JP2010502717A - インターロイキン１受容体関連キナーゼの調節物質 - Google Patents
インターロイキン１受容体関連キナーゼの調節物質 Download PDFInfo
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- JP2010502717A JP2010502717A JP2009527438A JP2009527438A JP2010502717A JP 2010502717 A JP2010502717 A JP 2010502717A JP 2009527438 A JP2009527438 A JP 2009527438A JP 2009527438 A JP2009527438 A JP 2009527438A JP 2010502717 A JP2010502717 A JP 2010502717A
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84280106P | 2006-09-07 | 2006-09-07 | |
| PCT/US2007/019588 WO2008030584A2 (en) | 2006-09-07 | 2007-09-07 | Indazole derivatives as modulators of interleukin- 1 receptor-associated kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010502717A true JP2010502717A (ja) | 2010-01-28 |
| JP2010502717A5 JP2010502717A5 (enExample) | 2011-01-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527438A Pending JP2010502717A (ja) | 2006-09-07 | 2007-09-07 | インターロイキン１受容体関連キナーゼの調節物質 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8293923B2 (enExample) |
| EP (1) | EP2061786A2 (enExample) |
| JP (1) | JP2010502717A (enExample) |
| KR (1) | KR20090049076A (enExample) |
| CN (1) | CN101616910A (enExample) |
| AU (1) | AU2007292929A1 (enExample) |
| BR (1) | BRPI0716549A2 (enExample) |
| CA (1) | CA2663100A1 (enExample) |
| IL (1) | IL197274A0 (enExample) |
| MX (1) | MX2009002377A (enExample) |
| NO (1) | NO20091326L (enExample) |
| NZ (1) | NZ575410A (enExample) |
| RU (1) | RU2459821C2 (enExample) |
| WO (1) | WO2008030584A2 (enExample) |
| ZA (1) | ZA200901529B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013544256A (ja) * | 2010-11-19 | 2013-12-12 | リガンド ファーマシューティカルズ インコーポレイテッド | 複素環式アミンおよびその使用 |
| JP2017502088A (ja) * | 2014-01-13 | 2017-01-19 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2017535585A (ja) * | 2014-11-26 | 2017-11-30 | バイエル・ファルマ・アクティエンゲゼルシャフト | 新規置換インダゾール、その製造方法、前記新規置換インダゾールを含む医薬製剤、および薬剤を製造するための前記新規置換インダゾールの使用 |
| JP2022539374A (ja) * | 2019-06-27 | 2022-09-08 | バイオジェン・エムエイ・インコーポレイテッド | ２ｈ－インダゾール誘導体及び疾患の処置におけるそれらの使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2243481A1 (en) * | 2009-04-24 | 2010-10-27 | PamGene B.V. | Irak kinase family as novel drug target for Alzheimer |
| WO2013185082A2 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Inhibitors of bruton's tyrosine kinase |
| US9586948B2 (en) | 2012-10-08 | 2017-03-07 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| US9598440B2 (en) | 2012-10-08 | 2017-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| EP2746259A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| EP2746260A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| RS56331B1 (sr) * | 2013-02-07 | 2017-12-29 | Merck Patent Gmbh | Derivati piridazinon-amida |
| LT2953952T (lt) * | 2013-02-07 | 2017-08-25 | Merck Patent Gmbh | Makrocikliniai piridazinono dariniai |
| WO2015006181A1 (en) | 2013-07-11 | 2015-01-15 | Merck Sharp & Dohme Corp. | Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4) |
| TWI667233B (zh) * | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
| JP2017505337A (ja) | 2014-01-10 | 2017-02-16 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としてのインダゾール化合物 |
