JP2010510286A5 - - Google Patents
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- Publication number
- JP2010510286A5 JP2010510286A5 JP2009537627A JP2009537627A JP2010510286A5 JP 2010510286 A5 JP2010510286 A5 JP 2010510286A5 JP 2009537627 A JP2009537627 A JP 2009537627A JP 2009537627 A JP2009537627 A JP 2009537627A JP 2010510286 A5 JP2010510286 A5 JP 2010510286A5
- Authority
- JP
- Japan
- Prior art keywords
- vinyl acetate
- ethylene
- drug
- formulation
- acetate copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000009472 formulation Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229920001169 thermoplastic Polymers 0.000 claims 1
Claims (8)
- ５００ダルトンを下回る分子量を有し、および２８％の酢酸ビニル含量を有するエチレン−酢酸ビニルコポリマー中に少なくとも０．１重量％の溶解度を有する固体非ステロイド非イオン化親水性薬物を投与するための徐放性製剤であって、
前記薬物は、膣徐放性製剤を用いて一日６０ｍｇ以下の量で治療的に有効であり、該製剤を受容した患者の血漿から利用可能になることにより治療的効果を発揮し、
ここで製剤が外皮を有する膣装置であり、該装置が熱可塑性ポリマー製の内部区画を含み、該ポリマーが前記薬物を含有していることを特徴とする、製剤。 - ポリマーが、５〜８０重量％の薬物を含有していることを特徴とする、請求項１に記載の製剤。
- 外皮が実質的に連続的であることを特徴とする、請求項１または２に記載の製剤。
- 装置がリングであることを特徴とする、請求項１〜３のいずれか一項に記載の製剤。
- 内部区画が、固体薬物を含有していないコアを含んでいることを特徴とする、請求項１〜４のいずれか一項に記載の製剤。
- 内部区画が、エチレン−酢酸ビニルコポリマー製であることを特徴とする、請求項１〜５のいずれか一項に記載の系。
- 外皮が、エチレン−酢酸ビニルコポリマー製であることを特徴とする、請求項１〜６のいずれか一項に記載の系。
- ６〜４０％の範囲内の酢酸ビニル含量を有するエチレン−酢酸ビニルコポリマーが用いられることを特徴とする、請求項６または７に記載の系。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06124598 | 2006-11-22 | ||
| PCT/EP2007/062626 WO2008062008A1 (en) | 2006-11-22 | 2007-11-21 | Delivery system for a non-steroidal non-ionized hydrophilic drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010510286A JP2010510286A (ja) | 2010-04-02 |
| JP2010510286A5 true JP2010510286A5 (ja) | 2011-01-13 |
Family
ID=37898528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537628A Withdrawn JP2010510287A (ja) | 2006-11-22 | 2007-11-21 | リスペリドン用送達システム |
| JP2009537627A Withdrawn JP2010510286A (ja) | 2006-11-22 | 2007-11-21 | 非ステロイド非イオン化親水性薬物の送達系 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537628A Withdrawn JP2010510287A (ja) | 2006-11-22 | 2007-11-21 | リスペリドン用送達システム |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100203104A1 (ja) |
| EP (2) | EP2094348A1 (ja) |
| JP (2) | JP2010510287A (ja) |
| CA (2) | CA2670157A1 (ja) |
| MX (2) | MX2009005444A (ja) |
| WO (2) | WO2008062008A1 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| US7858110B2 (en) * | 2003-08-11 | 2010-12-28 | Endo Pharmaceuticals Solutions, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| CA2437639C (en) | 2003-08-11 | 2016-07-05 | Valera Pharmaceuticals, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| CA2657533A1 (en) * | 2006-07-12 | 2008-01-17 | Controlled Therapeutics (Scotland) Ltd. | Drug delivery polymer with hydrochloride salt of clindamycin |
| GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| US20100203104A1 (en) * | 2006-11-22 | 2010-08-12 | N.V. Organon | Delivery system for risperidone |
| WO2009129459A1 (en) * | 2008-04-18 | 2009-10-22 | Combinent Biomedical Systems, Inc. | Devices that include ethylene-vinyl acetate copolymers and methods of making and using same |
| CA2739181C (en) * | 2008-09-30 | 2017-03-14 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the delivery of risperidone and methods of use thereof |
