JP2010502615A - 5−リポキシゲナーゼ活性化タンパク質(flap)の阻害剤 - Google Patents
5−リポキシゲナーゼ活性化タンパク質(flap)の阻害剤 Download PDFInfo
- Publication number
- JP2010502615A JP2010502615A JP2009526695A JP2009526695A JP2010502615A JP 2010502615 A JP2010502615 A JP 2010502615A JP 2009526695 A JP2009526695 A JP 2009526695A JP 2009526695 A JP2009526695 A JP 2009526695A JP 2010502615 A JP2010502615 A JP 2010502615A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- group
- pyridin
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *Cc1n[n]cc1 Chemical compound *Cc1n[n]cc1 0.000 description 12
- MCXLQFOCWZMFHV-UHFFFAOYSA-N C=Cc1n[nH]nc1 Chemical compound C=Cc1n[nH]nc1 MCXLQFOCWZMFHV-UHFFFAOYSA-N 0.000 description 1
- XUYRDKGAGMTGRC-UHFFFAOYSA-N CN(C)c1nnn[nH]1 Chemical compound CN(C)c1nnn[nH]1 XUYRDKGAGMTGRC-UHFFFAOYSA-N 0.000 description 1
- XORXZRQNXQSDQG-UHFFFAOYSA-N CNc1nnc[s]1 Chemical compound CNc1nnc[s]1 XORXZRQNXQSDQG-UHFFFAOYSA-N 0.000 description 1
- ZYMHCFYHVYGFMS-UHFFFAOYSA-N Cc1cnc[o]1 Chemical compound Cc1cnc[o]1 ZYMHCFYHVYGFMS-UHFFFAOYSA-N 0.000 description 1
- YWHMSDIXSIETOG-UHFFFAOYSA-N ICc1n[o]cc1 Chemical compound ICc1n[o]cc1 YWHMSDIXSIETOG-UHFFFAOYSA-N 0.000 description 1
- ACTKAGSPIFDCMF-UHFFFAOYSA-N Nc1ncc[o]1 Chemical compound Nc1ncc[o]1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84175806P | 2006-09-01 | 2006-09-01 | |
| US93388607P | 2007-06-08 | 2007-06-08 | |
| US96159807P | 2007-07-23 | 2007-07-23 | |
| PCT/US2007/018991 WO2008030369A1 (en) | 2006-09-01 | 2007-08-29 | Inhibitors of 5 -lipoxygenase activating protein ( flap) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010502615A true JP2010502615A (ja) | 2010-01-28 |
| JP2010502615A5 JP2010502615A5 (enExample) | 2010-09-16 |
Family
ID=38925607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009526695A Withdrawn JP2010502615A (ja) | 2006-09-01 | 2007-08-29 | 5−リポキシゲナーゼ活性化タンパク質(flap)の阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8440672B2 (enExample) |
| EP (1) | EP2064204B1 (enExample) |
| JP (1) | JP2010502615A (enExample) |
| AT (1) | ATE543810T1 (enExample) |
| AU (1) | AU2007293373A1 (enExample) |
| CA (1) | CA2666686A1 (enExample) |
| WO (1) | WO2008030369A1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013534245A (ja) * | 2010-08-16 | 2013-09-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害薬 |
| JP2013537909A (ja) * | 2010-09-23 | 2013-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| JP2013537908A (ja) * | 2010-09-23 | 2013-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| JP2013545810A (ja) * | 2010-12-16 | 2013-12-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のビアリールアミドインヒビター |
| JP2015505550A (ja) * | 2012-02-01 | 2015-02-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害薬としてのフェニル−c−オキサジアゾール誘導体併用療法 |
| JP2016535593A (ja) * | 2013-10-22 | 2016-11-17 | シレンティス・エセ・ア・ウ | FLAP遺伝子の発現を阻害するための方法及び組成物におけるsiRNA及びその使用 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007120574A2 (en) | 2006-04-11 | 2007-10-25 | Merck & Co., Inc. | Diaryl substituted alkanes |
| AU2007293373A1 (en) | 2006-09-01 | 2008-03-13 | Merck Sharp & Dohme Corp. | Inhibitors of 5 -lipoxygenase activating protein (FLAP) |
| EP2170065A4 (en) * | 2007-06-20 | 2011-11-23 | Merck Sharp & Dohme | DIPHENYL SUBSTITUTED ALKANES |
| JP5552121B2 (ja) | 2008-09-04 | 2014-07-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のインドリジン阻害剤 |
| US20110201649A1 (en) * | 2008-09-19 | 2011-08-18 | Sumitomo Chemical Company, Limited | agricultural composition |
| JP5690839B2 (ja) | 2009-12-04 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のベンゾイミダゾール阻害薬 |
| US9518032B2 (en) | 2010-04-30 | 2016-12-13 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of USP1 deubiquitinating enzyme activity |
| WO2012027322A1 (en) | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| WO2012058254A1 (en) | 2010-10-29 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| JP5789888B2 (ja) | 2010-11-01 | 2015-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| WO2013116182A1 (en) * | 2012-01-31 | 2013-08-08 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as inhibitors of leukotriene production |
| US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| WO2016065584A1 (en) * | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| WO2016149126A1 (en) | 2015-03-13 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU186654B (en) | 1982-12-28 | 1985-09-30 | Richter Gedeon Vegyeszet | Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them |
| US4853398A (en) | 1987-04-13 | 1989-08-01 | Eli Lilly And Company | Leukotriene antagonists and use thereas |
