EA200501018A1 - Офтальмологический препарат для профилактики и лечения болезненных состояний глаз - Google Patents

Офтальмологический препарат для профилактики и лечения болезненных состояний глаз

Info

Publication number
EA200501018A1
EA200501018A1 EA200501018A EA200501018A EA200501018A1 EA 200501018 A1 EA200501018 A1 EA 200501018A1 EA 200501018 A EA200501018 A EA 200501018A EA 200501018 A EA200501018 A EA 200501018A EA 200501018 A1 EA200501018 A1 EA 200501018A1
Authority
EA
Eurasian Patent Office
Prior art keywords
eye
conditions
age
drug
prevention
Prior art date
Application number
EA200501018A
Other languages
English (en)
Other versions
EA008496B1 (ru
Inventor
Раджив Бхусхан
Original Assignee
Чакшу Рисерч, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чакшу Рисерч, Инк. filed Critical Чакшу Рисерч, Инк.
Publication of EA200501018A1 publication Critical patent/EA200501018A1/ru
Publication of EA008496B1 publication Critical patent/EA008496B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Разработан офтальмологический препарат для профилактики и лечения неблагоприятных глазных состояний, включая пресбиопию (старческую дальнозоркость), помутнение роговицы (arcus senilis), возрастную дегенерацию желтого пятна и других состояний, связанных со старением. Препарат также можно использовать для профилактики и лечения других неблагоприятных глазных состояний, таких как связанные с окислительным и/или свободно радикальным повреждением глаза; данные состояния могут включать состояние, заболевание или нарушение роговицы, сетчатки, хрусталиков, склеры, переднего сегмента и заднего сегмента глаза. В одном варианте осуществления препарат содержит по крайней мере 0,6 мас.% биосовместимого хелатирующего агента, эффективное усиливающее проникновение количество усилителя проницаемости, такого как метилсульфонилметан (MSM), анти-AGE агент, т.е. соединение, которое служит для снижения присутствия конечных продуктов повышенного гликозилирования (AGE) в глазу, и фармацевтически приемлемый офтальмологический носитель, подходящий для конкретного типа препарата (например, глазные капли или мази). Предпочтительные компоненты препарата являются многофункциональными и имеют природное происхождение.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501018A 2002-12-20 2003-12-22 Офтальмологический препарат для профилактики и лечения болезненных состояний глаз EA008496B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43584902P 2002-12-20 2002-12-20
US50647403P 2003-09-26 2003-09-26
PCT/US2003/041141 WO2004058289A1 (en) 2002-12-20 2003-12-22 Ophthalmic formulation for the prevention and treatment of ocular conditions

Publications (2)

Publication Number Publication Date
EA200501018A1 true EA200501018A1 (ru) 2006-02-24
EA008496B1 EA008496B1 (ru) 2007-06-29

Family

ID=32685411

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501018A EA008496B1 (ru) 2002-12-20 2003-12-22 Офтальмологический препарат для профилактики и лечения болезненных состояний глаз

Country Status (11)

