JP2010503640A - オリゴヌクレオチド非ウイルスデリバリーシステム - Google Patents

オリゴヌクレオチド非ウイルスデリバリーシステム Download PDF

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Publication number
JP2010503640A
JP2010503640A JP2009527838A JP2009527838A JP2010503640A JP 2010503640 A JP2010503640 A JP 2010503640A JP 2009527838 A JP2009527838 A JP 2009527838A JP 2009527838 A JP2009527838 A JP 2009527838A JP 2010503640 A JP2010503640 A JP 2010503640A
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composition
sirna
molecular weight
low molecular
chitosan
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JP2010503640A5 (https=
Inventor
アーター スベン アターソン,パー
マーモウド イッサ,モハメド
プロカツコバ ストランド,サビナ
モーテン バルム,ジエル
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エフエムシー バイオポリマー エイエス
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Publication of JP2010503640A publication Critical patent/JP2010503640A/ja
Publication of JP2010503640A5 publication Critical patent/JP2010503640A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2009527838A 2006-09-15 2007-09-14 オリゴヌクレオチド非ウイルスデリバリーシステム Pending JP2010503640A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84472906P 2006-09-15 2006-09-15
PCT/EP2007/059740 WO2008031899A2 (en) 2006-09-15 2007-09-14 Oligonucleotide non-viral delivery systems

Publications (2)

Publication Number Publication Date
JP2010503640A true JP2010503640A (ja) 2010-02-04
JP2010503640A5 JP2010503640A5 (https=) 2010-07-29

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JP2009527838A Pending JP2010503640A (ja) 2006-09-15 2007-09-14 オリゴヌクレオチド非ウイルスデリバリーシステム

Country Status (9)

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US (1) US7875449B2 (https=)
EP (1) EP2061516A2 (https=)
JP (1) JP2010503640A (https=)
KR (1) KR20090058562A (https=)
CN (1) CN101588821A (https=)
BR (1) BRPI0716925A2 (https=)
CA (1) CA2662560A1 (https=)
IL (1) IL197497A (https=)
WO (1) WO2008031899A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016511255A (ja) * 2013-02-28 2016-04-14 チョン クン ダン ファーマシューティカル コーポレーション キトサンおよび液晶形成物質を含む遺伝子伝達用組成物
WO2018216792A1 (ja) * 2017-05-26 2018-11-29 公益財団法人川崎市産業振興財団 血中におけるrnaの安定性の改善剤および投与方法
US10646579B2 (en) 2015-11-04 2020-05-12 Tme Therapeutics Inc. Complex comprising RNAi molecule and N-acetylated chitosan
JP2023519754A (ja) * 2020-06-24 2023-05-12 珠海舒桐医療科技有限公司 膣ゲル製剤及びその調製方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602007013559D1 (de) * 2006-07-07 2011-05-12 Univ Aarhus Nanoteilchen zur abgabe von nukleinsäure
US9433684B2 (en) 2008-08-19 2016-09-06 Nektar Therapeutics Conjugates of small-interfering nucleic acids
WO2013059617A1 (en) * 2011-10-21 2013-04-25 Ndsu Research Foundation Liposome compositions and methods of use
CN104039356B (zh) 2012-01-27 2018-08-17 弗·哈夫曼-拉罗切有限公司 用于靶向递送的、与小分子整联蛋白拮抗剂共价连接的壳聚糖
CN121264645A (zh) * 2025-12-11 2026-01-06 长春中医药大学 一种增强免疫力的咀嚼片及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533078A (ja) * 2002-06-20 2005-11-04 バイオオーリアンス ファーマ 少なくとも1つのポリマー及び少なくとも1つの正帯電多糖類の均一サイズのナノ粒子を含むベクター化システム及びその調製方法
JP2005533016A (ja) * 2002-05-03 2005-11-04 エフエムシー バイオポリマー エイエス 非ウイルス性遺伝子送達システム

