JP2010513458A5 - - Google Patents
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- Publication number
- JP2010513458A5 JP2010513458A5 JP2009542256A JP2009542256A JP2010513458A5 JP 2010513458 A5 JP2010513458 A5 JP 2010513458A5 JP 2009542256 A JP2009542256 A JP 2009542256A JP 2009542256 A JP2009542256 A JP 2009542256A JP 2010513458 A5 JP2010513458 A5 JP 2010513458A5
- Authority
- JP
- Japan
- Prior art keywords
- och
- nhco
- compound
- pharmaceutically acceptable
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 239000012453 solvate Substances 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 claims 3
- 101710082112 Hematopoietic prostaglandin D synthase Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 claims 3
- -1 2-methyl-6-phenylpyridin-3-yl Chemical group 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- PFAOBAWKUJVDOZ-UHFFFAOYSA-N 6-(3-fluorophenyl)-n-[1-[9-(1-hydroxybutan-2-yl)purin-6-yl]piperidin-4-yl]pyridine-3-carboxamide Chemical compound N1=CN=C2N(C(CO)CC)C=NC2=C1N(CC1)CCC1NC(=O)C(C=N1)=CC=C1C1=CC=CC(F)=C1 PFAOBAWKUJVDOZ-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000009285 allergic inflammation Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87077706P | 2006-12-19 | 2006-12-19 | |
| US89165007P | 2007-02-26 | 2007-02-26 | |
| PCT/IB2007/003928 WO2008075172A2 (en) | 2006-12-19 | 2007-12-03 | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010513458A JP2010513458A (ja) | 2010-04-30 |
| JP2010513458A5 true JP2010513458A5 (cg-RX-API-DMAC7.html) | 2010-11-25 |
Family
ID=39523704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542256A Withdrawn JP2010513458A (ja) | 2006-12-19 | 2007-12-03 | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7902373B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2129660A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010513458A (cg-RX-API-DMAC7.html) |
| AR (1) | AR064389A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2672373C (cg-RX-API-DMAC7.html) |
| CL (1) | CL2007003705A1 (cg-RX-API-DMAC7.html) |
| PE (1) | PE20081385A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200833675A (cg-RX-API-DMAC7.html) |
| UY (1) | UY30804A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008075172A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (57)
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| DK2118074T3 (en) | 2007-02-01 | 2014-03-10 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
| CA2679198C (en) | 2007-02-26 | 2011-07-12 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| WO2009140364A2 (en) | 2008-05-13 | 2009-11-19 | Cayman Chemical Company | Methods for assaying compounds or agents for ability to displace potent ligands of hematopoietic prostaglandin d synthase |
| EP2307378A1 (en) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| EP2307377A1 (en) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| MY154000A (en) | 2008-09-22 | 2015-04-30 | Cayman Chem Co | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| WO2010103435A1 (en) * | 2009-03-10 | 2010-09-16 | Koninklijke Philips Electronics N.V. | Diagnosis of asthma |
| CN102427813A (zh) | 2009-03-18 | 2012-04-25 | 雷斯韦洛吉克斯公司 | 新的抗炎剂 |
| SG179199A1 (en) | 2009-10-08 | 2012-04-27 | Sanofi Sa | Phenyloxadiazole derivatives as pgds inhibitors |
| WO2012031383A1 (zh) * | 2010-09-06 | 2012-03-15 | 中国科学院广州生物医药与健康研究院 | 酰胺类化合物 |
| EP2651417B1 (en) | 2010-12-16 | 2016-11-30 | Calchan Limited | Ask1 inhibiting pyrrolopyrimidine derivatives |
| HUE034979T2 (en) * | 2011-09-12 | 2018-05-02 | Merck Patent Gmbh | Aminopyrimidine derivatives for use as modulators of kinase activity |
| WO2013170115A1 (en) * | 2012-05-11 | 2013-11-14 | Abbvie Inc. | Pyridazine and pyridine derivatives as nampt inhibitors |
| ES2690782T3 (es) | 2012-10-24 | 2018-11-22 | Nyu Winthrop Hospital | Biomarcador no invasivo para identificar sujetos en riesgo de parto prematuro |
| WO2014175370A1 (ja) * | 2013-04-25 | 2014-10-30 | 塩野義製薬株式会社 | ピロリジン誘導体およびそれらを含有する医薬組成物 |
| US9371282B2 (en) | 2013-05-17 | 2016-06-21 | Centrexion Therapeutics Corporation | Somatostatin receptor subtype 4 (SSTR4) agonists |
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| CN106715454B (zh) | 2014-07-24 | 2020-06-16 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
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| AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
