JP2010111679A5 - - Google Patents
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- JP2010111679A5 JP2010111679A5 JP2009288124A JP2009288124A JP2010111679A5 JP 2010111679 A5 JP2010111679 A5 JP 2010111679A5 JP 2009288124 A JP2009288124 A JP 2009288124A JP 2009288124 A JP2009288124 A JP 2009288124A JP 2010111679 A5 JP2010111679 A5 JP 2010111679A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- monoclonal antibody
- composition
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35882402P | 2002-02-21 | 2002-02-21 | |
| US60/358,824 | 2002-02-21 | ||
| US38306802P | 2002-05-23 | 2002-05-23 | |
| US60/383,068 | 2002-05-23 | ||
| US43149902P | 2002-12-05 | 2002-12-05 | |
| US60/431,499 | 2002-12-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508271A Division JP4488351B2 (ja) | 2002-02-21 | 2003-02-21 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248466A Division JP5271443B2 (ja) | 2002-02-21 | 2012-11-12 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010111679A JP2010111679A (ja) | 2010-05-20 |
| JP2010111679A5 true JP2010111679A5 (https=) | 2011-05-06 |
| JP5199228B2 JP5199228B2 (ja) | 2013-05-15 |
Family
ID=33425052
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508271A Expired - Fee Related JP4488351B2 (ja) | 2002-02-21 | 2003-02-21 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
| JP2008325146A Expired - Fee Related JP4514820B2 (ja) | 2002-02-21 | 2008-12-22 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡ ＩＸ）、ｓ−ＣＡ ＩＸを検出するためのアッセイ、ＣＡ ＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡ ＩＸ特異的モノクローナル抗体 |
| JP2009288124A Expired - Fee Related JP5199228B2 (ja) | 2002-02-21 | 2009-12-18 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
| JP2012248466A Expired - Fee Related JP5271443B2 (ja) | 2002-02-21 | 2012-11-12 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508271A Expired - Fee Related JP4488351B2 (ja) | 2002-02-21 | 2003-02-21 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
| JP2008325146A Expired - Fee Related JP4514820B2 (ja) | 2002-02-21 | 2008-12-22 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡ ＩＸ）、ｓ−ＣＡ ＩＸを検出するためのアッセイ、ＣＡ ＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡ ＩＸ特異的モノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248466A Expired - Fee Related JP5271443B2 (ja) | 2002-02-21 | 2012-11-12 | 可溶型の炭酸脱水酵素ＩＸ（ｓ−ＣＡＩＸ）、ｓ−ＣＡＩＸを検出するためのアッセイ、ＣＡＩＸとＨＥＲ−２／ｎｅｕ／ｃ−ｅｒｂＢ−２の同時発現、非免疫優性エピトープに対するＣＡＩＸ特異的モノクローナル抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US7846673B2 (https=) |
| EP (1) | EP1487972B1 (https=) |
| JP (4) | JP4488351B2 (https=) |
| AU (1) | AU2003217606C1 (https=) |
| CA (1) | CA2477163C (https=) |
| DK (2) | DK3031910T3 (https=) |
| HU (3) | HUE026218T2 (https=) |
| WO (1) | WO2004005348A1 (https=) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2508596B1 (en) * | 2002-02-21 | 2015-08-12 | Institute Of Virology | MN/CA IX-specific monoclonal antibodies generated from MN/CA IX-deficient mice and methods of use |
| DK3031910T3 (en) * | 2002-02-21 | 2017-10-23 | Inst Virology | MN / CA IX-SPECIFIC MONOCLONAL ANTIBODIES GENERATED BY MN / CA IX-DEFICIENT MOUSE AND METHODS OF USE |
| US20090162382A1 (en) * | 2002-03-01 | 2009-06-25 | Bernett Matthew J | Optimized ca9 antibodies and methods of using the same |
