 2013-11-14 | 2016-11-15 | Argent Development Group, Llc | Nutritional supplements for treatment of iron deficiency anemia |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| SG10201909401UA (en) * | 2015-01-14 | 2019-11-28 | Pfizer | Oral delivery product |
| KR101692546B1 (ko) * | 2015-08-05 | 2017-01-05 | 연세대학교 산학협력단 | 갑상선 질환 완화용 복합비타민 조성물 |
| WO2017065623A1 (en) * | 2015-10-16 | 2017-04-20 | Mendoza Wendell | Stable composition of vitamin c and zinc tablet |
| HK1256968A1 (zh) | 2016-01-15 | 2019-10-04 | 诺维克斯科技私人有限公司 | 稳定适口的维生素c和锌含片组合物 |
| WO2017182237A1 (en) | 2016-03-28 | 2017-10-26 | Opko Ireland Global Holdings, Limited | Methods of vitamin d treatment |
| CN107441117A (zh) * | 2016-05-30 | 2017-12-08 | 上海诺成药业股份有限公司 | 一种多维元素钙制剂及其制备方法 |
| WO2019100029A1 (en) * | 2017-11-17 | 2019-05-23 | Jacob Rosenstein | Nutraceutical composition for telomere lengthening, reduction of dna damage, and reduction of uv-induced skin aging |
| WO2020077156A1 (en) * | 2018-10-10 | 2020-04-16 | Weider Health And Fitness | Supplement |
| CN109730323A (zh) * | 2019-03-22 | 2019-05-10 | 北京斯利安药业有限公司 | 铁的氧化物、亚铁盐和/或其组合物在提高叶酸稳定性中的应用 |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| KR102437393B1 (ko) * | 2020-04-29 | 2022-08-30 | 주식회사 대호 | 가축용 성장촉진제의 제조방법 |
| JP2022076152A (ja) * | 2020-11-09 | 2022-05-19 | 株式会社ファンケル | 変色が抑制された経口組成物及びその変色抑制方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647450A (en) * | 1983-07-20 | 1987-03-03 | Warner-Lambert Company | Chewing gum compositions containing magnesium trisilicate absorbates |
| EP0514451B1 (en) * | 1990-02-05 | 1997-01-15 | LifeScience Corporation | Dietary supplements comprising vitamins and minerals |
| JP3078859B2 (ja) * | 1990-02-23 | 2000-08-21 | 武田薬品工業株式会社 | 安定な放出制御性製剤用コーティング剤 |
| DE9412374U1 (de) | 1994-08-01 | 1994-09-22 | Rauch-Petz, Gisela G., Dr., 80803 München | Nahrungsergänzungsmittel |
| EP0831728A2 (en) * | 1995-06-06 | 1998-04-01 | Campbell Soup Company | Mineral supplements for dietetic food |
| US5670344A (en) * | 1996-02-02 | 1997-09-23 | The Procter & Gamble Company | Preventing undesired color formation in iron fortified chocolate-flavored beverages by including edible acids or their salts |
| US6139872A (en) * | 1996-08-14 | 2000-10-31 | Henkel Corporation | Method of producing a vitamin product |
| US6103260A (en) | 1997-07-17 | 2000-08-15 | Mcneil-Ppc, Inc. | Simethicone/anhydrous calcium phosphate compositions |
| KR100267576B1 (ko) * | 1998-07-25 | 2000-11-01 | 허계성 | 활성성분을 분리함유한 츄잉 연질정제 및 그의 제조방법 |
| GB0007419D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Gmbh | Composition |
| US6361800B1 (en) * | 2000-04-13 | 2002-03-26 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
| JP4143251B2 (ja) * | 2000-09-26 | 2008-09-03 | 雪印乳業株式会社 | 栄養強化食品 |
| US20020077354A1 (en) * | 2000-10-05 | 2002-06-20 | Dusan Miljkovic | Methods and compositions for stabilizing oxidizable compounds |
| US6660297B2 (en) * | 2001-03-23 | 2003-12-09 | Bausch & Lomb Incorporated | Nutritional supplement to treat macular degeneration |
| UY27505A1 (es) * | 2001-10-23 | 2003-06-30 | Boehringer Ingelheim Int | Tableta masticable que contiene lisina |
| US7070804B2 (en) * | 2001-10-23 | 2006-07-04 | Boehringer Ingelheim International Gmbh | Chewable tablet containing lysine |
| ITMI20012462A1 (it) | 2001-11-22 | 2003-05-22 | Gnosis Srl | Processo per la preparazione di compresse comprendenti s-adenosilmetionina |
| FR2838645B1 (fr) * | 2002-04-19 | 2004-05-28 | Ravi Shrivastava | Nouvelles compositions synergiques de vitamines, de mineraux et d'oligo-elements pour stimuler l'elimination des lipides intracellulaires |
| US6565891B1 (en) * | 2002-08-23 | 2003-05-20 | Tsar Health Private Ltd. | Nutritional supplement for children |
