|
US4309776A
(en)
*
|
1980-05-13 |
1982-01-12 |
Ramon Berguer |
Intravascular implantation device and method of using the same
|
|
US4749570A
(en)
*
|
1981-12-31 |
1988-06-07 |
The Governors Of The University Of Alberta |
Targeting conjugates of albumin and therapeutic agents
|
|
US4522811A
(en)
*
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
JPS61502657A
(ja)
*
|
1984-07-13 |
1986-11-20 |
チロン コ−ポレイシヨン |
プレプロインシュリン様成長因子1及び2
|
|
US4801575A
(en)
*
|
1986-07-30 |
1989-01-31 |
The Regents Of The University Of California |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4902505A
(en)
*
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US5470828A
(en)
*
|
1987-12-24 |
1995-11-28 |
Gropep Pty. Ltd. |
Peptide analogs of insulin-like growth factor II
|
|
US5817623A
(en)
*
|
1995-03-06 |
1998-10-06 |
Univ Colorado State Res Found |
Method for treating diabetic peripheral neuropathy with IGF-I or IGF-II
|
|
US5236838A
(en)
*
|
1988-12-23 |
1993-08-17 |
Genzyme Corporation |
Enzymatically active recombinant glucocerebrosidase
|
|
US6451600B1
(en)
*
|
1989-12-22 |
2002-09-17 |
Genzyme Corporation |
Enzymatically active recombinant glucocerebrosidase
|
|
US5549892A
(en)
*
|
1988-12-23 |
1996-08-27 |
Genzyme Corporation |
Enhanced in vivo uptake of glucocerebrosidase
|
|
US5399346A
(en)
*
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
US5977307A
(en)
*
|
1989-09-07 |
1999-11-02 |
Alkermes, Inc. |
Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
|
|
US5356804A
(en)
*
|
1990-10-24 |
1994-10-18 |
Mount Sinai School Of Medicine Of The City Of New York |
Cloning and expression of biologically active human α-galactosidase A
|
|
US5401650A
(en)
*
|
1990-10-24 |
1995-03-28 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Cloning and expression of biologically active α-galactosidase A
|
|
US5633235A
(en)
*
|
1991-04-19 |
1997-05-27 |
Regents Of The University Of Michigan |
Triciribine and analogs as antiviral drugs
|
|
US5736363A
(en)
*
|
1991-07-29 |
1998-04-07 |
British Bio-Technology Limited |
IGF-II analogues
|
|
US6270989B1
(en)
*
|
1991-11-05 |
2001-08-07 |
Transkaryotic Therapies, Inc. |
Protein production and delivery
|
|
US5258453A
(en)
*
|
1992-01-21 |
1993-11-02 |
University Of Utah |
Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
|
|
EP0646178A1
(en)
*
|
1992-06-04 |
1995-04-05 |
The Regents Of The University Of California |
expression cassette with regularoty regions functional in the mammmlian host
|
|
US5981194A
(en)
*
|
1992-07-10 |
1999-11-09 |
University Of British Columbia |
Use of p97 and iron binding proteins as diagnostic and therapeutic agents
|
|
US5476779A
(en)
*
|
1992-09-30 |
1995-12-19 |
University Of Maryland At College Park |
DNA encoding insulin-like growth factor II isolated from rainbow trout
|
|
US5633234A
(en)
*
|
1993-01-22 |
1997-05-27 |
The Johns Hopkins University |
Lysosomal targeting of immunogens
|
|
US5798366A
(en)
*
|
1993-05-13 |
1998-08-25 |
Monsanto Company |
Method for treatment of CNS-involved lysosomal storage diseases
|
|
US5704910A
(en)
*
|
1995-06-05 |
1998-01-06 |
Nephros Therapeutics, Inc. |
Implantable device and use therefor
|
|
US6281010B1
(en)
*
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
US5817789A
(en)
*
|
1995-06-06 |
1998-10-06 |
Transkaryotic Therapies, Inc. |
Chimeric proteins for use in transport of a selected substance into cells
|
|
US6118045A
(en)
*
|
1995-08-02 |
2000-09-12 |
Pharming B.V. |
Lysosomal proteins produced in the milk of transgenic animals
|
|
US20020013953A1
(en)
*
|
1995-08-02 |
2002-01-31 |
Reuser Arnold J. |
Compositions and methods for treating enzyme deficiency
|
|
JP3713276B2
(ja)
*
|
1995-09-29 |
2005-11-09 |
バイオマリン ファーマシューティカル インコーポレイテッド |
炎症反応の軽減のためのヘパリナーゼの使用
|
|
US6348194B1
(en)
*
|
1995-11-13 |
2002-02-19 |
Ixsys Incorporated |
