JP4902149B2 - container - Google Patents

Description

  The present invention relates to a container having a heat seal portion that is easily peelable from a desired direction and hardly peelable from other directions. Furthermore, in the present invention, the void formed by surrounding the periphery with a strongly peelable seal portion is partitioned by a heat seal portion that is easily peelable from a desired direction and difficult to peel from other directions. It relates to a container having at least two compartments. More specifically, for example, a plurality of medicines can be stored separately, and can be used as a multi-chamber infusion container in which these medicines can be easily mixed at the time of use. The present invention relates to a container such as a multi-chamber infusion bag having a unidirectional peelable heat-sealing portion that varies depending on the direction.

  It has been practiced that a plurality of drugs are mixed and administered to a patient, such as a vitamin preparation mixed with physiological saline and injected or instilled into the patient. When a plurality of drugs are mixed in this way, depending on the type of the drug, if they are mixed in advance, the quality may deteriorate. Such a plurality of drugs that may be altered when mixed in advance can be stored separately in a multi-chamber infusion container that can store each drug separately and can be mixed immediately before use. In such a multi-chamber infusion container, the main body is usually formed of a thermoplastic resin film such as polyolefin or polyvinyl chloride.

  In a multi-chamber infusion container made of such a thermoplastic resin film, the boundary between the drug chamber and the drug chamber is liquid-tightly sealed before mixing a plurality of drugs. In this case, it is necessary that the boundary part can be easily peeled off and the medicines contained independently can be quickly mixed. For this reason, many researches have been made on methods for forming such boundary portions.

  For example, Patent Document 1 and Patent Document 2 disclose a technique for forming a part involved in adhesion from a specific material in order to form a boundary part that is easily peeled off. Patent Document 3 describes a method of applying an easily peelable coating agent containing a component imparting easy peelability to the inner surface of the boundary portion to facilitate peeling.

On the other hand, Patent Document 4 uses a combination of two bars formed with a seal edge of a specific shape as a heat seal bar used when sealing this boundary portion, and precisely positions the seal edges. A technique is disclosed in which the peel strength at the boundary portion is adjusted to an appropriate range by sandwiching the film after controlling the film thickness.
Patent Document 5 discloses a technique for forming a boundary portion that is easily peeled off by a specific seal bar having an area occupied by a strongly fused portion of less than 25%.

  However, in the techniques disclosed in Patent Document 1 and Patent Document 2, in order to form a boundary portion that is easy to peel off, the portion has to be made into a multilayer structure, and cannot be applied to a single layer film. There was a problem of becoming higher. Further, the technique described in Patent Document 3 requires a specific coating agent, which complicates the manufacturing process and results in an increase in manufacturing cost.

  On the other hand, in the method disclosed in Patent Document 4, it is not essential that the film has a multilayer structure or a coating agent is used, but the seal edge of the heat seal bar that seals this boundary portion is precisely positioned. When the positional deviation occurs, the formed boundary portion may have a large variation in peel strength for each multi-chamber infusion container. In addition, especially when the pitch of the heat seal bar is narrow, such alignment is particularly difficult, and even if the heat seal temperature is maintained at a constant temperature, the isolation strength is different for each multi-chamber infusion container. In some cases, it has been desired to stably produce a multi-chamber infusion container having a desired peel strength.

  Further, in the method of Patent Document 5, it is not essential that the film has a multilayer structure or a coating agent is used, and a technique for controlling the seal strength by using a plurality of fused portions having different fusion strengths is disclosed. There is no exemplification of a technique for making a difference in seal strength depending on the direction of peeling.

  In general, in a multi-chamber infusion container made of a thermoplastic resin film as described above, when a plurality of drugs are mixed, the drug chamber is pressurized, and the boundary seal portion is peeled and opened to mix the drugs. However, in the above prior art, the boundary seal part is peeled off regardless of which chamber of the boundary seal part is pressurized, and the chemical solution is mixed. Some chemical solutions have different chemical stability depending on the order of mixing, and in order to avoid erroneous opening, it is desirable that the peel strength of the boundary seal portion has directionality.

