JP2010518120A - ７−エチル−１０−ヒドロキシカンプトテシンのマルチアームポリマー複合体を用いた抵抗性または難治性の癌の治療方法 - Google Patents

７−エチル−１０−ヒドロキシカンプトテシンのマルチアームポリマー複合体を用いた抵抗性または難治性の癌の治療方法 Download PDF

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JP2010518120A
JP2010518120A JP2009549259A JP2009549259A JP2010518120A JP 2010518120 A JP2010518120 A JP 2010518120A JP 2009549259 A JP2009549259 A JP 2009549259A JP 2009549259 A JP2009549259 A JP 2009549259A JP 2010518120 A JP2010518120 A JP 2010518120A
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cancer
substituted
refractory
resistant
acid
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JP2010518120A5 (OSRAM
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ザオ，ホン
サプラ，プジャ
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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    • A—HUMAN NECESSITIES
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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  • Pregnancy & Childbirth (AREA)
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  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
JP2009549259A 2007-02-09 2008-02-08 ７−エチル−１０−ヒドロキシカンプトテシンのマルチアームポリマー複合体を用いた抵抗性または難治性の癌の治療方法 Pending JP2010518120A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90059207P 2007-02-09 2007-02-09
PCT/US2008/053438 WO2008098178A2 (en) 2007-02-09 2008-02-08 Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin

Publications (2)

Publication Number Publication Date
JP2010518120A true JP2010518120A (ja) 2010-05-27
JP2010518120A5 JP2010518120A5 (OSRAM) 2012-04-12

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JP2009549259A Pending JP2010518120A (ja) 2007-02-09 2008-02-08 ７−エチル−１０−ヒドロキシカンプトテシンのマルチアームポリマー複合体を用いた抵抗性または難治性の癌の治療方法

Country Status (13)

Country Link
US (2) US7928095B2 (OSRAM)
EP (1) EP2109448B1 (OSRAM)
JP (1) JP2010518120A (OSRAM)
KR (1) KR20090108082A (OSRAM)
CN (1) CN101605539B (OSRAM)
AU (1) AU2008213576B2 (OSRAM)
BR (1) BRPI0807232A2 (OSRAM)
CA (1) CA2677798A1 (OSRAM)
IL (1) IL200100A0 (OSRAM)
MX (1) MX2009008549A (OSRAM)
RU (1) RU2009133793A (OSRAM)
TW (1) TW200902066A (OSRAM)
WO (1) WO2008098178A2 (OSRAM)

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CN103772696B (zh) * 2014-01-06 2015-12-02 济南大学 一种羟基喜树碱的聚甘油脂肪酸酯衍生物
CN110448533B (zh) * 2014-12-05 2022-03-29 天津键凯科技有限公司 一种聚乙二醇修饰的喜树碱类衍生物的药物组合物及其制备方法
CN108727584B (zh) * 2017-04-21 2021-01-05 博瑞生物医药（苏州）股份有限公司 抗癌偶联物
CN107670050B (zh) * 2017-08-30 2019-06-07 重庆阿普格雷生物科技有限公司 基于pki-587的抗癌中间体和聚乙二醇偶联抗癌药物、及其制备方法和应用
WO2021143741A1 (zh) * 2020-01-15 2021-07-22 北京海步医药科技有限公司 靶向多肽-药物缀合物及其用途

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KR20090108082A (ko) 2009-10-14
AU2008213576A2 (en) 2009-09-03
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AU2008213576B2 (en) 2013-01-17
US20110195990A1 (en) 2011-08-11
RU2009133793A (ru) 2011-03-20
IL200100A0 (en) 2010-04-15
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AU2008213576A1 (en) 2008-08-14
US20080193408A1 (en) 2008-08-14
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