Tumor specific internalizing antigens and methods for targeting therapeutic agents
|
|
US6344436B1
(en)
*
|
1996-01-08 |
2002-02-05 |
Baylor College Of Medicine |
Lipophilic peptides for macromolecule delivery
|
|
JP2000501744A
(ja)
*
|
1996-01-22 |
2000-02-15 |
クリエイティブ バイオモレキゥルズ,インコーポレーテッド |
モルホゲン類似体およびその製法
|
|
US6020144A
(en)
*
|
1996-09-12 |
2000-02-01 |
Symbiontics, Inc. |
Sustained delivery device comprising a Leishmania protozoa and methods of making and using the same
|
|
US6458574B1
(en)
*
|
1996-09-12 |
2002-10-01 |
Transkaryotic Therapies, Inc. |
Treatment of a α-galactosidase a deficiency
|
|
US6083725A
(en)
*
|
1996-09-13 |
2000-07-04 |
Transkaryotic Therapies, Inc. |
Tranfected human cells expressing human α-galactosidase A protein
|
|
US6235874B1
(en)
*
|
1997-01-10 |
2001-05-22 |
Academia Sinica |
Production of biologically active recombinant insulin-like growth factor II polypeptides
|
|
US6329501B1
(en)
*
|
1997-05-29 |
2001-12-11 |
Auburn University |
Methods and compositions for targeting compounds to muscle
|
|
ATE359561T1
(de)
*
|
1997-06-02 |
2007-05-15 |
Univ Johns Hopkins |
Rechnerverfahren freie energieberechnung für ligandenentwurf verwendend und die voraussage von bindenden zielen
|
|
US6472140B1
(en)
*
|
1997-09-05 |
2002-10-29 |
The General Hospital Corporation |
α-2- macroglobulin therapies and drug screening methods for Alzheimer's disease.
|
|
IL135578A0
(en)
*
|
1997-10-29 |
2001-05-20 |
Genzyme Corp |
Compositions and methods for treating lysosomal storage disease
|
|
DE19832057C1
(de)
*
|
1998-07-16 |
2000-03-16 |
Siemens Ag |
Verfahren zur Regenerierung eines desaktivierten Katalysators
|
|
WO2000009725A2
(en)
*
|
1998-08-11 |
2000-02-24 |
Biosource Technologies, Inc. |
Method for recovering proteins from the interstitial fluid of plant tissues
|
|
DK1137762T3
(da)
*
|
1998-12-07 |
2009-02-02 |
Genzyme Corp |
Behandling af Pompes sygdom
|
|
US6596500B1
(en)
*
|
1998-12-08 |
2003-07-22 |
The General Hospital Corporation |
Binding of retinoids to M6P/IGF-II receptor
|
|
US6638727B1
(en)
*
|
1999-01-26 |
2003-10-28 |
Cytyc Health Corporation |
Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer
|
|
US6537785B1
(en)
*
|
1999-09-14 |
2003-03-25 |
Genzyme Glycobiology Research Institute, Inc. |
Methods of treating lysosomal storage diseases
|
|
US20020081654A1
(en)
*
|
2000-04-07 |
2002-06-27 |
Sandrin Mauro Sergio |
Targeting hydrolase enzymes
|
|
AU7194101A
(en)
*
|
2000-07-18 |
2002-01-30 |
Univ Duke |
Treatment of glycogen storage disease type ii
|
|
US20020142299A1
(en)
*
|
2001-01-09 |
2002-10-03 |
Davidson Beverly L. |
PTD-modified proteins
|
|
US7723296B2
(en)
*
|
2001-01-18 |
2010-05-25 |
Genzyme Corporation |
Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
|
|
US20030004236A1
(en)
*
|
2001-04-20 |
2003-01-02 |
Meade Thomas J. |
Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
|
|
US7560424B2
(en)
*
|
2001-04-30 |
2009-07-14 |
Zystor Therapeutics, Inc. |
Targeted therapeutic proteins
|
|
US7629309B2
(en)
*
|
2002-05-29 |
2009-12-08 |
Zystor Therapeutics, Inc. |
Targeted therapeutic proteins
|
|
ATE384736T1
(de)
*
|
2001-04-30 |
2008-02-15 |
Zystor Therapeutics Inc |
Subzelluläres targeting von therapeutischen proteinen
|
|
US20040005309A1
(en)
*
|
2002-05-29 |
2004-01-08 |
Symbiontics, Inc. |
Targeted therapeutic proteins
|
|
AU2003224880A1
(en)
*
|
2002-04-05 |
2003-10-27 |
Genzyme Corporation |
Methods of enhancing lysosomal storage disease therapy
|
|
ATE521701T1
(de)
*
|
2003-01-22 |
2011-09-15 |
Univ Duke |
Verbesserte konstrukte zur expression lysosomaler polypeptide
|
|
US20050026823A1
(en)
*
|
2003-06-20 |
2005-02-03 |
Biomarin Pharmaceutical Inc. |
Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
|
|
CN1922313B
(zh)
*
|
2004-02-10 |
2011-10-26 |
生物马林医药公司 |
酸性α-糖苷酶及其片段
|