JP2010518118A - 長期防除のための高用量長時間作用型の外部寄生生物駆除剤 - Google Patents
長期防除のための高用量長時間作用型の外部寄生生物駆除剤 Download PDFInfo
- Publication number
- JP2010518118A JP2010518118A JP2009549256A JP2009549256A JP2010518118A JP 2010518118 A JP2010518118 A JP 2010518118A JP 2009549256 A JP2009549256 A JP 2009549256A JP 2009549256 A JP2009549256 A JP 2009549256A JP 2010518118 A JP2010518118 A JP 2010518118A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dose
- metaflumizone
- control agent
- ectoparasite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000078703 ectoparasite Species 0.000 title claims abstract description 153
- 230000007774 longterm Effects 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 220
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 115
- 241001465754 Metazoa Species 0.000 claims abstract description 86
- 238000009472 formulation Methods 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 58
- 239000002904 solvent Substances 0.000 claims abstract description 45
- 206010061217 Infestation Diseases 0.000 claims abstract description 42
- 239000004094 surface-active agent Substances 0.000 claims abstract description 34
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 21
- 239000011877 solvent mixture Substances 0.000 claims abstract description 19
- 230000000699 topical effect Effects 0.000 claims abstract description 12
- 239000005914 Metaflumizone Substances 0.000 claims description 110
- MIFOMMKAVSCNKQ-HWIUFGAZSA-N Metaflumizone Chemical group C1=CC(OC(F)(F)F)=CC=C1NC(=O)N\N=C(C=1C=C(C=CC=1)C(F)(F)F)\CC1=CC=C(C#N)C=C1 MIFOMMKAVSCNKQ-HWIUFGAZSA-N 0.000 claims description 110
- 241000282326 Felis catus Species 0.000 claims description 94
- 238000011282 treatment Methods 0.000 claims description 82
- 230000037396 body weight Effects 0.000 claims description 66
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 47
- 239000005906 Imidacloprid Substances 0.000 claims description 34
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 claims description 34
- 229940056881 imidacloprid Drugs 0.000 claims description 34
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 claims description 33
- 239000005899 Fipronil Substances 0.000 claims description 33
- 229940013764 fipronil Drugs 0.000 claims description 33
- JBFHTYHTHYHCDJ-UHFFFAOYSA-N gamma-caprolactone Chemical compound CCC1CCC(=O)O1 JBFHTYHTHYHCDJ-UHFFFAOYSA-N 0.000 claims description 20
- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 claims description 16
- MWMQNVGAHVXSPE-UHFFFAOYSA-N Pyriprole Chemical compound ClC=1C=C(C(F)(F)F)C=C(Cl)C=1N1N=C(C#N)C(SC(F)F)=C1NCC1=CC=CC=N1 MWMQNVGAHVXSPE-UHFFFAOYSA-N 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 15
- 229920001577 copolymer Polymers 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 12
- 239000004971 Cross linker Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 229960002587 amitraz Drugs 0.000 claims description 11
- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 11
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 claims description 11
- 229960000490 permethrin Drugs 0.000 claims description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 claims description 8
- RFEJUZJILGIRHQ-XRIOVQLTSA-N 2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)C(O)C(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-XRIOVQLTSA-N 0.000 claims description 7
- 239000013057 ectoparasiticide Substances 0.000 claims description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 7
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 7
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 6
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 229960005233 cineole Drugs 0.000 claims description 6