Country Link
US (1) US20040137068A1 (ru)
EP (2) EP1972344A1 (ru)
JP (1) JP5583310B2 (ru)
CN (1) CN1753683B (ru)
AU (1) AU2003297511B2 (ru)
CA (1) CA2511217A1 (ru)
EA (1) EA008496B1 (ru)
IL (1) IL169287A (ru)
NZ (1) NZ540885A (ru)
TW (1) TWI361701B (ru)
WO (1) WO2004058289A1 (ru)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060166879A1 (en) * 2002-12-20 2006-07-27 Chakshu Research Inc Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders
US20060172972A1 (en) * 2002-12-20 2006-08-03 Chakshu Research Inc Formulation and method for administration of ophthalmologically active agents
US20060177430A1 (en) * 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
EP3093040A1 (en) 2004-07-02 2016-11-16 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
NZ556456A (en) 2005-01-20 2010-12-24 Inst Molecular Medicine Inc Methylphenidate derivatives and uses of them
US20060172951A1 (en) * 2005-01-28 2006-08-03 Dantzig Paul I Age related macular degeneration and cutaneous signs of mercury toxicity
WO2006102212A2 (en) * 2005-03-18 2006-09-28 Deborah Zelinsky Methods for diagnosis and treatment of processing difficulties, integration problems, imbalances and abnormal postures
DK1919290T3 (da) 2005-07-12 2014-04-22 Ampio Pharmaceuticals Inc Fremgangsmåder og produkter til behandling af sygdomme
US20100069335A1 (en) * 2005-07-15 2010-03-18 Rajiv Bhushan Prevention and Treatment of Ophthalmic Complications of Diabetes
CA2615231A1 (en) * 2005-07-15 2007-01-25 Chakshu Research Inc. Prevention and treatment of ophthalmic complications of diabetes
CA2615360A1 (en) * 2005-07-15 2007-01-25 Chakshu Research Inc. Formulation and method for administration of ophthalmologically active agents
WO2007013591A1 (ja) * 2005-07-29 2007-02-01 Santen Pharmaceutical Co., Ltd. ゲル状組成物を用いた後眼部組織への非侵襲性ドラッグデリバリーシステム
US8048896B2 (en) * 2005-10-05 2011-11-01 Cell Viable Corporation Methods for inhibiting and breaking AGE complex formation
US8053449B2 (en) * 2005-10-05 2011-11-08 Cell Viable Corporation Method for inhibiting AGE complex formation
US20070154523A1 (en) * 2005-12-30 2007-07-05 Rick Lewis Controlled pupil dilation for diagnostic and treatment of visual anomalies
CN101394844A (zh) * 2006-02-14 2009-03-25 东弗吉尼亚医学院 甲氧基聚乙二醇硫酯螯合物及其用途
KR101454674B1 (ko) * 2006-03-17 2014-10-27 존슨 앤드 존슨 비젼 케어, 인코포레이티드 산화에 불안정한 성분을 포함하는 안정화된 안과용 조성물
NZ571758A (en) 2006-03-31 2012-06-29 Quadra Logic Tech Inc A drug insert surrounded by a sheath to expose a polymer containing a drug to surrounding tissues or an eye
US20080138393A1 (en) * 2006-12-11 2008-06-12 Access To Business Group International Llc Water soluble extract of spinach for prevention and repair of DNA damage
BRPI0807943A2 (pt) * 2007-02-15 2014-10-21 Derma Young Ltd Composição farmacêutica ou nutracêutica e métodos para melhorar a administração de um ingrediente farmacêutico pela mucosa oral e para supressão de apetite
WO2009035562A2 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Drug cores for sustained release of therapeutic agents
CN101861135A (zh) 2007-09-07 2010-10-13 Qlt栓塞输送公司 泪道植入物检测
EP2254511A2 (en) * 2008-03-27 2010-12-01 Alcon, Inc. Hydrogel intraocular lens and method of forming same
WO2009134371A2 (en) 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
CN102123713A (zh) * 2008-05-09 2011-07-13 Qlt栓塞输送公司 治疗青光眼和眼高血压的活性剂的持续释放递送
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc METHODS AND THERAPEUTIC COMPOUNDS
IT1393402B1 (it) * 2008-08-28 2012-04-20 Sooft Italia Spa Uso di enhancer eventualmente con riboflavina, nonche' relative composizioni oftalmiche per cross-linking corneale del cheratocono o di altre patologie ectasiche corneali
CN102395401B (zh) * 2009-02-12 2015-08-19 因赛普特有限责任公司 经由水凝胶塞的药物递送