  In a packaging bag such as a confectionery bag, in addition to the infusion container as described above, it is common to seal the heat seal surface disposed on the inner surface side of the bag body by heat fusion. Various techniques are used, such as forming a scheduled opening portion in the heat seal portion, for example, so that opening can be performed from a desired position when opening such a packaging bag. For example, in Patent Document 6 and Patent Document 7, by forming a heat seal portion with a specific resin that does not have a very high heat seal strength, peeling is easy, and even without performing heat seal by a special method, A technique capable of forming an easily peelable and highly sealable seal portion is disclosed.

  However, these techniques have a problem that a special resin must be used for the heat seal surface of the resin film in order to form an easily peelable heat seal portion.

JP-A-2-4671 JP 2000-14746 A JP-A-11-169432 JP-A-8-24314 Japanese Patent Laid-Open No. 2004-476 Japanese Patent Laid-Open No. 11-1000048 Japanese Examined Patent Publication No. 1-4967

An object of this invention is to provide the container which has a heat seal part which can be easily peeled from a desired direction irrespective of the material and structure of a film.
Further, the present invention is a container in which the inside of the packaging bag is partitioned by the boundary seal portion, the boundary seal portion has a stable peel strength, and the peelability of the boundary seal portion is directional. The purpose is to provide.

  More specifically, regardless of the material and configuration of the film, the peel strength at the boundary portion between the plurality of drug chambers and the drug chamber is stable, and the possibility of the boundary seal portion being accidentally opened is reduced. An object of the present invention is to provide a multi-chamber infusion container having different seal strengths.

  The present invention is not limited to the above-described multi-chamber infusion container, and relates to a bag-like container that is opened and used, and the opening has a detachable direction.

In the container of the present invention, a thermoplastic resin film disposed so that the heat seal surfaces face each other is fused to form a strong seal portion around the periphery, and the space surrounded by the strong seal portion is liquid-tight and re-filled. A container defined by the first and second partition parts by a peelable easily peelable seal part;
The easily peelable seal portion has directionality in the fusion strength so that the fusion strength is smaller as it is closer to the first partition portion and the fusion strength is larger as it is closer to the second partition portion. And the easily peelable seal portion is formed by the following (1) and (2) ;
(1) The strong fusion part formed in the easily peelable seal part is a heat-sealed strong fusion part provided with a tapered surface on a heat seal bar for forming the strong fusion part. The thickness of the thermoplastic resin film on the second partition portion side is small, and an inclined portion is formed where the thickness of the thermoplastic resin film on the first partition portion side is large.
(2) The easily peelable seal portion has a plurality of strong fusion portions made of triangles in which the heat seal surfaces are closely adhered to each other, and the plurality of strong fusion portions made of these triangles are In addition, it is formed in such a manner that apexes are arranged on the second partition part side, and the plurality of strongly fused parts are sparser as they are closer to the first partition part and closer to the second partition part. It arrange | positions disperse | distributed with respect to the width direction of an easily peelable seal part so that it may become dense.

  The present inventor has conducted various studies on the peel strength and peelability of the heat seal part that is scheduled to be peeled off. By applying a certain direction to the unidirectionally and applying pressure in a single direction to form a unidirectional peelable heat fusion part that penetrates the partition wall, it is possible to solve the above problems at the time of mixing chemicals Obtained knowledge. By dividing the drug chamber with such a unidirectionally peelable heat-sealing part, it is possible to mix the drug solutions in a predetermined order.

In the present invention, the high fusion strength means that a large force is required to peel off the portion that has been fused and sealed.
Further, in the present invention, the fusion means that the thermoplastic resin film is pressed and adhered while heating, and refers to a state in which the thermoplastic resin film is melted and completely integrated and its boundary is unknown. In addition to this, as long as liquid tightness is maintained, it includes a state in which a boundary between thermoplastic resin films is recognized.