- 239000000575 pesticide Substances 0.000 claims description 6
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 238000011200 topical administration Methods 0.000 claims description 5
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- LLHKCFNBLRBOGN-UHFFFAOYSA-N propylene glycol methyl ether acetate Chemical compound COCC(C)OC(C)=O LLHKCFNBLRBOGN-UHFFFAOYSA-N 0.000 claims description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 3
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 3
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 3
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 claims description 3
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- 150000008575 L-amino acids Chemical class 0.000 claims description 3
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 3
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000003093 cationic surfactant Substances 0.000 claims description 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 229940031578 diisopropyl adipate Drugs 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 229960003639 laurocapram Drugs 0.000 claims description 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 229920000847 nonoxynol Polymers 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- 229920001897 terpolymer Polymers 0.000 claims description 3
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims description 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 3
- 239000003981 vehicle Substances 0.000 claims description 3
- WDQFELCEOPFLCZ-UHFFFAOYSA-N 1-(2-hydroxyethyl)pyrrolidin-2-one Chemical compound OCCN1CCCC1=O WDQFELCEOPFLCZ-UHFFFAOYSA-N 0.000 claims description 2
- KRUABTDBQQLWLS-UHFFFAOYSA-N 1-methylsulfinyltetradecane Chemical compound CCCCCCCCCCCCCCS(C)=O KRUABTDBQQLWLS-UHFFFAOYSA-N 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 239000010775 animal oil Substances 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 239000003208 petroleum Substances 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000005871 repellent Substances 0.000 claims 1
- 230000002940 repellent Effects 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 description 106
- 241000258242 Siphonaptera Species 0.000 description 43
- 241000258924 Ctenocephalides felis Species 0.000 description 33
- 239000004544 spot-on Substances 0.000 description 19
- 238000012360 testing method Methods 0.000 description 17
- 241000238876 Acari Species 0.000 description 12
- 239000004480 active ingredient Substances 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 239000002453 shampoo Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 206010040880 Skin irritation Diseases 0.000 description 8
- 230000008901 benefit Effects 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 230000036556 skin irritation Effects 0.000 description 8
- 231100000475 skin irritation Toxicity 0.000 description 8
- 206010067484 Adverse reaction Diseases 0.000 description 7
- 230000006838 adverse reaction Effects 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- -1 pryiprole Chemical compound 0.000 description 7
- 239000004005 microsphere Substances 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000490513 Ctenocephalides canis Species 0.000 description 5
- 239000005927 Pyriproxyfen Substances 0.000 description 5
- 229920002125 Sokalan® Polymers 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 239000002917 insecticide Substances 0.000 description 5
- 229920001983 poloxamer Polymers 0.000 description 5
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 description 5
- 241001494479 Pecora Species 0.000 description 4
