JP2010110385A - Medical multi-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical multi-chamber container capable of being manufactured without the need of a complicated process or a difficult technique, and preventing the erroneous administration of a liquid chemical before being mixed even while handleability is excellent. <P>SOLUTION: A mark is printed on at least one of a pair of transparent films 11a and 11b in an area to be below a liquid surface L<SB>1</SB>positioned highest among the respective liquid surfaces of the respective liquid chemicals inside a plurality of liquid chemical storage chambers 12a and 12b before opening a weakly sealed part 12c and to be equal to or above the liquid surface L<SB>M</SB>of a liquid chemical mixture for which the respective liquid chemicals are mixed after opening the weakly sealed part 12c when hanging the medical multi-chamber container so that a liquid chemical discharge port 14 is at the lower part. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a medical multi-chamber container that has a plurality of chemical solution storage chambers and mixes the chemical solutions in the chemical solution storage chambers immediately before use and uses them for infusion.

  2. Description of the Related Art Conventionally, there is known a medical multi-chamber container that has a plurality of partitioned chemical solution storage chambers, mixes the chemical solutions in the chemical solution storage chambers immediately before use, and uses them for infusion. The plurality of chemical solution storage chambers are partitioned liquid-tightly by, for example, a partition portion such as a weak seal portion that is peeled off and opened by applying pressure to the medical multi-chamber container from the outside. And after opening a partition part just before use and mixing a chemical | medical solution, the mixed chemical | medical solution is discharged | emitted from a discharge port, and is administered to a patient by drip etc.

    However, forgetting to open the partition, the drug solution that should originally be mixed and dispensed may not be mixed, and only a part of the drug solution before mixing may be administered to the patient. Therefore, various measures for medical multi-chamber containers are being studied.

    For example, in Patent Document 1, in addition to a plurality of chemical solution storage chambers, there is provided a compartment capable of communicating with one of these chemical solution storage chambers, and a medical compound discharge port provided with a chemical solution discharge port so as to communicate with this compartment. A chamber container is disclosed. This medical multi-chamber container is configured so that the closing means for partitioning the chemical solution storage chamber and the compartment is not opened unless the partitioning means for partitioning the chemical solution storage chambers is opened. Therefore, according to this medical multi-chamber container, the chemical solution before mixing is not accidentally discharged from the discharge port. Similarly, Patent Document 2 proposes a medical multi-chamber container configured such that a chemical solution is not discharged from a chemical solution outlet unless a plurality of chemical solutions are mixed.

  Patent Document 3 discloses a medical multi-chamber container in which a part of a medical multi-chamber container including a chemical solution discharge port is fixed in a bent state. According to this medical multi-chamber container, the liquid medicine can be discharged only after the weak seal portion that partitions the liquid medicine storage chamber is opened by external pressurization and the bent state is released at the same time. Therefore, even in this medical multi-chamber container, the chemical solution is not discharged from the chemical solution discharge port unless a plurality of chemical solutions are mixed.

On the other hand, Patent Document 4 discloses a medical device intended to prevent the administration of a drug solution before mixing by enabling easy visual confirmation whether or not the weak seal portions that divide a plurality of drug solution storage chambers are peeled off. Multi-chamber containers have been proposed. In this medical multi-chamber container, a visible treatment is applied to each of the two film sheet portions constituting the weak seal portion, and the weak seal portion is separated before and after the weak seal portion is peeled off. The appearance is made visually different.
JP-A-9-327498 JP 2005-342174 A JP 2007-282707 A JP 2004-141631 A

However, in the medical multi-chamber container of Patent Documents 1 and 2, when forming the weak seal portion that forms the closing means and the weak seal portion that forms the partition means, the seal strength of these weak seal portions must be strictly controlled. However, it was necessary to pay attention to fine adjustment of sealing conditions and selection of film materials. Moreover, when manufacturing the medical multi-chamber container of patent document 3, the process of fixing a part of medical multi-chamber container in the bending state was required. Thus, the manufacturing process of the medical multi-chamber container of Patent Documents 1 to 3 is complicated.
Furthermore, the medical multi-chamber container of Patent Documents 1 and 2 is different from the conventional general medical multi-chamber container in that it has a branch chamber. It differs from a conventional general medical multi-chamber container in that a part is fixed in a bent state. Therefore, when using the medical multi-chamber container of patent documents 1-3, it is necessary to handle by the method according to each medical multi-chamber container, and there also existed a problem that it was inferior to handleability.