US11464781B2 (en) * 2009-02-25 2022-10-11 Intra-Cellular Therapies, Inc. PDE1 inhibitors for ophthalmic disorders
IT1393712B1 (it) * 2009-05-13 2012-05-08 Bruschettini Srl Composizioni oftalmiche per la riepitelizzazione, la cicatrizzazione, e la disinfezione dei tessuti oculari
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US20100298335A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and Methods for Ameliorating or Reducing Presbyopia
SG177302A1 (en) * 2009-06-22 2012-02-28 Dmi Acquisition Corp Methods and products for treatment of diseases
SG2014008171A (en) 2009-06-22 2014-04-28 Ampio Pharmaceuticals Inc Method for treatment of diseases
WO2012021107A2 (en) 2010-08-12 2012-02-16 Nanyang Technological University A liposomal formulation for ocular drug delivery
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
US20120071502A1 (en) * 2010-09-17 2012-03-22 Cell Viable Corporation Novel phenoxyisobutyric acid compounds and methods for synthesis
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
EP2750660B1 (en) 2011-08-29 2016-10-12 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
WO2013148895A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
IN2014DN10291A (ru) * 2012-05-03 2015-08-07 Rajiv Bhushan
CN102988331B (zh) * 2012-05-31 2015-02-04 管孝君 2-巯基-3-丁醇用于制备抗晶状体混浊产品的用途
US10507245B2 (en) 2012-07-19 2019-12-17 Luis Felipe Vejarano Restrepo Ophthalmic formulation and method for ameliorating presbyopia
EP2908853B1 (en) 2012-10-21 2018-12-05 University Of Rochester Thy1 (cd90) as a therapy to control adipose tissue accumulation
BR112015014261A8 (pt) 2012-12-19 2019-10-08 Ampio Pharmaceuticals Inc composto de danazol, seu uso e formulação farmacêutica compreendendo este
RU2694758C2 (ru) * 2012-12-20 2019-07-16 Раджив Бхушан Антимикробные композиции
CN103040823A (zh) * 2013-01-22 2013-04-17 杭州雷索药业有限公司 长春西汀在制备抗血管生成类药物中的应用
US9956195B2 (en) 2014-01-07 2018-05-01 Nanyang Technological University Stable liposomal formulations for ocular drug delivery
HUE040373T2 (hu) 2015-04-29 2019-03-28 Sooft Italia S P A Kollagén-rostok javított térhálósító szerei cornealis ectasia kezelésében való alkalmazásra
EP4385521A2 (en) * 2015-06-18 2024-06-19 Lenz Therapeutics, Inc. Storage stable compositions and methods for the treatment of refractive errors of the eye
PT3352766T (pt) * 2015-09-24 2022-03-22 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e processos para o seu uso
US20190000754A1 (en) * 2015-10-05 2019-01-03 Seinda Biomedical Corporation Therapeutic compositions for the treatment of dry eye and related ocular surface diseases
CN108430496A (zh) * 2015-11-13 2018-08-21 加州大学洛杉矶分校医疗中心洛杉矶生物医学研究所 用于治疗角膜病症的蛋白酶体调节
PT109154B (pt) 2016-02-12 2019-11-05 Univ De Coimbra Tecnologia não-invasiva de inserto ocular para libertação controlada de fármacos
DE112017005954T8 (de) * 2016-11-24 2019-10-24 Groove X, Inc. Autonom agierender Roboter, der die Pupille verändert
WO2019136358A1 (en) * 2018-01-05 2019-07-11 Iveena Delivery Systems, Inc. Treatment of myopic progression
JP2021512847A (ja) * 2018-02-05 2021-05-20 リビオネックス・インコーポレイテッドＬｉｖｉｏｎｅｘ， Ｉｎｃ． キレート剤、浸透促進剤およびヒドロキシエチルセルロースを含む眼科疾患治療用製剤
CA3162141A1 (en) 2018-04-24 2019-10-31 Allergan, Inc. Presbyopia treatments
CA3145888A1 (en) * 2018-07-31 2020-02-06 Isilay KAVADARLI Ophthalmic formulations and uses thereof
EA202191683A1 (ru) * 2018-12-18 2021-09-01 Сантен Фармасьютикал Ко., Лтд. Средство, содержащее 4-фенилбутират, для профилактики или лечения пресбиопии
WO2020171889A1 (en) 2019-02-19 2020-08-27 University Of Rochester Blocking lipid accumulation or inflammation in thyroid eye disease
CN111632068A (zh) * 2020-06-30 2020-09-08 云南农业大学 一种犬、猫干细胞眼用制剂及其应用
TW202337462A (zh) * 2021-07-20 2023-10-01 海南先聲藥業有限公司 採用長春西汀治療近視的方法

