JP2010110386A - Medical multi-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical multi-chamber container capable of being manufactured without the need of a complicated process or a difficult technique, and preventing the erroneous administration of a liquid chemical before being mixed even while handleability is excellent. <P>SOLUTION: White printing is performed to at least one of a pair of transparent films 11a and 11b in an area to be below a liquid surface L<SB>1</SB>positioned highest among the respective liquid surfaces of the respective liquid chemicals inside a plurality of liquid chemical storage chambers 12a and 12b before opening a weakly sealed part 12c and to be equal to or above the liquid surface L<SB>M</SB>of a liquid chemical mixture for which the respective liquid chemicals are mixed after opening the weakly sealed part 12c when hanging the medical multi-chamber container so that a liquid chemical discharge port 14 is at the lower part. Also, when viewing the medical multi-chamber container 10A from the front, in an area P including at least the white printing, fine recessed and projected surface treatment is performed to the inner surface of at least one of the pair of transparent films 11a and 11b. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a medical multi-chamber container that has a plurality of chemical solution storage chambers and mixes the chemical solutions in the chemical solution storage chambers immediately before use and uses them for infusion.

  2. Description of the Related Art Conventionally, there is known a medical multi-chamber container that has a plurality of partitioned chemical solution storage chambers, mixes the chemical solutions in the chemical solution storage chambers immediately before use, and uses them for infusion. The plurality of chemical solution storage chambers are partitioned liquid-tightly by, for example, a partition portion such as a weak seal portion that is peeled off and opened by applying pressure to the medical multi-chamber container from the outside. And after opening a partition part just before use and mixing a chemical | medical solution, the mixed chemical | medical solution is discharged | emitted from a discharge port, and is administered to a patient by drip etc.

    However, forgetting to open the partition, the drug solution that should originally be mixed and dispensed may not be mixed, and only a part of the drug solution before mixing may be administered to the patient. Therefore, various measures for medical multi-chamber containers are being studied.

    For example, in Patent Document 1, in addition to a plurality of chemical solution storage chambers, there is provided a compartment capable of communicating with one of these chemical solution storage chambers, and a medical compound discharge port provided with a chemical solution discharge port so as to communicate with this compartment. A chamber container is disclosed. This medical multi-chamber container is configured so that the closing means for partitioning the chemical solution storage chamber and the compartment is not opened unless the partitioning means for partitioning the chemical solution storage chambers is opened. Therefore, according to this medical multi-chamber container, the chemical solution before mixing is not accidentally discharged from the discharge port. Similarly, Patent Document 2 proposes a medical multi-chamber container configured such that a chemical solution is not discharged from a chemical solution outlet unless a plurality of chemical solutions are mixed.

  Patent Document 3 discloses a medical multi-chamber container in which a part of a medical multi-chamber container including a chemical solution discharge port is fixed in a bent state. According to this medical multi-chamber container, the liquid medicine can be discharged only after the weak seal portion that partitions the liquid medicine storage chamber is opened by external pressurization and the bent state is released at the same time. Therefore, even in this medical multi-chamber container, the chemical solution is not discharged from the chemical solution discharge port unless a plurality of chemical solutions are mixed.

On the other hand, Patent Document 4 discloses a medical device intended to prevent the administration of a drug solution before mixing by enabling easy visual confirmation whether or not the weak seal portions that divide a plurality of drug solution storage chambers are peeled off. Multi-chamber containers have been proposed. In this medical multi-chamber container, a visible treatment is applied to each of the two film sheet portions constituting the weak seal portion, and the weak seal portion is separated before and after the weak seal portion is peeled off. The appearance is made visually different.
JP-A-9-327498 JP 2005-342174 A JP 2007-282707 A JP 2004-141631 A

However, in the medical multi-chamber container of Patent Documents 1 and 2, when forming the weak seal portion that forms the closing means and the weak seal portion that forms the partition means, the seal strength of these weak seal portions must be strictly controlled. However, it was necessary to pay attention to fine adjustment of sealing conditions and selection of film materials. Moreover, when manufacturing the medical multi-chamber container of patent document 3, the process of fixing a part of medical multi-chamber container in the bending state was required. Thus, the manufacturing process of the medical multi-chamber container of Patent Documents 1 to 3 is complicated.
Furthermore, the medical multi-chamber container of Patent Documents 1 and 2 is different from the conventional general medical multi-chamber container in that it has a branch chamber. It differs from a conventional general medical multi-chamber container in that a part is fixed in a bent state. Therefore, when using the medical multi-chamber container of patent documents 1-3, it is necessary to handle by the method according to each medical multi-chamber container, and there also existed a problem that it was inferior to handleability.

