JP2010518122A5 - - Google Patents
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- Publication number
- JP2010518122A5 JP2010518122A5 JP2009549268A JP2009549268A JP2010518122A5 JP 2010518122 A5 JP2010518122 A5 JP 2010518122A5 JP 2009549268 A JP2009549268 A JP 2009549268A JP 2009549268 A JP2009549268 A JP 2009549268A JP 2010518122 A5 JP2010518122 A5 JP 2010518122A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treprostinil
- pulmonary fibrosis
- kit
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 32
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 24
- 229960005032 treprostinil Drugs 0.000 claims 22
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 10
- 208000006673 asthma Diseases 0.000 claims 6
- 239000002552 dosage form Substances 0.000 claims 6
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000027932 Collagen disease Diseases 0.000 claims 2
- 206010073310 Occupational exposures Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000013061 administrable dose form Substances 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000018631 connective tissue disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 101100326804 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-2 gene Proteins 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90032007P | 2007-02-09 | 2007-02-09 | |
| US94021807P | 2007-05-25 | 2007-05-25 | |
| PCT/US2008/053467 WO2008098196A1 (en) | 2007-02-09 | 2008-02-08 | Treprostinil treatment for interstitial lung disease and asthma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116923A Division JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518122A JP2010518122A (ja) | 2010-05-27 |
| JP2010518122A5 true JP2010518122A5 (cg-RX-API-DMAC7.html) | 2011-03-10 |
Family
ID=39357950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549268A Withdrawn JP2010518122A (ja) | 2007-02-09 | 2008-02-08 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
| JP2013116923A Pending JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116923A Pending JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20080280986A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2120961A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2010518122A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20090117781A (cg-RX-API-DMAC7.html) |
| CN (2) | CN101678033A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2678258A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008098196A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2959852A1 (en) * | 2003-05-22 | 2005-01-27 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
| DE602005020269D1 (de) * | 2004-04-12 | 2010-05-12 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| US20070023047A1 (en) * | 2005-07-26 | 2007-02-01 | Moshe Zalsman | Face mask particularly useful as medical face mask |
| EP3067047B1 (en) | 2005-12-08 | 2022-04-20 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| US20080200449A1 (en) | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| KR101898407B1 (ko) | 2007-12-17 | 2018-09-12 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린®의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
| US8350079B2 (en) * | 2008-05-08 | 2013-01-08 | United Therapeutics Corporation | Treprostinil formulation |
| JP5649645B2 (ja) * | 2009-05-07 | 2015-01-07 | ユナイテッド セラピューティクス コーポレイション | プロスタサイクリンアナログの固形製剤 |
| PT2461812E (pt) * | 2009-08-07 | 2014-04-07 | Scipharm S Rl | Composição para o tratamento da fibrose cística |
| US8609728B2 (en) | 2010-03-15 | 2013-12-17 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
| CA3029711A1 (en) | 2010-06-03 | 2011-12-08 | United Therapeutics Corporation | Treprostinil production |
| WO2012006273A1 (en) * | 2010-07-09 | 2012-01-12 | United Therapeutics Corporation | Combination therapies with cox-2 inhibitors and treprostinil |
| WO2012107364A1 (en) * | 2011-02-07 | 2012-08-16 | Scipharm Sàrl | Novel composition for the treatment of cystic fibrosis |
| BR112013019335B1 (pt) | 2011-02-07 | 2022-05-31 | Scipharm Sàrl | Nova composição, método para aumentar o nível de camp em um célula e combinação terapêutica, para o tratamento da fibrose cística |
| US20130345471A1 (en) | 2011-03-02 | 2013-12-26 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| CA2843883C (en) | 2011-08-12 | 2020-04-28 | Ascendis Pharma A/S | Carrier-linked treprostinil prodrugs |
| WO2013024051A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| ES2733998T3 (es) * | 2012-10-29 | 2019-12-03 | Cardio Incorporated | Agente terapéutico específico de enfermedad pulmonar |