  In the container of the present invention, an easily peelable seal portion formed so that the thermoplastic resin film can be re-peeled is formed, and a strongly fused portion is formed by a specific method in this easily peelable seal portion. And the container in which the easily peelable seal | sticker part was formed in this way has directionality in peeling strength.

  In particular, the container of the present invention forms a readily peelable seal portion by a specific method in a space formed by surrounding the periphery with a strong seal portion, and separates the space. The liquid can be divided and stored. Thus, the container which is formed by forming the easily peelable seal portion by a predetermined method has a stable peel strength of the easily peelable seal portion and has directionality in the peelability. For example, even if pressure is applied to the compartment on one side of the compartment partitioned by the easily peelable seal portion, the easily peelable seal portion is difficult to peel off, but if pressure is applied from the compartment on the other side, The easily peelable seal part is easily peeled off, and the liquid contained in both compartments can be mixed.

  Although such a container can be used for various uses, it can be effectively used especially as a multi-chamber infusion container. That is, the infusion container comprising the container of the present invention is a multi-chamber infusion container formed of a thermoplastic resin film and separated into a plurality of drug chambers by a peelable easily peelable seal portion formed by fusing the films together. When the container is fractionated into multiple chambers, the container is partitioned by an easily peelable seal portion formed by a specific method as described above. The easily peelable seal portion is formed with a strong peel portion by a predetermined method. By forming this strongly peelable portion, the easily peelable seal portion is difficult to peel from one side, and the other It can be easily peeled from the side, and a peelable directionality can be imparted to the easily peelable seal portion.

  Such an easily peelable seal part not only forms the partition seal part as described above, but also by making the opening part of the container made of a thermoplastic resin film as an easily peelable seal part as described above. This container can be easily opened. Furthermore, since the peeling starts from the peeling start portion by forming a peeling start portion made of a peel seal in part, the container can be opened more easily.

The container of the present invention will be specifically described below.
First, the container of the present invention will be described by taking a multi-chamber infusion container as the container of the present invention as an example.
FIG. 1 shows an example of a multi-chamber infusion container 10 according to the present invention. The multi-chamber infusion container 10 is formed of a thermoplastic resin film and includes two drug chambers 11 and 12 filled with a drug. It is. In the multi-chamber infusion container 10 of this example, a drug input unit 13 is connected to one drug chamber 11, and a drug is input to the other drug chamber 12 and a drug is administered to a patient. A medicine loading / unloading section 14 for discharging the medicine from here is connected.

On the other hand, the two drug chambers 11 and 12 formed in the multi-chamber infusion container 10 are separated by a seal portion (unidirectional peelable fusion portion) 15 having different peel strength depending on the peel direction.
The seal part 15 having different peel strengths depending on this direction is desired to peel off the seal part 15 by applying an external force to one of the compartments after the medicine chambers 11 and 12 are filled with the medicine (filler). In this case, the drugs can be mixed quickly and easily. For example, when the medicine filled in the medicine chamber 11 (first partition part 11) is mixed with the medicine filled in the medicine chamber 12 (second partition part 12), the medicine chamber 11 ( first part) When the pressure is applied to one partition part 11), the partition wall 15 (seal part 15) penetrates, but when pressure is applied to the drug chamber 12 ( second partition part 12), the partition wall 15 (seal No peeling occurs in part 15). That is, the seal part 15 is easily peelable (weakly fusible) with respect to the pressure from the partition part 11, but hardly peelable (strongly melted) with respect to the pressure from the partition part 12. Wearability).

  The peripheral edge of the multi-chamber infusion container 10 is liquid-tightly closed by a strong seal portion 16 that does not peel even when force is applied from the outside of the drug chambers 11 and 12, and the thermoplastic resin film is heat-sealed and strongly It is formed by fusing. In this example, the strong seal portion 16 is formed over the entire circumference of the peripheral edge of the multi-chamber infusion container 10, but for example, when a cylindrical thermoplastic resin film is used as a material, the film Only the both ends in the length direction (the upper end and the lower end in the figure) may be the strong seal portion 16, and the strong seal portion 16 does not necessarily have to be formed around the entire periphery.

