JP2010516517A5 - - Google Patents
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- Publication number
- JP2010516517A5 JP2010516517A5 JP2009547433A JP2009547433A JP2010516517A5 JP 2010516517 A5 JP2010516517 A5 JP 2010516517A5 JP 2009547433 A JP2009547433 A JP 2009547433A JP 2009547433 A JP2009547433 A JP 2009547433A JP 2010516517 A5 JP2010516517 A5 JP 2010516517A5
- Authority
- JP
- Japan
- Prior art keywords
- polymeric material
- antioxidant
- oxidation
- resistant
- medical filler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 44
- 239000000463 material Substances 0.000 claims 32
- 239000003963 antioxidant agent Substances 0.000 claims 25
- 235000006708 antioxidants Nutrition 0.000 claims 25
- 230000003078 antioxidant effect Effects 0.000 claims 23
- 239000000945 filler Substances 0.000 claims 23
- 230000003647 oxidation Effects 0.000 claims 22
- 238000007254 oxidation reaction Methods 0.000 claims 22
- 239000000843 powder Substances 0.000 claims 8
- 239000002904 solvent Substances 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 7
- -1 flakes Substances 0.000 claims 7
- 230000005865 ionizing radiation Effects 0.000 claims 6
- 229920005989 resin Polymers 0.000 claims 6
- 239000011347 resin Substances 0.000 claims 6
- 238000009826 distribution Methods 0.000 claims 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 238000004132 cross linking Methods 0.000 claims 4
- 239000007789 gas Substances 0.000 claims 4
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000005855 radiation Effects 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical group CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- 229910052786 argon Inorganic materials 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 230000001678 irradiating effect Effects 0.000 claims 2
- 210000003127 knee Anatomy 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229920000098 polyolefin Polymers 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- 241001653121 Glenoides Species 0.000 claims 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical group CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920010741 Ultra High Molecular Weight Polyethylene (UHMWPE) Polymers 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 238000000748 compression moulding Methods 0.000 claims 1
- 210000002310 elbow joint Anatomy 0.000 claims 1
- 238000010894 electron beam technology Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 210000001145 finger joint Anatomy 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 239000001307 helium Substances 0.000 claims 1
- 229910052734 helium Inorganic materials 0.000 claims 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims 1
- 229920001903 high density polyethylene Polymers 0.000 claims 1
- 239000004700 high-density polyethylene Substances 0.000 claims 1
- 210000001624 hip Anatomy 0.000 claims 1
- 210000004394 hip joint Anatomy 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000001503 joint Anatomy 0.000 claims 1
- 229920000092 linear low density polyethylene Polymers 0.000 claims 1
- 239000004707 linear low-density polyethylene Substances 0.000 claims 1
- 229920001684 low density polyethylene Polymers 0.000 claims 1
- 239000004702 low-density polyethylene Substances 0.000 claims 1
- 238000003754 machining Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 229910052754 neon Inorganic materials 0.000 claims 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000004417 patella Anatomy 0.000 claims 1
- 229920001643 poly(ether ketone) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000002952 polymeric resin Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 230000003014 reinforcing effect Effects 0.000 claims 1
- 229920003002 synthetic resin Polymers 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 210000002303 tibia Anatomy 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 210000001226 toe joint Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 210000003857 wrist joint Anatomy 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
- 125000001020 α-tocopherol group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88652707P | 2007-01-25 | 2007-01-25 | |