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| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| FI3268379T3 (fi) | 2015-03-09 | 2023-12-15 | Grace W R & Co | Nikotiiniamidiribosidin kiteinen muoto |
| PL3277286T3 (pl) | 2015-03-31 | 2021-11-08 | Enanta Pharmaceuticals, Inc. | Pochodne kwasu żółciowego jako agonisty fxr/tgr5 i sposoby ich stosowania |
| UY37028A (es) | 2015-12-17 | 2017-07-31 | Astex Therapeutics Ltd | Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds |
| WO2017189652A1 (en) | 2016-04-26 | 2017-11-02 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
| WO2017189663A1 (en) | 2016-04-26 | 2017-11-02 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
| US10080742B2 (en) | 2016-04-26 | 2018-09-25 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
| WO2017201150A1 (en) | 2016-05-18 | 2017-11-23 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as fxr agonists and methods of use thereof |
| US10138228B2 (en) | 2016-05-18 | 2018-11-27 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use therof |
| WO2017201155A1 (en) | 2016-05-18 | 2017-11-23 | Enanta Pharmaceuticals, Inc. | lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF |
| AU2017338853A1 (en) * | 2016-10-04 | 2019-04-18 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
| JOP20190072A1 (ar) * | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| US10597391B2 (en) | 2016-10-26 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof |
| TW201908311A (zh) * | 2017-06-13 | 2019-03-01 | 英商葛蘭素史克智慧財產發展有限公司 | 化合物 |
| GB201711234D0 (en) | 2017-07-12 | 2017-08-23 | Galapagos Nv | Pyrrolopyrimidine and pyrrolopyridine derivatives |
| US20200264188A1 (en) | 2017-09-13 | 2020-08-20 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
| CA3079617A1 (en) | 2017-10-20 | 2019-04-25 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| WO2019118571A1 (en) | 2017-12-12 | 2019-06-20 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as fxr agonists and methods of use thereof |
| EP3724197A1 (en) | 2017-12-13 | 2020-10-21 | GlaxoSmithKline Intellectual Property Development Ltd | Fused pyridines which act as inhibitors of h-pgds |
| US11414407B2 (en) | 2017-12-22 | 2022-08-16 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| CA3090130A1 (en) * | 2018-02-02 | 2019-08-08 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| US10829486B2 (en) | 2018-02-14 | 2020-11-10 | Enanta Pharmacueticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
| UY38455A (es) | 2018-11-08 | 2020-05-29 | Glaxosmithkline Ip Dev Ltd | Nuevos compuestos inhibidores de la prostaglandina d sintasa hematopoyética (h-pgds) |
| WO2020191208A1 (en) | 2019-03-20 | 2020-09-24 | Emory University | Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto |
| WO2020231917A1 (en) | 2019-05-13 | 2020-11-19 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
| US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
| MX2021014443A (es) | 2019-05-31 | 2022-01-06 | Ikena Oncology Inc | Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos. |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
| JP7734129B2 (ja) | 2020-06-19 | 2025-09-04 | 佐藤製薬株式会社 | Ｈ－ｐｇｄｓを阻害する縮環化合物 |
| EP4259606A1 (en) * | 2020-12-11 | 2023-10-18 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| AR127055A1 (es) | 2021-09-14 | 2023-12-13 | Lilly Co Eli | Sales agonistas de sstr4 |
| KR20240121786A (ko) | 2021-12-17 | 2024-08-09 | 사토 세이야쿠 가부시키가이샤 | H－pgds를 저해하는 아자인돌 유도체 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
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| DE19744401A1 (de) | 1997-10-08 | 1999-04-15 | Bayer Ag | Verfahren zur Herstellung von Triazolinthion-Derivaten |
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-
2007
- 2007-12-03 CA CA2672373A patent/CA2672373C/en not_active Expired - Fee Related
- 2007-12-03 WO PCT/IB2007/003928 patent/WO2008075172A2/en not_active Ceased
- 2007-12-03 JP JP2009542256A patent/JP2010513458A/ja not_active Withdrawn
- 2007-12-03 EP EP07859056A patent/EP2129660A2/en not_active Withdrawn
- 2007-12-12 US US11/954,799 patent/US7902373B2/en not_active Expired - Fee Related
- 2007-12-14 PE PE2007001800A patent/PE20081385A1/es not_active Application Discontinuation
- 2007-12-17 AR ARP070105664A patent/AR064389A1/es not_active Application Discontinuation
- 2007-12-18 TW TW096148480A patent/TW200833675A/zh unknown
- 2007-12-18 UY UY30804A patent/UY30804A1/es not_active Application Discontinuation
- 2007-12-19 CL CL200703705A patent/CL2007003705A1/es unknown