JP2010516235A - アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル - Google Patents

アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル Download PDF

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JP2010516235A
JP2010516235A JP2009545932A JP2009545932A JP2010516235A JP 2010516235 A JP2010516235 A JP 2010516235A JP 2009545932 A JP2009545932 A JP 2009545932A JP 2009545932 A JP2009545932 A JP 2009545932A JP 2010516235 A JP2010516235 A JP 2010516235A
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qpct
mouse
transgenic
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transgene
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スチルリング ステプハン
クイニス ホルゲル
ホフフマンン トルステン
デムトフ ハンス‐ウルリクフ
ウエルマンン ミチャエル
スチュルズ カトリン
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プロビオドルグ エージー
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JP2009545932A 2007-01-19 2008-01-18 アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル Pending JP2010516235A (ja)

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Application Number Priority Date Filing Date Title
US88564907P 2007-01-19 2007-01-19
PCT/EP2008/050532 WO2008087197A1 (en) 2007-01-19 2008-01-18 In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders

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JP2010516235A true JP2010516235A (ja) 2010-05-20
JP2010516235A5 JP2010516235A5 (enExample) 2011-03-03

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JP2009545932A Pending JP2010516235A (ja) 2007-01-19 2008-01-18 アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル

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US (1) US20080200567A1 (enExample)
EP (2) EP2395095A1 (enExample)
JP (1) JP2010516235A (enExample)
AT (1) ATE521711T1 (enExample)
AU (1) AU2008206936B2 (enExample)
CA (1) CA2675192A1 (enExample)
DK (1) DK2121944T3 (enExample)
ES (1) ES2372229T3 (enExample)
HR (1) HRP20110651T1 (enExample)
NZ (1) NZ578513A (enExample)
SI (1) SI2121944T1 (enExample)
WO (1) WO2008087197A1 (enExample)
ZA (1) ZA200904353B (enExample)

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JP5675341B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体
ES2468551T3 (es) * 2007-04-18 2014-06-16 Probiodrug Ag Derivados de nitrovinil-diamina como inhibidores de la glutaminil ciclasa
WO2008128985A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
JP5675343B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としての尿素誘導体
EP2142515B1 (en) * 2007-04-18 2014-03-26 Probiodrug AG Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
EP2160380B1 (en) * 2007-04-18 2014-04-02 Probiodrug AG Cyano-guanidine derivatives as glutaminyl cyclase inhibitors
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
AU2008297070A1 (en) * 2007-09-12 2009-03-19 Probiodrug Ag Transgenic mice
WO2009090190A1 (en) * 2008-01-14 2009-07-23 Probiodrug Ag Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
EA025107B1 (ru) * 2008-07-31 2016-11-30 Пробиодруг Аг Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа
US11219696B2 (en) * 2008-12-19 2022-01-11 Nationwide Children's Hospital Delivery of polynucleotides using recombinant AAV9
ES2540467T3 (es) 2010-08-19 2015-07-09 Probiodrug Ag Estructura cristalina de glutaminil ciclasa
JP2013541938A (ja) 2010-09-02 2013-11-21 プロビオドルグ エージー アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル
US8741614B2 (en) 2010-11-02 2014-06-03 Probiodrug Ag Crystal structure of isoglutaminyl cyclase
WO2013024043A2 (en) 2011-08-12 2013-02-21 Probiodrug Ag In vivo screening models for treatment of qc-related disorders
CA2880653C (en) 2012-08-01 2022-05-17 Nationwide Children's Hospital Intrathecal delivery of recombinant adeno-associated virus 9
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MC200186B1 (fr) 2016-09-30 2017-10-18 Coronal Encoding Procédé de conversion, d'encodage stéréophonique, de décodage et de transcodage d'un signal audio tridimensionnel

