JP2010504367A5 - - Google Patents

Info

Publication number

JP2010504367A5

JP2010504367A5 JP2009529679A JP2009529679A JP2010504367A5 JP 2010504367 A5 JP2010504367 A5 JP 2010504367A5 JP 2009529679 A JP2009529679 A JP 2009529679A JP 2009529679 A JP2009529679 A JP 2009529679A JP 2010504367 A5 JP2010504367 A5 JP 2010504367A5

Authority

JP

Japan

Prior art keywords

compound

methyl

alkyl

ethyl

halo

Prior art date

2007-09-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 18
• 125000000217 alkyl group Chemical group 0.000 claims 17
• 125000005843 halogen group Chemical group 0.000 claims 6
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 239000001257 hydrogen Substances 0.000 claims 6
• 125000004429 atom Chemical group 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• PDLXDQOODGXTSQ-UHFFFAOYSA-N 1,6-dimethyl-5-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-3,4-dihydroquinolin-2-one Chemical compound CC1=CC=C2C(N3CCN(CC3)CCC3=C4CCC(=O)N(C4=CC=C3C)C)=CC=CC2=N1 PDLXDQOODGXTSQ-UHFFFAOYSA-N 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 229940125904 compound 1 Drugs 0.000 claims 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000001475 halogen functional group Chemical group 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 1
• SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims 1
• IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 claims 1
• UUWQIBYZFVEIMA-NRFANRHFSA-N 1,6-dimethyl-5-[2-[(2s)-2-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]quinolin-2-one Chemical compound CC1=CC=C2C(N3C[C@@H](N(CC3)CCC=3C=4C=CC(=O)N(C)C=4C=CC=3C)C)=CC=CC2=N1 UUWQIBYZFVEIMA-NRFANRHFSA-N 0.000 claims 1
• ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 claims 1
• -1 2-methylquinolin-5-yl Chemical group 0.000 claims 1
• XDDBLROZRANMSE-XOYNAWAESA-N 3,6-dimethyl-7-[2-[(2s)-2-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1a,7b-dihydro-1h-cyclopropa[c]quinolin-2-one Chemical compound CC1=CC=C2C(N3C[C@@H](N(CC3)CCC=3C=4C5CC5C(=O)N(C)C=4C=CC=3C)C)=CC=CC2=N1 XDDBLROZRANMSE-XOYNAWAESA-N 0.000 claims 1
• XBOCLCGHZJWWCY-FQEVSTJZSA-N 5-[2-[(2s)-4-(7-fluoro-2-methylquinolin-5-yl)-2-methylpiperazin-1-yl]ethyl]-1,6-dimethylquinolin-2-one Chemical compound CC1=CC=C2C(N3C[C@@H](N(CC3)CCC=3C=4C=CC(=O)N(C)C=4C=CC=3C)C)=CC(F)=CC2=N1 XBOCLCGHZJWWCY-FQEVSTJZSA-N 0.000 claims 1
• LDPZTEPHJATCEM-IBGZPJMESA-N 5-[2-[(2s)-4-(7-fluoro-2-methylquinolin-5-yl)-2-methylpiperazin-1-yl]ethyl]-6-methyl-3,4-dihydro-1h-quinolin-2-one Chemical compound CC1=CC=C2C(N3C[C@@H](N(CC3)CCC=3C=4CCC(=O)NC=4C=CC=3C)C)=CC(F)=CC2=N1 LDPZTEPHJATCEM-IBGZPJMESA-N 0.000 claims 1
• HRWBYOOBXRZGGR-UHFFFAOYSA-N 5-[2-[4-(7-fluoro-2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,6-dimethylquinolin-2-one Chemical compound CN1C(=O)C=CC2=C1C=CC(C)=C2CCN(CC1)CCN1C1=CC(F)=CC2=NC(C)=CC=C21 HRWBYOOBXRZGGR-UHFFFAOYSA-N 0.000 claims 1
• GOTWNFPSUDVYGZ-UHFFFAOYSA-N 5-[2-[4-(7-fluoro-2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-6-methyl-1h-quinolin-2-one Chemical compound N1C(=O)C=CC2=C1C=CC(C)=C2CCN(CC1)CCN1C1=CC(F)=CC2=NC(C)=CC=C21 GOTWNFPSUDVYGZ-UHFFFAOYSA-N 0.000 claims 1
• WJEBTWQLGLLSGW-UHFFFAOYSA-N 6-methyl-5-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1h-quinolin-2-one Chemical compound N1C(=O)C=CC2=C1C=CC(C)=C2CCN(CC1)CCN1C1=CC=CC2=NC(C)=CC=C21 WJEBTWQLGLLSGW-UHFFFAOYSA-N 0.000 claims 1
• BZFUYHDDVGBTOS-UHFFFAOYSA-N 6-methyl-5-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-3,4-dihydro-1h-quinolin-2-one Chemical compound N1C(=O)CCC2=C1C=CC(C)=C2CCN(CC1)CCN1C1=CC=CC2=NC(C)=CC=C21 BZFUYHDDVGBTOS-UHFFFAOYSA-N 0.000 claims 1
• WYKBJZPYLVTTKC-UHFFFAOYSA-N 6-methyl-5-[2-[4-(2-methylquinolin-5-yl)piperidin-1-yl]ethyl]-1h-quinolin-2-one Chemical compound N1C(=O)C=CC2=C1C=CC(C)=C2CCN(CC1)CCC1C1=CC=CC2=NC(C)=CC=C21 WYKBJZPYLVTTKC-UHFFFAOYSA-N 0.000 claims 1
• 229940126639 Compound 33 Drugs 0.000 claims 1
• OPFJDXRVMFKJJO-ZHHKINOHSA-N N-{[3-(2-benzamido-4-methyl-1,3-thiazol-5-yl)-pyrazol-5-yl]carbonyl}-G-dR-G-dD-dD-dD-NH2 Chemical compound S1C(C=2NN=C(C=2)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(N)=O)=C(C)N=C1NC(=O)C1=CC=CC=C1 OPFJDXRVMFKJJO-ZHHKINOHSA-N 0.000 claims 1
• 201000001880 Sexual dysfunction Diseases 0.000 claims 1
• PNUZDKCDAWUEGK-CYZMBNFOSA-N Sitafloxacin Chemical compound C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 PNUZDKCDAWUEGK-CYZMBNFOSA-N 0.000 claims 1
• KGNDCEVUMONOKF-UGPLYTSKSA-N benzyl n-[(2r)-1-[(2s,4r)-2-[[(2s)-6-amino-1-(1,3-benzoxazol-2-yl)-1,1-dihydroxyhexan-2-yl]carbamoyl]-4-[(4-methylphenyl)methoxy]pyrrolidin-1-yl]-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1CO[C@H]1CN(C(=O)[C@@H](CCC=2C=CC=CC=2)NC(=O)OCC=2C=CC=CC=2)[C@H](C(=O)N[C@@H](CCCCN)C(O)(O)C=2OC3=CC=CC=C3N=2)C1 KGNDCEVUMONOKF-UGPLYTSKSA-N 0.000 claims 1
• 229940126543 compound 14 Drugs 0.000 claims 1
• 229940125758 compound 15 Drugs 0.000 claims 1
• 229940126142 compound 16 Drugs 0.000 claims 1
• 229940125782 compound 2 Drugs 0.000 claims 1
• 229940126086 compound 21 Drugs 0.000 claims 1
• 229940125833 compound 23 Drugs 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
• 231100000872 sexual dysfunction Toxicity 0.000 claims 1