| CN106456609A (zh) * | 2014-06-20 | 2017-02-22 | 奥瑞基尼探索技术有限公司 | 作为irak4抑制剂的取代的吲唑化合物 |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| EP3288558B1 (en) | 2015-04-30 | 2022-05-11 | Bayer Pharma Aktiengesellschaft | Combinations of inhibitors of irak4 with inhibitors of btk |
| EP3195865A1 (de) | 2016-01-25 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Kombinationen von irak4 inhibitoren und btk inhibitoren |
| US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
| EP3219329A1 (en) | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
| SI3448848T1 (sl) | 2016-04-29 | 2024-01-31 | Bayer Pharma Aktiengesellschaft | Polimorfna oblika N-(6-(2-hidroksipropan-2-il)-2-(2-(metilsulfonil)etil)-2H-indazol-5-il) -6-(trifluormetil)piridin-2-karboksamida |
| PE20240651A1 (es) | 2016-04-29 | 2024-04-04 | Bayer Pharma AG | Sintesis de indazoles |
| EP3464266B1 (en) | 2016-06-01 | 2021-10-20 | Bayer Animal Health GmbH | Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals |
| CN106222183B (zh) * | 2016-07-25 | 2019-11-08 | 南通大学 | 靶向人irak1基因的小干扰rna及其应用 |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| CN120267671A (zh) | 2017-03-31 | 2025-07-08 | 奥锐金肿瘤有限公司 | 用于治疗血液病的化合物和组合物 |
| KR20200073216A (ko) | 2017-10-19 | 2020-06-23 | 바이엘 애니멀 헬스 게엠베하 | 동물에서의 질환의 치료 및 방지를 위한 융합된 헤테로방향족 피롤리돈의 용도 |
| JP7241747B2 (ja) | 2017-10-31 | 2023-03-17 | キュリス，インコーポレイテッド | 血液学的障害を治療するための化合物および組成物 |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| US12415816B2 (en) | 2018-11-07 | 2025-09-16 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| EP4146639A1 (en) | 2020-05-06 | 2023-03-15 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| TW202241889A (zh) | 2020-12-23 | 2022-11-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| CN117120054A (zh) | 2021-04-08 | 2023-11-24 | 柯里斯公司 | 治疗癌症的组合疗法 |
| CN115710253B (zh) * | 2021-08-23 | 2024-07-02 | 上海交通大学 | 一类含有氨基苯并咪唑类衍生物及其制备和用途 |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| JP7782035B2 (ja) | 2021-11-09 | 2025-12-08 | エイジャックス セラピューティクス， インコーポレイテッド | Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール |
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| JP2001518094A (ja) * | 1997-03-31 | 2001-10-09 | デュポン ファーマシューティカルズ カンパニー | Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素 |
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| WO2003082272A1 (en) * | 2002-03-29 | 2003-10-09 | Chiron Corporation | Substituted benzazoles and use thereof as raf kinase inhibitors |
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| GB8716111D0 (en) * | 1987-07-08 | 1987-08-12 | Unilever Plc | Edible plastic dispersion |
| WO1998022460A1 (en) * | 1996-11-15 | 1998-05-28 | Darwin Discovery Limited | Bicyclic aryl carboxamides and their therapeutic use |
| NZ516348A (en) * | 1999-06-23 | 2003-06-30 | Aventis Pharma Gmbh | Substituted benzimidazole |
-
2007
- 2007-09-07 KR KR1020097006123A patent/KR20090049076A/ko not_active Ceased
- 2007-09-07 WO PCT/US2007/019588 patent/WO2008030584A2/en not_active Ceased
- 2007-09-07 US US12/440,163 patent/US8293923B2/en not_active Expired - Fee Related
- 2007-09-07 CN CN200780041379A patent/CN101616910A/zh active Pending
- 2007-09-07 AU AU2007292929A patent/AU2007292929A1/en not_active Abandoned
- 2007-09-07 MX MX2009002377A patent/MX2009002377A/es not_active Application Discontinuation