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JPN6013013950; ＢＡＴＩＷＡＬＬＡ，Ｆ．Ｍ．　ｅｔ　ａｌ．: 'Ｐｅｒｉｐｈｅｒａｌ　ｂｌｏｏｄ　ｇｅｎｅ　ｅｘｐｒｅｓｓｉｏｎ　ｐｒｏｆｉｌｉｎｇ　ｉｎ　ｒｈｅｕｍａｔｏｉｄ　ａｒｔｈｒｉｔｉｓ．' Ｇｅｎｅｓ　Ｉｍｍｕｎ． Ｖｏｌ．６，　Ｎｏ．５, 200508, ｐｐ．３８８-９７ *
JPN6013013951; ＥＺＵＲＡ，Ｙ．　ｅｔ　ａｌ．: 'Ａｓｓｏｃｉａｔｉｏｎ　ｏｆ　ｍｕｌｔｉｐｌｅ　ｎｕｃｌｅｏｔｉｄｅ　ｖａｒｉａｔｉｏｎｓ　ｉｎ　ｔｈｅ　ｐｉｔｕｉｔａｒｙ　ｇｌｕｔａｍｉｎｙｌ　ｃｙｃｌａｓｅ　ｇｅｎｅ　（ＱＰＣＴ）　ｗｉｔｈ　ｌ' Ｊ．　Ｂｏｎｅ　Ｍｉｎｅｒ．　Ｒｅｓ． Ｖｏｌ．１９，　Ｎｏ．８, 200408, ｐｐ．１２９６-３０１ *
JPN6013013953; ＳＣＨＩＬＬＩＮＧ，Ｓ．　ｅｔ　ａｌ．: 'Ｇｌｕｔａｍｉｎｙｌ　ｃｙｃｌａｓｅ　ｉｎｈｉｂｉｔｉｏｎ　ａｔｔｅｎｕａｔｅｓ　ｐｙｒｏｇｌｕｔａｍａｔｅ　Ａｂｅｔａ　ａｎｄ　Ａｌｚｈｅｉｍｅｒ'ｓ　ｄｉｓｅａｓｅ-ｌｉｋｅ　ｐａｔｈｏｌｏｇｙ．' Ｎａｔ．　Ｍｅｄ． Ｖｏｌ．１４，　Ｎｏ．１０, 200810, ｐｐ．１１０６-１１ *
JPN6013013955; ＣＹＮＩＳ，Ｈ．　ｅｔ　ａｌ．: 'Ａｍｙｌｏｉｄｏｇｅｎｉｃ　ｐｒｏｃｅｓｓｉｎｇ　ｏｆ　ａｍｙｌｏｉｄ　ｐｒｅｃｕｒｓｏｒ　ｐｒｏｔｅｉｎ：　ｅｖｉｄｅｎｃｅ　ｏｆ　ａ　ｐｉｖｏｔａｌ　ｒｏｌｅ　ｏｆ　ｇｌｕｔａｍｉｎｙｌ　ｃｙｃｌ' Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４７，　Ｎｏ．２８, 20080715, ｐｐ．７４０５-１３ *
JPN6013013956; ＨＡＲＩＧＡＹＡ，Ｙ．　ｅｔ　ａｌ．: 'Ａｍｙｌｏｉｄ　ｂｅｔａ　ｐｒｏｔｅｉｎ　ｓｔａｒｔｉｎｇ　ｐｙｒｏｇｌｕｔａｍａｔｅ　ａｔ　ｐｏｓｉｔｉｏｎ　３　ｉｓ　ａ　ｍａｊｏｒ　ｃｏｍｐｏｎｅｎｔ　ｏｆ　ｔｈｅ　ａｍｙｌｏｉｄ　ｄｅｐｏｓｉ' Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．２７６，　Ｎｏ．２, 20000924, ｐｐ．４２２-７ *
JPN6013013957; ＳＡＩＤＯ，Ｔ．Ｃ．　ｅｔ　ａｌ．: 'Ｄｏｍｉｎａｎｔ　ａｎｄ　ｄｉｆｆｅｒｅｎｔｉａｌ　ｄｅｐｏｓｉｔｉｏｎ　ｏｆ　ｄｉｓｔｉｎｃｔ　ｂｅｔａ-ａｍｙｌｏｉｄ　ｐｅｐｔｉｄｅ　ｓｐｅｃｉｅｓ，　Ａ　ｂｅｔａ　Ｎ３（ｐＥ），　ｉｎ　ｓｅｎ' Ｎｅｕｒｏｎ Ｖｏｌ．１４，　Ｎｏ．２, 199502, ｐｐ．４５７-６６ *
JPN6014000142; ＹＯＳＨＩＭＵＲＡ，Ｍ．　ｅｔ　ａｌ．: 'Ｏｖｅｒｅｘｐｒｅｓｓｉｏｎ　ｏｆ　ｔｙｐｅ　７　ａｄｅｎｙｌｙｌ　ｃｙｃｌａｓｅ　ｉｎ　ｔｈｅ　ｍｏｕｓｅ　ｂｒａｉｎ　ｅｎｈａｎｃｅｓ　ａｃｕｔｅ　ａｎｄ　ｃｈｒｏｎｉｃ　ａｃｔｉｏｎｓ　ｏｆ　ｍ' Ｍｏｌ．　Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．５８，　Ｎｏ．５, 200011, ｐｐ．１０１１-６ *

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NZ578513A (en) 2012-01-12
EP2121944B1 (en) 2011-08-24
SI2121944T1 (sl) 2011-12-30
EP2395095A1 (en) 2011-12-14
ES2372229T3 (es) 2012-01-17
DK2121944T3 (da) 2011-10-31
US20080200567A1 (en) 2008-08-21
AU2008206936B2 (en) 2013-03-14
ATE521711T1 (de) 2011-09-15
HRP20110651T1 (hr) 2011-10-31
AU2008206936A1 (en) 2008-07-24
EP2121944A1 (en) 2009-11-25
CA2675192A1 (en) 2008-07-24
ZA200904353B (en) 2010-09-29

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