JP2010522718A5 - - Google Patents
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- Publication number
- JP2010522718A5 JP2010522718A5 JP2010500272A JP2010500272A JP2010522718A5 JP 2010522718 A5 JP2010522718 A5 JP 2010522718A5 JP 2010500272 A JP2010500272 A JP 2010500272A JP 2010500272 A JP2010500272 A JP 2010500272A JP 2010522718 A5 JP2010522718 A5 JP 2010522718A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- purin
- pyrazol
- phenyl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- -1 benzo [1,3] dioxolyl Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010010904 Convulsion Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 102000004257 Potassium Channel Human genes 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- DVQOPNIPUIOXHU-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 DVQOPNIPUIOXHU-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 108020001213 potassium channel Proteins 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- LAKYIPSTOCBIGH-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-9-(2-methoxyethyl)-n-phenylpurin-6-amine Chemical compound N1=C(N2C(=CC(C)=N2)C)N=C2N(CCOC)C=NC2=C1NC1=CC=CC=C1 LAKYIPSTOCBIGH-UHFFFAOYSA-N 0.000 claims 1
- HPIALDHBJZLANG-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-9-methyl-n-(2-phenylethyl)purin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NCCC=2C=CC=CC=2)=C(N=CN2C)C2=N1 HPIALDHBJZLANG-UHFFFAOYSA-N 0.000 claims 1
- LSDRWHLLIQWLAA-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-9-methyl-n-(4-nitrophenyl)purin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(=CC=2)[N+]([O-])=O)=C(N=CN2C)C2=N1 LSDRWHLLIQWLAA-UHFFFAOYSA-N 0.000 claims 1
- MDHRZOQHXZSEED-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-9-methyl-n-[4-(trifluoromethyl)phenyl]purin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(=CC=2)C(F)(F)F)=C(N=CN2C)C2=N1 MDHRZOQHXZSEED-UHFFFAOYSA-N 0.000 claims 1
- SWQBZPXHGALVPL-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-9-methyl-n-phenylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC=CC=2)=C(N=CN2C)C2=N1 SWQBZPXHGALVPL-UHFFFAOYSA-N 0.000 claims 1
- SFNDTYYCHFPNPJ-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-9-methyl-n-pyridin-4-ylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CN=CC=2)=C(N=CN2C)C2=N1 SFNDTYYCHFPNPJ-UHFFFAOYSA-N 0.000 claims 1
- FCHDAFWIYTYUTH-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-n-(4-fluorophenyl)-9-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(F)=CC=2)=C(N=CN2C)C2=N1 FCHDAFWIYTYUTH-UHFFFAOYSA-N 0.000 claims 1
- OWLCDPPNVHMZOB-UHFFFAOYSA-N 2-(3,5-dimethylpyrazol-1-yl)-n-phenyl-7h-purin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC=CC=2)=C(N=CN2)C2=N1 OWLCDPPNVHMZOB-UHFFFAOYSA-N 0.000 claims 1
- IVZJKPUNBLSGOH-UHFFFAOYSA-N 2-(4-chloro-3,5-dimethylpyrazol-1-yl)-n-(4-chlorophenyl)-9-methylpurin-6-amine Chemical compound CC1=C(Cl)C(C)=NN1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 IVZJKPUNBLSGOH-UHFFFAOYSA-N 0.000 claims 1
- DXFHHGPKNMVEHR-UHFFFAOYSA-N 2-(4-chloro-3-methylpyrazol-1-yl)-n-(4-chlorophenyl)-9-methylpurin-6-amine Chemical compound C1=C(Cl)C(C)=NN1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 DXFHHGPKNMVEHR-UHFFFAOYSA-N 0.000 claims 1