  On the other hand, in the medical multi-chamber container of Patent Document 4, a pattern is given in advance to each of the two film sheet portions constituting the weak seal portion, and then the portions printed in this way are put together. It is necessary to heat seal to make a weak seal. In this case, since heat is applied to the printed pattern portion, the pattern shape and the like may be disturbed, and there is a problem that it is technically difficult to heat-seal without affecting the pattern shape. Further, since the seal width of the weak seal portion is usually as narrow as about 10 mm, even if printing or the like is applied to this portion, it is difficult to visually determine whether the weak seal portion is before or after peeling.

  The present invention has been made in view of the above circumstances, and can be manufactured without requiring complicated processes and difficult techniques, while being easy to handle, it can prevent misadministration of a drug solution before mixing. It is an object to provide a chamber container.

The medical multi-chamber container of the present invention is formed of a pair of transparent films facing each other, and includes a container body in which a plurality of chemical solution storage chambers partitioned by an openable partition portion are formed, and the plurality of chemical solution storage chambers A medical multi-chamber container provided in communication with one of the medical multi-chamber containers, wherein when the medical multi-chamber container is suspended so that the medicinal liquid discharge port is downward, the partition Before the opening of the section, the liquid level is lower than the uppermost liquid level among the liquid levels of the chemical liquids in the plurality of chemical liquid storage chambers. In the region above the liquid level, white printing is applied to at least one of the pair of transparent films, and the region including at least the white printing when the medical multi-chamber container is viewed from the front. Of the pair of transparent films Wherein the fine uneven surface treatment on at least one of the inner surface is subjected Chino.
It is preferable that the fine uneven surface treatment is applied to the transparent film on which the white printing is performed.

  According to the medical multi-chamber container of the present invention, it is possible to manufacture without requiring complicated processes and difficult techniques, and it is possible to prevent erroneous administration of the drug solution before mixing while being easy to handle.

Hereinafter, the embodiment of the medical multi-chamber container of the present invention will be described in detail.
FIG. 1 is a front view showing an example of the medical multi-chamber container 10A of the present invention.
The medical multi-chamber container 10A is formed of a pair of opposing rectangular transparent films 11a and 11b whose peripheral portions are fused so as not to be peeled, and includes a first chemical solution storage chamber 12a and a second chemical solution storage chamber 12b. Has a container body 12 formed side by side in the longitudinal direction. Between the first chemical solution storage chamber 12a and the second chemical solution storage chamber 12b, a liquid-tight weak seal portion 12c is linearly formed as an openable partition portion. A space between the first chemical solution storage chamber 12a and the second chemical solution storage chamber 12b is defined. In the medical multi-chamber container 10A, after the first chemical solution is stored in the first chemical solution storage chamber 12a and the second chemical solution is stored in the second chemical solution storage chamber 12b, at least one of the chemical solution storage chambers 12a. By applying a force from the outside to 12b, the weak seal portion 12c is peeled and opened, the first chemical solution and the second chemical solution are mixed, and the mixed chemical solution is prepared in the container body 12. ing. FIG. 1 shows the medical multi-chamber container 10A in a state where neither the first chemical solution nor the second chemical solution is stored.

A suspension hole 13 for suspending the medical multi-chamber container 10A is formed at the longitudinal end of the peripheral portion of the container body 12 on the side where the first chemical solution storage chamber 12a is formed. Yes. On the other hand, at the end in the longitudinal direction on the side where the second chemical solution storage chamber 12b is formed, a hollow chemical solution that communicates with the second chemical solution storage chamber 12b and is closed by a needle plug that can be inserted into the needle. A discharge port 14 is provided. Accordingly, the weak seal portion 12c is opened, and the hanging hole 13 of the medical multi-chamber container 10A is hooked on the drip stand hook or the like so that the drug solution outlet 14 is located downward, and for example, a drip needle is attached to the rubber stopper. By inserting, the mixed chemical liquid prepared in the container main body 12 is discharged from the chemical liquid discharge port 14 and is administered to the patient by instillation or the like.
The chemical solution discharge port 14 is also used as an injection port for injecting the second chemical solution into the second chemical solution storage chamber 12b. Further, the first chemical liquid is injected into the first chemical liquid storage chamber 12a from a first chemical liquid injection port (not shown).