- 230000003292 diminished effect Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 241000238421 Arthropoda Species 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000283086 Equidae Species 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000004540 pour-on Substances 0.000 description 3
- 210000001991 scapula Anatomy 0.000 description 3
- 210000003625 skull Anatomy 0.000 description 3
- 150000003462 sulfoxides Chemical class 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 2
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 2
- 241000272517 Anseriformes Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- RZTOWFMDBDPERY-UHFFFAOYSA-N Delta-Hexanolactone Chemical compound CC1CCCC(=O)O1 RZTOWFMDBDPERY-UHFFFAOYSA-N 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- 241000282324 Felis Species 0.000 description 2
- 241001674048 Phthiraptera Species 0.000 description 2
- VQXSOUPNOZTNAI-UHFFFAOYSA-N Pyrethrin I Natural products CC(=CC1CC1C(=O)OC2CC(=O)C(=C2C)CC=C/C=C)C VQXSOUPNOZTNAI-UHFFFAOYSA-N 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000001217 buttock Anatomy 0.000 description 2
- 239000007963 capsule composition Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000002949 juvenile hormone Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003217 pyrazoles Chemical class 0.000 description 2
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 2
- VJFUPGQZSXIULQ-XIGJTORUSA-N pyrethrin II Chemical compound CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VJFUPGQZSXIULQ-XIGJTORUSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960004906 thiomersal Drugs 0.000 description 2
- CKGQJOFAVYEVFG-KXQOOQHDSA-N 2-fluoro-4-[[(1R)-6-[2-[4-[1-(4-methoxyphenyl)-5-methyl-6-oxopyridazin-3-yl]triazol-1-yl]ethoxy]-1-methyl-1-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]-3,4-dihydro-2H-isoquinolin-7-yl]oxy]benzoic acid Chemical compound COc1ccc(cc1)-n1nc(cc(C)c1=O)-c1cn(CCOc2cc3CCN[C@](C)(CC(=O)Nc4nccs4)c3cc2Oc2ccc(C(O)=O)c(F)c2)nn1 CKGQJOFAVYEVFG-KXQOOQHDSA-N 0.000 description 1
- DFEMJYIRAXUQQB-UHFFFAOYSA-N 3-ethyloxolan-2-one Chemical compound CCC1CCOC1=O DFEMJYIRAXUQQB-UHFFFAOYSA-N 0.000 description 1
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 description 1
- 241000157302 Bison bison athabascae Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241000692095 Cuterebra Species 0.000 description 1
- ABIKNKURIGPIRJ-UHFFFAOYSA-N DL-4-hydroxy caproic acid Chemical compound CCC(O)CCC(O)=O ABIKNKURIGPIRJ-UHFFFAOYSA-N 0.000 description 1
- 241000202813 Dermatobia Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241001660203 Gasterophilus Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000257176 Hypoderma <fly> Species 0.000 description 1
- 241000257162 Lucilia <blowfly> Species 0.000 description 1
- 241000289581 Macropus sp. Species 0.000 description 1
- 241000771994 Melophagus ovinus Species 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 1
- 241000282335 Procyon Species 0.000 description 1
- 241000283011 Rangifer Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000256103 Simuliidae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000012681 biocontrol agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 description 1
- 150000007659 semicarbazones Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88926107P | 2007-02-09 | 2007-02-09 | |
| US96683207P | 2007-08-30 | 2007-08-30 | |
| PCT/US2008/053416 WO2008098168A2 (en) | 2007-02-09 | 2008-02-08 | High-dose, long-acting ectoparasiticide for extended control |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518118A true JP2010518118A (ja) | 2010-05-27 |
| JP2010518118A5 JP2010518118A5 (https=) | 2012-02-16 |