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US3922260A (en) * 1973-08-24 1975-11-25 Quintin P Peniston Process for depolymerization of chitosan
US6184037B1 (en) * 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
SE9904475D0 (sv) * 1999-12-08 1999-12-08 Artursson Nucleic acid delivery system
US20030134810A1 (en) * 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
NO317654B1 (no) * 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som inneholder en nukleinsyre og et kitosan, fremgangsmate for fremstilling av formuleringen, samt anvendelser derav.
WO2004074314A2 (en) 2003-02-14 2004-09-02 University Of South Florida Chistosan-microparticles for ifn gene delivery
WO2005113770A1 (en) 2004-05-13 2005-12-01 Institut Gustave Roussy Anti-rhoa and -rhoc sirnas and therapeutic compositions comprising them.
US8399025B2 (en) * 2004-06-04 2013-03-19 Board Of Regents, The University Of Texas System Polyamine modified particles
WO2007059605A1 (en) * 2005-11-04 2007-05-31 Bio Syntech Canada Inc. Composition and method for efficient delivery of nucleic acids to cells using chitosan
AU2007285472B2 (en) * 2006-03-30 2013-10-24 Engene, Inc. Non-viral compositions and methods for transfecting gut cells in vivo
DE602007013559D1 (de) 2006-07-07 2011-05-12 Univ Aarhus Nanoteilchen zur abgabe von nukleinsäure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533016A (ja) * 2002-05-03 2005-11-04 エフエムシー バイオポリマー エイエス 非ウイルス性遺伝子送達システム
JP2005533078A (ja) * 2002-06-20 2005-11-04 バイオオーリアンス ファーマ 少なくとも1つのポリマー及び少なくとも1つの正帯電多糖類の均一サイズのナノ粒子を含むベクター化システム及びその調製方法

Non-Patent Citations (1)

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Title
JPN6012052387; GAO S ET AL: 'Targeting delivery of oligonucleotide and plasmid DNA to hepatocyte via galactosylated chitosan vect' EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS vol. 60, no. 3, 200508, pages 327-334 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016511255A (ja) * 2013-02-28 2016-04-14 チョン クン ダン ファーマシューティカル コーポレーション キトサンおよび液晶形成物質を含む遺伝子伝達用組成物
US11318215B2 (en) 2013-02-28 2022-05-03 Chong Kun Dang Pharmaceutical Corp. Composition for gene delivery comprising chitosan and liquid crystal formation material
US10646579B2 (en) 2015-11-04 2020-05-12 Tme Therapeutics Inc. Complex comprising RNAi molecule and N-acetylated chitosan
WO2018216792A1 (ja) * 2017-05-26 2018-11-29 公益財団法人川崎市産業振興財団 血中におけるrnaの安定性の改善剤および投与方法
JPWO2018216792A1 (ja) * 2017-05-26 2020-03-26 公益財団法人川崎市産業振興財団 血中におけるrnaの安定性の改善剤および投与方法
JP7237825B2 (ja) 2017-05-26 2023-03-13 公益財団法人川崎市産業振興財団 血中におけるrnaの安定性の改善剤および投与方法
JP2023519754A (ja) * 2020-06-24 2023-05-12 珠海舒桐医療科技有限公司 膣ゲル製剤及びその調製方法
AU2020455080B2 (en) * 2020-06-24 2024-05-23 Zhuhai Shu Tong Medical Technology Co., Ltd. Vaginal gel preparation and preparation method therefor
JP7612228B2 (ja) 2020-06-24 2025-01-14 珠海舒桐医療科技有限公司 膣ゲル製剤及びその調製方法

Also Published As

Publication number Publication date
US20080131371A1 (en) 2008-06-05
IL197497A0 (en) 2009-12-24
CN101588821A (zh) 2009-11-25
WO2008031899A2 (en) 2008-03-20
WO2008031899A3 (en) 2008-05-08
EP2061516A2 (en) 2009-05-27
CA2662560A1 (en) 2008-03-20
US7875449B2 (en) 2011-01-25
IL197497A (en) 2013-06-27
KR20090058562A (ko) 2009-06-09
BRPI0716925A2 (pt) 2013-09-17

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