  And, as will be described in detail later, in the single-direction peelable heat-sealed portion 15 of the multi-chamber infusion container 10 of this example, a two-layered thermoplastic resin film is formed with a specific seal edge on the seal surface. These two (one pair) heat seal bars are formed by being sandwiched from both sides thereof, and as shown in part in the enlarged plan view of FIG. Two fused portions, that is, the strongly fused portion 15a and the weakly fused portion 15b coexist.

  The unidirectionally peelable heat fusion part 15 having such a strong fusion part and a weak fusion part forms irregularities on two heat seal bars, and the heat seal bar having such irregularities is formed. It can be formed by making a difference in the pressure applied to the thermoplastic resin film and separating the strongly fused portion and the weakly fused portion and heat-sealing. That is, the thermoplastic resin film is thermocompression-bonded by contacting the heated film with the unevenness of the seal bar at a predetermined pressure and time, and the convex part is pressed with a stronger pressure during this thermocompression bonding. Since it adheres to each other, it becomes a strongly fused part, and on the other hand, the concave part has a weak pressure bonding force, so that the adhesive force of the thermoplastic resin film becomes low and becomes a weakly fused part.

  In the embodiment of FIG. 2, the triangular partition 15 (seal part 15), that is, the strong fusion part 15a, has the same ratio on both the first partition part 11 side and the second partition part 12 side. There is no dense or sparse relationship in the arrangement of the landing portion 15a. Therefore, this embodiment of FIG. 2 is a reference example, not an embodiment of the present invention.

There is no particular limitation on the shape related to the unevenness formed on the seal bar, and a piece shape such as a round shape, a square shape, or a rhombus shape may be adopted, or the unevenness may be provided with a line having a certain width.
Further, the unevenness may be formed on each of the upper and lower heat seal bars, or may be formed on only one of them. In addition, when forming unevenness on the upper and lower heat seal bars, respectively, it is possible to form unevenness of different shapes on the upper and lower heat seal bars, or by the uneven arrangement formed on the upper and lower heat seal bars, It is also possible to arrange the strong fusion part and the weak fusion part at a desired position.

Furthermore, it is possible to provide a gentle slope between the convex portion and the concave portion formed on the heat seal bar.
As a matter of course, a fusion part having intermediate strength may be formed between the strong fusion part and the weak fusion part.

  The formation ratio of the strongly fused portion and the weakly fused portion can be appropriately selected so that directionality is exhibited in peeling, but the area of the strongly fused portion is the same as that of the unidirectional peelable heat fused portion. The proportion of the total area is usually 0.01 to 70%, preferably 0.01 to 60%, particularly preferably 0.1 to 50%. When the area of the strong fusion part is less than 0.01% or more than 70%, it is difficult to control the seal strength.

The method to impart directionality to the fusion strength, can be a method of lower SL.
1) the fusion strength of TsuyoToruchaku parts per width direction shall be the asymmetric tapered. That is, by providing the heat seal bar for forming the strongly fused portion with a tapered surface, and using the heat seal bar having the tapered surface in this way, the second fusion portion side of the strongly fused portion is provided. An inclined portion is formed in which the thickness of the thermoplastic resin film is thin and the thickness of the thermoplastic resin film on the first partition portion side is increased.

In addition to this, it may be formed by the following method (2);
(2) The easily peelable seal portion has a plurality of strong fusion portions made of triangles in which the heat seal surfaces are closely adhered to each other, and the plurality of strong fusion portions made of these triangles are In addition, it is formed in such a manner that apexes are arranged on the second partition part side, and the plurality of strongly fused parts are sparser as they are closer to the first partition part and closer to the second partition part. It arrange | positions disperse | distributed with respect to the width direction of an easily peelable seal part so that it may become dense.