| EP2547332B1 (en) | 2010-03-16 | 2018-08-29 | Titan Pharmaceuticals, Inc. | Heterogeneous implantable devices for drug delivery |
| US20170319833A1 (en) * | 2010-03-28 | 2017-11-09 | Evestra, Inc. | Intravaginal drug delivery device |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| DE102013011399A1 (de) | 2012-07-31 | 2014-02-06 | Amw Gmbh | Implantat mit Risperidon |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| JP2021524841A (ja) | 2018-05-24 | 2021-09-16 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| CN111989068A (zh) | 2018-05-24 | 2020-11-24 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016251A (en) * | 1972-08-17 | 1977-04-05 | Alza Corporation | Vaginal drug dispensing device |
| US4469671A (en) * | 1983-02-22 | 1984-09-04 | Eli Lilly And Company | Contraceptive device |
| GB9326255D0 (en) * | 1993-12-23 | 1994-02-23 | Roussel Lab Ltd | Medical device for the prevention and treatment of cancer |
| US6544546B1 (en) * | 1995-07-04 | 2003-04-08 | Akzo Nobel, N.V. | Ring-shaped devices |
| US20040044080A1 (en) * | 1997-10-28 | 2004-03-04 | Place Virgil A. | Treatment of dyspareunia with topically administered nitroglycerin formulations |
| JP4959907B2 (ja) * | 2001-03-27 | 2012-06-27 | ワーナー チルコット（アイルランド）リミティド | 抗菌剤投与のための膣内用ドラッグデリバリーデバイス |
| US6887270B2 (en) * | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
| WO2004020189A1 (en) * | 2002-08-30 | 2004-03-11 | Alza Corporation | Embossable and writable multilaminate backing construction |
| WO2005070332A1 (en) * | 2004-01-12 | 2005-08-04 | The Trustees Of The University Of Pennsylvania | Long-term delivery formulations and methods of use thereof |
| CA2559224C (en) * | 2004-03-24 | 2011-12-13 | N.V. Organon | Drug delivery system based on polyethylene vinylacetate copolymers |
| DK1824460T3 (en) * | 2004-11-10 | 2015-01-19 | Tolmar Therapeutics Inc | Stabilized polymeric delivery system |
| US20100203104A1 (en) * | 2006-11-22 | 2010-08-12 | N.V. Organon | Delivery system for risperidone |
| AU2007324467A1 (en) * | 2006-11-22 | 2008-05-29 | N.V. Organon | Vaginal delivery system for mirtazapine |
-
2007
- 2007-11-21 US US12/515,882 patent/US20100203104A1/en not_active Abandoned
- 2007-11-21 MX MX2009005444A patent/MX2009005444A/es not_active Application Discontinuation
- 2007-11-21 MX MX2009005445A patent/MX2009005445A/es not_active Application Discontinuation
- 2007-11-21 EP EP07822772A patent/EP2094348A1/en not_active Withdrawn
- 2007-11-21 WO PCT/EP2007/062626 patent/WO2008062008A1/en active Application Filing
- 2007-11-21 CA CA002670157A patent/CA2670157A1/en not_active Abandoned
- 2007-11-21 US US12/515,897 patent/US20100104619A1/en not_active Abandoned
- 2007-11-21 CA CA002670454A patent/CA2670454A1/en not_active Abandoned
- 2007-11-21 WO PCT/EP2007/062628 patent/WO2008062009A1/en active Application Filing
- 2007-11-21 JP JP2009537628A patent/JP2010510287A/ja not_active Withdrawn
- 2007-11-21 EP EP07822774A patent/EP2094270A1/en not_active Withdrawn
- 2007-11-21 JP JP2009537627A patent/JP2010510286A/ja not_active Withdrawn
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