JP2010507686A5 - - Google Patents
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- Publication number
- JP2010507686A5 JP2010507686A5 JP2009534846A JP2009534846A JP2010507686A5 JP 2010507686 A5 JP2010507686 A5 JP 2010507686A5 JP 2009534846 A JP2009534846 A JP 2009534846A JP 2009534846 A JP2009534846 A JP 2009534846A JP 2010507686 A5 JP2010507686 A5 JP 2010507686A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- photoinitiator compound
- tissue
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000000126 substance Substances 0.000 claims 8
- 210000004087 cornea Anatomy 0.000 claims 7
- 201000002287 Keratoconus Diseases 0.000 claims 6
- 206010073286 Pathologic myopia Diseases 0.000 claims 5
- 230000008859 change Effects 0.000 claims 5
- 208000001309 degenerative myopia Diseases 0.000 claims 5
- 230000004340 degenerative myopia Effects 0.000 claims 5
- 210000003786 sclera Anatomy 0.000 claims 5
- 239000013043 chemical agent Substances 0.000 claims 4
- 230000010339 dilation Effects 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 208000025747 Rheumatic disease Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 208000001491 myopia Diseases 0.000 claims 3
- 230000004379 myopia Effects 0.000 claims 3
- 230000002093 peripheral effect Effects 0.000 claims 3
- 230000000552 rheumatic effect Effects 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- ZBQZBWKNGDEDOA-UHFFFAOYSA-N eosin B Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC([N+]([O-])=O)=C(O)C(Br)=C1OC1=C2C=C([N+]([O-])=O)C(O)=C1Br ZBQZBWKNGDEDOA-UHFFFAOYSA-N 0.000 claims 2
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000009467 reduction Effects 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- -1 eosin Y compound Chemical class 0.000 claims 1
- 238000005286 illumination Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 230000002186 photoactivation Effects 0.000 claims 1
- 239000000906 photoactive agent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85394906P | 2006-10-24 | 2006-10-24 | |
| US60/853,949 | 2006-10-24 | ||
| US95454107P | 2007-08-07 | 2007-08-07 | |
| US60/954,541 | 2007-08-07 | ||
| PCT/US2007/082435 WO2008052081A2 (en) | 2006-10-24 | 2007-10-24 | Photochemical therapy to affect mechanical and/or chemical properties of body tissue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507686A JP2010507686A (ja) | 2010-03-11 |
| JP2010507686A5 true JP2010507686A5 (https=) | 2011-04-21 |
| JP5559540B2 JP5559540B2 (ja) | 2014-07-23 |
Family
ID=39325405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534846A Expired - Fee Related JP5559540B2 (ja) | 2006-10-24 | 2007-10-24 | 体組織の機械的および／または化学的性質に影響を及ぼすための光化学療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8414911B2 (https=) |
| JP (1) | JP5559540B2 (https=) |
| KR (2) | KR101502632B1 (https=) |
| SG (1) | SG175568A1 (https=) |
| WO (1) | WO2008052081A2 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| WO2008124009A2 (en) * | 2007-04-02 | 2008-10-16 | The Cleveland Clinic Foundation | Treating glaucoma |
| EP2227197A4 (en) * | 2007-12-05 | 2011-06-22 | Avedro Inc | EYE THERAPY SYSTEM |
| CZ18420U1 (cs) * | 2008-01-25 | 2008-04-07 | Benedík@Jaroslav | Prístroj na zjištování kvality a pevnosti cévní steny |
| WO2009114513A2 (en) * | 2008-03-14 | 2009-09-17 | Euclid Systems Corporation | Ultraviolet irradiation to treat corneal weakness disorders |
| GB0816399D0 (en) * | 2008-09-09 | 2008-10-15 | Sharma Anant | Irradiation treatment |
| US8366689B2 (en) * | 2008-09-30 | 2013-02-05 | Avedro, Inc. | Method for making structural changes in corneal fibrils |