| JP2007524690A (ja) * | 2004-02-17 | 2007-08-30 | ヴェーリ・インター・アーゲー | 活性物質の生体内利用効率を高めるためのガラクトマンナン及び／又はグルコマンナン |
| DE602004017514D1 (de) | 2004-06-02 | 2008-12-11 | Galephar M F | Stabile orale pharmazeutische zusammensetzungen von buprenorphin und salz davon |
| JP2008539729A (ja) * | 2005-05-03 | 2008-11-20 | イノゼン・インコーポレイテッド | 栄養補助食品の経粘膜送達のための可食性フィルム |
| US8491937B2 (en) * | 2007-02-15 | 2013-07-23 | Wyeth Llc | Stability in vitamin and mineral supplements |
-
2007
- 2007-02-15 US US11/706,923 patent/US8491937B2/en active Active
-
2008
- 2008-02-14 RU RU2009130333/13A patent/RU2460340C2/ru active
- 2008-02-14 NZ NZ578781A patent/NZ578781A/xx unknown
- 2008-02-14 JP JP2009549719A patent/JP5554069B2/ja active Active
- 2008-02-14 AU AU2008216234A patent/AU2008216234C1/en active Active
- 2008-02-14 WO PCT/US2008/053960 patent/WO2008101076A1/en not_active Ceased
- 2008-02-14 CA CA2676607A patent/CA2676607C/en active Active
- 2008-02-14 CN CN201510364518.8A patent/CN105029442A/zh active Pending
- 2008-02-14 CN CNA2008800048639A patent/CN101605468A/zh active Pending
- 2008-02-14 MY MYPI20093352A patent/MY154534A/en unknown
- 2008-02-14 EP EP12168308A patent/EP2491800A1/en not_active Withdrawn
- 2008-02-14 MX MX2009008768A patent/MX2009008768A/es active IP Right Grant
- 2008-02-14 PT PT87298584T patent/PT2111126E/pt unknown
- 2008-02-14 ES ES08729858.4T patent/ES2438600T3/es active Active
- 2008-02-14 BR BRPI0807742-8A2A patent/BRPI0807742A2/pt active IP Right Grant
- 2008-02-14 PL PL08729858T patent/PL2111126T3/pl unknown
- 2008-02-14 EP EP08729858.4A patent/EP2111126B1/en active Active
- 2008-02-14 DK DK08729858.4T patent/DK2111126T3/da active
- 2008-02-14 KR KR1020097019280A patent/KR101535310B1/ko active Active
- 2008-02-15 TW TW097105459A patent/TWI410258B/zh active
- 2008-02-16 SA SA08290068A patent/SA08290068B1/ar unknown
-
2009
- 2009-08-11 IL IL200339A patent/IL200339A/en active IP Right Grant
- 2009-08-13 EC EC2009009575A patent/ECSP099575A/es unknown
- 2009-08-14 ZA ZA200905679A patent/ZA200905679B/xx unknown
-
2013
- 2013-03-11 JP JP2013047661A patent/JP2013106619A/ja active Pending
- 2013-06-20 US US13/922,863 patent/US20140220151A1/en not_active Abandoned
-
2014
- 2014-03-24 IL IL231681A patent/IL231681B/en active IP Right Grant
-
2015
- 2015-12-16 HK HK15112396.8A patent/HK1211440A1/xx unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5554069B2 (ja) | ビタミンおよびミネラル補助食品における改善された安定性 | |
| JP2010518822A5 (enExample) | ||
| JP4668513B2 (ja) | 粒状化可能な混合物の調製方法及びカルニチン・マグネシウム・ヒドロキシクエン酸塩 | |
| CZ322199A3 (cs) | Stabilní pevný prostředek obsahující vitamin D3 a trikalciumfosfát | |
| EP2335698B1 (en) | Pharmaceutical solid preparation having active ingredients separated by boundary therein | |
| JP6374879B2 (ja) | 骨粗しょう症治療用の安定な医薬組成物 | |
| JP2013234124A (ja) | 安定化方法 | |
| JP2024012181A (ja) | 複数のビタミン及びミネラルのコリン含有組成物、その調製方法及び用途 | |
| JP6919117B2 (ja) | 鉄化合物含有組成物の粒子、鉄化合物の変色抑制方法、並びに鉄化合物及びビタミンｃ含有組成物 | |
| WO2020218517A1 (ja) | 医薬製剤およびその製造方法 | |
| KR20230065181A (ko) | 티아민 또는 그의 유도체와 피돌산 마그네슘을 포함하는 경구용 조성물 및 복합 제제 | |
| HK1135573B (en) | Improved stability in vitamin and mineral supplements | |
| KR100844261B1 (ko) | 안정성이 향상된 복합철분제 및 그 제조방법 | |
| BRPI0807742B1 (pt) | Composição multivitamínica e mineral; método para preparar uma composição multivitamínica e mineral; método para reduzir o manchamento induzido pela oxidação em um comprimido multivitamínico e mineral; suplemento multivitamínico e mineral; e método para estabilizar o comportamento de desintegração dos comprimidos multivitamínicos e minerais ao longo do tempo | |
| HK1152652B (en) | Pharmaceutical solid preparation having active ingredients separated by boundary therein |