Family
ID=39682425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549256A Pending JP2010518118A (ja) | 2007-02-09 | 2008-02-08 | 長期防除のための高用量長時間作用型の外部寄生生物駆除剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080194642A1 (https=) |
| EP (1) | EP2120583A2 (https=) |
| JP (1) | JP2010518118A (https=) |
| KR (1) | KR20090118961A (https=) |
| AR (1) | AR065265A1 (https=) |
| AU (1) | AU2008213566A1 (https=) |
| BR (1) | BRPI0807233A2 (https=) |
| CA (1) | CA2676832A1 (https=) |
| CL (1) | CL2008000401A1 (https=) |
| CO (1) | CO6210774A2 (https=) |
| EA (1) | EA200970749A1 (https=) |
| MX (1) | MX2009008411A (https=) |
| TW (1) | TW200846029A (https=) |
| WO (1) | WO2008098168A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016536272A (ja) * | 2013-09-30 | 2016-11-24 | ゾエティス・サービシーズ・エルエルシー | 長時間作用型スピロイソキサゾリン製剤 |
| JP2019504873A (ja) * | 2015-11-09 | 2019-02-21 | メリアル インコーポレイテッド | ペットケアクレンジング組成物 |
| JP2020500914A (ja) * | 2016-12-12 | 2020-01-16 | コントラクト ファーマシューティカルズ リミテッド | ピレスロイドスプレー製剤およびそれを使用する方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080112993A1 (en) * | 2005-05-24 | 2008-05-15 | Wyeth | High-dose, long-lasting ectoparasiticide for extended control |
| US20100015191A1 (en) * | 2008-07-21 | 2010-01-21 | Wyeth | Device and method for controlling insects |
| WO2010042395A1 (en) | 2008-10-08 | 2010-04-15 | Wyeth Llc | Benzimidazole anthelmintic compositions |
| ES2781828T3 (es) | 2008-11-19 | 2020-09-08 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones que comprenden un aril pirazol y/o una formamidina, procedimientos y usos de las mismas |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| WO2010096623A1 (en) * | 2009-02-23 | 2010-08-26 | Wyeth Llc | Improved-scent ectoparasiticidal formulation |
| BR112012006514A2 (pt) * | 2009-09-22 | 2015-09-08 | Sergeants Pet Care Prod Inc | composição de pesticida spot-on |
| JP2011153129A (ja) * | 2009-12-28 | 2011-08-11 | Sumitomo Chemical Co Ltd | 動物外部寄生虫防除組成物 |
| KR20130130761A (ko) | 2010-12-27 | 2013-12-02 | 인터벳 인터내셔널 비.브이. | 국소 적용 이속사졸린 제제 |
| US9040068B2 (en) * | 2011-05-21 | 2015-05-26 | Ensystex Inc. | Control of bed bugs |
| US9622478B2 (en) | 2012-10-16 | 2017-04-18 | Solano S.P. Ltd. | Topical formulations for treating parasitic infestations |
| US10721930B2 (en) * | 2014-12-23 | 2020-07-28 | Cap Innovet, Inc. | Dermal compositions |
| HUE057664T2 (hu) | 2015-07-10 | 2022-05-28 | Ceva Sante Animale | Dinotefurán/permetrin/piriproxifen kombinációt tartalmazó részekbõl álló kit topikális alkalmazásra és orális milbemicin oxim dirofilariózis elterjedésének szabályozására |
| EP3120846A1 (en) * | 2015-07-24 | 2017-01-25 | Ceva Sante Animale | Compositions and uses thereof for controlling ectoparasites in non-human mammals |
| US10512628B2 (en) | 2016-04-24 | 2019-12-24 | Solano S.P. Ltd. | Dinotefuran liquid flea and tick treatment |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57165306A (en) * | 1981-03-16 | 1982-10-12 | Janssen Pharmaceutica Nv | Vermicidal control for epizoons |
| JPH09169644A (ja) * | 1995-09-29 | 1997-06-30 | Rhone Merieux | ペット寄生虫の治療・予防用組成物 |
| JPH11508276A (ja) * | 1996-03-29 | 1999-07-21 | メリアル | 哺乳動物、特に犬猫のノミを防除するための殺虫剤の組合せ |
| JP2001503390A (ja) * | 1996-09-19 | 2001-03-13 | メリアル | 殺寄生虫薬の新規な組み合せ |
| WO2002010153A1 (en) * | 2000-07-31 | 2002-02-07 | Nihon Nohyaku Co., Ltd. | Pyrazole derivatives, pest controllers containing the same as the active ingredient and process for their production |
| JP2004143172A (ja) * | 2002-10-21 | 2004-05-20 | Wyeth | 恒温動物における外部寄生虫を調節するためのニューロンナトリウムチャネルアンタゴニストの使用 |
| JP2004525188A (ja) * | 2001-04-09 | 2004-08-19 | バイエル アクチェンゲゼルシャフト | 動物の寄生虫を抑制するための皮膚に施用する液体組成物 |
