JP2010509233A5 - - Google Patents
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- Publication number
- JP2010509233A5 JP2010509233A5 JP2009535482A JP2009535482A JP2010509233A5 JP 2010509233 A5 JP2010509233 A5 JP 2010509233A5 JP 2009535482 A JP2009535482 A JP 2009535482A JP 2009535482 A JP2009535482 A JP 2009535482A JP 2010509233 A5 JP2010509233 A5 JP 2010509233A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- methylamino
- triazin
- cyclohexanecarboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 69
- -1 4-methyl-1-piperazinyl Chemical group 0.000 claims 42
- 125000005843 halogen group Chemical group 0.000 claims 34
- 229910052739 hydrogen Inorganic materials 0.000 claims 31
- 239000001257 hydrogen Substances 0.000 claims 28
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 24
- 229910052799 carbon Inorganic materials 0.000 claims 24
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 2
- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 235000010233 benzoic acid Nutrition 0.000 claims 2
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 claims 2
- YCJBWWJKCCZLRM-UHFFFAOYSA-N cyclohexanecarboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NC(=O)C1CCCCC1 YCJBWWJKCCZLRM-UHFFFAOYSA-N 0.000 claims 2
- IBNWGIFHWSUUCL-UHFFFAOYSA-N cyclohexanecarboxamide;hydrochloride Chemical compound Cl.NC(=O)C1CCCCC1 IBNWGIFHWSUUCL-UHFFFAOYSA-N 0.000 claims 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 229940095102 methyl benzoate Drugs 0.000 claims 2
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- YLEWPMOGNCMYOM-UHFFFAOYSA-N 4-[[4-(azepan-1-yl)-6-(methylamino)-1,3,5-triazin-2-yl]amino]-n-[[2-(trifluoromethoxy)phenyl]methyl]cyclohexane-1-carboxamide Chemical compound N=1C(N2CCCCCC2)=NC(NC)=NC=1NC(CC1)CCC1C(=O)NCC1=CC=CC=C1OC(F)(F)F YLEWPMOGNCMYOM-UHFFFAOYSA-N 0.000 claims 1
- CWGGAJOYHPQCLI-UHFFFAOYSA-N 4-[[4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl]amino]-n-[[2-(trifluoromethyl)phenyl]methyl]cyclohexane-1-carboxamide Chemical compound N=1C(N2CCN(C)CC2)=NC(NC)=NC=1NC(CC1)CCC1C(=O)NCC1=CC=CC=C1C(F)(F)F CWGGAJOYHPQCLI-UHFFFAOYSA-N 0.000 claims 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86417806P | 2006-11-03 | 2006-11-03 | |
| PCT/US2007/083449 WO2008105968A1 (en) | 2006-11-03 | 2007-11-02 | Novel seh inhibitors and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010509233A JP2010509233A (ja) | 2010-03-25 |
| JP2010509233A5 true JP2010509233A5 (https=) | 2011-01-06 |
Family
ID=39721528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535482A Withdrawn JP2010509233A (ja) | 2006-11-03 | 2007-11-02 | 新規ｓＥＨ阻害剤およびそれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7994317B2 (https=) |
| EP (1) | EP2097378B1 (https=) |
| JP (1) | JP2010509233A (https=) |
| WO (1) | WO2008105968A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009049157A1 (en) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| ES2404580T3 (es) | 2007-10-11 | 2013-05-28 | Glaxosmithkline Llc | Novedosos inhibidores de la ehs y uso de los mismos |
| US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
| AU2011336764B2 (en) * | 2010-11-29 | 2017-02-23 | Galleon Pharmaceuticals, Inc. | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
| WO2014111465A1 (en) | 2013-01-17 | 2014-07-24 | Sanofi | Isomannide derivatives as inhibitors of soluble epoxide hydrolase |
| CN113846062B (zh) | 2014-07-25 | 2025-02-21 | 赛拉福柯蒂斯公司 | 用于嵌合抗原受体分子的调控表达的慢病毒载体 |
| EP3463470A1 (en) | 2016-05-25 | 2019-04-10 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Treatment and diagnosis of non-proliferative diabetic retinopathy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US20050197350A1 (en) | 2003-03-31 | 2005-09-08 | Taisho Pharmaceutical Co., Ltd. | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| WO2009049157A1 (en) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| US20100210655A1 (en) | 2007-10-11 | 2010-08-19 | Yun Ding | NOVEL sEH INHIBITORS AND THEIR USE |
| ES2404580T3 (es) | 2007-10-11 | 2013-05-28 | Glaxosmithkline Llc | Novedosos inhibidores de la ehs y uso de los mismos |
-
2007
- 2007-11-02 EP EP07871337A patent/EP2097378B1/en active Active
- 2007-11-02 WO PCT/US2007/083449 patent/WO2008105968A1/en not_active Ceased
- 2007-11-02 JP JP2009535482A patent/JP2010509233A/ja not_active Withdrawn
- 2007-11-02 US US12/513,186 patent/US7994317B2/en not_active Expired - Fee Related
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