JP2010503640A - オリゴヌクレオチド非ウイルスデリバリーシステム - Google Patents
オリゴヌクレオチド非ウイルスデリバリーシステム Download PDFInfo
- Publication number
- JP2010503640A JP2010503640A JP2009527838A JP2009527838A JP2010503640A JP 2010503640 A JP2010503640 A JP 2010503640A JP 2009527838 A JP2009527838 A JP 2009527838A JP 2009527838 A JP2009527838 A JP 2009527838A JP 2010503640 A JP2010503640 A JP 2010503640A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- sirna
- molecular weight
- low molecular
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84472906P | 2006-09-15 | 2006-09-15 | |
PCT/EP2007/059740 WO2008031899A2 (en) | 2006-09-15 | 2007-09-14 | Oligonucleotide non-viral delivery systems |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010503640A true JP2010503640A (ja) | 2010-02-04 |
JP2010503640A5 JP2010503640A5 (zh) | 2010-07-29 |
Family
ID=39092312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009527838A Pending JP2010503640A (ja) | 2006-09-15 | 2007-09-14 | オリゴヌクレオチド非ウイルスデリバリーシステム |
Country Status (9)
Country | Link |
---|---|
US (1) | US7875449B2 (zh) |
EP (1) | EP2061516A2 (zh) |
JP (1) | JP2010503640A (zh) |
KR (1) | KR20090058562A (zh) |
CN (1) | CN101588821A (zh) |
BR (1) | BRPI0716925A2 (zh) |
CA (1) | CA2662560A1 (zh) |
IL (1) | IL197497A (zh) |
WO (1) | WO2008031899A2 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016511255A (ja) * | 2013-02-28 | 2016-04-14 | チョン クン ダン ファーマシューティカル コーポレーション | キトサンおよび液晶形成物質を含む遺伝子伝達用組成物 |
WO2018216792A1 (ja) * | 2017-05-26 | 2018-11-29 | 公益財団法人川崎市産業振興財団 | 血中におけるrnaの安定性の改善剤および投与方法 |
US10646579B2 (en) | 2015-11-04 | 2020-05-12 | Tme Therapeutics Inc. | Complex comprising RNAi molecule and N-acetylated chitosan |
JP2023519754A (ja) * | 2020-06-24 | 2023-05-12 | 珠海舒桐医療科技有限公司 | 膣ゲル製剤及びその調製方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2295045A1 (en) * | 2006-07-07 | 2011-03-16 | Aarhus Universitet | Nanoparticles for nucleic acid delivery |
EP2326351B1 (en) | 2008-08-19 | 2017-12-27 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
WO2013059617A1 (en) * | 2011-10-21 | 2013-04-25 | Ndsu Research Foundation | Liposome compositions and methods of use |
RU2014132564A (ru) | 2012-01-27 | 2016-03-20 | Ф. Хоффманн-Ля Рош Аг | Хитозан, ковалентно связанный с низкомолекулярным антагонистом интегрина, для нацеленной доставки |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005533078A (ja) * | 2002-06-20 | 2005-11-04 | バイオオーリアンス ファーマ | 少なくとも1つのポリマー及び少なくとも1つの正帯電多糖類の均一サイズのナノ粒子を含むベクター化システム及びその調製方法 |
JP2005533016A (ja) * | 2002-05-03 | 2005-11-04 | エフエムシー バイオポリマー エイエス | 非ウイルス性遺伝子送達システム |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3922260A (en) * | 1973-08-24 | 1975-11-25 | Quintin P Peniston | Process for depolymerization of chitosan |
US6184037B1 (en) * | 1996-05-17 | 2001-02-06 | Genemedicine, Inc. | Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell |
SE9904475D0 (sv) | 1999-12-08 | 1999-12-08 | Artursson | Nucleic acid delivery system |
US20030134810A1 (en) | 2001-10-09 | 2003-07-17 | Chris Springate | Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents |
NO317654B1 (no) * | 2002-05-03 | 2004-11-29 | Stiftelsen Biopolymer | Formulering som inneholder en nukleinsyre og et kitosan, fremgangsmate for fremstilling av formuleringen, samt anvendelser derav. |
