JP2010512781A - Vegfrの変化体ならびに妊娠関連の医学的状態の診断および処置におけるその使用 - Google Patents

Vegfrの変化体ならびに妊娠関連の医学的状態の診断および処置におけるその使用 Download PDF

Info

Publication number
JP2010512781A
JP2010512781A JP2009542395A JP2009542395A JP2010512781A JP 2010512781 A JP2010512781 A JP 2010512781A JP 2009542395 A JP2009542395 A JP 2009542395A JP 2009542395 A JP2009542395 A JP 2009542395A JP 2010512781 A JP2010512781 A JP 2010512781A
Authority
JP
Japan
Prior art keywords
sflt
seq
vegf
antibody
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009542395A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010512781A5 (enExample
Inventor
エリ ケシェト,
シェイ セラ,
アフバ イティン,
シムチャ ヤゲル,
Original Assignee
イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド
ハダシット メディカル リサーチ サーヴィシーズ アンド ディヴェロップメント リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド, ハダシット メディカル リサーチ サーヴィシーズ アンド ディヴェロップメント リミテッド filed Critical イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド
Publication of JP2010512781A publication Critical patent/JP2010512781A/ja
Publication of JP2010512781A5 publication Critical patent/JP2010512781A5/ja
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
JP2009542395A 2006-12-20 2007-12-20 Vegfrの変化体ならびに妊娠関連の医学的状態の診断および処置におけるその使用 Pending JP2010512781A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87582206P 2006-12-20 2006-12-20
PCT/IL2007/001589 WO2008075363A1 (en) 2006-12-20 2007-12-20 Variants of vegfr and their use in the diagnosis and treatment of pregnancy associated medical conditions

Publications (2)

Publication Number Publication Date
JP2010512781A true JP2010512781A (ja) 2010-04-30
JP2010512781A5 JP2010512781A5 (enExample) 2010-12-24

Family

ID=39271517

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009542395A Pending JP2010512781A (ja) 2006-12-20 2007-12-20 Vegfrの変化体ならびに妊娠関連の医学的状態の診断および処置におけるその使用

Country Status (6)

Country Link
US (3) US20100136012A1 (enExample)
EP (1) EP2099913B1 (enExample)
JP (1) JP2010512781A (enExample)
AT (1) ATE547523T1 (enExample)
CA (1) CA2673222A1 (enExample)
WO (1) WO2008075363A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2099913B1 (en) 2006-12-20 2012-02-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Variants of vegfr and their use in the diagnosis and treatment of pregnancy associated medical conditions
JPWO2010106997A1 (ja) * 2009-03-19 2012-09-20 株式会社カネカ 核酸の検出方法及びキット、デバイス
US20130164270A1 (en) 2009-07-29 2013-06-27 Yissum Research Developement Company of the Hebrew University of Jerusalem Ltd. Polynucleotides and constructs encoding sflt1-14 and method for efficient propagation and expression thereof
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
RU2670747C1 (ru) * 2017-10-19 2018-10-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Способ определения показаний для срочного родоразрешения при преэклампсии
FR3081707A1 (fr) * 2018-05-30 2019-12-06 Universite De Rouen Normandie Traitement des troubles neurologiques causes par l'alcoolisation foetale
WO2020171777A1 (en) * 2019-02-18 2020-08-27 Agency For Science, Technology And Research A membrane-bound fit-1 decoy and uses thereof
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069373A2 (en) * 2004-12-21 2006-06-29 Yale University Diagnosis of preeclampsia
WO2007039903A2 (en) * 2005-10-03 2007-04-12 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710174B2 (en) * 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
AU2001238347A1 (en) * 2000-02-28 2001-09-12 Hyseq, Inc. Novel nucleic acids and polypeptides
US20040216828A1 (en) * 2001-08-17 2004-11-04 Ortega Albert E. Nonwoven fabrics with two or more filament cross sections
KR101215701B1 (ko) * 2002-07-19 2012-12-26 베스 이스라엘 데코니스 메디칼 센터 자간전증 또는 자간의 진단 및 치료 방법
US7939634B2 (en) * 2004-01-27 2011-05-10 Compugen Ltd. Polynucleotides encoding polypeptides and methods using same
US20080305493A1 (en) 2004-03-08 2008-12-11 Avalon Pharmaceuticals Determining Cancer-Linked Genes and Therapeutic Targets Using Molecular Cytogenetic Methods
EP2099913B1 (en) 2006-12-20 2012-02-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Variants of vegfr and their use in the diagnosis and treatment of pregnancy associated medical conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069373A2 (en) * 2004-12-21 2006-06-29 Yale University Diagnosis of preeclampsia
WO2007039903A2 (en) * 2005-10-03 2007-04-12 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis

Also Published As

Publication number Publication date
US9797911B2 (en) 2017-10-24
ATE547523T1 (de) 2012-03-15
US20130084583A1 (en) 2013-04-04
EP2099913A1 (en) 2009-09-16
US20100136012A1 (en) 2010-06-03
WO2008075363A1 (en) 2008-06-26
EP2099913B1 (en) 2012-02-29
CA2673222A1 (en) 2008-06-26
US20140295454A1 (en) 2014-10-02

Similar Documents

Publication Publication Date Title
US9797911B2 (en) Composition for use in detection of sFlt-14
JP5650876B2 (ja) 子癇前症または子癇の診断方法および治療方法
EP1565482A2 (en) A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same
US20120135424A1 (en) Mer diagnostic and therapeutic agents
JPWO2008032876A1 (ja) Er陰性およびher2陰性である乳癌の予防または治療剤およびそのスクリーニング方法
US11318158B2 (en) Pappalysin regulator
JP2007524622A (ja) 抗癌治療に対する腫瘍細胞の感受性を回復させてアポトーシスを誘導するための組成物及び方法
CN101103044B (zh) 抗α9整联蛋白抗体及其用途
US20090214517A1 (en) Compositions and methods of use for modulators of nectin 4, semaphorin 4b, igsf9, and kiaa0152 in treating disease
KR20080099248A (ko) 항페리오스틴에 대한 항체, 및 페리오스틴이 관여하는 질환의 예방 또는 치료를 위해 그것을 함유하는 약제학적 조성물
ES2800328T3 (es) Métodos para diagnosticar y tratar la leucemia linfocítica crónica de linfocitos B en base a la detección e inhibición de CD84
WO1991011462A2 (en) Merosin, nucleic acids encoding, fragments and uses thereof
US7357929B2 (en) Placental growth factor as a target for the treatment of osteoporosis
CN106102772B (zh) 用于预防和/或治疗与dennd1a变体2相关疾病的组合物和方法
WO2006014903A2 (en) Compositions and methods of use for adam12 antagonists in treating disease
JPH10502252A (ja) Dp−1及びその他のdpタンパク質の阻害剤のアッセイ
MXPA06014972A (es) Metodos y composiciones para el tratamiento de enfermedades poliquisticas.
JP4712692B2 (ja) 癌の診断と治療において有用な新規ポリペプチド
US20220227882A1 (en) Anti-adam8 antibodies and uses of the same
JP2004208583A (ja) 新規免疫抑制性受容体
WO2005021739A1 (ja) Nox1ポリペプチドに対する抗体、Nox1遺伝子を利用したガン診断方法、及びガン増殖抑制物質のスクリーニング方法
JP2003169683A (ja) 新規脱共役蛋白質mt0029
JPWO2001002564A1 (ja) 新規ポリペプチドおよびそのdna
JP2009031307A (ja) 絨毛外栄養膜細胞特異的蛋白質

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101104

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101104

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121127

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130510