JP2010516254A - ユビキチンに対する新規活性化および転移カスケード - Google Patents

ユビキチンに対する新規活性化および転移カスケード Download PDF

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Publication number
JP2010516254A
JP2010516254A JP2009546507A JP2009546507A JP2010516254A JP 2010516254 A JP2010516254 A JP 2010516254A JP 2009546507 A JP2009546507 A JP 2009546507A JP 2009546507 A JP2009546507 A JP 2009546507A JP 2010516254 A JP2010516254 A JP 2010516254A
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JP
Japan
Prior art keywords
uba6
ubiquitin
protein
compound
activity
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JP2009546507A
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English (en)
Japanese (ja)
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JP2010516254A5 (https=
Inventor
ハーパー、ジェフリー、ウェイド
ジン、ジァンピン
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Harvard University
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Harvard University
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Publication of JP2010516254A publication Critical patent/JP2010516254A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2009546507A 2007-01-18 2008-01-17 ユビキチンに対する新規活性化および転移カスケード Pending JP2010516254A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88543107P 2007-01-18 2007-01-18
US94675707P 2007-06-28 2007-06-28
PCT/US2008/051312 WO2008089329A2 (en) 2007-01-18 2008-01-17 Novel activation and transfer cascade for ubiquitin

Publications (2)

Publication Number Publication Date
JP2010516254A true JP2010516254A (ja) 2010-05-20
JP2010516254A5 JP2010516254A5 (https=) 2013-12-26

Family

ID=39636707

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009546507A Pending JP2010516254A (ja) 2007-01-18 2008-01-17 ユビキチンに対する新規活性化および転移カスケード

Country Status (4)

Country Link
US (3) US8198059B2 (https=)
EP (1) EP2102657A4 (https=)
JP (1) JP2010516254A (https=)
WO (1) WO2008089329A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022530853A (ja) * 2019-04-18 2022-07-04 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 構造的に安定化されたペプチドによるユビキチンおよびユビキチン様ｅ１活性化酵素の選択的標的化

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12059413B2 (en) 2016-11-02 2024-08-13 The Research Foundation For The State University Of New York Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction
WO2023218453A1 (en) * 2022-05-09 2023-11-16 Ramot At Tel-Aviv University Ltd. Methods of treating diseases associated with polyalanine expansion mutations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006485A2 (en) * 2000-07-13 2002-01-24 Millennium Pharmaceuticals Inc. 47885, a novel human ubiquitin-activating enzyme and uses therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040043386A1 (en) * 2002-08-30 2004-03-04 Todd Pray Methods and compositions for functional ubiquitin assays
RS52458B (sr) * 2005-02-04 2013-02-28 Millennium Pharmaceuticals Inc. Inhibitori e1 aktivirajućih enzima

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006485A2 (en) * 2000-07-13 2002-01-24 Millennium Pharmaceuticals Inc. 47885, a novel human ubiquitin-activating enzyme and uses therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013019868; ＧＵ　Ｘ　ｅｔ　ａｌ．，　Ｃｌｏｎｉｎｇ　ａｎｄ　ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ　ｏｆ　ａ　ｇｅｎｅ　ｅｎｃｏｄｉｎｇ　ｔｈｅ　ｈｕｍａｎ　ｐｕｔａｔｉｖｅ　ｕｂｉｑｕｉｔｉｎ　ｃｏｎｊｕｇａｔｉｎ *
JPN6013019869; 今堀　和友　他　監修，　生化学辞典（第３版），　東京化学同人，　２００２年，　１４４２ページ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022530853A (ja) * 2019-04-18 2022-07-04 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 構造的に安定化されたペプチドによるユビキチンおよびユビキチン様ｅ１活性化酵素の選択的標的化
US12358960B2 (en) 2019-04-18 2025-07-15 Dana-Farber Cancer Institute, Inc. Selective targeting of ubiquitin- and ubiquitin-like E1-activating enzymes by structurally-stabilized peptides
JP7727551B2 (ja) 2019-04-18 2025-08-21 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 構造的に安定化されたペプチドによるユビキチンおよびユビキチン様ｅ１活性化酵素の選択的標的化

Also Published As

Publication number Publication date
WO2008089329A9 (en) 2008-09-12
WO2008089329A2 (en) 2008-07-24
US20120302623A1 (en) 2012-11-29
US20150105446A1 (en) 2015-04-16
EP2102657A4 (en) 2010-09-08
US8198059B2 (en) 2012-06-12
EP2102657A2 (en) 2009-09-23
US8846360B2 (en) 2014-09-30
US20100047255A1 (en) 2010-02-25
WO2008089329A3 (en) 2008-11-27

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