JP2010508816A - Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 - Google Patents
Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Epidemiology (AREA)
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Applications Claiming Priority (2)
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| US85659206P | 2006-11-02 | 2006-11-02 | |
| PCT/US2007/023217 WO2008057461A2 (en) | 2006-11-02 | 2007-11-02 | Alk1 receptor and ligand antagonists and uses thereof |
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| JP2013142324A Division JP2013199496A (ja) | 2006-11-02 | 2013-07-08 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
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| JP2013142324A Withdrawn JP2013199496A (ja) | 2006-11-02 | 2013-07-08 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
| JP2015089239A Expired - Fee Related JP6348448B2 (ja) | 2006-11-02 | 2015-04-24 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
| JP2018071503A Withdrawn JP2018127471A (ja) | 2006-11-02 | 2018-04-03 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
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| JP2013142324A Withdrawn JP2013199496A (ja) | 2006-11-02 | 2013-07-08 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
| JP2015089239A Expired - Fee Related JP6348448B2 (ja) | 2006-11-02 | 2015-04-24 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
| JP2018071503A Withdrawn JP2018127471A (ja) | 2006-11-02 | 2018-04-03 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
| JP2020108938A Pending JP2020150955A (ja) | 2006-11-02 | 2020-06-24 | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
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| EP (2) | EP2087001B1 (zh) |
| JP (5) | JP2010508816A (zh) |
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| CN (2) | CN111518218A (zh) |
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| BR (1) | BRPI0717964A2 (zh) |
| CA (1) | CA2668411C (zh) |
| DK (1) | DK2087001T3 (zh) |
| ES (1) | ES2612755T3 (zh) |
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| MX (1) | MX2009004718A (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2016036322A (ja) * | 2014-08-11 | 2016-03-22 | 日本化薬株式会社 | 血管新生因子と結合するキメラタンパク質 |
| JP2018070625A (ja) * | 2011-04-20 | 2018-05-10 | アクセレロン ファーマ インコーポレイテッドＡｃｃｅｌｅｒｏｎ Ｐｈａｒｍａ，Ｉｎｃ． | エンドグリンポリペプチドおよびその使用 |
| JP2018517664A (ja) * | 2015-04-06 | 2018-07-05 | アクセルロン ファーマ， インコーポレイテッド | シングルアームｉ型およびｉｉ型受容体融合タンパク質およびその使用 |
| JP2018127471A (ja) * | 2006-11-02 | 2018-08-16 | アクセルロン ファーマ， インコーポレイテッド | Ａｌｋ１受容体およびリガンドアンタゴニストならびにその使用 |
| US11590201B2 (en) | 2013-10-25 | 2023-02-28 | Acceleron Pharma, Inc. | Endoglin peptides to treat fibrotic diseases |
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| US8764725B2 (en) | 2004-02-09 | 2014-07-01 | Covidien Lp | Directional anchoring mechanism, method and applications thereof |
| US7897581B2 (en) * | 2005-02-24 | 2011-03-01 | Massachusetts Eye & Ear Infirmary | Methods and compounds for promoting vessel regression |
| US8642031B2 (en) | 2006-11-02 | 2014-02-04 | Acceleron Pharma, Inc. | Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof |
| US10059756B2 (en) * | 2006-11-02 | 2018-08-28 | Acceleron Pharma Inc. | Compositions comprising ALK1-ECD protein |
| ES2554812T3 (es) * | 2007-11-09 | 2015-12-23 | Genentech, Inc. | Composiciones de antagonistas de quinasa 1 de tipo receptor de activina y métodos de uso |
| US7855564B2 (en) * | 2008-02-14 | 2010-12-21 | Delaware Capital Formation, Inc. | Acoustic wave device physical parameter sensor |
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| WO2009139891A2 (en) * | 2008-05-15 | 2009-11-19 | Acceleron Pharma, Inc. | Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof |
| WO2010126169A1 (ja) * | 2009-04-30 | 2010-11-04 | 協和発酵キリン株式会社 | Alk1阻害剤を有効成分とする血管障害を抑制するための医薬組成物 |
| WO2011056494A1 (en) * | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
| KR101421171B1 (ko) * | 2011-08-31 | 2014-07-22 | 재단법인 제이씨비 공동생물과학연구소 | 인간 골형성 단백질 수용체 1ａ의 세포외 도메인을 유효성분으로 포함하는 피부 상태 개선용 조성물 |
| JP2015506961A (ja) * | 2012-02-02 | 2015-03-05 | アクセルロン ファーマ， インコーポレイテッド | Ａｌｋ１アンタゴニストおよび腎細胞癌の治療におけるその使用 |
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| GB201412290D0 (en) * | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
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| EA201792561A1 (ru) * | 2015-06-05 | 2018-04-30 | Новартис Аг | Антитела, нацеленные на морфогенетический белок кости 9 (bmp9), и способы их применения |
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- 2007-11-02 JP JP2009535341A patent/JP2010508816A/ja not_active Withdrawn
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- 2007-11-02 KR KR1020147033523A patent/KR20150008889A/ko not_active Application Discontinuation
- 2007-11-02 AU AU2007317926A patent/AU2007317926A1/en not_active Abandoned
- 2007-11-02 RU RU2009120695/10A patent/RU2559532C2/ru active
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2009
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2013
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- 2013-07-22 RU RU2013134324/10A patent/RU2013134324A/ru not_active Application Discontinuation
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2015
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2017
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2018
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2020
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2021
- 2021-12-09 US US17/546,983 patent/US20220296708A1/en active Pending
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| JP2018070625A (ja) * | 2011-04-20 | 2018-05-10 | アクセレロン ファーマ インコーポレイテッドＡｃｃｅｌｅｒｏｎ Ｐｈａｒｍａ，Ｉｎｃ． | エンドグリンポリペプチドおよびその使用 |
| JP2020202844A (ja) * | 2011-04-20 | 2020-12-24 | アクセレロン ファーマ インコーポレイテッドＡｃｃｅｌｅｒｏｎ Ｐｈａｒｍａ，Ｉｎｃ． | エンドグリンポリペプチドおよびその使用 |
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| JP2016036322A (ja) * | 2014-08-11 | 2016-03-22 | 日本化薬株式会社 | 血管新生因子と結合するキメラタンパク質 |
| JP2018517664A (ja) * | 2015-04-06 | 2018-07-05 | アクセルロン ファーマ， インコーポレイテッド | シングルアームｉ型およびｉｉ型受容体融合タンパク質およびその使用 |
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