| SI2352488T1 (sl) | 2008-11-07 | 2017-07-31 | Klox Technologies Inc. | Oksidativni fotoaktiviran sestavek za pomlajevanje kože, ki vsebuje hialuronsko kislino, glukozamin ali alantoin |
| SG177635A1 (en) | 2009-07-17 | 2012-03-29 | Klox Technologies Inc | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| US20110077468A1 (en) * | 2009-09-30 | 2011-03-31 | Finger Paul T | Drug eluting eyelid speculum |
| WO2011050164A1 (en) * | 2009-10-21 | 2011-04-28 | Avedro, Inc. | Eye therapy |
| DE102010008146B4 (de) | 2010-02-12 | 2022-03-31 | Carl Zeiss Meditec Ag | Messsystem und Verfahren zum Ermitteln des Innendrucks eines Auges sowie Verfahren und System zum Einstellen des Augeninnendrucks |
| JP6377906B2 (ja) * | 2010-03-19 | 2018-08-22 | アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． | 眼治療を適用およびモニターするためのシステム |
| DE102010020194B4 (de) | 2010-05-07 | 2022-09-08 | Carl Zeiss Meditec Ag | Vorrichtung zur Stabilisierung der Augenhornhaut |
| US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
| US20120310141A1 (en) * | 2011-05-06 | 2012-12-06 | Kornfield Julia A | Light delivery device and related compositions, methods and systems |
| WO2012162529A1 (en) | 2011-05-24 | 2012-11-29 | Avedro, Inc. | Systems and methods for reshaping an eye feature |
| WO2012167260A2 (en) * | 2011-06-02 | 2012-12-06 | Avedro, Inc. | Systems and methods for monitoring time based photo active agent delivery or photo active marker presence |
| RU2632439C2 (ru) | 2011-08-23 | 2017-10-04 | Йеда Рисерч Энд Дивелопмент Ко., Лтд. | Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств |
| WO2013148895A1 (en) | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular cross-linking system and method for sealing corneal wounds |
| EP2830627B1 (en) | 2012-03-29 | 2024-05-01 | Epion Therapeutics, Inc. | Ocular treatment solutions, delivery devices and delivery augmentation methods |
| ES2986057T3 (es) | 2012-03-29 | 2024-11-08 | Epion Therapeutics Inc | Composiciones y métodos para tratar o prevenir enfermedades asociadas al estrés oxidativo |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| EP2872081B2 (en) | 2012-07-16 | 2025-07-16 | Avedro, Inc. | Systems for corneal cross-linking with pulsed light |
| US20140105832A1 (en) | 2012-09-14 | 2014-04-17 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
| DE102013004482A1 (de) | 2013-03-12 | 2014-09-18 | Carl Zeiss Meditec Ag | Vorrichtung und Verfahren zur Stabilisierung der Augenhornhaut |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| EP2967986A4 (en) * | 2013-03-14 | 2016-11-16 | Cxl Ophthalmics Llc | EYE TREATMENT DEVICE, SYSTEM AND METHOD OF USE |
| US9498114B2 (en) | 2013-06-18 | 2016-11-22 | Avedro, Inc. | Systems and methods for determining biomechanical properties of the eye for applying treatment |
| US9498122B2 (en) | 2013-06-18 | 2016-11-22 | Avedro, Inc. | Systems and methods for determining biomechanical properties of the eye for applying treatment |
| US10881736B2 (en) | 2013-07-03 | 2021-01-05 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
| US9920147B2 (en) | 2013-09-13 | 2018-03-20 | Brandeis University | Polymeric materials having active cross-linkers, methods for making them, and use thereof |
| CA2944201A1 (en) | 2014-04-01 | 2015-10-08 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| KR102545628B1 (ko) | 2014-10-27 | 2023-06-20 | 아베드로 인코퍼레이티드 | 눈의 교차-결합 처리를 위한 시스템 및 방법 |
| KR20170077153A (ko) | 2014-10-31 | 2017-07-05 | 클록스 테크놀로지스 인크. | 광활성 섬유 및 직물 매질 |
| WO2016077747A1 (en) | 2014-11-13 | 2016-05-19 | Avedro, Inc. | Multipass virtually imaged phased array etalon |
| EP3285704B1 (en) | 2015-04-24 | 2020-11-18 | Avedro Inc. | Systems for photoactivating a photosensitizer applied to an eye |
