JP2010229138A5 - - Google Patents
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- Publication number
- JP2010229138A5 JP2010229138A5 JP2010110683A JP2010110683A JP2010229138A5 JP 2010229138 A5 JP2010229138 A5 JP 2010229138A5 JP 2010110683 A JP2010110683 A JP 2010110683A JP 2010110683 A JP2010110683 A JP 2010110683A JP 2010229138 A5 JP2010229138 A5 JP 2010229138A5
- Authority
- JP
- Japan
- Prior art keywords
- celiac disease
- agent
- epitope
- peptide
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 238000000034 method Methods 0.000 claims 20
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 208000015943 Coeliac disease Diseases 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 241000209219 Hordeum Species 0.000 claims 4
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 4
- 241000209140 Triticum Species 0.000 claims 4
- 235000021307 Triticum Nutrition 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- 108091008874 T cell receptors Proteins 0.000 claims 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108060008539 Transglutaminase Proteins 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 208000032309 susceptibility to 1 celiac disease Diseases 0.000 claims 3
- 230000009261 transgenic effect Effects 0.000 claims 3
- 102000003601 transglutaminase Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047762 HLA-DQ8 antigen Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010061711 Gliadin Proteins 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212885.8 | 2002-06-05 | ||
| GBGB0212885.8A GB0212885D0 (en) | 2002-06-05 | 2002-06-05 | Therapeutic epitopes and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Division JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021737A Division JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Division JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010229138A JP2010229138A (ja) | 2010-10-14 |
| JP2010229138A5 true JP2010229138A5 (cg-RX-API-DMAC7.html) | 2010-12-02 |
| JP5635302B2 JP5635302B2 (ja) | 2014-12-03 |
Family
ID=9937994
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Withdrawn JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
| JP2010110683A Expired - Lifetime JP5635302B2 (ja) | 2002-06-05 | 2010-05-12 | 治療用エピトープ及びそれらの使用 |
| JP2013021737A Expired - Lifetime JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Expired - Lifetime JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
| JP2014198382A Pending JP2015052599A (ja) | 2002-06-05 | 2014-09-29 | 治療用エピトープ及びそれらの使用 |
| JP2016037111A Expired - Lifetime JP6438423B2 (ja) | 2002-06-05 | 2016-02-29 | 治療用エピトープ及びそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Withdrawn JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021737A Expired - Lifetime JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Expired - Lifetime JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
| JP2014198382A Pending JP2015052599A (ja) | 2002-06-05 | 2014-09-29 | 治療用エピトープ及びそれらの使用 |
| JP2016037111A Expired - Lifetime JP6438423B2 (ja) | 2002-06-05 | 2016-02-29 | 治療用エピトープ及びそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10053497B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1513873B1 (cg-RX-API-DMAC7.html) |
| JP (6) | JP2006512893A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003244771B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2488218C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1115730T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1513873T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2510440T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0212885D0 (cg-RX-API-DMAC7.html) |
| MX (2) | MXPA04012117A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ537226A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1513873E (cg-RX-API-DMAC7.html) |
| SI (1) | SI1513873T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003104273A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200409740B (cg-RX-API-DMAC7.html) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923306D0 (en) | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| EP2409711B1 (en) | 2002-02-14 | 2018-11-21 | The Board of Trustees of the Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| AU2003234634A1 (en) * | 2002-05-14 | 2003-12-02 | Felix Hausch | Drug therapy for celiac sprue |
| WO2004045392A2 (en) * | 2002-11-20 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| US7202216B2 (en) * | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| GB0212885D0 (en) | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| EP1765395B1 (en) * | 2004-04-16 | 2011-02-09 | The Governors of the University of Alberta | Anti-gluten egg yolk antibodies for the treatment of celiac disease |
| US7628985B2 (en) * | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| US7534426B2 (en) * | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7563864B2 (en) * | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
| EP2412380B1 (en) * | 2004-04-28 | 2021-01-06 | BTG International Limited | Epitopes related to coeliac disease |
| US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| EP2136833B1 (en) | 2007-03-16 | 2019-05-01 | The Board of Trustees of the Leland Stanford Junior University | Combination enzyme therapy for digestion of dietary gluten |
| US8282928B2 (en) | 2007-05-30 | 2012-10-09 | The Governors Of The University Of Alberta | Anti-gluten egg yolk antibodies for the treatment of celiac disease |