In this example, in a specific region of one transparent film 11a of the pair of transparent films 11a and 11b, a mark composed of characters "not opened" indicating that the weak seal portion 12c is not opened. Printed in white.
As shown in FIG. 2, the specific area where white printing is performed is a medical multi-chamber container 10A in which the first chemical liquid and the second chemical liquid are accommodated so that the chemical liquid discharge port 14 is located below. Is hung on the drip stand hook F or the like before the weak seal portion 12c is opened (FIG. 2 (a)), each chemical solution stored in each chemical solution storage chamber 12a, 12b (in this example, the first Among the liquid levels of one chemical liquid and the second chemical liquid), the weak seal portion 12c is a region that is lower than the uppermost liquid level (in this example, the liquid level L ₁ of the first chemical liquid). after the opening (2 (b)) is that of the upper and a region than the liquid level L _M of the mixed drug solution prepared. In FIG. 2 (a), _{L 2} is a liquid level of the second chemical liquid before the opening of the weak seal portion 12c.

Further, in the region including at least the above-described white printing (in this example, a rectangular region P surrounded by a solid line in the drawing), the inner surface (in contact with the chemical solution, the outside air) of the transparent film 11a on the side on which the white printing is performed The surface not touching the surface is subjected to a fine uneven surface treatment.
Here, the fine irregular surface treatment is performed during or after the molding of the transparent film 11a.
As a method of processing during molding, by forming a streak or unevenness at the exit of a molding machine for forming a melted resin film, fine streaks such as stripes or ground glass are formed on the surface of the film discharged therefrom. There is a way. As a method of processing after forming, for example, a blasting process such as a sand blasting process, a concavo-convex process using a metal brush, or the like is performed on the film surface to form fine streaks such as stripes or ground glass. When the surface subjected to the surface treatment for fine irregularities is not in contact with a chemical solution, light is reflected and refracted on the surface in a complicated manner due to the fine irregularities, and thus appears white and cloudy. On the other hand, when it comes into contact with the chemical solution, the surface becomes smooth and reflection and refraction of light are suppressed, so that it looks transparent.

According to such a medical multi-chamber container 10A, as shown in FIG. 2A, before the weak seal portion 12c is opened, the white print consisting of the characters “not opened” is the first It is located below the liquid level L ₁ of the chemical. Also, regions P fine unevenness surface-treated, is positioned lower than its entirety in this example the liquid level L ₁ of the first chemical liquid.
Therefore, before the opening of the weak seal portion 12c, the inner surface of the region P that has been subjected to the fine uneven surface treatment is in contact with the first chemical solution and appears transparent to the user. Therefore, the user can clearly see the letters “not opened” made of white printing applied in the transparent region P, and the medical multi-chamber container 10A has a weak seal portion 12c. Can be clearly recognized as not being opened.

However, as shown in FIG. 2 (b), when opening the weak seal portion 12c, the first chemical liquid and the second chemical liquid is being mixed chemical solution is prepared mixing, the liquid level L _M is the first pre-opening It becomes lower position than the liquid level L ₁ of the chemical, as a result, the character is located above the liquid level L _M of the mixed chemical solution of "not open". Also, regions P fine uneven surface treatment is applied, in this example will be located above the liquid level L _M of the whole is mixed chemical solution.
Therefore, after the opening of the weak seal portion 12c, the inner surface of the region P on which the fine uneven surface treatment is performed does not come into contact with the chemical solution, and the entire region P appears white and cloudy to the user. In other words, the color of the region P appears to be the same white as the character “not opened”. Therefore, it becomes difficult for the user to visually recognize the letters “not opened” made of white printing applied in the area P which appears to be cloudy white, and as a result, the medical multi-chamber container 10A has been opened. It can be understood that it is.