- MFIDWIAONNDJDA-UHFFFAOYSA-N 2-(5-chloro-3-methylpyrazol-1-yl)-n-(4-chlorophenyl)-9-methylpurin-6-amine Chemical compound N1=C(C)C=C(Cl)N1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 MFIDWIAONNDJDA-UHFFFAOYSA-N 0.000 claims 1
- ANQNLWGEHMNWBN-UHFFFAOYSA-N 2-[3,5-bis(trifluoromethyl)pyrazol-1-yl]-n-(4-chlorophenyl)-9-methylpurin-6-amine Chemical compound N1=C(N2C(=CC(=N2)C(F)(F)F)C(F)(F)F)N=C2N(C)C=NC2=C1NC1=CC=C(Cl)C=C1 ANQNLWGEHMNWBN-UHFFFAOYSA-N 0.000 claims 1
- DXYSJRWJZSLBCS-UHFFFAOYSA-N 4-[[2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-yl]amino]benzonitrile Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(=CC=2)C#N)=C(N=CN2C)C2=N1 DXYSJRWJZSLBCS-UHFFFAOYSA-N 0.000 claims 1
- IMFNNVDXBUGETE-UHFFFAOYSA-N 4-n-[2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-yl]benzene-1,4-diamine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(N)=CC=2)=C(N=CN2C)C2=N1 IMFNNVDXBUGETE-UHFFFAOYSA-N 0.000 claims 1
- PBHFDUNUQBRNOP-UHFFFAOYSA-N 6-(4-chlorophenyl)sulfanyl-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurine Chemical compound N1=C(C)C=C(C)N1C1=NC(SC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 PBHFDUNUQBRNOP-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003225 Arteriospasm coronary Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010048994 Bladder spasm Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000003890 Coronary Vasospasm Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000008238 Muscle Spasticity Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010061876 Obstruction Diseases 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010047163 Vasospasm Diseases 0.000 claims 1
- 208000005946 Xerostomia Diseases 0.000 claims 1
- KFXJAONTTAGDMF-UHFFFAOYSA-N [2-[6-(4-chloroanilino)-9-methylpurin-2-yl]-5-methylpyrazol-3-yl]methanol Chemical compound N1=C(C)C=C(CO)N1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 KFXJAONTTAGDMF-UHFFFAOYSA-N 0.000 claims 1
- 208000028311 absence seizure Diseases 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000011634 coronary artery vasospasm Diseases 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013781 dry mouth Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- JILGOVQTCFFYRU-UHFFFAOYSA-N ethyl 1-[6-(4-chloroanilino)-9-methylpurin-2-yl]-5-methylpyrazole-3-carboxylate Chemical compound N1=C(C(=O)OCC)C=C(C)N1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 JILGOVQTCFFYRU-UHFFFAOYSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000003274 myotonic effect Effects 0.000 claims 1
- QTSMUSVACRPCBF-UHFFFAOYSA-N n-(1,3-benzodioxol-5-yl)-2-(3,5-dimethylpyrazol-1-yl)-9-ethylpurin-6-amine Chemical compound N1=C2N(CC)C=NC2=C(NC=2C=C3OCOC3=CC=2)N=C1N1N=C(C)C=C1C QTSMUSVACRPCBF-UHFFFAOYSA-N 0.000 claims 1
- PNDJDUPBDDSPKP-UHFFFAOYSA-N n-(4-bromophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(Br)=CC=2)=C(N=CN2C)C2=N1 PNDJDUPBDDSPKP-UHFFFAOYSA-N 0.000 claims 1
- LBKYEDHQRCYISU-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(3,5-diethylpyrazol-1-yl)-9-methylpurin-6-amine Chemical compound N1=C(CC)C=C(CC)N1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 LBKYEDHQRCYISU-UHFFFAOYSA-N 0.000 claims 1
- UGZACSMZFZCJLF-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-7-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N(C)C=N2)C2=N1 UGZACSMZFZCJLF-UHFFFAOYSA-N 0.000 claims 1