| DE102007044673A1 (de) * | 2007-09-18 | 2009-03-19 | Zimmer, Klaus-Peter, Prof. Dr. med. | Impfstoff zur Behandlung von Zöliakie und Verfahren zur Herstellung des Impfstoffes, Verwendung einer mit einem bakteriellen Toxin konjugierten Peptidsequenz zur Aktivierung des Immunsystems gegen Prolamine sowie Designerpeptid |
| AU2013204429B9 (en) * | 2008-11-30 | 2017-01-05 | Immusant, Inc. | Compositions and methods for treatment of celiac disease |
| MX346450B (es) | 2008-11-30 | 2017-03-17 | Immusant Inc * | Composiciones y métodos para el tratamiento de la enfermedad celíaca. |
| US9518087B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US20140037661A1 (en) * | 2011-02-08 | 2014-02-06 | Phadia Ab | Wheat Antigens and Peptides for Diagnosis of Wheat Induced Hypersensitivity |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| CA3191015A1 (en) | 2012-02-07 | 2013-08-15 | Vibrant Holdings, Llc | Substrates, peptide arrays, and methods |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| CA2923379C (en) | 2013-02-15 | 2023-01-03 | Vibrant Holdings, Llc | Methods and compositions for amplified electrochemiluminescence detection |
| EP3043812A1 (en) | 2013-09-10 | 2016-07-20 | Immusant Inc. | Dosage of a gluten peptide composition |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| CN106456743A (zh) | 2014-02-21 | 2017-02-22 | 洛桑聚合联合学院 | 糖靶向性治疗剂 |
| WO2015164747A1 (en) | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Methods for diagnosing celiac disease using circulating cytokines/chemokines |
| JP6887945B2 (ja) * | 2014-09-10 | 2021-06-16 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | セリアック病に関するペプチドマイクロアレイおよび新規バイオマーカー |
| CA2962933A1 (en) | 2014-09-29 | 2016-04-07 | Immusant, Inc. | Use of hla genetic status to assess or select treatment of celiac disease |
| US10473647B1 (en) | 2014-11-21 | 2019-11-12 | Immusant, Inc. | Peptides for use in treatment and diagnosis of type 1 diabetes |
| EP3109255A1 (en) * | 2015-06-26 | 2016-12-28 | Institut National De La Recherche Agronomique | Immunogenic composition |
| EP3313868A1 (en) * | 2015-06-26 | 2018-05-02 | Institut National De La Recherche Agronomique (INRA) | Immunogenic composition |
| WO2017146118A1 (ja) * | 2016-02-23 | 2017-08-31 | 田中貴金属工業株式会社 | グリアジン検出用免疫クロマト分析装置、免疫クロマト分析キットおよび免疫クロマト分析方法 |
| WO2018218250A2 (en) | 2017-05-26 | 2018-11-29 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| JP6568193B2 (ja) * | 2017-12-19 | 2019-08-28 | ホーユー株式会社 | エピトープ |
| KR20210010879A (ko) | 2018-05-09 | 2021-01-28 | 더 유니버서티 오브 시카고 | 면역 관용 관여 조성물 및 방법 |
| AU2019266303B2 (en) | 2018-05-09 | 2025-12-18 | Vibrant Holdings, Llc | Methods of synthesizing a polynucleotide array using photactivated agents |
| CA3145972A1 (en) * | 2019-07-04 | 2021-01-07 | Ukko Inc. | De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity |
| CN114761028A (zh) | 2019-09-27 | 2022-07-15 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 乳糜泻的治疗 |
| GB202113858D0 (en) * | 2021-09-28 | 2021-11-10 | Nextera As | Peptides |
| CN115124606B (zh) * | 2022-06-27 | 2025-03-28 | 上海理工大学 | 含有氨基酸结构pqqp的寡肽及其制备方法和应用 |
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-
2002
- 2002-06-05 GB GBGB0212885.8A patent/GB0212885D0/en not_active Ceased
-
2003
- 2003-06-05 US US10/516,837 patent/US10053497B2/en active Active
- 2003-06-05 WO PCT/GB2003/002450 patent/WO2003104273A2/en not_active Ceased
- 2003-06-05 ES ES03738256.1T patent/ES2510440T3/es not_active Expired - Lifetime
- 2003-06-05 MX MXPA04012117A patent/MXPA04012117A/es active IP Right Grant
- 2003-06-05 PT PT37382561T patent/PT1513873E/pt unknown
- 2003-06-05 NZ NZ537226A patent/NZ537226A/en not_active IP Right Cessation
- 2003-06-05 SI SI200332396T patent/SI1513873T1/sl unknown
- 2003-06-05 JP JP2004511341A patent/JP2006512893A/ja not_active Withdrawn
- 2003-06-05 EP EP03738256.1A patent/EP1513873B1/en not_active Expired - Lifetime
- 2003-06-05 EP EP10181717.9A patent/EP2292649B1/en not_active Expired - Lifetime
- 2003-06-05 AU AU2003244771A patent/AU2003244771B2/en not_active Expired
- 2003-06-05 DK DK03738256.1T patent/DK1513873T3/da active
- 2003-06-05 EP EP14184972.9A patent/EP2826787B1/en not_active Expired - Lifetime
- 2003-06-05 CA CA2488218A patent/CA2488218C/en not_active Expired - Lifetime
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2004
- 2004-12-01 ZA ZA200409740A patent/ZA200409740B/en unknown
- 2004-12-03 MX MX2012011506A patent/MX338122B/es unknown
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2010
- 2010-05-12 JP JP2010110683A patent/JP5635302B2/ja not_active Expired - Lifetime
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2013
- 2013-02-06 JP JP2013021737A patent/JP6055689B2/ja not_active Expired - Lifetime
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2014
- 2014-08-08 JP JP2014162664A patent/JP5977293B2/ja not_active Expired - Lifetime
- 2014-09-29 JP JP2014198382A patent/JP2015052599A/ja active Pending
- 2014-11-07 CY CY20141100928T patent/CY1115730T1/el unknown
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2016
- 2016-02-29 JP JP2016037111A patent/JP6438423B2/ja not_active Expired - Lifetime
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2018
- 2018-04-11 US US15/951,116 patent/US20180334484A1/en not_active Abandoned
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