JP2010505794A5 - - Google Patents
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- Publication number
- JP2010505794A5 JP2010505794A5 JP2009530875A JP2009530875A JP2010505794A5 JP 2010505794 A5 JP2010505794 A5 JP 2010505794A5 JP 2009530875 A JP2009530875 A JP 2009530875A JP 2009530875 A JP2009530875 A JP 2009530875A JP 2010505794 A5 JP2010505794 A5 JP 2010505794A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- cycloalkyl
- indazol
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 8
- 125000004103 aminoalkyl group Chemical group 0.000 claims 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- -1 2-indazolyl Chemical class 0.000 claims 3
- 206010010904 Convulsion Diseases 0.000 claims 3
- 102000004257 Potassium Channel Human genes 0.000 claims 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 108020001213 potassium channel Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- BZRGWNYKWFAOMR-UHFFFAOYSA-N n-(4-chlorophenyl)-2-indazol-2-yl-6-methylpyrimidin-4-amine Chemical compound N=1C(N2N=C3C=CC=CC3=C2)=NC(C)=CC=1NC1=CC=C(Cl)C=C1 BZRGWNYKWFAOMR-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- CZAADHJQSOAANV-UHFFFAOYSA-N 2-[4-(4-chloroanilino)pyrimidin-2-yl]indazol-6-amine Chemical compound N1=C2C=C(N)C=CC2=CN1C(N=1)=NC=CC=1NC1=CC=C(Cl)C=C1 CZAADHJQSOAANV-UHFFFAOYSA-N 0.000 claims 1
- RFUMIUICOZSINX-UHFFFAOYSA-N 4-n-(4-chlorophenyl)-2-indazol-2-ylpyrimidine-4,5-diamine Chemical compound NC1=CN=C(N2N=C3C=CC=CC3=C2)N=C1NC1=CC=C(Cl)C=C1 RFUMIUICOZSINX-UHFFFAOYSA-N 0.000 claims 1
- NMDNQKSQYHTRKR-UHFFFAOYSA-N 6-(3-chloroindazol-1-yl)-n-(4-chlorophenyl)pyridin-2-amine Chemical compound C12=CC=CC=C2C(Cl)=NN1C(N=1)=CC=CC=1NC1=CC=C(Cl)C=C1 NMDNQKSQYHTRKR-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003225 Arteriospasm coronary Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010048994 Bladder spasm Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000003890 Coronary Vasospasm Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000008238 Muscle Spasticity Diseases 0.000 claims 1
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 claims 1
- 206010036600 Premature labour Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010047163 Vasospasm Diseases 0.000 claims 1
- 208000028311 absence seizure Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000011634 coronary artery vasospasm Diseases 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013781 dry mouth Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- GOOFDKIMFIZGRV-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(5-nitroindazol-2-yl)pyrimidin-4-amine Chemical compound C1=C2C=C([N+](=O)[O-])C=CC2=NN1C(N=1)=NC=CC=1NC1=CC=C(Cl)C=C1 GOOFDKIMFIZGRV-UHFFFAOYSA-N 0.000 claims 1
- BUKLUWFZTMICFQ-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(6-nitroindazol-2-yl)pyrimidin-4-amine Chemical compound N1=C2C=C([N+](=O)[O-])C=CC2=CN1C(N=1)=NC=CC=1NC1=CC=C(Cl)C=C1 BUKLUWFZTMICFQ-UHFFFAOYSA-N 0.000 claims 1
- JJDDIEUKPRBQNR-UHFFFAOYSA-N n-(4-chlorophenyl)-2-indazol-1-yl-6-methylpyrimidin-4-amine Chemical compound N=1C(N2C3=CC=CC=C3C=N2)=NC(C)=CC=1NC1=CC=C(Cl)C=C1 JJDDIEUKPRBQNR-UHFFFAOYSA-N 0.000 claims 1
- PGCZVHJXSVRWTL-UHFFFAOYSA-N n-(4-chlorophenyl)-6-indazol-1-ylpyrazin-2-amine Chemical compound C1=CC(Cl)=CC=C1NC1=CN=CC(N2C3=CC=CC=C3C=N2)=N1 PGCZVHJXSVRWTL-UHFFFAOYSA-N 0.000 claims 1
- SGDLUZVNNSOSBZ-UHFFFAOYSA-N n-(4-chlorophenyl)-6-indazol-1-ylpyridin-2-amine Chemical compound C1=CC(Cl)=CC=C1NC1=CC=CC(N2C3=CC=CC=C3C=N2)=N1 SGDLUZVNNSOSBZ-UHFFFAOYSA-N 0.000 claims 1
- XVQDXTZYCOTRLI-UHFFFAOYSA-N n-(4-chlorophenyl)-6-indazol-2-ylpyrazin-2-amine Chemical compound C1=CC(Cl)=CC=C1NC1=CN=CC(N2N=C3C=CC=CC3=C2)=N1 XVQDXTZYCOTRLI-UHFFFAOYSA-N 0.000 claims 1