- YASLNLYVBLBRCK-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-(2-ethoxyethyl)purin-6-amine Chemical compound N1=C(N2C(=CC(C)=N2)C)N=C2N(CCOCC)C=NC2=C1NC1=CC=C(Cl)C=C1 YASLNLYVBLBRCK-UHFFFAOYSA-N 0.000 claims 1
- OXFVPYHKTKDQIN-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-(2-methylpropyl)purin-6-amine Chemical compound N1=C(N2C(=CC(C)=N2)C)N=C2N(CC(C)C)C=NC2=C1NC1=CC=C(Cl)C=C1 OXFVPYHKTKDQIN-UHFFFAOYSA-N 0.000 claims 1
- AGPUJPIPIGWWIE-UHFFFAOYSA-N n-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-ethylpurin-6-amine Chemical compound N1=C(N2C(=CC(C)=N2)C)N=C2N(CC)C=NC2=C1NC1=CC=C(Cl)C=C1 AGPUJPIPIGWWIE-UHFFFAOYSA-N 0.000 claims 1
- SMRVGEMZXQTXMU-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[3-(furan-2-yl)-5-methylpyrazol-1-yl]-9-methylpurin-6-amine Chemical compound CC1=CC(C=2OC=CC=2)=NN1C(N=C1N(C)C=NC1=1)=NC=1NC1=CC=C(Cl)C=C1 SMRVGEMZXQTXMU-UHFFFAOYSA-N 0.000 claims 1
- WQFMOPBXKIKQIA-UHFFFAOYSA-N n-(4-chlorophenyl)-9-methyl-2-(3,4,5-trimethylpyrazol-1-yl)purin-6-amine Chemical compound CC1=C(C)C(C)=NN1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 WQFMOPBXKIKQIA-UHFFFAOYSA-N 0.000 claims 1
- HKLGPONAUCIKNP-UHFFFAOYSA-N n-(4-chlorophenyl)-9-methyl-2-(5-methyl-3-phenylpyrazol-1-yl)purin-6-amine Chemical compound CC1=CC(C=2C=CC=CC=2)=NN1C(N=C1N(C)C=NC1=1)=NC=1NC1=CC=C(Cl)C=C1 HKLGPONAUCIKNP-UHFFFAOYSA-N 0.000 claims 1
- BQXNAWLDYCXWNU-UHFFFAOYSA-N n-(4-chlorophenyl)-9-methyl-2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]purin-6-amine Chemical compound CC1=CC(C(F)(F)F)=NN1C1=NC(NC=2C=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 BQXNAWLDYCXWNU-UHFFFAOYSA-N 0.000 claims 1
- GZTZZLOZIOCJJN-UHFFFAOYSA-N n-(5-chloropyridin-2-yl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2N=CC(Cl)=CC=2)=C(N=CN2C)C2=N1 GZTZZLOZIOCJJN-UHFFFAOYSA-N 0.000 claims 1
- GTZYKPFKLYHYCT-UHFFFAOYSA-N n-(6-chloropyridin-3-yl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC=2C=NC(Cl)=CC=2)=C(N=CN2C)C2=N1 GTZYKPFKLYHYCT-UHFFFAOYSA-N 0.000 claims 1
- CMYJVPVMHKLTAQ-UHFFFAOYSA-N n-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-7-methylpurin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC2CCCCC2)=C(N(C)C=N2)C2=N1 CMYJVPVMHKLTAQ-UHFFFAOYSA-N 0.000 claims 1
- ZVXURWKWHMNVFM-UHFFFAOYSA-N n-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-7h-purin-6-amine Chemical compound N1=C(C)C=C(C)N1C1=NC(NC2CCCCC2)=C(N=CN2)C2=N1 ZVXURWKWHMNVFM-UHFFFAOYSA-N 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000020629 overactive bladder Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000030761 polycystic kidney disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 201000009881 secretory diarrhea Diseases 0.000 claims 1
- 208000018198 spasticity Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90850307P | 2007-03-28 | 2007-03-28 | |
| DKPA200700482 | 2007-03-28 | ||
| US60/908,503 | 2007-03-28 | ||
| DKPA200700482 | 2007-03-28 | ||
| PCT/EP2008/053648 WO2008116909A1 (en) | 2007-03-28 | 2008-03-27 | Purinyl derivatives and their use as potassium channel modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010522718A JP2010522718A (ja) | 2010-07-08 |
| JP2010522718A5 true JP2010522718A5 (cg-RX-API-DMAC7.html) | 2011-05-12 |
| JP5703432B2 JP5703432B2 (ja) | 2015-04-22 |
Family
ID=41658005