If the shape of the fused portion is triangular in general, strength required for opening increases toward the vertex side from the bottom side of the triangle. Therefore, in the case where the strongly fused portion is triangular as shown in FIG. 3, when peeling from the top side to the bottom side of the triangle, as shown in FIG. On the other hand, as shown in FIG. 3B, when peeling from the bottom of the triangle toward the top, it is easy to peel off.

In FIG. 4, the strong fusion part is represented by a rectangle. In the upper part of FIG. 4, many strong fusion parts are formed, whereas in the lower part, the number of strong fusion parts is small. Therefore, peeling from the direction indicated by the peeling direction (a) in FIG. 4 is easy peeling, whereas peeling from the direction indicated by the peeling direction (b) in FIG. 4 is difficult peeling. In this way, by making a difference in the distribution of the strongly fused portions, directionality occurs in the peel strength. In addition, the shape of the strong melt | fusion part which concerns on this invention is not a square but a triangle.

FIG. 5 is a diagram showing the correspondence 1).
As shown in FIG. 5, by providing a taper in the shape of the heat seal bar forming the strongly fused portion, the pressure bonding strength becomes asymmetric with respect to the width direction of the seal portion, and the peel strength is directional. The strongly fused portion is not a quadrangle but a triangle.

In FIG. 5, the shape of the heat seal bar is a square, but the shape of the heat seal bar applied in the present invention is a triangle .
In addition, each left figure of FIGS. 5-7 is the figure which expanded and looked at the heat seal part (heat seal bar) from the perpendicular | vertical direction (direction perpendicular | vertical with respect to the paper surface of FIG. 1) . Each right figure is a view of a heat seal bar for forming the heat seal portion as viewed from the side. The vertical direction corresponds to the width direction of the seal portion 15, and the entire three-drawing shape or rhombus corresponds to the strongly fused portion.

  When the film is welded using the heat seal bar having the shape exemplified above, the temperature setting of the upper and lower two heat seal bars is not particularly limited, and if the resin is set to be in a semi-molten state. Good.

  For example, the temperature of the upper seal bar and the lower seal bar may be set evenly, or a temperature difference may be given up and down. Further, as for the sealing time and the sealing pressure, arbitrary values are used as long as the resin used maintains a semi-molten state.

  In addition, by generating a temperature distribution in the width direction of the heat seal bar, it is also possible to form a difference in the fusion strength at both edges in the width direction of the seal portion. The edge portion can be a strong fusion portion, and the other edge portion can be a weak fusion portion.

In the container of the present invention, for example, the unidirectional peelable heat-sealed part of the weak seal part of the multi-chamber infusion container has anisotropy in the strength required for peeling depending on the peeling direction.
The opening strength when peeled from one end in the width direction of the seal portion is F1, the opening strength when peeled from the other is F2, and the relationship of F1 <F2 holds. That is, the opening strength F2 is higher than F1. When it is large, the peel strength of F1 is preferably 1 to 6 Nmm / 15 width, more preferably 2 to 6 N / 15 mm width as an initial value.

  It is preferable that the opening strength F1 is 1 N / 15 mm width or more at the initial value because the sealing strength is moderate and there is no fear of opening by a slight impact or stress. Moreover, it is preferable for the opening strength F1 to be 6 N / 15 mm width or less at the initial value, since it can be opened by applying a force to mix the liquid during use.

  The opening strength F2 may be a value higher than the opening strength F1, but from the viewpoint of unidirectional peelability, a larger difference from F1 is preferable. The F2 / F1 ratio is usually about 1.05 to 100 times.