| EP1501939B1 (en) * | 2002-04-16 | 2009-07-22 | The Regents of The University of California | Methods or renal cell carcinoma prognosis and treatment selection with carbonic anhydrase ix |
| US20090239247A1 (en) * | 2002-12-13 | 2009-09-24 | Harris Adrian L | MN and Hypoxia |
| CN102746336B (zh) | 2005-06-29 | 2015-08-19 | 施瑞修德制药公司 | 氨基磷酸酯烷化剂前体药物 |
| EP2837697B1 (en) * | 2006-10-10 | 2016-12-07 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Prostate cancer-specific alterations in ERG gene expression and detection methods based on those alternations |
| US7820159B2 (en) * | 2006-10-31 | 2010-10-26 | Instiute of Virology of the Slovak Academy of Sciences | MN/CA IX and EGFR pathway inhibition |
| EP2219668A1 (en) * | 2007-11-02 | 2010-08-25 | Wilex AG | Binding epitopes for g250 antibody |
| CN101868445B (zh) | 2007-11-19 | 2014-06-18 | 旭化成化学株式会社 | 异氰酸酯和芳香族羟基化合物的制造方法 |
| ES2890501T3 (es) | 2009-03-02 | 2022-01-20 | Massachusetts Inst Technology | Métodos y productos para la creación de perfiles enzimáticos in vivo |
| EP2295975B1 (en) * | 2009-09-10 | 2014-06-18 | Bruker Daltonik GmbH | Determining the expression status of human epidermal growth factor receptor 2 (HER2) in biological samples |
| CA2830235C (en) | 2011-03-15 | 2023-10-24 | Massachusetts Institute Of Technology | Multiplexed detection with isotope-coded reporters |
| US9080849B2 (en) | 2011-07-29 | 2015-07-14 | Milwaukee Electric Tool Corporation | Tape measure |
| CA2784047C (en) | 2011-07-29 | 2015-08-11 | Milwaukee Electric Tool Corporation | Tape measure |
| US8863399B2 (en) | 2011-08-26 | 2014-10-21 | Milwaukee Electric Tool Corporation | Tape measure |
| EP2508890A1 (en) * | 2011-10-25 | 2012-10-10 | Roche Diagnostics GmbH | CAIX based diagnosis of heart failure |
| WO2013096687A1 (en) | 2011-12-22 | 2013-06-27 | Threshold Pharmaceuticals, Inc. | Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer |
| US9267778B2 (en) | 2012-01-19 | 2016-02-23 | Milwaukee Electric Tool Corporation | Tape measure |
| EP2810076A4 (en) * | 2012-01-31 | 2015-07-01 | Threshold Pharmaceuticals Inc | PRÄDIKTIVER BIOMARKER FOR HYPOXIA-ACTIVATED PRODRUGTHERAPY |
| JP2015155795A (ja) * | 2012-05-21 | 2015-08-27 | 東レ株式会社 | 癌の検出方法 |
| USD733597S1 (en) | 2012-07-30 | 2015-07-07 | Milwaukee Electric Tool Corporation | Tape measure |
| CN104837502B (zh) | 2012-10-12 | 2018-08-10 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
| JP6847660B2 (ja) * | 2013-06-07 | 2021-03-24 | マサチューセッツ インスティテュート オブ テクノロジー | リガンドをコードする合成バイオマーカーのアフィニティベースの検出 |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
| JP6882978B2 (ja) | 2014-10-29 | 2021-06-02 | バイスクルアールディー・リミテッド | Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド |
| EP3286337A4 (en) * | 2015-04-23 | 2018-12-12 | Cedars-Sinai Medical Center | Automated delineation of nuclei for three dimensional (3-d) high content screening |
| USD785476S1 (en) | 2015-12-10 | 2017-05-02 | Milwaukee Electric Tool Corporation | Tape measure |
| USD785475S1 (en) | 2015-12-10 | 2017-05-02 | Milwaukee Electric Tool Corporation | Tape measure |
| USD783429S1 (en) | 2016-01-07 | 2017-04-11 | Milwaukee Electric Tool Corporation | Tape measure |
| USD783430S1 (en) | 2016-01-07 | 2017-04-11 | Milwaukee Electric Tool Corporation | Tape measure |
| USD787347S1 (en) | 2016-01-07 | 2017-05-23 | Milwaukee Electric Tool Corporation | Tape measure |
