JP2010509229A5 - - Google Patents
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- Publication number
- JP2010509229A5 JP2010509229A5 JP2009535417A JP2009535417A JP2010509229A5 JP 2010509229 A5 JP2010509229 A5 JP 2010509229A5 JP 2009535417 A JP2009535417 A JP 2009535417A JP 2009535417 A JP2009535417 A JP 2009535417A JP 2010509229 A5 JP2010509229 A5 JP 2010509229A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- catheter
- tenecteplase
- bfr
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010039185 Tenecteplase Proteins 0.000 claims description 66
- 229960000216 tenecteplase Drugs 0.000 claims description 66
- 238000001631 haemodialysis Methods 0.000 claims description 34
- 230000000322 hemodialysis Effects 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 29
- 241000124008 Mammalia Species 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 230000004872 arterial blood pressure Effects 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 239000008227 sterile water for injection Substances 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 69
- 230000004064 dysfunction Effects 0.000 claims 3
- 230000007774 longterm Effects 0.000 claims 3
- 239000008228 bacteriostatic water for injection Substances 0.000 claims 2
- 239000008215 water for injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86475806P | 2006-11-07 | 2006-11-07 | |
| US60/864,758 | 2006-11-07 | ||
| US98348907P | 2007-10-29 | 2007-10-29 | |
| US60/983,489 | 2007-10-29 | ||
| PCT/US2007/082933 WO2008070353A2 (en) | 2006-11-07 | 2007-10-30 | Tissue plasminogen activator variant uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509229A JP2010509229A (ja) | 2010-03-25 |
| JP2010509229A5 true JP2010509229A5 (enExample) | 2011-12-15 |
| JP5871449B2 JP5871449B2 (ja) | 2016-03-01 |
Family
ID=39362326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535417A Active JP5871449B2 (ja) | 2006-11-07 | 2007-10-30 | 組織プラスミノゲン活性化因子バリアントの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8916148B2 (enExample) |
| EP (1) | EP2086571A2 (enExample) |
| JP (1) | JP5871449B2 (enExample) |
| AR (1) | AR063603A1 (enExample) |
| CA (1) | CA2668347C (enExample) |
| CL (1) | CL2007003211A1 (enExample) |
| PE (2) | PE20081488A1 (enExample) |
| TW (1) | TW200826981A (enExample) |
| UY (1) | UY30693A1 (enExample) |
| WO (1) | WO2008070353A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS46204A (sr) | 2001-11-26 | 2006-10-27 | Genentech Inc. | Preparat za kateter i njegova upotreba |
| US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
| JP5871449B2 (ja) | 2006-11-07 | 2016-03-01 | ジェネンテック， インコーポレイテッド | 組織プラスミノゲン活性化因子バリアントの使用 |
| AU2011346515B2 (en) | 2010-12-23 | 2017-01-19 | Gennova Biopharmaceuticals Ltd. | Pharmaceutical compositions of tenecteplase |
| GB201415062D0 (en) * | 2014-08-26 | 2014-10-08 | Aplagon Oy | Therapeutic |
| DK3209767T3 (da) * | 2014-10-21 | 2020-11-02 | Gennova Biopharmaceuticals Ltd | Hidtil ukendt oprensningsfremgangsmåde til isolering og kommerciel fremstilling af rekombinant tnk-tpa (tenecteplase) |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI831484A7 (fi) | 1982-05-05 | 1983-11-06 | Genentech Inc | Ihmiskudoksen plasminogeenien aktivaattori. |
| US5000185A (en) | 1986-02-28 | 1991-03-19 | Cardiovascular Imaging Systems, Inc. | Method for intravascular two-dimensional ultrasonography and recanalization |
| US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| US5270198A (en) | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
| GB8820945D0 (en) | 1988-09-07 | 1988-10-05 | Smith & Nephew | Medical articles |
| NZ230808A (en) | 1988-10-24 | 1993-04-28 | Squibb & Sons Inc | Pharmaceutical compositions and combinations containing an angiotensin-converting enzyme inhibitor and a thrombolytic agent |
| AU7998091A (en) | 1990-05-17 | 1991-12-10 | Harbor Medical Devices, Inc. | Medical device polymer |
| US5399158A (en) | 1990-05-31 | 1995-03-21 | The United States Of America As Represented By The Secretary Of The Army | Method of lysing thrombi |
| US5363754A (en) | 1991-09-03 | 1994-11-15 | Grainco Queensland Co-Operative Association Limited | Apparatus for preparing animal feedstuff from cotton seed |
| DE69333127T2 (de) | 1992-06-03 | 2004-05-06 | Genentech, Inc., South San Francisco | Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung |
| US5362754A (en) | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
| US5688516A (en) | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| NZ276633A (en) | 1993-11-24 | 1998-04-27 | Du Pont Merck Pharma | Isoxazole and isoxazoline derivatives and pharmaceutical compositions thereof |