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500273A Pending JP2010522719A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| JP2010500276A Pending JP2010522722A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| JP2010500272A Active JP5703432B2 (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| JP2010500275A Pending JP2010522721A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| JP2010500274A Pending JP2010522720A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500273A Pending JP2010522719A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| JP2010500276A Pending JP2010522722A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500275A Pending JP2010522721A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| JP2010500274A Pending JP2010522720A (ja) | 2007-03-28 | 2008-03-27 | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20120004246A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2402341B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP2010522719A (cg-RX-API-DMAC7.html) |
| KR (1) | KR101564233B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101646669B (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0808746B8 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ579248A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2468026C2 (cg-RX-API-DMAC7.html) |
| UA (1) | UA98482C2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200905796B (cg-RX-API-DMAC7.html) |
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| JP2010522719A (ja) * | 2007-03-28 | 2010-07-08 | ノイロサーチ アクティーゼルスカブ | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| WO2008116910A1 (en) | 2007-03-28 | 2008-10-02 | Neurosearch A/S | Purinyl derivatives and their use as potassium channel modulators |
| WO2009037247A1 (en) | 2007-09-17 | 2009-03-26 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| JP2011521968A (ja) * | 2008-05-30 | 2011-07-28 | ジェネンテック， インコーポレイテッド | プリンｐｉ３ｋ阻害剤化合物および使用方法 |
| WO2010026087A1 (en) * | 2008-09-02 | 2010-03-11 | Neurosearch A/S | Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators |
| WO2010034706A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| WO2010034707A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| DK2414365T3 (da) | 2009-04-01 | 2014-03-31 | Aniona Aps | SUBSTITUEREDE [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINER OG ANVENDELSE HERAF SOM KALIUMKANALMODULATORER |
| US8685987B2 (en) | 2009-04-01 | 2014-04-01 | Ataxion, Inc. | Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators |
| AR079814A1 (es) | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos |
| JP6121658B2 (ja) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | 治療用化合物、及び関連する使用の方法 |
| CN104411703A (zh) | 2012-06-26 | 2015-03-11 | 萨尼奥纳有限责任公司 | 苯基三唑衍生物及其调节gabaa受体复合体的用途 |
| MX2015010466A (es) * | 2013-03-05 | 2015-10-30 | Hoffmann La Roche | Inhibidores de tirosina cinasa de bruton. |
| HK1220972A1 (zh) * | 2013-03-06 | 2017-05-19 | Bayer Pharma Aktiengesellschaft | 取代的噻唑并嘧啶 |
| DK3154947T3 (en) * | 2014-06-11 | 2018-06-18 | Bayer Cropscience Ag | PROCEDURE FOR PREPARING 3,5-BIS (HALOGENAL COOL) PYRAZOLES BY ACYLATION OF KETIMINES |
| WO2017210545A1 (en) | 2016-06-02 | 2017-12-07 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| US10647713B2 (en) * | 2016-10-21 | 2020-05-12 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
| PL3571193T3 (pl) | 2017-01-23 | 2022-04-25 | Cadent Therapeutics, Inc. | Modulatory kanału potasowego |