| WO2017177115A1 (en) | 2016-04-08 | 2017-10-12 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
| US11428689B2 (en) | 2016-05-05 | 2022-08-30 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| USD788611S1 (en) | 2016-06-01 | 2017-06-06 | Milwaukee Electric Tool Corporation | Tape measure |
| CN109862919A (zh) | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| WO2018115203A1 (en) | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| CA3059358A1 (en) | 2017-04-07 | 2018-10-11 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| WO2018197893A1 (en) | 2017-04-27 | 2018-11-01 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| JP7301757B2 (ja) | 2017-06-26 | 2023-07-03 | バイスクルアールディー・リミテッド | 検出可能部分を持つ二環式ペプチドリガンドおよびその使用 |
| CN111183147B (zh) | 2017-08-04 | 2024-07-05 | 拜斯科技术开发有限公司 | Cd137特异性的双环肽配体 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| JP2021514953A (ja) | 2018-02-23 | 2021-06-17 | バイスクルテクス・リミテッド | 多量体二環式ペプチドリガンド |
| US11054428B2 (en) | 2018-03-05 | 2021-07-06 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| US11732009B2 (en) | 2018-06-08 | 2023-08-22 | Glympse Bio, Inc. | Activity sensor with tunable analyte |
| US11028425B2 (en) | 2018-06-08 | 2021-06-08 | Glympse Bio, Inc. | Diagnosis and monitoring of liver disease |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| EP3856921B1 (en) | 2018-09-25 | 2026-04-29 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| JP2022514618A (ja) | 2018-12-21 | 2022-02-14 | バイスクルテクス・リミテッド | Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド |
| US12551567B2 (en) | 2018-12-21 | 2026-02-17 | Bicyclerd Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| WO2020150560A1 (en) | 2019-01-17 | 2020-07-23 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
| JP7740987B2 (ja) | 2019-02-28 | 2025-09-17 | ジョージア・テック・リサーチ・コーポレーション | 生物学的活性の論理ゲート化プロファイリングのための組成物および方法 |
| WO2020226612A1 (en) * | 2019-05-06 | 2020-11-12 | Navi Bio-Therapeutics, Llc | Anti-carbonic anhydrase ix antibody |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| MX2022005332A (es) * | 2019-11-05 | 2022-05-26 | Mabpro A S | Anticuerpos anti-ca ix humanizados y metodos de su uso. |
| CN111273036B (zh) * | 2020-03-06 | 2021-06-15 | 中国农业科学院兰州兽医研究所 | 检测口蹄疫非结构蛋白抗体的单抗竞争化学发光试剂盒 |
| IL300248A (en) | 2020-08-03 | 2023-03-01 | Bicycletx Ltd | peptide-based linkers |
| EP4211468A4 (en) | 2020-09-11 | 2024-10-09 | Glympse Bio, Inc. | DETECTION OF EX VIVO PROTEASE ACTIVITY FOR DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT OF DISEASES |
| US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| CN116167592B (zh) * | 2023-04-20 | 2023-06-23 | 交通运输部天津水运工程科学研究所 | 一种河流溢油风险防控和决策支持系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| US6204370B1 (en) | 1992-03-11 | 2001-03-20 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US5989838A (en) | 1992-03-11 | 1999-11-23 | Institute Of Virology, Slovak Academy Of Sciences | Immunological methods of detecting MN proteins and MN polypeptides |
| US6774117B1 (en) | 1992-03-11 | 2004-08-10 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US6027887A (en) | 1992-03-11 | 2000-02-22 | Institute Of Virology, Solvak Academy Of Sciences | MN gene and protein |
| US6093548A (en) | 1992-03-11 | 2000-07-25 | Institute Of Virology, Slovak Academy Of Sciences | Detection and quantitation of MN-specific antibodies. |