  Various resin films can be used as the resin film used to form the container 10 of the present invention, and a thermoplastic resin film is preferably used. Such a thermoplastic resin film can be used without any particular limitation, but a polyolefin-based resin is preferable in view of a balance between price and physical properties (transparency, flexibility, etc.). Examples of the thermoplastic resin film include high-density polyethylene, medium-density polyethylene, high-pressure low-density polyethylene, low-density polyethylene, linear low-density polyethylene, ethylene-vinyl acetate copolymer and other polyethylene resins, ethylene-butene Examples thereof include olefin elastomers such as random copolymers, polypropylene resins such as polypropylene, ethylene-propylene random copolymers, α-olefin-propylene random copolymers, and mixtures thereof. In addition, when the container of the present invention is the multi-chamber infusion container 10 as described above, it is not particularly necessary to select and use a specific resin as long as the seal strength has directionality as described above. Therefore, as long as it is used in the medical field as a thermoplastic resin film can be used without any particular limitation, vinyl chloride, ethylene vinyl acetate copolymer, polyethersulfone, cyclic polyolefin, cyclic polyolefin copolymer, A film made of a styrene elastomer such as a hydrogenated styrene ethylene butadiene copolymer, a mixture of these resins, a mixture of these with the above polyolefin resin, or the like can also be used. These resins may be partially crosslinked for the purpose of improving heat resistance.

  Furthermore, the thermoplastic resin film used may be a single-layer film made of one type of film or a multilayer film in which a plurality of types of films are laminated. When the thermoplastic resin film is a single layer film, it is excellent in transparency and flexibility, so that linear low density polyethylene, polypropylene, propylene ethylene random copolymer, propylene ethylene block copolymer, propylene resin and Films such as a mixture of an ethylene elastomer, a mixture of a propylene resin and a propylene elastomer, a mixture of a propylene resin and a styrene elastomer are preferred. When the thermoplastic resin film is a multilayer film, from the outside of the multi-chamber infusion container, high density polyethylene / linear low density polyethylene, medium density polyethylene / low density polyethylene / high density polyethylene, high density polyethylene / low density Examples include polyethylene / high density polyethylene.

Moreover, in a multilayer film, the inner layer may be comprised from the resin composition which enables an easy peel.
The method for producing the thermoplastic film used in the present invention is not particularly limited, and examples thereof include production methods by T-die molding, water-cooled inflation molding, air-cooled inflation molding, blow molding, lamination molding, and the like. From the viewpoint of transparency, T-die molding and water-cooled inflation molding are preferable.

Moreover, the thickness of the thermoplastic resin film used by this invention is 5-1000 micrometers normally, Preferably it is about 50-500 micrometers.
The multi-chamber infusion container formed from the thermoplastic resin film as described above has a strong seal portion formed in four directions, and a unidirectional peelable fusion portion is formed in the space surrounded by the strong seal portion. The peel strength F1 from the partition section 1 partitioned by the unidirectional peelable fusion section is different from the peel strength F2 from the partition section 2, and the unidirectional stripping occurs when pressure is applied to one partition section. However, the container of the present invention has three directions as strong seal portions and the other one is easily peeled off. It may be a container used as a sealable seal.

Further, in the multi-chamber infusion container of the present invention, a small container may be accommodated in the partition part, and this may be fixed to the inner wall surface facing the partition part by heat fusion.
FIG. 12A shows an example of a multi-chamber infusion container in which the small container 20 is accommodated in the partition part 11. Moreover, FIG.12 (b) and FIG.12 (c) are XX sectional drawing in Fig.12 (a). In FIG. 12, the same number is attached | subjected to the member common to the member shown in FIG.

  In addition, when the said small container applies a pressure to either of the division parts 11 and 12 and peels off the seal part 15, the easy peeling part 35 (shaded part) of the small container 20 is also peeled off simultaneously. Yes. As this method, when the peeling part 15 peels from the state of FIG.12 (b), it pulls on the container film opened by the force shown by the arrow F of FIG.12 (b), and the easy peeling of the small container 20 is carried out. There is a method in which the portion 35 is peeled off and the state shown in FIG.

  In FIG. 13A, the seal part 15 is preferably easily peelable with respect to the pressure from the partition part 12. In this way, by applying pressure to the partition portion in which the small container is not accommodated, pressure is applied to the entire seal portion 15 and it is possible to reliably peel and penetrate.