| WO2005058038A1 (en) * | 2003-12-17 | 2005-06-30 | Merial Limited | Topical formulations comprising a 1-n-arylpyrazole derivative and a formamidine |
| WO2006042099A1 (en) * | 2004-10-08 | 2006-04-20 | Wyeth | Amitraz compositions |
| WO2006127399A2 (en) * | 2005-05-24 | 2006-11-30 | Wyeth | Versatile high load concentrate compositions comprising metaflumizone for control of ecto-parasites |
| WO2006127487A1 (en) * | 2005-05-24 | 2006-11-30 | Wyeth | Useful high load concentrate compositions for control of ecto-and endo-parasites |
| WO2006127406A2 (en) * | 2005-05-24 | 2006-11-30 | Wyeth | Gel compositions for control of ecto-parasites |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560553A (en) * | 1981-07-07 | 1985-12-24 | Merck & Co., Inc. | Use of eucalyptol for enhancing skin permeation of bio-affecting agents |
| GB8525447D0 (en) * | 1985-10-16 | 1985-11-20 | Fbc Ltd | Pesticidal compositions |
| US5116850A (en) * | 1987-11-30 | 1992-05-26 | E. I. Du Pont De Nemours And Co. | Heterocyclic pyrazoline carboxanilides |
| DE69119301T2 (de) * | 1990-06-16 | 1996-10-17 | Nihon Nohyaku Co Ltd | Hydrazincarboxamidderivate, Verfahren für ihre Herstellung und ihre Verwendung |
| EP0486937B1 (en) * | 1990-11-17 | 1995-03-22 | Nihon Nohyaku Co., Ltd. | Hydrazone derivatives, processes for production thereof, and uses thereof |
| US5462938A (en) * | 1990-12-21 | 1995-10-31 | Annus; Gary D. | Arthropodicidal oxadiazinyl, thiadiazinyl and triazinyl carboxanilides |
| US5250532A (en) * | 1991-04-11 | 1993-10-05 | Dowelanco | 3,4,N-trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides |
| DE4417742A1 (de) * | 1994-05-20 | 1995-11-23 | Bayer Ag | Nicht-systemische Bekämpfung von Parasiten |
| IE970215A1 (en) * | 1996-03-29 | 1997-10-08 | Rhone Merieux | Direct pour-on skin solution for antiparasitic use in cattle¹and sheep |
| US5968990A (en) * | 1997-10-14 | 1999-10-19 | Isp Investments Inc. | Water-dilutable, microemulsion concentrate and pour-on formulations thereof |
| US5965137A (en) * | 1998-11-16 | 1999-10-12 | Advanced Medical Instruments | Insect repellent composition and method for inhibiting the transmission and treatment of symptoms of vector-borne diseases |
| AUPQ441699A0 (en) * | 1999-12-02 | 2000-01-06 | Eli Lilly And Company | Pour-on formulations |
| US20040122075A1 (en) * | 2002-12-16 | 2004-06-24 | Wyeth | N-phenyl-3-cyclopropylpyrazole-4-carbonitriles as ectoparasiticidal agents |
| US20080112993A1 (en) * | 2005-05-24 | 2008-05-15 | Wyeth | High-dose, long-lasting ectoparasiticide for extended control |
| DE102006061537A1 (de) * | 2006-12-27 | 2008-07-03 | Bayer Healthcare Ag | Mittel zur Bekämpfung von Parasiten an Tieren |
-
2008
- 2008-02-05 TW TW097104678A patent/TW200846029A/zh unknown
- 2008-02-07 CL CL200800401A patent/CL2008000401A1/es unknown
- 2008-02-08 EP EP08729387A patent/EP2120583A2/en not_active Withdrawn
- 2008-02-08 AR ARP080100548A patent/AR065265A1/es not_active Application Discontinuation
- 2008-02-08 BR BRPI0807233-7A patent/BRPI0807233A2/pt not_active Application Discontinuation
- 2008-02-08 WO PCT/US2008/053416 patent/WO2008098168A2/en not_active Ceased
- 2008-02-08 KR KR1020097018784A patent/KR20090118961A/ko not_active Withdrawn
- 2008-02-08 MX MX2009008411A patent/MX2009008411A/es not_active Application Discontinuation
- 2008-02-08 AU AU2008213566A patent/AU2008213566A1/en not_active Abandoned
- 2008-02-08 EA EA200970749A patent/EA200970749A1/ru unknown
- 2008-02-08 US US12/028,219 patent/US20080194642A1/en not_active Abandoned
- 2008-02-08 JP JP2009549256A patent/JP2010518118A/ja active Pending
- 2008-02-08 CA CA002676832A patent/CA2676832A1/en not_active Abandoned
-