| US5981711A (en) | 1992-03-11 | 1999-11-09 | Institute Of Virology, Slovak Academy Of Sciences | MN-specific antibodies and hybridomas |
| US6297051B1 (en) | 1997-01-24 | 2001-10-02 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US6069242A (en) | 1992-03-11 | 2000-05-30 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US6297041B1 (en) * | 1992-03-11 | 2001-10-02 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| US5972353A (en) | 1992-03-11 | 1999-10-26 | Institute Of Virology, Slovak Academy Of Sciences | MN proteins, polypeptides, fusion proteins and fusion polypeptides |
| US5955075A (en) | 1992-03-11 | 1999-09-21 | Institute Of Virology, Slovak Academy Of Sciences | Method of inhibiting tumor growth using antibodies to MN protein |
| US5387676A (en) * | 1992-03-11 | 1995-02-07 | Ciba Corning Diagnostics Corp. | MN gene and protein |
| CA2192678C (en) * | 1994-06-15 | 2010-12-14 | Jan Zavada | Mn gene and protein |
| US6451977B1 (en) * | 1998-02-26 | 2002-09-17 | Genentech, Inc. | Fused polypeptides |
| JP3910798B2 (ja) | 1998-10-23 | 2007-04-25 | インスティトゥート オブ ヴァイロロジー | Ｍｎ遺伝子およびタンパク質 |
| AU2002351208A1 (en) * | 2001-12-03 | 2003-06-17 | Abgenix, Inc. | Antibodies against carbonic anhydrase IX (CA IX) tumor antigen |
| DK3031910T3 (en) * | 2002-02-21 | 2017-10-23 | Inst Virology | MN / CA IX-SPECIFIC MONOCLONAL ANTIBODIES GENERATED BY MN / CA IX-DEFICIENT MOUSE AND METHODS OF USE |
| EP1576010A4 (en) | 2002-08-23 | 2006-12-27 | Chiron Corp | THERAPEUTIC COMPOSITIONS AND METHODS FOR CANCER CHARACTERIZED BY EXPRESSION OF MN / CA IX ANTIGEN ASSOCIATED WITH TUMORS |
| WO2008103327A2 (en) | 2007-02-20 | 2008-08-28 | Bayer Pharmaceuticals Corporation | Mn/ca ix and bladder cancer |
| EP2219668A1 (en) * | 2007-11-02 | 2010-08-25 | Wilex AG | Binding epitopes for g250 antibody |
-
2003
- 2003-02-21 DK DK15180634.6T patent/DK3031910T3/en active
- 2003-02-21 JP JP2004508271A patent/JP4488351B2/ja not_active Expired - Fee Related
- 2003-02-21 HU HUE12157145A patent/HUE026218T2/en unknown
- 2003-02-21 HU HUE15180634A patent/HUE036891T2/hu unknown
- 2003-02-21 AU AU2003217606A patent/AU2003217606C1/en not_active Ceased
- 2003-02-21 EP EP03713562.1A patent/EP1487972B1/en not_active Expired - Lifetime
- 2003-02-21 DK DK03713562.1T patent/DK1487972T3/en active
- 2003-02-21 HU HUE03713562A patent/HUE026277T2/en unknown
- 2003-02-21 CA CA2477163A patent/CA2477163C/en not_active Expired - Fee Related
- 2003-02-22 WO PCT/US2003/005137 patent/WO2004005348A1/en not_active Ceased
-
2004
- 2004-08-19 US US10/921,590 patent/US7846673B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/933,101 patent/US7833728B2/en not_active Expired - Fee Related
- 2007-10-31 US US11/932,777 patent/US20080177046A1/en not_active Abandoned
- 2007-10-31 US US11/933,065 patent/US7816493B2/en not_active Expired - Fee Related
-
2008
- 2008-12-22 JP JP2008325146A patent/JP4514820B2/ja not_active Expired - Fee Related
-
2009
- 2009-12-18 JP JP2009288124A patent/JP5199228B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-12 JP JP2012248466A patent/JP5271443B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-30 US US14/529,138 patent/US20150266971A1/en not_active Abandoned
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