ES2385317T3 - Método para la preparación de materiales poliméricos reticulados resistentes a la oxidación - Google Patents

Método para la preparación de materiales poliméricos reticulados resistentes a la oxidación Download PDF

Info

Publication number
ES2385317T3
ES2385317T3 ES08728244T ES08728244T ES2385317T3 ES 2385317 T3 ES2385317 T3 ES 2385317T3 ES 08728244 T ES08728244 T ES 08728244T ES 08728244 T ES08728244 T ES 08728244T ES 2385317 T3 ES2385317 T3 ES 2385317T3
Authority
ES
Spain
Prior art keywords
vitamin
uhmwpe
tocopherol
polymeric material
antioxidant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08728244T
Other languages
English (en)
Spanish (es)
Inventor
Orhun K. Muratoglu
Edward T. Kopesky
Ebru Oral
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Cambridge Polymer Group Inc
Original Assignee
General Hospital Corp
Cambridge Polymer Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Cambridge Polymer Group Inc filed Critical General Hospital Corp
Application granted granted Critical
Publication of ES2385317T3 publication Critical patent/ES2385317T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F10/02—Ethene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/003—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/02—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles
    • B29C43/18—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
    • B29C71/04—After-treatment of articles without altering their shape; Apparatus therefor by wave energy or particle radiation, e.g. for curing or vulcanising preformed articles
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04—Polymers of ethylene
    • B29K2023/06—PE, i.e. polyethylene
    • B29K2023/0658—PE, i.e. polyethylene characterised by its molecular weight
    • B29K2023/0683—UHMWPE, i.e. ultra high molecular weight polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/06—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts
    • B29K2105/20—Inserts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F110/00—Homopolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F110/02—Ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/012—Additives improving oxygen scavenging properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
  • Heating, Cooling, Or Curing Plastics Or The Like In General (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
ES08728244T 2007-01-25 2008-01-25 Método para la preparación de materiales poliméricos reticulados resistentes a la oxidación Active ES2385317T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US88652707P 2007-01-25 2007-01-25
US886527P 2007-01-25
US88903707P 2007-02-09 2007-02-09
US889037P 2007-02-09
US89234607P 2007-03-01 2007-03-01
US892346P 2007-03-01
PCT/US2008/051982 WO2008092047A1 (en) 2007-01-25 2008-01-25 Methods for making oxidation-resistant cross-linked polymeric materials

Publications (1)

Publication Number Publication Date
ES2385317T3 true ES2385317T3 (es) 2012-07-23

Family

ID=39644889

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08728244T Active ES2385317T3 (es) 2007-01-25 2008-01-25 Método para la preparación de materiales poliméricos reticulados resistentes a la oxidación

Country Status (8)

