JP2010505432A - Ｐｃｓｋ９を調節するためのｒｎａアンタゴニスト化合物 - Google Patents

Ｐｃｓｋ９を調節するためのｒｎａアンタゴニスト化合物 Download PDF

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JP2010505432A
JP2010505432A JP2009531824A JP2009531824A JP2010505432A JP 2010505432 A JP2010505432 A JP 2010505432A JP 2009531824 A JP2009531824 A JP 2009531824A JP 2009531824 A JP2009531824 A JP 2009531824A JP 2010505432 A JP2010505432 A JP 2010505432A
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seq
oligomer
pcsk9
sequence
lna
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JP2010505432A5 (OSRAM
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エレン・マリー・ストラールップ
ニルス・フィスケル・ニルセン
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
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    • C12Y304/21—Serine endopeptidases (3.4.21)
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JP2009531824A 2006-10-09 2007-10-09 Ｐｃｓｋ９を調節するためのｒｎａアンタゴニスト化合物 Withdrawn JP2010505432A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82873506P 2006-10-09 2006-10-09
US97293207P 2007-09-17 2007-09-17
US97740907P 2007-10-04 2007-10-04
PCT/EP2007/060703 WO2008043753A2 (en) 2006-10-09 2007-10-09 Rna antagonist compounds for the modulation of pcsk9

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JP2010505432A true JP2010505432A (ja) 2010-02-25
JP2010505432A5 JP2010505432A5 (OSRAM) 2010-12-02

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US (1) US20100216864A1 (OSRAM)
EP (2) EP2076597A2 (OSRAM)
JP (1) JP2010505432A (OSRAM)
AU (1) AU2007306361A1 (OSRAM)
CA (1) CA2666191C (OSRAM)
ES (1) ES2603379T3 (OSRAM)
IL (1) IL197668A0 (OSRAM)
MX (1) MX2009003729A (OSRAM)
WO (1) WO2008043753A2 (OSRAM)

Cited By (3)

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WO2014007305A1 (ja) * 2012-07-04 2014-01-09 国立大学法人大阪大学 オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤
WO2018216785A1 (ja) * 2017-05-26 2018-11-29 国立研究開発法人国立循環器病研究センター Ｐｃｓｋ９を標的としたアンチセンス核酸
JP2021119148A (ja) * 2015-03-20 2021-08-12 オーフス ウニベルシテット リポタンパク質代謝障害の治療のためのｐｃｓｋ９阻害剤

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WO2019167995A1 (ja) 2018-02-28 2019-09-06 国立大学法人東京医科歯科大学 虚血病変部位特異的な遺伝子治療法
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WO2019181946A1 (ja) 2018-03-19 2019-09-26 国立大学法人東京医科歯科大学 毒性が軽減した核酸
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JP7262816B2 (ja) 2018-03-22 2023-04-24 国立大学法人 東京医科歯科大学 ヘテロ核酸のｂｂｂ通過脂質リガンド
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