| US60/886,527 | 2007-01-25 | ||
| US88903707P | 2007-02-09 | 2007-02-09 | |
| US60/889,037 | 2007-02-09 | ||
| US89234607P | 2007-03-01 | 2007-03-01 | |
| US60/892,346 | 2007-03-01 | ||
| PCT/US2008/051982 WO2008092047A1 (en) | 2007-01-25 | 2008-01-25 | Methods for making oxidation-resistant cross-linked polymeric materials |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516517A JP2010516517A (ja) | 2010-05-20 |
| JP2010516517A5 true JP2010516517A5 (cg-RX-API-DMAC7.html) | 2011-03-17 |
| JP5535650B2 JP5535650B2 (ja) | 2014-07-02 |
Family
ID=39644889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547433A Expired - Fee Related JP5535650B2 (ja) | 2007-01-25 | 2008-01-25 | 耐酸化性架橋重合体状材料の製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8293811B2 (cg-RX-API-DMAC7.html) |
| EP (4) | EP2456283B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5535650B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE555636T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008207807B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2674955C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2385317T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008092047A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005074619A2 (en) * | 2004-02-03 | 2005-08-18 | Massachusetts General Hospital | Highly crystalline cross-linked oxidation-resistant polyethylene |
| EP2277561B1 (en) | 2005-08-18 | 2012-09-19 | Zimmer GmbH | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| JP5535650B2 (ja) | 2007-01-25 | 2014-07-02 | ザ・ジェネラル・ホスピタル・コーポレイション | 耐酸化性架橋重合体状材料の製造方法 |
| WO2008101134A1 (en) * | 2007-02-14 | 2008-08-21 | Brigham And Women's Hospital, Inc. | Crosslinked polymers and methods of making the same |
| JP2010529213A (ja) * | 2007-03-02 | 2010-08-26 | ザ・ジェネラル・ホスピタル・コーポレイション | 酸化防止剤含有ポリマーの架橋 |
| ATE544476T1 (de) | 2007-04-10 | 2012-02-15 | Zimmer Inc | Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten |
| US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| CA2712559C (en) | 2008-01-30 | 2015-03-31 | Zimmer, Inc. | Orthopedic component of low stiffness |
| KR20110052571A (ko) | 2008-06-13 | 2011-05-18 | 마이클 제이. 파렐라 | 전기를 생산하기 위하여 천공된 유정 내에서 지열을 포착하는 시스템 및 방법 |
| JP5311457B2 (ja) * | 2008-06-20 | 2013-10-09 | ナカシマメディカル株式会社 | 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材 |
| US9423158B2 (en) | 2008-08-05 | 2016-08-23 | Michael J. Parrella | System and method of maximizing heat transfer at the bottom of a well using heat conductive components and a predictive model |
| US20100270001A1 (en) * | 2008-08-05 | 2010-10-28 | Parrella Michael J | System and method of maximizing grout heat conductibility and increasing caustic resistance |
| EP2346941A1 (en) | 2008-11-20 | 2011-07-27 | Zimmer GmbH | Polyethylene materials |
| US8933145B2 (en) | 2009-02-20 | 2015-01-13 | The General Hospital Corporation | High temperature melting |
| JP5902083B2 (ja) * | 2009-05-04 | 2016-04-13 | スミス アンド ネフュー インコーポレーテッド | Ｕｈｍｗｐｅにおける複数の添加剤のブレンドによる相乗効果 |
| GB0922339D0 (en) | 2009-12-21 | 2010-02-03 | Mcminn Derek J W | Acetabular cup prothesis and introducer thereof |
| JP2011173979A (ja) * | 2010-02-24 | 2011-09-08 | Nakashima Medical Co Ltd | 超高分子量ポリエチレンの成形品 |
| JP5765797B2 (ja) * | 2010-02-24 | 2015-08-19 | ナカシマメディカル株式会社 | 超高分子量ポリエチレンの成形品 |
| US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
| US8966868B2 (en) * | 2011-05-09 | 2015-03-03 | Abbott Cardiovascular Systems Inc. | Methods of stabilizing molecular weight of polymer stents after sterilization |
| EP2731522B1 (en) | 2011-07-13 | 2017-11-15 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Devices for knee joint replacement with anterior cruciate ligament substitution |
| US20160215117A1 (en) * | 2012-04-04 | 2016-07-28 | Mitral Tech Ltd. | Peroxide cross-linking of polymeric materials in the presence of antioxidants |
| WO2013170005A1 (en) * | 2012-05-11 | 2013-11-14 | The General Hospital Corporation | Antioxidant-stabilized joint implants |
| US9889224B2 (en) * | 2012-08-06 | 2018-02-13 | The General Hospital Corporation | Spatial control of additives by high temperature |