| FR3066761B1 (fr) | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| CN107698500A (zh) * | 2017-10-17 | 2018-02-16 | 扬子江药业集团四川海蓉药业有限公司 | 一种奈妥匹坦的制备方法 |
| BR112021007552A2 (pt) | 2018-10-22 | 2021-07-27 | Cadent Therapeutics, Inc. | formas cristalinas de moduladores de canal de potássio |
| CN116178374B (zh) * | 2023-01-13 | 2024-10-08 | 河北医科大学 | 小电导钙激活钾离子通道激动剂及其合成和应用 |
| CN119684293A (zh) * | 2024-11-25 | 2025-03-25 | 山东第一医科大学(山东省医学科学院) | 嘌呤类化合物及其在制备防治脑衰老药物中的应用 |
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| DE19834044A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
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| JP2007502776A (ja) * | 2003-08-15 | 2007-02-15 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｒｔｋ阻害剤としての６−置換アニリノプリン類 |
| US20050165029A1 (en) * | 2004-01-13 | 2005-07-28 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| GB0407723D0 (en) * | 2004-04-05 | 2004-05-12 | Novartis Ag | Organic compounds |
| FR2876583B1 (fr) * | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | Utilisation de derives de purines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| GB0505219D0 (en) * | 2005-03-14 | 2005-04-20 | Novartis Ag | Organic compounds |
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| US7419599B2 (en) * | 2005-07-12 | 2008-09-02 | Ge Healthcare Bio-Sciences Ab | Automated packing system and method for chromatography columns |
| JP2009519995A (ja) * | 2005-12-20 | 2009-05-21 | ノイロサーチ アクティーゼルスカブ | 呼吸器疾患の治療のためのカリウムチャンネル調節剤としての２−ピリジン−２−イル−キナゾリン誘導体 |
| WO2008094737A2 (en) * | 2007-01-26 | 2008-08-07 | Irm Llc | Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases |
| JP2010517970A (ja) * | 2007-02-02 | 2010-05-27 | ノイロサーチ アクティーゼルスカブ | ピリジニル−ピラゾール誘導体及びカリウムチャネル調節剤としてのそれらの使用 |
| JP2010522719A (ja) * | 2007-03-28 | 2010-07-08 | ノイロサーチ アクティーゼルスカブ | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| WO2008116910A1 (en) * | 2007-03-28 | 2008-10-02 | Neurosearch A/S | Purinyl derivatives and their use as potassium channel modulators |
| WO2009050199A1 (en) * | 2007-10-17 | 2009-04-23 | Novartis Ag | Purine derivatives as adenosine al receptor ligands |
| WO2010034707A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| WO2010034706A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
-
2008
- 2008-03-27 JP JP2010500273A patent/JP2010522719A/ja active Pending
- 2008-03-27 CN CN2008800099645A patent/CN101646669B/zh active Active
- 2008-03-27 KR KR1020097020281A patent/KR101564233B1/ko active Active
- 2008-03-27 RU RU2009132881/04A patent/RU2468026C2/ru active
- 2008-03-27 NZ NZ579248A patent/NZ579248A/en unknown
- 2008-03-27 US US12/593,220 patent/US20120004246A1/en not_active Abandoned
- 2008-03-27 JP JP2010500276A patent/JP2010522722A/ja active Pending
- 2008-03-27 JP JP2010500272A patent/JP5703432B2/ja active Active
- 2008-03-27 JP JP2010500275A patent/JP2010522721A/ja active Pending
- 2008-03-27 EP EP11182703.6A patent/EP2402341B1/en active Active
- 2008-03-27 US US12/593,269 patent/US20100105705A1/en not_active Abandoned
- 2008-03-27 JP JP2010500274A patent/JP2010522720A/ja active Pending
- 2008-03-27 UA UAA200908793A patent/UA98482C2/ru unknown
- 2008-03-27 ZA ZA200905796A patent/ZA200905796B/xx unknown
- 2008-03-27 BR BRPI0808746A patent/BRPI0808746B8/pt active IP Right Grant
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