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US659151A (en) * 1900-02-19 1900-10-02 Johann Muellfarth Rotary engine.
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4863748A (en) * 1979-08-30 1989-09-05 Herschler R J Dietary products and uses comprising methylsulfonylmethane
US4488148A (en) * 1982-02-19 1984-12-11 Becton, Dickinson And Company Combination switching and display electronic modular control unit
US4510778A (en) * 1983-12-27 1985-04-16 The Maytag Company Control system for a combined appliance
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5989579A (en) * 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4923693A (en) * 1988-01-21 1990-05-08 Sundrops Enterprises, Inc. Ultraviolet radiation screening method for eyes
US5360611A (en) * 1988-10-03 1994-11-01 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
US5182258A (en) * 1989-03-20 1993-01-26 Orbon Corporation Systemic delivery of polypeptides through the eye
US5278142A (en) * 1989-03-20 1994-01-11 Orbon Corporation Systemic delivery of polypeptides through the eye
AU5929190A (en) * 1989-06-02 1991-01-07 Aisi Research Corporation Appliance interface for exchanging data
US5005996A (en) * 1989-09-15 1991-04-09 International Business Machines Corporation Ribbon cartridge with endless ribbon reinking mechanism
IL95942A0 (en) * 1989-10-13 1991-07-18 Syntex Inc Collagen-containing ophthalmic formulation
US5660851A (en) * 1989-12-26 1997-08-26 Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem Ocular inserts
US5300295A (en) * 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
WO1993004690A1 (en) * 1991-09-09 1993-03-18 Peptide Technology Limited Method for the treatment of the complications and pathology of diabetes
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
US5270051A (en) * 1991-10-15 1993-12-14 Harris Donald H Enzyme-orthokeratology
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5982355A (en) * 1993-11-05 1999-11-09 Jaeger; Denny Multiple purpose controls for electrical systems
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
ATE315939T1 (de) * 1993-11-19 2006-02-15 Univ Sydney Verfahren zur prophylaxe oder kontrolle des katarakts
FI119756B (fi) * 1995-01-18 2009-03-13 Alteon Inc Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa
MX9705449A (es) * 1995-01-18 1998-02-28 Alteon Inc Uso de compuestos de tiazolio para evitar y revertir la formacion de productos finales de glicosilacion avanzada.
US5916288A (en) * 1996-09-03 1999-06-29 Ut Automotive Dearborn, Inc. Multi-functional control switch arrangement
CA2267320A1 (en) * 1996-10-14 1998-04-23 Hiroshi Miyata Secondary cataract inhibitor
DE19645678C2 (de) * 1996-11-06 2000-05-25 Preh Elektro Feinmechanik Bedieneinheit zum Schalten und Steuern von Haushaltsgeräten
CN1185953A (zh) * 1996-12-27 1998-07-01 刘伟中 富氧舒眼液及其生产工艺
JP3638071B2 (ja) * 1997-01-31 2005-04-13 矢崎総業株式会社 システムスイッチ
MX9701946A (es) * 1997-03-14 1998-04-30 Arturo Jimenez Bayardo Solucion oftalmica transportadora.
US5817630A (en) 1997-03-18 1998-10-06 Austin Nutriceutical Corporation Glutathione antioxidant eye drops
DE69816980T2 (de) * 1997-03-31 2004-07-22 Alza Corp., Palo Alto Implantierbares diffusionabgabesystem
EP0872991B1 (en) * 1997-04-15 2006-07-26 Hewlett-Packard Company, A Delaware Corporation Method and apparatus for device interaction by format
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
RU2115412C1 (ru) * 1997-04-22 1998-07-20 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Вагинальные суппозитории антибактериального действия
US6265444B1 (en) 1997-05-23 2001-07-24 Insite Vision Incorporated Ophthalmic composition
US6159458A (en) * 1997-11-04 2000-12-12 Insite Vision Sustained release ophthalmic compositions containing water soluble medicaments
US6144888A (en) * 1997-11-10 2000-11-07 Maya Design Group Modular system and architecture for device control
US6555522B1 (en) * 1998-02-05 2003-04-29 Mount Sinai School Of Medicine Of The City Of New York Peptides and other small molecules derived from regions of interacting proteins and uses thereof
US6197934B1 (en) * 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
SE9802207D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
WO2000024425A1 (en) * 1998-10-27 2000-05-04 Alcon Laboratories, Inc. Preservative system for topically administrable pharmaceutical compositions
US6171337B1 (en) * 1999-03-31 2001-01-09 Miles A. Galin Positive power anterior chamber ocular implant
CA2368688C (en) * 1999-04-05 2009-08-11 City Of Hope Novel inhibitors of formation of advanced glycation endproducts (age's)
US6548059B1 (en) * 1999-07-22 2003-04-15 The Schepens Eye Research Institute, Inc. Promotion of proliferation of adult corneal endothelial cells
US6463343B1 (en) * 1999-08-10 2002-10-08 International Business Machines Corporation System and method for controlling remote devices from a client computer using digital images
US6573299B1 (en) * 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
CA2385703A1 (en) * 1999-10-07 2001-04-12 Human Genome Sciences, Inc. Plasminogen-like polynucleotides, polypeptides, and antibodies
EP1225879A2 (en) * 1999-10-22 2002-07-31 Orbon Corporation Ophthalmic formulation of dopamine antagonists
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6348508B1 (en) 2000-04-04 2002-02-19 Bausch & Lomb Incorporated Method for treating dry eye
RU2165749C1 (ru) * 2000-07-06 2001-04-27 Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" Способ восстановления эндотелия роговицы
WO2002024116A1 (en) * 2000-09-20 2002-03-28 Shahinian, Lee, Jr. Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications
US6587739B1 (en) * 2000-09-29 2003-07-01 Sunbeam Products, Inc. Appliance communication and control system and appliances for use in same
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US6533769B2 (en) * 2001-05-03 2003-03-18 Holmen Joergen Method for use in cataract surgery
AU2002310325A1 (en) * 2001-06-08 2002-12-23 Baylor College Of Medicine Use of ozone for the prevention of infection caused by medical devices
BR0206984A (pt) * 2001-11-14 2004-02-03 Alza Corp Composições de depósito injetáveis e uso destas
JP2003171276A (ja) * 2001-11-30 2003-06-17 Menicon Co Ltd 眼精疲労改善眼科用組成物
US20030114460A1 (en) * 2001-12-14 2003-06-19 Allergan Sales, Inc. Pharmaceutical conjugates with enhanced pharmacokinetic characteristics
US20040038864A1 (en) * 2002-06-27 2004-02-26 Per Balschmidt Use of dimethyl sulfone as isotonicity agent
JP2006504701A (ja) * 2002-09-30 2006-02-09 マーク・エー・バビザイェフ 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段
WO2005041870A2 (en) * 2003-10-24 2005-05-12 Ader Enterprises, Inc. Composition and method for the treatment of eye disease

