JP2010516235A5 - - Google Patents
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- Publication number
- JP2010516235A5 JP2010516235A5 JP2009545932A JP2009545932A JP2010516235A5 JP 2010516235 A5 JP2010516235 A5 JP 2010516235A5 JP 2009545932 A JP2009545932 A JP 2009545932A JP 2009545932 A JP2009545932 A JP 2009545932A JP 2010516235 A5 JP2010516235 A5 JP 2010516235A5
- Authority
- JP
- Japan
- Prior art keywords
- qpct
- mouse
- transgene
- human animal
- transgenic non
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700019146 Transgenes Proteins 0.000 claims 20
- 230000009261 transgenic effect Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 15
- 108010044467 Isoenzymes Proteins 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 claims 3
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 238000011830 transgenic mouse model Methods 0.000 claims 3
- 208000023697 ABri amyloidosis Diseases 0.000 claims 2
- 208000017227 ADan amyloidosis Diseases 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 201000000162 ITM2B-related cerebral amyloid angiopathy 1 Diseases 0.000 claims 2
- 201000000194 ITM2B-related cerebral amyloid angiopathy 2 Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000028996 humoral immune response Effects 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 2
- 238000013508 migration Methods 0.000 claims 2
- 230000009826 neoplastic cell growth Effects 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims 1
- 208000012639 Balance disease Diseases 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 206010019375 Helicobacter infections Diseases 0.000 claims 1
- 206010023421 Kidney fibrosis Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 230000037007 arousal Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- 230000037149 energy metabolism Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000003284 homeostatic effect Effects 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88564907P | 2007-01-19 | 2007-01-19 | |
| PCT/EP2008/050532 WO2008087197A1 (en) | 2007-01-19 | 2008-01-18 | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516235A JP2010516235A (ja) | 2010-05-20 |
| JP2010516235A5 true JP2010516235A5 (enExample) | 2011-03-03 |
Family
ID=39271322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545932A Pending JP2010516235A (ja) | 2007-01-19 | 2008-01-18 | アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080200567A1 (enExample) |
| EP (2) | EP2121944B1 (enExample) |
| JP (1) | JP2010516235A (enExample) |
| AT (1) | ATE521711T1 (enExample) |
| AU (1) | AU2008206936B2 (enExample) |
| CA (1) | CA2675192A1 (enExample) |
| DK (1) | DK2121944T3 (enExample) |
| ES (1) | ES2372229T3 (enExample) |
| HR (1) | HRP20110651T1 (enExample) |
| NZ (1) | NZ578513A (enExample) |
| SI (1) | SI2121944T1 (enExample) |
| WO (1) | WO2008087197A1 (enExample) |
| ZA (1) | ZA200904353B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9277737B2 (en) | 2006-09-21 | 2016-03-08 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the QPCTL-gene |
| JP5612860B2 (ja) * | 2007-03-09 | 2014-10-22 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体 |
| JP5675341B2 (ja) * | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体 |
| ES2473621T3 (es) * | 2007-04-18 | 2014-07-07 | Probiodrug Ag | Derivados de nitrovinil-diamina como inhibidores de glutaminil ciclasa |
| WO2008128986A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
| JP5675340B2 (ja) * | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | 新規阻害剤 |
| WO2008128983A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
| DK2142514T3 (da) * | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
| WO2008128984A1 (en) * | 2007-04-20 | 2008-10-30 | Probiodrug Ag | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| NZ583799A (en) * | 2007-09-12 | 2011-12-22 | Probiodrug Ag | Transgenic mice comprising a DNA transgene encoding ABeta peptide |