| CN107849265A (zh) | 2015-05-14 | 2018-03-27 | 加州理工学院 | 使用上转换纳米颗粒和近红外(nir)光的光可调人工晶状体 |
| US10028657B2 (en) | 2015-05-22 | 2018-07-24 | Avedro, Inc. | Systems and methods for monitoring cross-linking activity for corneal treatments |
| KR102706856B1 (ko) | 2015-07-21 | 2024-09-19 | 아베드로 인코퍼레이티드 | 광증감제로 눈을 치료하기 위한 시스템 및 방법 |
| KR102149590B1 (ko) | 2015-12-03 | 2020-08-28 | 아베드로 인코퍼레이티드 | 마스크 장치로 눈을 치료하기 위한 시스템 및 방법 |
| DE102016208012A1 (de) | 2016-05-10 | 2017-11-16 | Carl Zeiss Meditec Ag | Augenchirurgisches Verfahren |
| US10765777B2 (en) | 2017-06-28 | 2020-09-08 | California Institute Of Technology | Light adjustable intraocular lenses using upconverting core-shell nanoparticles and near infrared (NIR) light |
| EP4260834B1 (en) | 2018-03-05 | 2025-05-07 | Avedro, Inc. | System for eye tracking during eye treatment |
| WO2019173762A1 (en) | 2018-03-08 | 2019-09-12 | Avedro, Inc. | Micro-devices for treatment of an eye |
| US12144546B2 (en) | 2018-09-19 | 2024-11-19 | Avedro, Inc. | Systems and methods for eye tracking during eye treatment |
| CN113329723A (zh) | 2018-09-19 | 2021-08-31 | 艾维德洛公司 | 治疗角膜扩张型疾病的系统和方法 |
| CA3113120A1 (en) | 2018-10-09 | 2020-04-16 | Avedro, Inc. | Photoactivation systems and methods for corneal cross-linking treatments |
| US11702546B2 (en) | 2018-10-24 | 2023-07-18 | California Institute Of Technology | Near-infrared heptamethine dyes for generation of singlet oxygen |
| CN111140774B (zh) * | 2019-01-31 | 2025-10-14 | 中国科学院昆明动物研究所 | 一种可抑制眼轴过度增长的新型光源及其模拟方法、灯具 |
| WO2020176598A1 (en) | 2019-02-26 | 2020-09-03 | Avedro, Inc. | Systems and methods for cross-linking treatments of an eye |
| JP6853446B2 (ja) * | 2019-02-28 | 2021-03-31 | 地方独立行政法人神奈川県立産業技術総合研究所 | 流動体試料の内部構造観察装置及び内部構造解析システム、流動体試料の内部構造観察方法及び内部構造解析方法、並びにセラミックスの製造方法 |
| US11298263B2 (en) * | 2019-07-16 | 2022-04-12 | Jack T. Holladay | Method of mitigating myopia development and related instrumentation |
| US11642244B2 (en) | 2019-08-06 | 2023-05-09 | Avedro, Inc. | Photoactivation systems and methods for corneal cross-linking treatments |
| WO2022192237A1 (en) | 2021-03-08 | 2022-09-15 | Avedro, Inc. | Systems and methods for generating patient-specific corneal cross-linking treatment patterns |
| DE102021131244A1 (de) * | 2021-11-29 | 2023-06-01 | Philipps-Universität Marburg, Körperschaft des öffentlichen Rechts | Orts- und zeitaufgelöste Bestimmung der dermalen Penetration von nicht- oder schwachfluoreszierenden Substanzen |
| WO2025255364A1 (en) * | 2024-06-07 | 2025-12-11 | The Regents Of The University Of California | Methods and devices for transscleral multiphoton imaging and laser therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6161544A (en) * | 1998-01-28 | 2000-12-19 | Keratoform, Inc. | Methods for accelerated orthokeratology |
| JP2002058695A (ja) * | 1999-09-03 | 2002-02-26 | Carl Zeiss Jena Gmbh | 眼の照射方法及び装置 |
| WO2005110397A1 (en) | 2004-05-07 | 2005-11-24 | The Regents Of The University Of California | Treatment of myopia |
| US20060276777A1 (en) * | 2005-04-08 | 2006-12-07 | Coroneo Minas T | Corneal shaping |
| WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
-
2007
- 2007-10-24 US US11/923,575 patent/US8414911B2/en active Active
- 2007-10-24 KR KR1020097009723A patent/KR101502632B1/ko not_active Expired - Fee Related
- 2007-10-24 JP JP2009534846A patent/JP5559540B2/ja not_active Expired - Fee Related
- 2007-10-24 WO PCT/US2007/082435 patent/WO2008052081A2/en not_active Ceased
- 2007-10-24 KR KR1020147016403A patent/KR101551590B1/ko not_active Expired - Fee Related
- 2007-10-24 SG SG2011070554A patent/SG175568A1/en unknown
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