| US5885967A (en) | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
| US5509896A (en) | 1994-09-09 | 1996-04-23 | Coraje, Inc. | Enhancement of thrombolysis with external ultrasound |
| US5556380A (en) | 1995-04-05 | 1996-09-17 | Duke University | Method for removing fibrin sheaths from catheters |
| CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
| US5772640A (en) | 1996-01-05 | 1998-06-30 | The Trustees Of Columbia University Of The City Of New York | Triclosan-containing medical devices |
| US5932299A (en) | 1996-04-23 | 1999-08-03 | Katoot; Mohammad W. | Method for modifying the surface of an object |
| US5840733A (en) | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| US5837688A (en) | 1996-11-27 | 1998-11-17 | Gelfand; Mathew I. | Use of thrombolytic reagents for prevention of vascular disease |
| GB9626795D0 (en) | 1996-12-23 | 1997-02-12 | Geistlich Soehne Ag | Combating infection in delivery systems |
| WO1998028326A1 (en) | 1996-12-23 | 1998-07-02 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
| US5981826A (en) | 1997-05-05 | 1999-11-09 | Georgia Tech Research Corporation | Poly(vinyl alcohol) cryogel |
| JPH10328293A (ja) | 1997-06-04 | 1998-12-15 | Unitika Ltd | 医療用具及びその製造方法 |
| US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
| US6166007A (en) | 1998-07-02 | 2000-12-26 | Sodemann; Klaus | Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof |
| US6174537B1 (en) | 1998-09-25 | 2001-01-16 | Becton, Dickinson And Company | Catheter flush solution and method for its use |
| KR20020005614A (ko) | 1999-03-11 | 2002-01-17 | 블레어 큐. 퍼거슨 | Ｘａ 인자 저해제와 아스피린, 조직 플라스미노겐활성화인자(ＴＰＡ), ＧＰⅡｂ／Ⅲａ 길항제, 저분자량헤파린 또는 헤파린의 병용에 의한 혈전증 치료 |
| CA2364252A1 (en) | 1999-03-11 | 2000-09-14 | Bristol-Myers Squibb Pharma Company | Synergy between low molecular weight heparin and platelet aggregation inhibitors, providing a combination therapy for the prevention and treatment of various thromboembolic disorders |
| CA2302720C (en) | 1999-03-29 | 2009-07-14 | Ed Geistlich Sohne Ag Fur Chemische Industrie | Anticoagulant/sterilizing compositions and methods |
| US6187768B1 (en) | 1999-06-01 | 2001-02-13 | Becton, Dickinson And Company | Kit for flushing medical devices and method of preparation |
| EP1060747A3 (en) | 1999-06-16 | 2001-12-05 | New York Blood Center, Inc. | Fibrin(ogen) degradation and clot lysis by fibrinolytic metalloproteinase |
| US6592564B2 (en) | 1999-07-23 | 2003-07-15 | Vasca, Inc. | Methods and kits for locking and disinfecting implanted catheters |
| US6350251B1 (en) * | 2000-01-18 | 2002-02-26 | Biolink Corporation | Biocidal locks |
| US20010031981A1 (en) | 2000-03-31 | 2001-10-18 | Evans Michael A. | Method and device for locating guidewire and treating chronic total occlusions |
| WO2001085249A1 (en) | 2000-05-10 | 2001-11-15 | Ash Medical Systems, Inc. | A catheter lock solution including a photo-oxidant |
| JP2004507473A (ja) | 2000-08-25 | 2004-03-11 | オルガン リカヴァリー システムス インコーポレイテッド | 血栓溶解性器官処理および修復法 |
| US20050215978A1 (en) * | 2001-05-25 | 2005-09-29 | Ash Stephen R | Method of enhancing catheter patency using a citrate salt catheter lock solution |
| RS46204A (sr) | 2001-11-26 | 2006-10-27 | Genentech Inc. | Preparat za kateter i njegova upotreba |
| US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
| DE60311958T2 (de) | 2003-02-03 | 2007-11-08 | Polaschegg, Hans-Dietrich, Dr. | Zusammensetzung zur Prävention von Infektionen durch subkutane Prothesen |
| US7696182B2 (en) * | 2004-11-02 | 2010-04-13 | Nd Partners, Llc | Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin |
| US7749529B2 (en) | 2005-02-08 | 2010-07-06 | Ash Access Technology, Inc. | Catheter lock solution comprising citrate and a paraben |
| JP5871449B2 (ja) | 2006-11-07 | 2016-03-01 | ジェネンテック， インコーポレイテッド | 組織プラスミノゲン活性化因子バリアントの使用 |
-
2007
- 2007-10-30 JP JP2009535417A patent/JP5871449B2/ja active Active
- 2007-10-30 CA CA2668347A patent/CA2668347C/en active Active
- 2007-10-30 WO PCT/US2007/082933 patent/WO2008070353A2/en not_active Ceased
- 2007-10-30 EP EP07871279A patent/EP2086571A2/en not_active Ceased
- 2007-10-30 US US12/447,838 patent/US8916148B2/en active Active
- 2007-11-06 PE PE2007001525A patent/PE20081488A1/es not_active Application Discontinuation
- 2007-11-06 PE PE2011001779A patent/PE20120639A1/es not_active Application Discontinuation
- 2007-11-07 CL CL200703211A patent/CL2007003211A1/es unknown
- 2007-11-07 TW TW096142107A patent/TW200826981A/zh unknown
- 2007-11-07 AR ARP070104960A patent/AR063603A1/es not_active Application Discontinuation
- 2007-11-07 UY UY30693A patent/UY30693A1/es not_active Application Discontinuation
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