| WO2009090190A1 (en) * | 2008-01-14 | 2009-07-23 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
| EA025107B1 (ru) * | 2008-07-31 | 2016-11-30 | Пробиодруг Аг | Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа |
| US11219696B2 (en) * | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
| ES2540467T3 (es) | 2010-08-19 | 2015-07-09 | Probiodrug Ag | Estructura cristalina de glutaminil ciclasa |
| JP2013541938A (ja) | 2010-09-02 | 2013-11-21 | プロビオドルグ エージー | アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル |
| EP2635675B1 (en) | 2010-11-02 | 2016-01-06 | Probiodrug AG | Crystal structure of isoglutaminyl cyclase |
| US20130052203A1 (en) | 2011-08-12 | 2013-02-28 | Probiodrug Ag | In vivo screening models for treatment of qc-related disorders |
| BR112015002168A2 (pt) | 2012-08-01 | 2017-11-07 | Nationwide Childrens Hospital | liberação intratecal de vírus 9 adeno-associado recombinante |
| US20180318260A1 (en) * | 2015-11-04 | 2018-11-08 | The Scripps Research Institute | Compositions and methods for treating cystic fibrosis |
| MC200185B1 (fr) | 2016-09-16 | 2017-10-04 | Coronal Audio | Dispositif et procédé de captation et traitement d'un champ acoustique tridimensionnel |
| MC200186B1 (fr) | 2016-09-30 | 2017-10-18 | Coronal Encoding | Procédé de conversion, d'encodage stéréophonique, de décodage et de transcodage d'un signal audio tridimensionnel |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5602299A (en) | 1992-09-23 | 1997-02-11 | Mount Sinai School Of Medicine Of The City University Of New York | Transgenic animal models for neurodegenerative disease |
| JPH07132033A (ja) | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
| US6066778A (en) | 1996-11-06 | 2000-05-23 | The Regents Of The University Of Michigan | Transgenic mice expressing APC resistant factor V |
| US5981830A (en) | 1997-05-30 | 1999-11-09 | Schering Aktiengesellschaft | Knockout mice and their progeny with a disrupted hepsin gene |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| PL1620082T3 (pl) | 2003-05-05 | 2010-10-29 | Probiodrug Ag | Medyczne zastosowanie inhibitorów cyklazy glutaminylowej i glutaminianowej do leczenia choroby Alzheimera i zespołu Downa |
| DE602004026289D1 (de) * | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| DK2206496T3 (da) * | 2003-05-05 | 2014-12-15 | Probiodrug Ag | Screening af inhibitorer af pyroglutaminsyredannelse i amyloid beta-peptid |
| AU2004290499C1 (en) * | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| AU2005210004B2 (en) * | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| GB0704100D0 (en) | 2006-03-17 | 2007-04-11 | Vodafone Plc | Improvements in an ehspa architecture |
| MX2009003090A (es) * | 2006-09-21 | 2009-04-02 | Probiodrug Ag | Genes novedosos relacionados con ciclasa de glutaminilo. |
-
2008
- 2008-01-18 AU AU2008206936A patent/AU2008206936B2/en not_active Ceased
- 2008-01-18 EP EP08707977A patent/EP2121944B1/en not_active Not-in-force
- 2008-01-18 NZ NZ578513A patent/NZ578513A/en not_active IP Right Cessation
- 2008-01-18 AT AT08707977T patent/ATE521711T1/de active
- 2008-01-18 ZA ZA200904353A patent/ZA200904353B/xx unknown
- 2008-01-18 ES ES08707977T patent/ES2372229T3/es active Active
- 2008-01-18 WO PCT/EP2008/050532 patent/WO2008087197A1/en not_active Ceased
- 2008-01-18 EP EP11178419A patent/EP2395095A1/en not_active Withdrawn
- 2008-01-18 HR HR20110651T patent/HRP20110651T1/hr unknown
- 2008-01-18 CA CA002675192A patent/CA2675192A1/en not_active Abandoned
- 2008-01-18 US US12/016,266 patent/US20080200567A1/en not_active Abandoned
- 2008-01-18 SI SI200830434T patent/SI2121944T1/sl unknown
- 2008-01-18 DK DK08707977.8T patent/DK2121944T3/da active
- 2008-01-18 JP JP2009545932A patent/JP2010516235A/ja active Pending
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