| EP3581186A1 (en) | 2012-11-29 | 2019-12-18 | Insmed Incorporated | Stabilized vancomycin formulations |
| JP6542128B2 (ja) | 2013-01-11 | 2019-07-10 | コルセア ファーマ インコーポレイテッド | トレプロスチニルのプロドラッグ |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| CA3212313A1 (en) | 2013-03-14 | 2014-10-02 | United Therapeutics Corporation | Solid forms of treprostinil |
| KR102405650B1 (ko) | 2013-03-15 | 2022-06-03 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐의 염 |
| ES2676447T3 (es) | 2013-03-25 | 2018-07-19 | United Therapeutics Corporation | Procedimiento de fabricación de compuestos de prostaciclina con tiol de unión y formas pegiladas |
| MX382833B (es) | 2013-10-25 | 2025-03-13 | Insmed Inc | Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| KR20240018675A (ko) | 2014-05-15 | 2024-02-13 | 인스메드 인코포레이티드 | 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법 |
| CA2950527A1 (en) * | 2014-06-03 | 2015-12-10 | Novartis Ag | Pulmonary hypertension biomarker |
| US20170095432A1 (en) | 2014-06-13 | 2017-04-06 | United Therapeutics Corporation | Treprostinil formulations |
| ES2778274T3 (es) | 2014-10-20 | 2020-08-10 | United Therapeutics Corp | Síntesis de productos intermedios para producir derivados de prostaciclina |
| JP6866043B2 (ja) | 2014-11-18 | 2021-04-28 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 |
| WO2016088119A1 (en) | 2014-12-03 | 2016-06-09 | Steadymed Ltd | Preservative-free treprostinil formulations and methods and devices for use with same |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| EP3515430A1 (en) | 2016-09-26 | 2019-07-31 | United Therapeutics Corporation | Treprostinil prodrugs |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| CN108379557A (zh) * | 2018-01-15 | 2018-08-10 | 吉林大学 | 使用白介素因子-37治疗特发性肺纤维化 |
| WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| EA202190552A1 (ru) | 2018-09-18 | 2021-06-18 | Эли Лилли Энд Компани | Эрбуминовая соль трепростинила |
| JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| CN115916212A (zh) * | 2020-04-17 | 2023-04-04 | 联合治疗公司 | 曲前列尼尔用于治疗间质性肺病 |
| AU2021289336B2 (en) | 2020-06-09 | 2025-08-28 | Mannkind Corporation | Fumaryl diketopiperidine prodrugs of treprostinil |
| CN117062605A (zh) | 2020-12-14 | 2023-11-14 | 联合治疗公司 | 使用曲前列环素前药治疗疾病的方法 |
| CN117479946A (zh) | 2021-03-03 | 2024-01-30 | 联合治疗公司 | 含曲前列环素及其前药并还包含(e)-3,6-双[4-(n-羰基-2-丙烯基)酰胺丁基]-2,5-二酮哌嗪(fdkp)的干粉组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| GB8814438D0 (en) * | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| HU207220B (en) * | 1988-06-17 | 1993-03-29 | Wellcome Found | Process for producing pharmaceutical composition for diminishing enhanced pressure of the pulmonary circulation |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6054486A (en) * | 1997-11-14 | 2000-04-25 | United Technology Corporation | Use of 9-Deoxy-2',9-α-methano-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylen e)-13,14-dihydro-prostaglandin f1 to treat peripheral vascular disease |
| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| ES2296613T3 (es) * | 1999-03-18 | 2008-05-01 | Queen Mary And Westfield College | Inhibidores de la sintesis de endotelina-1. |
| US6756047B2 (en) * | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| CA2959852A1 (en) | 2003-05-22 | 2005-01-27 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
| US20080200449A1 (en) * | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
-
2008
- 2008-02-08 CA CA002678258A patent/CA2678258A1/en not_active Abandoned
- 2008-02-08 KR KR1020097018462A patent/KR20090117781A/ko not_active Ceased
- 2008-02-08 WO PCT/US2008/053467 patent/WO2008098196A1/en not_active Ceased
- 2008-02-08 CN CN200880004381A patent/CN101678033A/zh active Pending
- 2008-02-08 CN CN2012100599979A patent/CN102648916A/zh active Pending
- 2008-02-08 EP EP08729432A patent/EP2120961A1/en not_active Withdrawn
- 2008-02-08 JP JP2009549268A patent/JP2010518122A/ja not_active Withdrawn
- 2008-02-08 EP EP12162497A patent/EP2491932A3/en not_active Withdrawn
- 2008-02-08 US US12/028,471 patent/US20080280986A1/en not_active Abandoned
-
2012
- 2012-01-30 US US13/360,961 patent/US20120129941A1/en not_active Abandoned
- 2012-12-10 US US13/709,270 patent/US20130096200A1/en not_active Abandoned
-
2013
- 2013-06-03 JP JP2013116923A patent/JP2013189459A/ja active Pending
- 2013-09-18 US US14/030,500 patent/US20140018431A1/en not_active Abandoned