  Moreover, in FIG. 12A, it is preferable to impart unidirectional peelability to the easy peel portion 35 of the small container 20. In this way, the easy peeling portion of the small container can be reliably peeled in the intended direction. For example, if the unidirectional peeling part in the form of FIG. 12D is formed, peeling can be easily performed from the bottom to the top of the figure, and the easy peeling part 35 of the small container can be reliably peeled. Increases nature.

Although omitted in FIG. 12, a peeling start portion may be formed on the unidirectional peeling portion so as to facilitate opening when pressurized.
The container of the present invention preferably has a configuration in which a plurality of partition portions are partitioned by a unidirectional peelable fusion portion (easy peelable seal portion) as described above. Also good. That is, as shown in FIG. 11 and FIG. 13, the opening of the single chamber container is formed with the above-described easily peelable seal portion, and the easily peelable seal portion that forms this opening is formed from the side to be opened. It is preferable to use a unidirectional peelable fusion part so that peeling is easy. Fig.11 (a) is a schematic diagram which shows the container in which the easily peelable seal part was formed as an opening part of a single chamber container, FIG.11 (b) is aa sectional drawing, and it is easy for one part. A peeling start portion 17 made of a peelable seal is formed. FIG. 11B shows a peeling start portion 17 partially made of an easy peel seal on the side where opening is started. As described above, the peeling start portion 17 is formed with the strong fusion portion and the weak fusion portion, and the peeling from the inside of the container is facilitated. When this container is pulled in both directions with a resin film slightly below the peeling start part, peeling starts from the peeling start part, and the container can be easily opened. And since the opening start part is formed, the opening start position is always this peeling start part, and a container can be opened in the always constant state.

  FIG. 13 (a) schematically shows a container in which a peeling start portion, part of which is an easily peelable seal, is formed so that the container can be easily opened from the outside. (B) is bb sectional drawing. In this single-chamber container, the thermoplastic resin film forming the container is extended to the outside from the seal portion, and when the container is opened, the extended thermoplastic resin film 18 is held. By pulling outward, the container can be opened by peeling from the peeling start portion 17.

  When forming the peeling start part 17 which consists of an easily peelable seal | sticker in part as mentioned above, it is preferable to make peeling strength high toward this outer side centering on this peeling start part 17. FIG. Furthermore, it is preferable to increase the peeling strength from the peeling start portion 17 toward the depth direction of the seal portion. That is, when such a peeling start part 17 is formed, the container can always be opened from the peeling start part 17 by controlling the peeling strength of the peeling start part 17 to the lowest.

Such a peeling start portion 17 can be similarly formed in a unidirectional peelable fusion portion of a container such as a multi-chamber infusion bag having the above-described unidirectional peelable heat fusion portion. Of course.
Then attached to the container of the present invention to explain.

[ Reference Example 1]
A 300 μm-thick film made of linear low-density polyethylene (MFR = 2 g / 10 min (190 ° C.), density 920 kg / m ³ ) was prepared by a water-cooled inflation method.
Two films were stacked and sandwiched between two heat seal bars to create a seal portion having anisotropy in peel strength.

In addition, the seal | sticker part (single direction peelable fusion | fusion part) which has anisotropy in peeling strength was formed in the center part of the length direction of the multi-chamber infusion container 10 by 10 mm length. Also, of the two heat seal bars used at this time, the upper bar uses the bar having the triangular fused portion shown in the specific example of FIG. 6, and the lower bar uses the flat bar. used. Heat sealing was performed under conditions of a sealing pressure of 0.3 MPa and a sealing time of 3.4 seconds.

Seal strength when the peel strength was measured from both sides of the seal portion created using the embodiment of FIG. 6 of this are shown in Table 1.
The seal strength was measured according to ASTM F88. Specifically, a film including a part fused by a heat seal bar is cut out to a width of 15 mm, and a part not sealed is sandwiched between jigs of a tensile tester. The force at the time of pulling upward at a speed of 200 mm / min and peeling off the fused part was defined as the seal strength. The results are shown in Table 1 and FIG.

[Reference Example 2]
Table 2 and FIG. 9 show the results of sealing and measuring the anisotropy of peel strength in the same manner as in Example 1 except that the seal bar shown in FIG. 5 was used in Reference Example 2 .