  According to such a medical multi-chamber container 10A, the user can recognize that the weak seal portion 12c is not opened only by visual observation, and the first chemical solution and the second chemical solution are not opened when the weak seal portion 12c is not opened. In spite of not being mixed, it can prevent that the chemical | medical solution before mixing (in this case only 2nd chemical | medical solution) is accidentally administered from the chemical | medical solution discharge port 14. FIG. Moreover, according to this medical multi-chamber container 10A, since it can manufacture without requiring a complicated process and a difficult technique and can be used with a normal handling method, the point of handleability is also favorable.

Further, in this example, among the pair of transparent films 11a and 11b, the fine uneven surface treatment is also applied to the transparent film 11a on the side subjected to white printing. Therefore, compared with the case where the fine uneven surface treatment is applied to the transparent film 11b on the side not subjected to the white printing, the user prints the white printing after the opening of the weak seal portion 12c (FIG. 2B). There is also an effect that it becomes more difficult to visually recognize the characters.
However, if both the white printing and the fine uneven surface treatment are applied to at least one of the pair of transparent films 11a and 11b, the white printing can be visually recognized before the opening of the weak seal portion 12c. Can obtain the effect of being difficult to visually recognize. Therefore, the medical multi-chamber container of the present invention is not limited to a form in which white printing and fine uneven surface treatment are performed on the same transparent film. For example, when white printing is applied to one of the pair of transparent films 11a and 11b, as long as the medical multi-chamber container is viewed from the front, it is fine on the other inner surface as long as the area includes white printing. An uneven surface treatment may be applied. Moreover, both white printing and fine uneven | corrugated surface treatment may be given to both the transparent films 11a and 11b.
When white printing is applied to only one of the pair of transparent films 11a and 11b, it is possible to use the white film by hanging it so that the transparent film on the side on which the white printing is performed is the front side. It is preferable in terms of visibility.

In this example, a rectangular region P surrounded by a solid line in the drawing is shown as a region on which fine uneven surface treatment is performed. However, as long as the region includes white printing, there is no particular limitation on the size or shape thereof. Absent. For example, it may be a rectangular region P ′ wider than the region P as shown in FIG. 3, or may be an elliptical region P ″ as shown in FIG. 4. Furthermore, the pair of transparent films 11a and 11b At least one of the entire regions may be a region that is subjected to a fine uneven surface treatment, and in any of these cases, the same effect as the medical multi-chamber container 10A of FIG.
For example, when the fine uneven surface treatment is applied to at least one of the pair of transparent films 11a and 11b, before the opening of the weak seal portion 12c, the upper portion of the region subjected to the fine uneven surface treatment is usually so that the the liquid level L ₁ of the first chemical liquid located above. Therefore, even before the opening of the weak seal portion 12c, the portion looks white and cloudy. However, even in this case, the peripheral portion of the white printing in the case where the multi-chamber medical container is viewed from the front, in order to contact the chemical positioned lower than at least the liquid level L _1, appears transparent. Therefore, the user can visually recognize white printing without any problem. On the other hand, when the opening is weak seal portion 12c, the first chemical liquid and the second chemical liquid is being mixed chemical solution is prepared mixing, its liquid level L _M, a first position lower than the liquid level L ₁ of the liquid medicine prior to opening become. Then, now located above the liquid level L _M of the well mixed chemical peripheral portion of the white printing appears transparent before opening looks cloudy white. As a result, it becomes difficult for the user to visually recognize the white print, and it can be understood that the weak seal portion 12c is open.

  In this example, as the mark to be printed in white, the mark made up of the characters “not opened” indicating that the weak seal portion 12c is not opened is illustrated, but it can be understood that the mark is not opened. If it is a thing, it will not be limited to a character, A figure may be sufficient and what combined these may be sufficient. In addition, the character type is not limited to “not open”, but may be other characters, and the graphic type may be, for example, a symbol such as ○, ×, △, an arrow, a pattern, or a combination thereof. There are no restrictions. However, it is preferable that the white print includes characters indicating that it is not opened because the intention of the white print is clearly transmitted to the user.