- 2007-09-07 EP EP07837920A patent/EP2061786A2/en not_active Withdrawn
- 2007-09-07 BR BRPI0716549-8A2A patent/BRPI0716549A2/pt not_active IP Right Cessation
- 2007-09-07 NZ NZ575410A patent/NZ575410A/en not_active IP Right Cessation
- 2007-09-07 CA CA002663100A patent/CA2663100A1/en not_active Abandoned
- 2007-09-07 RU RU2009112598/04A patent/RU2459821C2/ru not_active IP Right Cessation
- 2007-09-07 JP JP2009527438A patent/JP2010502717A/ja active Pending
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2009
- 2009-02-26 IL IL197274A patent/IL197274A0/en unknown
- 2009-03-03 ZA ZA200901529A patent/ZA200901529B/xx unknown
- 2009-04-01 NO NO20091326A patent/NO20091326L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001518094A (ja) * | 1997-03-31 | 2001-10-09 | デュポン ファーマシューティカルズ カンパニー | Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素 |
| WO2003030902A1 (en) * | 2001-10-09 | 2003-04-17 | Tularik Inc. | Imidazole derivates as anti-inflammatory agents |
| WO2003082272A1 (en) * | 2002-03-29 | 2003-10-09 | Chiron Corporation | Substituted benzazoles and use thereof as raf kinase inhibitors |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013544256A (ja) * | 2010-11-19 | 2013-12-12 | リガンド ファーマシューティカルズ インコーポレイテッド | 複素環式アミンおよびその使用 |
| JP2017014271A (ja) * | 2010-11-19 | 2017-01-19 | リガンド ファーマシューティカルズ インコーポレイテッド | 複素環式アミンおよびその使用 |
| JP2023085526A (ja) * | 2014-01-13 | 2023-06-20 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2019077729A (ja) * | 2014-01-13 | 2019-05-23 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2020164546A (ja) * | 2014-01-13 | 2020-10-08 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2022024021A (ja) * | 2014-01-13 | 2022-02-08 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP7262553B2 (ja) | 2014-01-13 | 2023-04-21 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2017502088A (ja) * | 2014-01-13 | 2017-01-19 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP7601937B2 (ja) | 2014-01-13 | 2024-12-17 | アウリジーン オンコロジー リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2025032208A (ja) * | 2014-01-13 | 2025-03-11 | アウリジーン オンコロジー リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP7775430B2 (ja) | 2014-01-13 | 2025-11-25 | アウリジーン オンコロジー リミテッド | Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体 |
| JP2017535585A (ja) * | 2014-11-26 | 2017-11-30 | バイエル・ファルマ・アクティエンゲゼルシャフト | 新規置換インダゾール、その製造方法、前記新規置換インダゾールを含む医薬製剤、および薬剤を製造するための前記新規置換インダゾールの使用 |
| JP2022539374A (ja) * | 2019-06-27 | 2022-09-08 | バイオジェン・エムエイ・インコーポレイテッド | ２ｈ－インダゾール誘導体及び疾患の処置におけるそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2061786A2 (en) | 2009-05-27 |
| IL197274A0 (en) | 2009-12-24 |
| RU2459821C2 (ru) | 2012-08-27 |
| WO2008030584A2 (en) | 2008-03-13 |
| BRPI0716549A2 (pt) | 2013-09-24 |
| MX2009002377A (es) | 2009-03-13 |
| CN101616910A (zh) | 2009-12-30 |
| NZ575410A (en) | 2012-03-30 |
| ZA200901529B (en) | 2009-11-25 |
| AU2007292929A1 (en) | 2008-03-13 |
| WO2008030584A3 (en) | 2008-07-17 |
| KR20090049076A (ko) | 2009-05-15 |
| NO20091326L (no) | 2009-04-01 |
| US8293923B2 (en) | 2012-10-23 |
| US20110152260A1 (en) | 2011-06-23 |
| RU2009112598A (ru) | 2010-10-20 |
| CA2663100A1 (en) | 2008-03-13 |
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