  On the other hand, in the medical multi-chamber container of Patent Document 4, a pattern is given in advance to each of the two film sheet portions constituting the weak seal portion, and then the portions printed in this way are put together. It is necessary to heat seal to make a weak seal. In this case, since heat is applied to the printed pattern portion, the pattern shape and the like may be disturbed, and there is a problem that it is technically difficult to heat-seal without affecting the pattern shape. Further, since the seal width of the weak seal portion is usually as narrow as about 10 mm, even if printing or the like is applied to this portion, it is difficult to visually determine whether the weak seal portion is before or after peeling.

  The present invention has been made in view of the above circumstances, and can be manufactured without requiring complicated processes and difficult techniques, while being easy to handle, it can prevent misadministration of a drug solution before mixing. It is an object to provide a chamber container.

The medical multi-chamber container of the present invention is composed of a pair of opposing transparent films, a container body in which a plurality of chemical solution storage chambers defined by openable partition portions are formed, and the plurality of chemical solution storage chambers A medical multi-chamber container having a chemical solution discharge port provided in communication with the one, and the partition portion when the medical multi-chamber container is suspended so that the chemical solution discharge port is downward Before the opening of the plurality of chemical solutions in the plurality of chemical solution storage chambers is lower than the uppermost liquid level, and after the opening of the partition portion, the mixed chemical solution mixed with the respective chemical solutions Printing is performed on at least one of the pair of transparent films in a region that is equal to or higher than the liquid level.
The pair of transparent films are a front-side transparent film and a back-side transparent film, and it is preferable that characters are included in the printing, and the printing is performed at least on the back-side transparent film. In that case, the said printing may be given only to the said back side transparent film.
The pair of transparent films may be a front-side transparent film and a back-side transparent film, part of which may be applied to the front-side transparent film and the remaining part may be applied to the back-side transparent film.

  According to the medical multi-chamber container of the present invention, it is possible to manufacture without requiring complicated processes and difficult techniques, and it is possible to prevent erroneous administration of the drug solution before mixing while being easy to handle.

  Hereinafter, the embodiment of the medical multi-chamber container of the present invention will be described in detail.

[First Embodiment]
1 is a perspective view of the medical multi-chamber container 10A of the first embodiment, FIG. 2 (a) is a front view of the medical multi-chamber container 10A of FIG. 1, and FIG. 2 (b) is the medical use of FIG. It is a rear view of multi-chamber container 10A.
This medical multi-chamber container 10A is composed of a pair of opposing rectangular transparent films 11a and 11b whose peripheral portions are fused so as not to be peeled, and the first chemical solution storage chamber 12a and the second chemical solution storage chamber 12b are composed of a pair. It has the container main body 12 formed side by side in the longitudinal direction. Between the first chemical solution storage chamber 12a and the second chemical solution storage chamber 12b, a liquid-tight weak seal portion 12c is linearly formed as an openable partition portion. A space between the first chemical solution storage chamber 12a and the second chemical solution storage chamber 12b is defined. In the medical multi-chamber container 10A, after the first chemical solution is stored in the first chemical solution storage chamber 12a and the second chemical solution is stored in the second chemical solution storage chamber 12b, at least one of the chemical solution storage chambers 12a. By applying a force from the outside to 12b, the weak seal portion 12c is peeled and opened, the first chemical solution and the second chemical solution are mixed, and the mixed chemical solution is prepared in the container body 12. ing.

A suspension hole 13 for suspending the medical multi-chamber container 10A is formed at the longitudinal end of the peripheral portion of the container body 12 on the side where the first chemical solution storage chamber 12a is formed. Yes. On the other hand, at the end in the longitudinal direction on the side where the second chemical solution storage chamber 12b is formed, a hollow chemical solution that communicates with the second chemical solution storage chamber 12b and is closed by a needle plug that can be inserted into the needle. A discharge port 14 is provided. Accordingly, the weak seal portion 12c is opened, and the hanging hole 13 of the medical multi-chamber container 10A is hooked on the drip stand hook or the like so that the drug solution outlet 14 is located downward, and for example, a drip needle is attached to the rubber stopper. By inserting, the mixed chemical liquid prepared in the container main body 12 is discharged from the chemical liquid discharge port 14 and is administered to the patient by instillation or the like.
The chemical solution discharge port 14 is also used as an injection port for injecting the second chemical solution into the second chemical solution storage chamber 12b. Further, the first chemical liquid is injected into the first chemical liquid storage chamber 12a from a first chemical liquid injection port (not shown).