Country Link
US (4) US8293811B2 (cg-RX-API-DMAC7.html)
EP (4) EP2456283B1 (cg-RX-API-DMAC7.html)
JP (1) JP5535650B2 (cg-RX-API-DMAC7.html)
AT (1) ATE555636T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008207807B2 (cg-RX-API-DMAC7.html)
CA (1) CA2674955C (cg-RX-API-DMAC7.html)
ES (1) ES2385317T3 (cg-RX-API-DMAC7.html)
WO (1) WO2008092047A1 (cg-RX-API-DMAC7.html)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005074619A2 (en) * 2004-02-03 2005-08-18 Massachusetts General Hospital Highly crystalline cross-linked oxidation-resistant polyethylene
EP2277561B1 (en) 2005-08-18 2012-09-19 Zimmer GmbH Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
JP5535650B2 (ja) 2007-01-25 2014-07-02 ザ・ジェネラル・ホスピタル・コーポレイション 耐酸化性架橋重合体状材料の製造方法
WO2008101134A1 (en) * 2007-02-14 2008-08-21 Brigham And Women's Hospital, Inc. Crosslinked polymers and methods of making the same
JP2010529213A (ja) * 2007-03-02 2010-08-26 ザ・ジェネラル・ホスピタル・コーポレイション 酸化防止剤含有ポリマーの架橋
ATE544476T1 (de) 2007-04-10 2012-02-15 Zimmer Inc Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
CA2712559C (en) 2008-01-30 2015-03-31 Zimmer, Inc. Orthopedic component of low stiffness
KR20110052571A (ko) 2008-06-13 2011-05-18 마이클 제이. 파렐라 전기를 생산하기 위하여 천공된 유정 내에서 지열을 포착하는 시스템 및 방법
JP5311457B2 (ja) * 2008-06-20 2013-10-09 ナカシマメディカル株式会社 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材
US9423158B2 (en) 2008-08-05 2016-08-23 Michael J. Parrella System and method of maximizing heat transfer at the bottom of a well using heat conductive components and a predictive model
US20100270001A1 (en) * 2008-08-05 2010-10-28 Parrella Michael J System and method of maximizing grout heat conductibility and increasing caustic resistance
EP2346941A1 (en) 2008-11-20 2011-07-27 Zimmer GmbH Polyethylene materials
US8933145B2 (en) 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
JP5902083B2 (ja) * 2009-05-04 2016-04-13 スミス アンド ネフュー インコーポレーテッド Ｕｈｍｗｐｅにおける複数の添加剤のブレンドによる相乗効果
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
JP2011173979A (ja) * 2010-02-24 2011-09-08 Nakashima Medical Co Ltd 超高分子量ポリエチレンの成形品
JP5765797B2 (ja) * 2010-02-24 2015-08-19 ナカシマメディカル株式会社 超高分子量ポリエチレンの成形品
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
US8966868B2 (en) * 2011-05-09 2015-03-03 Abbott Cardiovascular Systems Inc. Methods of stabilizing molecular weight of polymer stents after sterilization
EP2731522B1 (en) 2011-07-13 2017-11-15 The General Hospital Corporation d/b/a Massachusetts General Hospital Devices for knee joint replacement with anterior cruciate ligament substitution
US20160215117A1 (en) * 2012-04-04 2016-07-28 Mitral Tech Ltd. Peroxide cross-linking of polymeric materials in the presence of antioxidants
WO2013170005A1 (en) * 2012-05-11 2013-11-14 The General Hospital Corporation Antioxidant-stabilized joint implants
US9889224B2 (en) * 2012-08-06 2018-02-13 The General Hospital Corporation Spatial control of additives by high temperature
AU2013323337B2 (en) 2012-09-27 2018-02-15 The General Hospital Corporation D/B/A Massachusetts General Hospital Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants
EP3052562B1 (en) 2013-10-01 2017-11-08 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
EP3058017A4 (en) 2013-10-17 2017-10-04 The General Hospital Corporation Peroxide cross-linking and high temperature melting
WO2015138137A1 (en) * 2014-03-12 2015-09-17 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US10265891B2 (en) 2014-12-03 2019-04-23 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
JP2016173328A (ja) * 2015-03-17 2016-09-29 日本ポリプロ株式会社 ポリオレフィン中に含まれる添加剤の定量分析方法
WO2017083476A1 (en) 2015-11-12 2017-05-18 The General Hospital Corporation Methods of making therapeutic polymeric material
AU2017214566A1 (en) 2016-02-05 2018-08-23 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
WO2017192347A1 (en) 2016-05-02 2017-11-09 The General Hospital Corporation Implant surfaces for pain control
DE102016110500B4 (de) * 2016-06-07 2019-03-14 Karl Leibinger Medizintechnik Gmbh & Co. Kg Implantatherstellverfahren mittels additivem selektivem Lasersintern und Implantat
WO2019046243A2 (en) 2017-08-29 2019-03-07 The General Hospital Corporation UV-INITIATED REACTIONS IN POLYMERIC MATERIALS
US11376128B2 (en) 2018-12-31 2022-07-05 Depuy Ireland Unlimited Company Acetabular orthopaedic prosthesis and method
US12171666B2 (en) 2019-12-10 2024-12-24 Depuy Ireland Unlimited Company Metal reinforced acetabular shell liner
US11628066B2 (en) 2019-12-11 2023-04-18 Depuy Ireland Unlimited Company Ceramic acetabular shell liner with a metal ring having a lead-in surface
US11291549B2 (en) 2019-12-11 2022-04-05 Depuy Ireland Unlimited Company Ceramic acetabular shell liners with augments
US11952439B2 (en) * 2020-06-25 2024-04-09 b-ONE Medical (Suzhou) Co., Ltd. Surface gradient cross-linking method of ultra-high molecular weight polyethylene and the application thereof
EP4171220A1 (en) 2020-06-30 2023-05-03 Texas Tech University System Method and apparatus for collection of fluid samples
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE
US12042389B2 (en) 2021-04-30 2024-07-23 Depuy Ireland Unlimited Company Apparatus and method for installing an acetabular liner on an acetabular cup
US12376964B2 (en) 2021-04-30 2025-08-05 Depuy Ireland Unlimited Company Apparatus and method for locking an acetabular liner to an acetabular cup
CN114292431A (zh) * 2021-11-22 2022-04-08 苏州微创关节医疗科技有限公司 超高分子量聚乙烯植入体及其制备方法和关节假体
WO2023201037A2 (en) * 2022-04-15 2023-10-19 Anuj Bellare Methods for inducing crystallization in crystallizable polymers, and articles therefrom