US20070116767A1 (en) | 2003-02-14 | 2007-05-24 | Mohapatra Shyam S | Chitosan-microparticles for ifn gene delivery |
WO2005113770A1 (en) | 2004-05-13 | 2005-12-01 | Institut Gustave Roussy | Anti-rhoa and -rhoc sirnas and therapeutic compositions comprising them. |
US8399025B2 (en) * | 2004-06-04 | 2013-03-19 | Board Of Regents, The University Of Texas System | Polyamine modified particles |
US20090075383A1 (en) * | 2005-11-04 | 2009-03-19 | Bio Syntech Canada Inc. | Composition and method for efficient delivery of nucleic acids to cells using chitosan |
EP2034954B1 (en) * | 2006-03-30 | 2019-02-20 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
EP2295045A1 (en) * | 2006-07-07 | 2011-03-16 | Aarhus Universitet | Nanoparticles for nucleic acid delivery |
-
2007
- 2007-09-14 JP JP2009527838A patent/JP2010503640A/ja active Pending
- 2007-09-14 CN CNA2007800343442A patent/CN101588821A/zh active Pending
- 2007-09-14 CA CA002662560A patent/CA2662560A1/en not_active Abandoned
- 2007-09-14 WO PCT/EP2007/059740 patent/WO2008031899A2/en active Application Filing
- 2007-09-14 BR BRPI0716925-6A2A patent/BRPI0716925A2/pt not_active IP Right Cessation
- 2007-09-14 EP EP07803506A patent/EP2061516A2/en not_active Withdrawn
- 2007-09-14 KR KR1020097007646A patent/KR20090058562A/ko not_active Application Discontinuation
- 2007-09-14 US US11/855,193 patent/US7875449B2/en not_active Expired - Fee Related
-
2009
- 2009-03-09 IL IL197497A patent/IL197497A/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005533016A (ja) * | 2002-05-03 | 2005-11-04 | エフエムシー バイオポリマー エイエス | 非ウイルス性遺伝子送達システム |
JP2005533078A (ja) * | 2002-06-20 | 2005-11-04 | バイオオーリアンス ファーマ | 少なくとも1つのポリマー及び少なくとも1つの正帯電多糖類の均一サイズのナノ粒子を含むベクター化システム及びその調製方法 |
Non-Patent Citations (1)
Title |
---|
JPN6012052387; GAO S ET AL: 'Targeting delivery of oligonucleotide and plasmid DNA to hepatocyte via galactosylated chitosan vect' EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS vol. 60, no. 3, 200508, pages 327-334 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016511255A (ja) * | 2013-02-28 | 2016-04-14 | チョン クン ダン ファーマシューティカル コーポレーション | キトサンおよび液晶形成物質を含む遺伝子伝達用組成物 |
US11318215B2 (en) | 2013-02-28 | 2022-05-03 | Chong Kun Dang Pharmaceutical Corp. | Composition for gene delivery comprising chitosan and liquid crystal formation material |
US10646579B2 (en) | 2015-11-04 | 2020-05-12 | Tme Therapeutics Inc. | Complex comprising RNAi molecule and N-acetylated chitosan |
WO2018216792A1 (ja) * | 2017-05-26 | 2018-11-29 | 公益財団法人川崎市産業振興財団 | 血中におけるrnaの安定性の改善剤および投与方法 |
JPWO2018216792A1 (ja) * | 2017-05-26 | 2020-03-26 | 公益財団法人川崎市産業振興財団 | 血中におけるrnaの安定性の改善剤および投与方法 |
JP7237825B2 (ja) | 2017-05-26 | 2023-03-13 | 公益財団法人川崎市産業振興財団 | 血中におけるrnaの安定性の改善剤および投与方法 |
JP2023519754A (ja) * | 2020-06-24 | 2023-05-12 | 珠海舒桐医療科技有限公司 | 膣ゲル製剤及びその調製方法 |
Also Published As
Publication number | Publication date |
---|---|
IL197497A (en) | 2013-06-27 |
BRPI0716925A2 (pt) | 2013-09-17 |
IL197497A0 (en) | 2009-12-24 |
KR20090058562A (ko) | 2009-06-09 |
WO2008031899A3 (en) | 2008-05-08 |
EP2061516A2 (en) | 2009-05-27 |
CN101588821A (zh) | 2009-11-25 |
US7875449B2 (en) | 2011-01-25 |
US20080131371A1 (en) | 2008-06-05 |
WO2008031899A2 (en) | 2008-03-20 |
CA2662560A1 (en) | 2008-03-20 |
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