Also Published As

Publication number Publication date
US20040137068A1 (en) 2004-07-15
CN1753683A (zh) 2006-03-29
EP1972344A1 (en) 2008-09-24
TW200512014A (en) 2005-04-01
EP1592435A1 (en) 2005-11-09
EA008496B1 (ru) 2007-06-29
NZ540885A (en) 2009-02-28
TWI361701B (en) 2012-04-11
JP2006514696A (ja) 2006-05-11
CA2511217A1 (en) 2004-07-15
WO2004058289A1 (en) 2004-07-15
JP5583310B2 (ja) 2014-09-03
AU2003297511B2 (en) 2010-01-21
IL169287A (en) 2010-12-30
EP1592435A4 (en) 2008-01-23
AU2003297511A1 (en) 2004-07-22
CN1753683B (zh) 2010-05-26

Similar Documents

Publication Publication Date Title
EA200501018A1 (ru) Офтальмологический препарат для профилактики и лечения болезненных состояний глаз
EP1904108B1 (en) Ophthalmological formulation comprising methylsulfonylmethane and ciprofloxacin
US6273092B1 (en) Methods for treating various eye disorders
Alfonso et al. Posterior chamber phakic intraocular lenses after penetrating keratoplasty
CN101304727A (zh) 大分子聚集体存在相关病症，尤其是眼科疾病的治疗
ZA200604403B (en) Amelioration of macular degeneration and other ophthalmic diseases
EP1669075A1 (en) Therapeutic agent for ageing macular degeneration
EP3980017A1 (en) Using parasympathomimetic drugs alone or, in combination with one or more alpha agonists in pseudophakic patients, to create multi-focality
AU2014382677A1 (en) Pharmacological ophthalmic composition for use in the correction of presbyopia and its administration
KR20230042077A (ko) 노안, 원시, 난시, 감소된 입체시, 및 감소된 대비 감도를 치료하기 위한 조성물 및 방법
KR20170043655A (ko) 멜라닌 및 멜라닌 유사체, 전구체, 및 유도체로 안과 질병, 질환, 및 증상의 치료 및 예방을 위한 방법
CN105188702A (zh) 使用双嘧达莫的用于治疗眼睛疾病的组合物
US20040106644A1 (en) Composition for treatment of night sight problems(halos, comas and glare) after refractive surgery, intra ocular lens implant after lensectomy or intraocular implant in phakic patients comprising aceclidine employed at low concentrations
Cockburn et al. Herpes zoster ophthalmicus
Rathi et al. Surgically induced astigmatism in frown versus chevron incision in MSICS
MacGregor et al. collagen cross-linking for Pellucid Marginal degeneration
Tidake et al. Effect of UV Light on Diabetic Retinopathy in Pseudophakic Eye
US20230210821A1 (en) Using parasympathomimetic drugs alone or, in combination with one or more alpha agonists in pseudophakic patients, to create multi-focality
Monden Intraocular lenses in patients with uveitis
Bellamkonda et al. Factors affecting post-operative astigmatism in superior and temporal approaches in Manual Small Incision Cataract Surgery
Nashi To Study the Causes of Subnormal Vision After Manual Small Incision Cataract Surgery in Department of Ophthalmology, Kims Hubli
Curtis et al. Complications of neodymium: yttrium-aluminum-garnet laser capsulotomy
SU1397037A1 (ru) Способ хирургического лечени близорукости и астигматизма
Assouline March consultation# 4
Kahook December consultation# 7

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM