JP2010506596A5 - - Google Patents
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- Publication number
- JP2010506596A5 JP2010506596A5 JP2009533527A JP2009533527A JP2010506596A5 JP 2010506596 A5 JP2010506596 A5 JP 2010506596A5 JP 2009533527 A JP2009533527 A JP 2009533527A JP 2009533527 A JP2009533527 A JP 2009533527A JP 2010506596 A5 JP2010506596 A5 JP 2010506596A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- chain region
- specifically binds
- notch3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85286106P | 2006-10-19 | 2006-10-19 | |
| US60/852,861 | 2006-10-19 | ||
| US87921807P | 2007-01-06 | 2007-01-06 | |
| US60/879,218 | 2007-01-06 | ||
| PCT/US2007/081797 WO2008051797A2 (en) | 2006-10-19 | 2007-10-18 | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506596A JP2010506596A (ja) | 2010-03-04 |
| JP2010506596A5 true JP2010506596A5 (cg-RX-API-DMAC7.html) | 2010-12-09 |
| JP5478254B2 JP5478254B2 (ja) | 2014-04-23 |
Family
ID=39325263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533527A Expired - Fee Related JP5478254B2 (ja) | 2006-10-19 | 2007-10-18 | 抗ノッチ３アゴニスト抗体とノッチ３関連疾患の治療におけるその使用 |
Country Status (19)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| WO2005111072A2 (en) * | 2004-04-29 | 2005-11-24 | The Trustees Of Columbia University In The City Of New York | Notch-based fusion proteins and uses thereof |
| WO2008057144A2 (en) * | 2006-05-15 | 2008-05-15 | The Brigham And Women's Hospital, Inc. | Functional negative regulatory domain sequences from human notch1 and 2 and isolated lnr domains from human notch1 |
| US7919092B2 (en) | 2006-06-13 | 2011-04-05 | Oncomed Pharmaceuticals, Inc. | Antibodies to notch receptors |
| CL2007002989A1 (es) * | 2006-10-19 | 2008-05-16 | Genentech Inc | Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para el diagnostico de enfermedades relacionadas con notch3. |
| CA2666672A1 (en) | 2006-10-19 | 2008-05-02 | Genentech, Inc. | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
| AU2007333805B2 (en) | 2006-12-18 | 2013-07-25 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
| US8148147B2 (en) | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| JP5618544B2 (ja) * | 2007-01-24 | 2014-11-05 | オンコメッドファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
| US20090208491A1 (en) * | 2007-02-14 | 2009-08-20 | Austin Gurney | Compositions and Methods for Diagnosing and Treating Cancer |
| PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
| US9127085B2 (en) * | 2007-08-23 | 2015-09-08 | The Trustees Of Columbia University In The City Of New York | Compositions of humanized notch fusion proteins and methods of treatment |
| MX2011000233A (es) * | 2008-07-08 | 2011-05-19 | Oncomed Pharm Inc | Agentes de union del receptor notch1 y metodos para su uso. |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| SG193873A1 (en) * | 2008-08-22 | 2013-10-30 | Univ Columbia | Human notch3 based fusion proteins as decoy inhibitors of notch3 signaling |
| US8404239B2 (en) * | 2008-10-01 | 2013-03-26 | Genentech, Inc. | Anti-Notch2 NRR antibodies |
| WO2010141249A2 (en) * | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-notch3 antibodies |
| JP5113812B2 (ja) * | 2009-08-31 | 2013-01-09 | 清 中川 | コロニーピッキング装置、コロニーピッキング方法、及び融合細胞クローン作製方法 |
| EP2483311B1 (en) | 2009-09-30 | 2016-05-18 | F.Hoffmann-La Roche Ag | Anti-Notch3 antagonistic antibodies for treating of a gamma-secretase inhibitor positive T-cell leukemia that does not respond to an anti-Notch1 antagonistic antibody. |
