CA2477163C - Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes - Google Patents

Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes Download PDF

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Publication number
CA2477163C
CA2477163C CA2477163A CA2477163A CA2477163C CA 2477163 C CA2477163 C CA 2477163C CA 2477163 A CA2477163 A CA 2477163A CA 2477163 A CA2477163 A CA 2477163A CA 2477163 C CA2477163 C CA 2477163C
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antibodies
protein
domain
cells
seq
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Expired - Fee Related
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CA2477163A
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English (en)
French (fr)
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CA2477163A1 (en
Inventor
Jaromir Pastorek
Silvia Pastorekova
Miriam Zatovicova
Jan Zavada
Marta Ortova Gut
Zuzanna Zavadova
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Biomedical Research Centre Of Slovak Academy Of Sciences
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Institute of Virology (Slovak Academy of Science)
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Priority to CA2704273A priority Critical patent/CA2704273C/en
Priority claimed from PCT/US2003/005136 external-priority patent/WO2003100029A2/en
Publication of CA2477163A1 publication Critical patent/CA2477163A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2477163A 2002-02-21 2003-02-21 Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes Expired - Fee Related CA2477163C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2704273A CA2704273C (en) 2002-02-21 2003-02-21 Mn/ca ix-antibody binding specifically to non-immunodominant epitope of mn/ca ix and uses thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US35882402P 2002-02-21 2002-02-21
US60/358,824 2002-02-21
US38306802P 2002-05-23 2002-05-23
US60/383,068 2002-05-23
US43149902P 2002-12-05 2002-12-05
US60/431,499 2002-12-05
PCT/US2003/005136 WO2003100029A2 (en) 2002-02-21 2003-02-21 Mn/ca ix-specific monoclonal antibodies generated from mn/ca ix-deficient mice and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2704273A Division CA2704273C (en) 2002-02-21 2003-02-21 Mn/ca ix-antibody binding specifically to non-immunodominant epitope of mn/ca ix and uses thereof

Publications (2)

Publication Number Publication Date
CA2477163A1 CA2477163A1 (en) 2003-12-04
CA2477163C true CA2477163C (en) 2010-07-27

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CA2477163A Expired - Fee Related CA2477163C (en) 2002-02-21 2003-02-21 Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes

Country Status (8)

Country Link
US (5) US7846673B2 (https=)
EP (1) EP1487972B1 (https=)
JP (4) JP4488351B2 (https=)
AU (1) AU2003217606C1 (https=)
CA (1) CA2477163C (https=)
DK (2) DK3031910T3 (https=)
HU (3) HUE026218T2 (https=)
WO (1) WO2004005348A1 (https=)

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DK3031910T3 (en) 2017-10-23
US7816493B2 (en) 2010-10-19
US7846673B2 (en) 2010-12-07
HUE026218T2 (en) 2016-05-30
JP2013060452A (ja) 2013-04-04
HUE036891T2 (hu) 2018-08-28
AU2003217606B2 (en) 2007-11-22
JP2010111679A (ja) 2010-05-20
US20080176258A1 (en) 2008-07-24
US20050031623A1 (en) 2005-02-10
HK1226095B (en) 2017-09-22
WO2004005348A1 (en) 2004-01-15
JP2009114198A (ja) 2009-05-28
AU2003217606A2 (en) 2003-12-12
JP5199228B2 (ja) 2013-05-15
US20150266971A1 (en) 2015-09-24
JP4514820B2 (ja) 2010-07-28
JP2005535601A (ja) 2005-11-24
HUE026277T2 (en) 2016-05-30
US20080176310A1 (en) 2008-07-24
CA2477163A1 (en) 2003-12-04
JP4488351B2 (ja) 2010-06-23
EP1487972A2 (en) 2004-12-22
JP5271443B2 (ja) 2013-08-21
US7833728B2 (en) 2010-11-16
DK1487972T3 (en) 2015-10-19
AU2003217606A1 (en) 2003-12-12
US20080177046A1 (en) 2008-07-24
EP1487972A4 (en) 2006-05-31
EP1487972B1 (en) 2015-08-12
AU2003217606B8 (en) 2003-12-12
HK1177474A1 (en) 2013-08-23
AU2003217606C1 (en) 2008-07-17

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