2009
- 2009-08-05 CO CO09081847A patent/CO6210774A2/es not_active Application Discontinuation
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57165306A (en) * | 1981-03-16 | 1982-10-12 | Janssen Pharmaceutica Nv | Vermicidal control for epizoons |
| JPH09169644A (ja) * | 1995-09-29 | 1997-06-30 | Rhone Merieux | ペット寄生虫の治療・予防用組成物 |
| JPH11508276A (ja) * | 1996-03-29 | 1999-07-21 | メリアル | 哺乳動物、特に犬猫のノミを防除するための殺虫剤の組合せ |
| JP2001503390A (ja) * | 1996-09-19 | 2001-03-13 | メリアル | 殺寄生虫薬の新規な組み合せ |
| WO2002010153A1 (en) * | 2000-07-31 | 2002-02-07 | Nihon Nohyaku Co., Ltd. | Pyrazole derivatives, pest controllers containing the same as the active ingredient and process for their production |
| JP2004525188A (ja) * | 2001-04-09 | 2004-08-19 | バイエル アクチェンゲゼルシャフト | 動物の寄生虫を抑制するための皮膚に施用する液体組成物 |
| JP2004143172A (ja) * | 2002-10-21 | 2004-05-20 | Wyeth | 恒温動物における外部寄生虫を調節するためのニューロンナトリウムチャネルアンタゴニストの使用 |
| WO2005058038A1 (en) * | 2003-12-17 | 2005-06-30 | Merial Limited | Topical formulations comprising a 1-n-arylpyrazole derivative and a formamidine |
| WO2006042099A1 (en) * | 2004-10-08 | 2006-04-20 | Wyeth | Amitraz compositions |
| WO2006127399A2 (en) * | 2005-05-24 | 2006-11-30 | Wyeth | Versatile high load concentrate compositions comprising metaflumizone for control of ecto-parasites |
| WO2006127487A1 (en) * | 2005-05-24 | 2006-11-30 | Wyeth | Useful high load concentrate compositions for control of ecto-and endo-parasites |
| WO2006127406A2 (en) * | 2005-05-24 | 2006-11-30 | Wyeth | Gel compositions for control of ecto-parasites |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016536272A (ja) * | 2013-09-30 | 2016-11-24 | ゾエティス・サービシーズ・エルエルシー | 長時間作用型スピロイソキサゾリン製剤 |
| JP2019504873A (ja) * | 2015-11-09 | 2019-02-21 | メリアル インコーポレイテッド | ペットケアクレンジング組成物 |
| JP2020500914A (ja) * | 2016-12-12 | 2020-01-16 | コントラクト ファーマシューティカルズ リミテッド | ピレスロイドスプレー製剤およびそれを使用する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CO6210774A2 (es) | 2010-10-20 |
| CA2676832A1 (en) | 2008-08-14 |
| WO2008098168A2 (en) | 2008-08-14 |
| CL2008000401A1 (es) | 2008-04-25 |
| KR20090118961A (ko) | 2009-11-18 |
| BRPI0807233A2 (pt) | 2014-05-06 |
| AU2008213566A1 (en) | 2008-08-14 |
| US20080194642A1 (en) | 2008-08-14 |
| TW200846029A (en) | 2008-12-01 |
| EA200970749A1 (ru) | 2010-02-26 |
| AR065265A1 (es) | 2009-05-27 |
| EP2120583A2 (en) | 2009-11-25 |
| MX2009008411A (es) | 2009-08-13 |
| WO2008098168A3 (en) | 2009-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010518118A (ja) | 長期防除のための高用量長時間作用型の外部寄生生物駆除剤 | |
| AU2005294257B2 (en) | Amitraz compositions | |
| EP2398318B1 (en) | Improved-scent ectoparasiticidal formulation | |
| AU2008259807B2 (en) | Stable non-aqueous pour-on compositions | |
| WO2006127399A2 (en) | Versatile high load concentrate compositions comprising metaflumizone for control of ecto-parasites | |
| US20080112993A1 (en) | High-dose, long-lasting ectoparasiticide for extended control | |
| CN101605458A (zh) | 用于延长控制的高剂量、长效性杀体外寄生虫药 | |
| CN100566566C (zh) | 三亚螨（amitraz）组合物 | |
| HK1134889A (en) | High-dose, long-acting ectoparasiticide for extended control | |
| AU2012200929A1 (en) | High-dose, long-acting ectoparasiticide for extended control | |
| HK1162857A (en) | Improved-scent ectoparasiticidal formulation | |
| HK1136944A (en) | Stable non-aqueous pour-on compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110120 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110120 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111214 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20130410 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130415 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130926 |