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3011505A (en) 1957-02-08 1961-12-05 Askania Regulator Co Ejector for use in a jet-type hydraulic relay regulator
US3879400A (en) 1973-11-16 1975-04-22 Upjohn Co 1-Lower alkyl-(1-adamantylmethyl)piperidines and process for their preparation
US4880696A (en) * 1988-06-27 1989-11-14 James River Ii, Inc. Flexible packaging material containing an antioxidant
US5055328A (en) * 1989-06-16 1991-10-08 Viskase Corporation Differentially cross-linked multilayer film
US5414049A (en) * 1993-06-01 1995-05-09 Howmedica Inc. Non-oxidizing polymeric medical implant
EP0863775B1 (en) * 1995-08-11 2000-10-18 Smith & Nephew PLC Adhesives
US5879400A (en) 1996-02-13 1999-03-09 Massachusetts Institute Of Technology Melt-irradiated ultra high molecular weight polyethylene prosthetic devices
RU2211008C2 (ru) * 1996-02-13 2003-08-27 Массачусетс Институт Оф Текнолоджи Протезные устройства из полиэтилена сверхвысокой молекулярной массы, обработанного облучением и плавлением
US5753182A (en) * 1996-02-14 1998-05-19 Biomet, Inc. Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components
US6228900B1 (en) * 1996-07-09 2001-05-08 The Orthopaedic Hospital And University Of Southern California Crosslinking of polyethylene for low wear using radiation and thermal treatments
US5827904A (en) 1996-09-27 1998-10-27 Hahn; David Medical implant composition
US6017975A (en) * 1996-10-02 2000-01-25 Saum; Kenneth Ashley Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
FR2762428B1 (fr) 1997-04-16 1999-06-11 Schlumberger Ind Sa Dispositif de visualisation d'un message sur un distributeur de carburant
JP4315261B2 (ja) * 1998-02-25 2009-08-19 ナカシマメディカル株式会社 人工関節用摺動部材および製造方法
US6692679B1 (en) * 1998-06-10 2004-02-17 Depuy Orthopaedics, Inc. Cross-linked molded plastic bearings
EP0995449A1 (de) * 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate
SE9900519D0 (sv) * 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
US6620198B2 (en) * 1999-10-07 2003-09-16 Exactech, Inc. Composite bearing inserts for total knee joints
AU6108301A (en) * 2000-04-27 2001-11-07 Orthopaedic Hospital Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them
US6818172B2 (en) * 2000-09-29 2004-11-16 Depuy Products, Inc. Oriented, cross-linked UHMWPE molding for orthopaedic applications
WO2002026464A1 (en) 2000-09-29 2002-04-04 Depuy Orthopaedics, Inc. Supercritical fluid treatment of irradiated polyethylene
JP3548169B2 (ja) 2001-12-11 2004-07-28 住友ゴム工業株式会社 空気入りタイヤ
EP2671538A1 (en) 2003-01-16 2013-12-11 Massachusetts General Hospital Methods For Making Oxidation Resistant Polymeric Material
JP2004348118A (ja) 2003-04-30 2004-12-09 Toshiba Corp フォトマスク及びそれを用いた露光方法、データ発生方法
AT412969B (de) * 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
ATE353042T1 (de) 2003-10-14 2007-02-15 Saab Ab Verfahren zur herstellung einer verbundstruktur
US7833452B2 (en) * 2004-05-11 2010-11-16 The General Hospital Corporation Method for making oxidation resistant polymeric material
JP4913370B2 (ja) * 2005-06-28 2012-04-11 株式会社アクトメント 医療材料及びその製造方法
EP2277561B1 (en) * 2005-08-18 2012-09-19 Zimmer GmbH Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
JP5535650B2 (ja) 2007-01-25 2014-07-02 ザ・ジェネラル・ホスピタル・コーポレイション 耐酸化性架橋重合体状材料の製造方法
JP2010529213A (ja) * 2007-03-02 2010-08-26 ザ・ジェネラル・ホスピタル・コーポレイション 酸化防止剤含有ポリマーの架橋
US8641959B2 (en) * 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
US8872847B2 (en) 2008-08-28 2014-10-28 Google Inc. Architectures and methods for creating and representing time-dependent imagery
US8933145B2 (en) * 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
WO2013126592A2 (en) 2012-02-21 2013-08-29 Cameron International Corporation Well tree hub and interface for retrievable processing modules

Also Published As

Publication number Publication date
US20140097559A1 (en) 2014-04-10
US9433705B2 (en) 2016-09-06
EP2456283B1 (en) 2015-12-16
CA2674955C (en) 2015-05-26
US9968709B2 (en) 2018-05-15
EP2110002B1 (en) 2012-04-25
EP2110002A4 (en) 2010-03-03
US20100190882A1 (en) 2010-07-29
ATE555636T1 (de) 2012-05-15
EP3037442A1 (en) 2016-06-29
US8293811B2 (en) 2012-10-23
EP2110002A1 (en) 2009-10-21
US8569395B2 (en) 2013-10-29
AU2008207807B2 (en) 2013-05-16
CA2674955A1 (en) 2008-07-31
US20170049934A1 (en) 2017-02-23
JP5535650B2 (ja) 2014-07-02
JP2010516517A (ja) 2010-05-20
AU2008207807A1 (en) 2008-07-31
WO2008092047A1 (en) 2008-07-31
EP2456283A1 (en) 2012-05-23
US20120292816A1 (en) 2012-11-22
EP2464195A1 (en) 2012-06-13

Similar Documents

Publication Publication Date Title
ES2385317T3 (es) Método para la preparación de materiales poliméricos reticulados resistentes a la oxidación
ES2372742T3 (es) Material polimérico homogeneizado resistente a oxidación.
AU2005244062B2 (en) Methods for making oxidation resistant polymeric material
US9889224B2 (en) Spatial control of additives by high temperature
JP2012120855A (ja) 耐酸化性ポリマー物質の製造方法
AU2013205248B2 (en) Methods for making oxidation-resistant cross-linked polymeric materials
AU2012254872B2 (en) Methods for making oxidation resistant polymeric material