| AU2013323337B2 (en) | 2012-09-27 | 2018-02-15 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants |
| EP3052562B1 (en) | 2013-10-01 | 2017-11-08 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
| EP3058017A4 (en) | 2013-10-17 | 2017-10-04 | The General Hospital Corporation | Peroxide cross-linking and high temperature melting |
| WO2015138137A1 (en) * | 2014-03-12 | 2015-09-17 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
| US10265891B2 (en) | 2014-12-03 | 2019-04-23 | Zimmer, Inc. | Antioxidant-infused ultra high molecular weight polyethylene |
| JP2016173328A (ja) * | 2015-03-17 | 2016-09-29 | 日本ポリプロ株式会社 | ポリオレフィン中に含まれる添加剤の定量分析方法 |
| WO2017083476A1 (en) | 2015-11-12 | 2017-05-18 | The General Hospital Corporation | Methods of making therapeutic polymeric material |
| AU2017214566A1 (en) | 2016-02-05 | 2018-08-23 | The General Hospital Corporation | Drug eluting polymer composed of biodegradable polymers applied to surface of medical device |
| WO2017192347A1 (en) | 2016-05-02 | 2017-11-09 | The General Hospital Corporation | Implant surfaces for pain control |
| DE102016110500B4 (de) * | 2016-06-07 | 2019-03-14 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Implantatherstellverfahren mittels additivem selektivem Lasersintern und Implantat |
| WO2019046243A2 (en) | 2017-08-29 | 2019-03-07 | The General Hospital Corporation | UV-INITIATED REACTIONS IN POLYMERIC MATERIALS |
| US11376128B2 (en) | 2018-12-31 | 2022-07-05 | Depuy Ireland Unlimited Company | Acetabular orthopaedic prosthesis and method |
| US12171666B2 (en) | 2019-12-10 | 2024-12-24 | Depuy Ireland Unlimited Company | Metal reinforced acetabular shell liner |
| US11628066B2 (en) | 2019-12-11 | 2023-04-18 | Depuy Ireland Unlimited Company | Ceramic acetabular shell liner with a metal ring having a lead-in surface |
| US11291549B2 (en) | 2019-12-11 | 2022-04-05 | Depuy Ireland Unlimited Company | Ceramic acetabular shell liners with augments |
| US11952439B2 (en) * | 2020-06-25 | 2024-04-09 | b-ONE Medical (Suzhou) Co., Ltd. | Surface gradient cross-linking method of ultra-high molecular weight polyethylene and the application thereof |
| EP4171220A1 (en) | 2020-06-30 | 2023-05-03 | Texas Tech University System | Method and apparatus for collection of fluid samples |
| US11970600B2 (en) | 2021-03-31 | 2024-04-30 | The General Hospital Corporation | Di-cumyl peroxide crosslinking of UHMWPE |
| US12042389B2 (en) | 2021-04-30 | 2024-07-23 | Depuy Ireland Unlimited Company | Apparatus and method for installing an acetabular liner on an acetabular cup |
| US12376964B2 (en) | 2021-04-30 | 2025-08-05 | Depuy Ireland Unlimited Company | Apparatus and method for locking an acetabular liner to an acetabular cup |
| CN114292431A (zh) * | 2021-11-22 | 2022-04-08 | 苏州微创关节医疗科技有限公司 | 超高分子量聚乙烯植入体及其制备方法和关节假体 |
| WO2023201037A2 (en) * | 2022-04-15 | 2023-10-19 | Anuj Bellare | Methods for inducing crystallization in crystallizable polymers, and articles therefrom |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3011505A (en) | 1957-02-08 | 1961-12-05 | Askania Regulator Co | Ejector for use in a jet-type hydraulic relay regulator |
| US3879400A (en) | 1973-11-16 | 1975-04-22 | Upjohn Co | 1-Lower alkyl-(1-adamantylmethyl)piperidines and process for their preparation |
| US4880696A (en) * | 1988-06-27 | 1989-11-14 | James River Ii, Inc. | Flexible packaging material containing an antioxidant |
| US5055328A (en) * | 1989-06-16 | 1991-10-08 | Viskase Corporation | Differentially cross-linked multilayer film |
| US5414049A (en) * | 1993-06-01 | 1995-05-09 | Howmedica Inc. | Non-oxidizing polymeric medical implant |
| EP0863775B1 (en) * | 1995-08-11 | 2000-10-18 | Smith & Nephew PLC | Adhesives |
| US5879400A (en) | 1996-02-13 | 1999-03-09 | Massachusetts Institute Of Technology | Melt-irradiated ultra high molecular weight polyethylene prosthetic devices |
| RU2211008C2 (ru) * | 1996-02-13 | 2003-08-27 | Массачусетс Институт Оф Текнолоджи | Протезные устройства из полиэтилена сверхвысокой молекулярной массы, обработанного облучением и плавлением |
| US5753182A (en) * | 1996-02-14 | 1998-05-19 | Biomet, Inc. | Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components |
