JP2010180206A5 - - Google Patents

Info

Publication number

JP2010180206A5

JP2010180206A5 JP2010003318A JP2010003318A JP2010180206A5 JP 2010180206 A5 JP2010180206 A5 JP 2010180206A5 JP 2010003318 A JP2010003318 A JP 2010003318A JP 2010003318 A JP2010003318 A JP 2010003318A JP 2010180206 A5 JP2010180206 A5 JP 2010180206A5

Authority

JP

Japan

Prior art keywords

salts

diphenhydramine

ascorbic acid

mucopolysaccharides

salt

Prior art date

2010-01-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims 11
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 10
• 238000000034 method Methods 0.000 claims 7
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 5
• 229960005070 ascorbic acid Drugs 0.000 claims 5
• 235000010323 ascorbic acid Nutrition 0.000 claims 5
• 239000011668 ascorbic acid Substances 0.000 claims 5
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 5
• 229960000520 diphenhydramine Drugs 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• 238000002845 discoloration Methods 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
• 229920001499 Heparinoid Polymers 0.000 claims 2
• 229940059329 chondroitin sulfate Drugs 0.000 claims 2
• 239000002554 heparinoid Substances 0.000 claims 2
• 229920000045 Dermatan sulfate Polymers 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
• 229940051593 dermatan sulfate Drugs 0.000 claims 1
• 239000000839 emulsion Substances 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1