[Comparative Example 1]
Instead of the heat seal bar used in Reference Example 1, a rhombus-shaped seal bar as shown in FIG. 7 was used for sealing in the same manner as in Reference Example 1, and the anisotropy of peel strength was measured. The results are shown in Table 3 and FIG. When the bar shape and arrangement were symmetrical, the peel strength could not be made anisotropic.

FIG. 1 is a schematic plan view showing an example of a multi-chamber infusion container of the present invention. FIG. 2 is a reference diagram in which triangular strong fusion portions are arranged at a uniform ratio in the width direction of the easily peelable seal portion of the multi-chamber infusion container shown in FIG. FIG. 3 is a schematic view showing an example of a shape in which the direction of the fusion strength of the strongly fused portion is provided in the peelable easily peelable seal portion. FIG. 4 shows an example in which strong fusion parts are scattered in the peelable easily peelable seal part so that the fusion strength becomes denser to sparse in the width direction of the easily peelable seal part. FIG. FIG. 5 is a schematic view showing an example in which a taper is formed on a heat seal bar in order to provide a taper at a heat-sealed strong fusion bonded part in a peelable easily peelable seal part. FIG. 6 is a diagram showing the shape and dimensions of a heat seal bar for forming a triangular strong fusion part. FIG. 7 is a diagram showing the shape and dimensions of a heat seal bar for forming the strongly fused portion used in Comparative Example 1. FIG. 8 is a graph showing the relationship between the heat seal temperature and peel strength in Reference Example 1. FIG. 9 is a graph showing the relationship between the heat seal temperature and peel strength in Reference Example 2. FIG. 10 is a graph showing the relationship between the heat seal temperature of Comparative Example 1 and the peel strength. FIG. 11: is the front view and aa sectional drawing which show typically the single chamber container in which the opening start part was formed in the inner edge part of an easily peelable seal part. FIG. 12 is a front view showing an example of a multi-chamber infusion container in which three compartments are formed, and an XX cross-sectional view schematically showing an unsealed state when pressurized. FIG. 13: is the front view and bb sectional drawing which show typically the single chamber container in which the opening start part was formed in the outer edge part of an easily peelable seal part, and a thermoplastic resin film is extended in the upper part Yes.

10 ... Container 11 ... Drug room (first compartment)
12 ... Drug room (second compartment)
13 ... Drug input part 14 ... Drug in / out part 15 ... Seal part (unidirectional peelable fusion part)
15a .. Strongly fused portion 15b .. Weakly fused portion 16... Strongly sealed portion 17... Peeling start portion 18 .. Extending thermoplastic resin film 20. ... Easy peeling part

Claims (1)

A thermoplastic resin film arranged so that the heat seal surfaces face each other is fused to form a strong seal part around it, and the void surrounded by the strong seal part is liquid-tight and easy to peel off A container defined by a seal section into a first partition section and a second partition section;
The easily peelable seal portion has directionality in the fusion strength so that the fusion strength is smaller as it is closer to the first partition portion and the fusion strength is larger as it is closer to the second partition portion. A container wherein the easily peelable seal portion is formed by the following (1) and (2) ;
(1) The strong fusion part formed in the easily peelable seal part is a heat-sealed strong fusion part provided with a tapered surface on a heat seal bar for forming the strong fusion part. The thickness of the thermoplastic resin film on the second partition portion side is small, and an inclined portion is formed where the thickness of the thermoplastic resin film on the first partition portion side is large.
(2) The easily peelable seal portion has a plurality of strong fusion portions made of triangles in which the heat seal surfaces are closely adhered to each other, and the plurality of strong fusion portions made of these triangles are In addition, it is formed in such a manner that apexes are arranged on the second partition part side, and the plurality of strongly fused parts are sparser as they are closer to the first partition part and closer to the second partition part. It arrange | positions disperse | distributed with respect to the width direction of an easily peelable seal part so that it may become dense.

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