| CN102958534B (zh) | 2010-01-13 | 2014-11-05 | 昂考梅德药品有限公司 | Notch1结合剂及其使用方法 |
| US20130095493A1 (en) * | 2011-10-03 | 2013-04-18 | The Johns Hopkins University | Identification of the gene notch3 as a novel biomarker for human metastatic melanoma |
| TW201329105A (zh) | 2011-10-04 | 2013-07-16 | Thr Trustees Of Columbia University In The City Of New York | 人類ｎｏｔｃｈ１引誘物 |
| US20150140043A1 (en) * | 2012-05-10 | 2015-05-21 | Institut National De La Sante De La Recherche Medical (Inserm) | Immunomodulatory methods using notch agonists |
| MX2015005810A (es) * | 2012-11-07 | 2015-09-23 | Pfizer | Anticuerpos anti-notch y conjugados de anticuerpo-farmaco. |
| DK2935330T3 (da) * | 2012-12-19 | 2019-07-22 | Aveo Pharmaceuticals Inc | Anti-notch3-antistoffer |
| EP2970479B1 (en) * | 2013-03-14 | 2019-04-24 | Novartis AG | Antibodies against notch 3 |
| US9683039B2 (en) * | 2013-03-14 | 2017-06-20 | New York University | Notch agonists for the treatment of cancer |
| BR112016028537A2 (pt) * | 2014-06-04 | 2017-08-22 | Hutchinson Fred Cancer Res | expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2 |
| BR112017000130A2 (pt) | 2014-07-11 | 2018-01-09 | Genentech Inc | método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer |
| WO2016046053A1 (en) * | 2014-09-25 | 2016-03-31 | H. Lundbeck A/S | Immunological treatment of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| CN109715206B (zh) | 2016-03-31 | 2023-11-07 | 恩格姆生物制药公司 | 结合蛋白及其使用方法 |
| ES2931955T3 (es) * | 2016-04-29 | 2023-01-05 | Aveo Pharmaceuticals Inc | Anticuerpo anti-Notch3 |
| WO2018183213A1 (en) | 2017-03-27 | 2018-10-04 | The Schepens Eye Research Institute, Inc. | Blood biomarkers and diagnostic methods for small vessel diseases |
| US11453718B2 (en) | 2017-03-27 | 2022-09-27 | The Schepens Eye Research Institute, Inc. | NOTCH3 agonist compositions and methods for treating small vessel diseases |
| CA3074126A1 (en) * | 2017-08-29 | 2019-03-07 | Veritas Therapeutics Inc. | Fgl2 antibodies and binding fragments thereof and uses thereof |
| CA3110089A1 (en) | 2018-08-28 | 2020-03-05 | Fred Hutchinson Cancer Research Center | Methods and compositions for adoptive t cell therapy incorporating induced notch signaling |
| JP6892180B2 (ja) * | 2018-12-03 | 2021-06-23 | 株式会社ｍＡｂＰｒｏｔｅｉｎ | 活性型インターロイキン−１８タンパク質のネオエピトープを認識する抗体、及びその応用 |
| CN115943163A (zh) * | 2020-06-30 | 2023-04-07 | 中外制药株式会社 | 位点特异性Notch激活分子及其用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US20050112121A1 (en) | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| AU696293B2 (en) | 1993-12-08 | 1998-09-03 | Genzyme Corporation | Process for generating specific antibodies |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20050158859A1 (en) | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| FR2751986B1 (fr) | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
| US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| FR2777285B1 (fr) | 1998-04-10 | 2000-05-19 | Bio Merieux | Ligand peptidique presentant une affinite specifique vis-a-vis de la proteine p24 du retrovirus hiv-1 |
| JP2002526109A (ja) | 1998-10-02 | 2002-08-20 | ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ | アポトーシス誘導物質と方法 |
| US8084258B2 (en) | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| AU2001288628A1 (en) * | 2000-08-31 | 2002-03-13 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
| JP4365583B2 (ja) | 2000-09-22 | 2009-11-18 | ジェネンテック・インコーポレーテッド | ノッチレセプターアゴニスト及び用途 |