| US6051573A (en) | 1994-06-28 | 2000-04-18 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists |
| US5668146A (en) | 1995-10-03 | 1997-09-16 | Abbott Laboratories | Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5795900A (en) | 1995-10-03 | 1998-08-18 | Abbott Laboratories | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US6468781B1 (en) | 1999-07-08 | 2002-10-22 | Bristol-Myers Squibb Company | Stereoselective reductive amination of ketones |
| CA2337230A1 (en) | 1998-07-15 | 2000-01-27 | Bristol-Myers Squibb Company | Stereoselective reductive amination of ketones |
| EP1157007A1 (en) | 1999-02-25 | 2001-11-28 | Merck Frosst Canada Inc. | Pde iv inhibiting compounds, compositions and methods of treatment |
| AU2002215360A1 (en) | 2000-10-17 | 2002-04-29 | Pcbu Services, Inc. | Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system |
| DE10112401A1 (de) | 2001-03-13 | 2002-09-19 | Degussa | Alkohol-Dehydrogenase und deren Verwendung |
| EP1374030A1 (en) | 2001-03-26 | 2004-01-02 | An, Hyun-gi | Multimedia calendar system |
| BRPI0411514A (pt) | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
| JP2006528630A (ja) | 2003-07-24 | 2006-12-21 | メルク エンド カムパニー インコーポレーテッド | ジフェニル置換シクロアルカン類、そのような化合物を含む組成物、ならびに使用方法 |
| EP1732906A4 (en) | 2004-03-30 | 2007-11-21 | Merck & Co Inc | 2-AMINOTHIAZONE COMPOUNDS SUITABLE AS ASPARTYL PROTEASE INHIBITORS |
| EP1814877B1 (en) | 2004-10-18 | 2009-03-11 | Merck & Co., Inc. | Diphenyl substituted alkanes as flap inhibitors |
| CA2600860A1 (en) | 2005-03-09 | 2006-09-21 | Merck & Co., Inc. | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use |
| UY29610A1 (es) * | 2005-06-21 | 2007-01-31 | Cancer Rec Tech Ltd | Aril-alquilaminas y heteroaril-alquilaminas como inhibidores de la quinasa proteínica |
| EP1911738A4 (en) | 2005-07-29 | 2009-12-16 | Takeda Pharmaceutical | COMPOUND OF PHENOXYALKANOIC ACID |
| EP1954128A4 (en) | 2005-11-04 | 2010-09-22 | Merck Sharp & Dohme | DIPHENYLMETHANE DERIVATIVES AS AN INHIBITORS OF THE LEUKOTRIEN BIOSYNTHESIS |
| WO2007120574A2 (en) | 2006-04-11 | 2007-10-25 | Merck & Co., Inc. | Diaryl substituted alkanes |
| AU2007293373A1 (en) | 2006-09-01 | 2008-03-13 | Merck Sharp & Dohme Corp. | Inhibitors of 5 -lipoxygenase activating protein (FLAP) |
| EP2170065A4 (en) | 2007-06-20 | 2011-11-23 | Merck Sharp & Dohme | DIPHENYL SUBSTITUTED ALKANES |
| JP2011500563A (ja) | 2007-10-10 | 2011-01-06 | メルク・シャープ・エンド・ドーム・コーポレイション | ジフェニル置換されたシクロアルカン |
| EP2257167B1 (en) | 2008-02-28 | 2015-07-22 | Merck Sharp & Dohme Corp. | 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease |
-
2007
- 2007-08-29 AU AU2007293373A patent/AU2007293373A1/en not_active Abandoned
- 2007-08-29 JP JP2009526695A patent/JP2010502615A/ja not_active Withdrawn
- 2007-08-29 EP EP07837478A patent/EP2064204B1/en not_active Not-in-force
- 2007-08-29 AT AT07837478T patent/ATE543810T1/de active
- 2007-08-29 US US12/377,136 patent/US8440672B2/en not_active Expired - Fee Related
- 2007-08-29 CA CA002666686A patent/CA2666686A1/en not_active Abandoned
- 2007-08-29 WO PCT/US2007/018991 patent/WO2008030369A1/en not_active Ceased
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013534245A (ja) * | 2010-08-16 | 2013-09-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害薬 |
| JP2013537909A (ja) * | 2010-09-23 | 2013-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| JP2013537908A (ja) * | 2010-09-23 | 2013-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| JP2013545810A (ja) * | 2010-12-16 | 2013-12-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のビアリールアミドインヒビター |
| JP2015505550A (ja) * | 2012-02-01 | 2015-02-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害薬としてのフェニル−c−オキサジアゾール誘導体併用療法 |
| JP2016535593A (ja) * | 2013-10-22 | 2016-11-17 | シレンティス・エセ・ア・ウ | FLAP遺伝子の発現を阻害するための方法及び組成物におけるsiRNA及びその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007293373A1 (en) | 2008-03-13 |
| US8440672B2 (en) | 2013-05-14 |
| WO2008030369A1 (en) | 2008-03-13 |
| US20100168076A1 (en) | 2010-07-01 |
| CA2666686A1 (en) | 2008-03-13 |
| EP2064204A1 (en) | 2009-06-03 |
| EP2064204B1 (en) | 2012-02-01 |
| ATE543810T1 (de) | 2012-02-15 |
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Legal Events
| Date | Code | Title | Description |
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| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100727 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100727 |
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| A761 | Written withdrawal of application |
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