- SXTZVSCCGYEFOY-UHFFFAOYSA-N n-[(4-chlorophenyl)methyl]-2-indazol-1-ylpyrimidin-4-amine Chemical compound C1=CC(Cl)=CC=C1CNC1=CC=NC(N2C3=CC=CC=C3C=N2)=N1 SXTZVSCCGYEFOY-UHFFFAOYSA-N 0.000 claims 1
- TXGZRDGSNSTOIW-UHFFFAOYSA-N n-[(4-chlorophenyl)methyl]-2-indazol-2-ylpyrimidin-4-amine Chemical compound C1=CC(Cl)=CC=C1CNC1=CC=NC(N2N=C3C=CC=CC3=C2)=N1 TXGZRDGSNSTOIW-UHFFFAOYSA-N 0.000 claims 1
- KRNGNUGXFMBNJY-UHFFFAOYSA-N n-[2-[4-(4-chloroanilino)pyrimidin-2-yl]indazol-6-yl]acetamide Chemical compound N1=C2C=C(NC(=O)C)C=CC2=CN1C(N=1)=NC=CC=1NC1=CC=C(Cl)C=C1 KRNGNUGXFMBNJY-UHFFFAOYSA-N 0.000 claims 1
- BYGNIUVYBFGPQY-UHFFFAOYSA-N n-cyclohexyl-2-indazol-1-yl-6-methylpyrimidin-4-amine Chemical compound N=1C(N2C3=CC=CC=C3C=N2)=NC(C)=CC=1NC1CCCCC1 BYGNIUVYBFGPQY-UHFFFAOYSA-N 0.000 claims 1
- QIWUMMHCYOXAED-UHFFFAOYSA-N n-cyclohexyl-2-indazol-1-ylpyrimidin-4-amine Chemical compound C1CCCCC1NC1=CC=NC(N2C3=CC=CC=C3C=N2)=N1 QIWUMMHCYOXAED-UHFFFAOYSA-N 0.000 claims 1
- JUIOOVGJSHADDZ-UHFFFAOYSA-N n-cyclohexyl-2-indazol-1-ylquinazolin-4-amine Chemical compound C1CCCCC1NC1=NC(N2C3=CC=CC=C3C=N2)=NC2=CC=CC=C12 JUIOOVGJSHADDZ-UHFFFAOYSA-N 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000030761 polycystic kidney disease Diseases 0.000 claims 1
- 208000026440 premature labor Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 201000009881 secretory diarrhea Diseases 0.000 claims 1
- 208000018198 spasticity Diseases 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82794006P | 2006-10-03 | 2006-10-03 | |
| DKPA200601280 | 2006-10-03 | ||
| PCT/EP2007/060493 WO2008040753A1 (en) | 2006-10-03 | 2007-10-03 | Indazolyl derivatives useful as potassium channel modulating agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505794A JP2010505794A (ja) | 2010-02-25 |
| JP2010505794A5 true JP2010505794A5 (cg-RX-API-DMAC7.html) | 2010-11-11 |
Family
ID=38959688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530875A Abandoned JP2010505794A (ja) | 2006-10-03 | 2007-10-03 | カリウムチャネル調節剤として有用なインダゾリル誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8222262B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2074113A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010505794A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007304195A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2665398A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009003142A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008040753A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT4193B (en) | 1994-04-01 | 1997-07-25 | Microcide Pharmaceuticals Inc | Cephalosporin antibiotics |
| WO2008028935A2 (en) * | 2006-09-07 | 2008-03-13 | Neurosearch A/S | Pyridinyl-pyrimidine derivatives useful as potassium channel modulating agents |
| JP2010517970A (ja) * | 2007-02-02 | 2010-05-27 | ノイロサーチ アクティーゼルスカブ | ピリジニル−ピラゾール誘導体及びカリウムチャネル調節剤としてのそれらの使用 |
| WO2008116910A1 (en) | 2007-03-28 | 2008-10-02 | Neurosearch A/S | Purinyl derivatives and their use as potassium channel modulators |
| WO2009037247A1 (en) | 2007-09-17 | 2009-03-26 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| RU2011105810A (ru) | 2008-07-17 | 2012-08-27 | Асахи Касеи Фарма Корпорейшн (Jp) | Азотсодержащие бициклические гетероциклические соединения |
| WO2010026087A1 (en) * | 2008-09-02 | 2010-03-11 | Neurosearch A/S | Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators |
| WO2010034706A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| WO2010034707A1 (en) | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| AU2009322836B2 (en) * | 2008-11-25 | 2013-04-04 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| EP2549875B1 (en) | 2010-03-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| CA2800541C (en) | 2010-05-27 | 2016-03-22 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US8895583B2 (en) | 2010-10-28 | 2014-11-25 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| CN104411703A (zh) | 2012-06-26 | 2015-03-11 | 萨尼奥纳有限责任公司 | 苯基三唑衍生物及其调节gabaa受体复合体的用途 |
| TWI623531B (zh) | 2012-11-21 | 2018-05-11 | Ｐｔｃ治療公司 | 經取代反向嘧啶ｂｍｉ－１抑制劑 |
| US9802904B2 (en) | 2012-12-28 | 2017-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof |
| JP6524094B2 (ja) | 2013-08-30 | 2019-06-05 | ピーティーシー セラピューティクス， インコーポレイテッド | 置換ピリミジンＢｍｉ−１阻害剤 |
| EP3071553A4 (en) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| EP3080101A1 (en) | 2013-12-10 | 2016-10-19 | Cleave Biosciences, Inc. | Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex |
| MX374379B (es) | 2014-01-20 | 2025-03-06 | Cleave Biosciences Inc | PIRIMIDINAS FUSIONADAS QUE TIENEN UN ANILLO HETEROCÍCLICO 5:6 COMO INHIBIDORES DEL COMPLEJO p97 Y EL USO DE LAS MISMAS EN EL TRATAMIENTO DE AFECCIONES NEOPLÁSICAS. |
| WO2017133664A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Bicyclic pyridine and pyrimidine derivatives and their use in the treatment， amelioration or prevention of influenza |
| WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
| WO2017210545A1 (en) | 2016-06-02 | 2017-12-07 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| PL3571193T3 (pl) | 2017-01-23 | 2022-04-25 | Cadent Therapeutics, Inc. | Modulatory kanału potasowego |
| US11161854B2 (en) | 2017-10-11 | 2021-11-02 | Merck Sharp & Dohme Corp. | Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof |
| EP3694331B1 (en) * | 2017-10-11 | 2022-11-16 | Merck Sharp & Dohme LLC | Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| AU2019340402B2 (en) | 2018-08-17 | 2025-04-03 | Ptc Therapeutics, Inc. | Method for treating pancreatic cancer |
| BR112021007552A2 (pt) | 2018-10-22 | 2021-07-27 | Cadent Therapeutics, Inc. | formas cristalinas de moduladores de canal de potássio |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0207975A (pt) * | 2001-03-15 | 2004-06-15 | Basf Ag | Composto, processo para preparar 5 fenilpiridinas, produto intermediário, agente adequado para combater fungos nocivos fitopatogênicos, e, processo para combater fungos nocivos fitopatogênicos |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| PT1689739T (pt) * | 2003-12-03 | 2016-07-13 | Ym Biosciences Australia Pty | Inibidores de cinases baseados em azol |
| US8252806B2 (en) | 2005-03-14 | 2012-08-28 | Neurosearch A/S | Potassium channel modulating agents and their medical use |
| JP2008534472A (ja) | 2005-03-22 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | カリウムチャンネル調節剤としてのピラゾリル−ピリミジン及びその医学的使用 |
| US20090124645A1 (en) | 2005-10-14 | 2009-05-14 | Neurosearch A/S | Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels |
| JP2009519995A (ja) * | 2005-12-20 | 2009-05-21 | ノイロサーチ アクティーゼルスカブ | 呼吸器疾患の治療のためのカリウムチャンネル調節剤としての２−ピリジン−２−イル−キナゾリン誘導体 |
-
2007
- 2007-10-03 US US12/444,344 patent/US8222262B2/en active Active
- 2007-10-03 MX MX2009003142A patent/MX2009003142A/es active IP Right Grant
- 2007-10-03 EP EP07820871A patent/EP2074113A1/en not_active Withdrawn
- 2007-10-03 WO PCT/EP2007/060493 patent/WO2008040753A1/en not_active Ceased
- 2007-10-03 AU AU2007304195A patent/AU2007304195A1/en not_active Abandoned
- 2007-10-03 JP JP2009530875A patent/JP2010505794A/ja not_active Abandoned
- 2007-10-03 CA CA002665398A patent/CA2665398A1/en not_active Abandoned
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