| US6228900B1 (en) * | 1996-07-09 | 2001-05-08 | The Orthopaedic Hospital And University Of Southern California | Crosslinking of polyethylene for low wear using radiation and thermal treatments |
| US5827904A (en) | 1996-09-27 | 1998-10-27 | Hahn; David | Medical implant composition |
| US6017975A (en) * | 1996-10-02 | 2000-01-25 | Saum; Kenneth Ashley | Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance |
| FR2762428B1 (fr) | 1997-04-16 | 1999-06-11 | Schlumberger Ind Sa | Dispositif de visualisation d'un message sur un distributeur de carburant |
| JP4315261B2 (ja) * | 1998-02-25 | 2009-08-19 | ナカシマメディカル株式会社 | 人工関節用摺動部材および製造方法 |
| US6692679B1 (en) * | 1998-06-10 | 2004-02-17 | Depuy Orthopaedics, Inc. | Cross-linked molded plastic bearings |
| EP0995449A1 (de) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-Polyethylen für Implantate |
| SE9900519D0 (sv) * | 1999-02-17 | 1999-02-17 | Lars Lidgren | A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof |
| US6620198B2 (en) * | 1999-10-07 | 2003-09-16 | Exactech, Inc. | Composite bearing inserts for total knee joints |
| AU6108301A (en) * | 2000-04-27 | 2001-11-07 | Orthopaedic Hospital | Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them |
| US6818172B2 (en) * | 2000-09-29 | 2004-11-16 | Depuy Products, Inc. | Oriented, cross-linked UHMWPE molding for orthopaedic applications |
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| JP3548169B2 (ja) | 2001-12-11 | 2004-07-28 | 住友ゴム工業株式会社 | 空気入りタイヤ |
| EP2671538A1 (en) | 2003-01-16 | 2013-12-11 | Massachusetts General Hospital | Methods For Making Oxidation Resistant Polymeric Material |
| JP2004348118A (ja) | 2003-04-30 | 2004-12-09 | Toshiba Corp | フォトマスク及びそれを用いた露光方法、データ発生方法 |
| AT412969B (de) * | 2003-05-19 | 2005-09-26 | Klaus Dr Lederer | Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe) |
| ATE353042T1 (de) | 2003-10-14 | 2007-02-15 | Saab Ab | Verfahren zur herstellung einer verbundstruktur |
| US7833452B2 (en) * | 2004-05-11 | 2010-11-16 | The General Hospital Corporation | Method for making oxidation resistant polymeric material |
| JP4913370B2 (ja) * | 2005-06-28 | 2012-04-11 | 株式会社アクトメント | 医療材料及びその製造方法 |
| EP2277561B1 (en) * | 2005-08-18 | 2012-09-19 | Zimmer GmbH | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| JP5535650B2 (ja) | 2007-01-25 | 2014-07-02 | ザ・ジェネラル・ホスピタル・コーポレイション | 耐酸化性架橋重合体状材料の製造方法 |
| JP2010529213A (ja) * | 2007-03-02 | 2010-08-26 | ザ・ジェネラル・ホスピタル・コーポレイション | 酸化防止剤含有ポリマーの架橋 |
| US8641959B2 (en) * | 2007-07-27 | 2014-02-04 | Biomet Manufacturing, Llc | Antioxidant doping of crosslinked polymers to form non-eluting bearing components |
| US8872847B2 (en) | 2008-08-28 | 2014-10-28 | Google Inc. | Architectures and methods for creating and representing time-dependent imagery |
| US8933145B2 (en) * | 2009-02-20 | 2015-01-13 | The General Hospital Corporation | High temperature melting |
| WO2013126592A2 (en) | 2012-02-21 | 2013-08-29 | Cameron International Corporation | Well tree hub and interface for retrievable processing modules |
-
2008
- 2008-01-25 JP JP2009547433A patent/JP5535650B2/ja not_active Expired - Fee Related
- 2008-01-25 EP EP11007297.2A patent/EP2456283B1/en not_active Not-in-force
- 2008-01-25 AT AT08728244T patent/ATE555636T1/de active
- 2008-01-25 EP EP15200276.2A patent/EP3037442A1/en not_active Withdrawn
- 2008-01-25 US US12/522,728 patent/US8293811B2/en active Active
- 2008-01-25 AU AU2008207807A patent/AU2008207807B2/en not_active Ceased
- 2008-01-25 EP EP08728244A patent/EP2110002B1/en not_active Not-in-force
- 2008-01-25 WO PCT/US2008/051982 patent/WO2008092047A1/en not_active Ceased
- 2008-01-25 ES ES08728244T patent/ES2385317T3/es active Active
- 2008-01-25 CA CA2674955A patent/CA2674955C/en not_active Expired - Fee Related
- 2008-01-25 EP EP12150677A patent/EP2464195A1/en not_active Withdrawn
-
2012
- 2012-07-31 US US13/562,867 patent/US8569395B2/en not_active Expired - Fee Related
-
2013
- 2013-09-25 US US14/036,586 patent/US9433705B2/en not_active Expired - Fee Related
-
2016
- 2016-06-24 US US15/191,857 patent/US9968709B2/en not_active Expired - Fee Related
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