| JP2006513260A (ja) | 2002-08-03 | 2006-04-20 | ロランティス リミテッド | Ｎｏｔｃｈシグナル伝達経路調節因子の複合体およびその薬物治療への使用 |
| US7837993B2 (en) * | 2004-03-19 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for regeneration of aged skeletal muscle tissues |
| WO2006017173A1 (en) | 2004-07-10 | 2006-02-16 | Alexion Pharmaceuticals, Inc. | Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby |
| US20070077245A1 (en) | 2004-08-04 | 2007-04-05 | The Brigham And Women's Hospital, Inc. | NOTCH mutations leading to increased receptor signaling |
| WO2006053063A2 (en) | 2004-11-05 | 2006-05-18 | The Regents Of The University Of California | Notch-1 assay to detect neurodegenerative diseases |
| WO2006068822A1 (en) | 2004-12-20 | 2006-06-29 | Genentech, Inc. | Notch receptor agonists and uses |
| EP1962895B2 (en) * | 2005-12-16 | 2016-01-20 | Regeneron Pharmaceuticals, Inc. | THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH |
| WO2008057144A2 (en) | 2006-05-15 | 2008-05-15 | The Brigham And Women's Hospital, Inc. | Functional negative regulatory domain sequences from human notch1 and 2 and isolated lnr domains from human notch1 |
| CL2007002989A1 (es) | 2006-10-19 | 2008-05-16 | Genentech Inc | Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para el diagnostico de enfermedades relacionadas con notch3. |
| CA2666672A1 (en) | 2006-10-19 | 2008-05-02 | Genentech, Inc. | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
| AU2007333805B2 (en) * | 2006-12-18 | 2013-07-25 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
| PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
-
2007
- 2007-10-18 CA CA002666672A patent/CA2666672A1/en not_active Abandoned
- 2007-10-18 AR ARP070104625A patent/AR063494A1/es unknown
- 2007-10-18 MX MX2009004106A patent/MX2009004106A/es active IP Right Grant
- 2007-10-18 US US11/874,682 patent/US7915390B2/en active Active
- 2007-10-18 WO PCT/US2007/081797 patent/WO2008051797A2/en not_active Ceased
- 2007-10-18 BR BRPI0715989A patent/BRPI0715989A8/pt not_active IP Right Cessation
- 2007-10-18 KR KR1020097010122A patent/KR101525629B1/ko not_active Expired - Fee Related
- 2007-10-18 KR KR1020157004016A patent/KR20150023953A/ko not_active Ceased
- 2007-10-18 US US11/874,645 patent/US7994285B2/en not_active Expired - Fee Related
- 2007-10-18 RU RU2009118621/10A patent/RU2461569C2/ru not_active IP Right Cessation
- 2007-10-18 TW TW096139048A patent/TW200824707A/zh unknown
- 2007-10-18 PE PE2007001412A patent/PE20081264A1/es not_active Application Discontinuation
- 2007-10-18 EP EP07844405.6A patent/EP2087006B1/en active Active
- 2007-10-18 JP JP2009533527A patent/JP5478254B2/ja not_active Expired - Fee Related
- 2007-10-18 CL CL200702987A patent/CL2007002987A1/es unknown
- 2007-10-18 AU AU2007309229A patent/AU2007309229B8/en not_active Ceased
-
2009
- 2009-04-17 CR CR10730A patent/CR10730A/es not_active Application Discontinuation
- 2009-05-14 MA MA31887A patent/MA30900B1/fr unknown
- 2009-05-18 CO CO09050698A patent/CO6180445A2/es active IP Right Grant
- 2009-05-18 NO NO20091926A patent/NO20091926L/no not_active Application Discontinuation
-
2011
- 2011-02-23 US US13/033,500 patent/US8187839B2/en active Active
-
2012
- 2012-04-23 US US13/453,817 patent/US20120213785A1/en not_active Abandoned
-
2013
- 2013-08-21 US US13/972,443 patent/US9518124B2/en not_active Expired - Fee Related
-
2015
- 2015-03-17 PH PH12015500576A patent/PH12015500576A1/en unknown