  Moreover, although white printing should just be given to any one of the outer surface or inner surface of transparent film 11a, 11b, it is preferable from a viewpoint of the contamination suppression to a chemical | medical solution that printing and a chemical | medical solution do not contact directly. Therefore, it is preferable to be applied to the outer surface of the transparent film (the surface on the side in contact with the outside air but not on the chemical solution).

  In this example, the container body 12 is exemplified by a pair of opposing rectangular transparent films 11a and 11b whose peripheral portions are fused so as not to be peeled off. However, the container body 12 is formed of, for example, a cylindrical transparent film. And the thing of the form fuse | melted only the both ends of the longitudinal direction among the peripheral parts so that peeling was not possible may be sufficient, and the shape of a transparent film is not limited to a rectangle.

Further, the transparent films 11a and 11b are not limited as long as they are made of a flexible material and can be used for medical purposes, but polyolefin resins, polyamide resins, polyester resins, (meth) acrylic resins, vinyl chloride resins, A synthetic resin film made of vinylidene chloride resin, polyethersulfone, ethylene-vinyl alcohol copolymer or the like is preferable. Of these, polyolefin resins are preferred because they are excellent in transparency, flexibility, hygiene, and low cost.
Examples of the polyolefin resin include polyethylene resins such as high density polyethylene, medium density polyethylene, high pressure method low density polyethylene, linear low density polyethylene, and ethylene-vinyl acetate copolymer; ethylene-α olefin random copolymer Olefin elastomers; polypropylene resins such as polypropylene, ethylene-propylene random copolymers, α-olefin-propylene random copolymers; cyclic polyolefin resins; and mixtures thereof. Further, these resins may be partially crosslinked for the purpose of improving heat resistance.
Moreover, the transparent films 11a and 11b may be a single layer or a multilayer, and the thickness is preferably 50 to 1000 μm, more preferably 100 to 500 μm.

As a method for forming the weak seal portion 12c, for example, the inner surface side of the container body 12 is formed of a composition made of a plurality of resins having different melting points and compatibility (for example, polyethylene and polypropylene), and the melting temperature of the high melting point resin. The method of sealing is mentioned below. In addition, heat sealing is performed at a low temperature and weakly bonded in a semi-welded state, a method using a flexible material previously cross-linked with an electron beam or the like on the weak seal portion 12c formation portion, and a strong fusion portion is specified. Examples include a method using a seal bar generated at an area ratio, and a method in which an easily peelable resin tape is sandwiched between two flexible materials.
In addition, the openable partition section that divides the chemical solution storage chamber may partition the chemical solution storage chamber in a liquid-tight manner before opening, as long as it can be opened immediately before use of the medical multi-chamber container. It may be composed of a resin partition member or the like.
Moreover, the number of the chemical | medical solution storage chambers formed in the medical multi-chamber container is not limited to two as in this example, and may be three or more.

It is a front view which shows an example of a medical multi-chamber container. It is a front view which shows (a) before opening of a weak seal part and (b) after opening of a weak seal part about the medical multiple-chamber container of FIG. It is a front view which shows another example of a medical multi-chamber container. It is a front view which shows another example of a medical multiple-chamber container.

Explanation of symbols

10A: Medical multi-chamber container 11a: Transparent film 11b: Transparent film 12a: First chemical solution storage chamber 12b: Second chemical solution storage chamber 12c: Weak seal part (partition part)
13: Hanging hole 14: Chemical solution outlet

Claims (2)

A container main body formed with a plurality of chemical solution storage chambers formed from a pair of opposing transparent films and partitioned by an openable partition, and provided in communication with one of the plurality of chemical solution storage chambers A medical multi-chamber container having a chemical solution outlet,
When the medical multi-chamber container is suspended so that the chemical solution discharge port is downward, before opening the partition portion, the uppermost of the liquid levels of the chemical solutions in the plurality of chemical solution storage chambers White printing is performed on at least one of the pair of transparent films in a region that is lower than the liquid level positioned and is higher than the liquid level of the mixed chemical mixed with each chemical after the partition is opened. As well as
When the medical multi-chamber container is viewed from the front, at least one inner surface of the pair of transparent films is subjected to a fine uneven surface treatment in an area including at least the white printing. Multi-chamber container.   The medical multi-chamber container according to claim 1, wherein the fine uneven surface treatment is applied to the transparent film on the side on which the white printing is performed.

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