In this example, the character “opened” indicating that the weak seal portion 12c is opened in a specific region in the back side transparent film 11b of the pair of transparent films 11a and 11b, A mark consisting of a straight line attached below is printed.
As in this example, printing is a content reminiscent of opening. In addition, in the case where characters are included in the printing applied to a specific region, as shown in FIG. 2, when the user of the medical multi-chamber container 10A visually recognizes the characters, On the front side (FIG. 2A), the side where the characters appear to be reversed left and right is the back side (FIG. 2B).

Here, as shown in FIG. 3, the specific region refers to the medical multi-chamber container 10 </ b> A in which the first chemical solution and the second chemical solution are accommodated so that the chemical solution discharge port 14 is positioned downward, as shown in FIG. 3. In this case, before the weak seal portion 12c is opened (FIG. 3A), each chemical solution stored in each chemical solution storage chamber 12a, 12b (in this example, the first chemical solution and the second chemical solution). ) In the region below the uppermost liquid level (in this example, the liquid level L ₁ of the first chemical liquid) and after opening the weak seal portion 12c (FIG. 3). (B)) refers to a region that is _{equal to} or higher than the liquid level LM of the prepared mixed drug solution. 3 in (a), _{L 2} is a liquid level of the second chemical liquid before the opening of the weak seal portion 12c.
In this example, the characters "open completed", after opening of the weak seal portion 12c, is printed in a position above the the liquid level L _M of the mixed drug solution prepared, the line is weak seal portion 12c the post-opening, are printed in a position that coincides with the liquid level L _M of the mixed drug solution prepared.

According to such a multi-chamber medical container 10A, printing consisting of a character and a line of "open completed" before opening of the weak seal portion 12c is located below the liquid level L ₁ of the first chemical liquid is doing. However, when opening the weak seal portion 12c, the first chemical liquid and the second chemical liquid is being mixed chemical solution is prepared mixing, its liquid level L _M, a first position lower than the liquid level L ₁ of the liquid medicine prior to opening become. As a result, characters "open completed" is located above the liquid level L _M of the mixed chemical solution line is to match the liquid level L _M of the mixed chemical solution.
By thus the liquid level L _M of the line and mixing chemical match, first chemical liquid and the second results of chemical and are mixed by opening the weak seal portion 12c, the liquid level L _M of the mixed drug solution given It becomes clear to the user that the position (position indicated by the line) is reached.
Therefore, according to this medical multi-chamber container 10A, the user can recognize that the weak seal portion 12c is opened only by visual observation, and the first chemical solution and the second chemical solution are not opened when the weak seal portion 12c is not opened. Although it is not mixed, it is possible to prevent the chemical solution before mixing (in this case, only the second chemical solution) from being erroneously administered from the chemical solution discharge port 14. Moreover, according to this medical multi-chamber container 10A, since it can manufacture without requiring a complicated process and a difficult technique and can be used with a normal handling method, the point of handleability is also favorable.

Further, in this example, among the pair of transparent films 11a and 11b, printing is performed particularly on the back side transparent film 11b.
Therefore, as shown in FIG. 4, before opening the weak seal portion 12c (FIG. 4A), the front side transparent film 11a and the One chemical solution is interposed, and the user visually recognizes the printing through the front transparent film 11a and the first chemical solution. Therefore, compared with the case where printing is performed on the front transparent film 11a, it is difficult for the user to see the printing. However, after the opening of the weak seal portion 12c (FIG. 4B), no chemical is present between the user and the printing, and the front side transparent film 11a and the back side transparent film 11b of the printed portion are printed. Since it comes into close contact with each other, printing can be clearly seen.
That is, when printing is performed on the back surface side transparent film 11b, since the difference in visibility of printing before and after opening of the weak seal portion 12c is large, the user more clearly indicates that the weak seal portion 12c is opened. The effect that it is easy to recognize can also be acquired.
Further, in this case, if the first chemical liquid is colored, the difference in the visibility of printing before and after opening of the weak seal portion 12c is further increased, so that the printing is performed on the back side transparent film 11b. Preferably it is. Examples of the colored first drug solution include a white and opaque fat emulsion.

In this example, as the mark to be printed, a character of "open completed" indicating that the opening is subjected to underlying has illustrated a mark consisting of a line that coincides with the liquid level L _M of the mixed drug solution Either one of them may be used, and the combination of characters and lines is not limited.
However, it is preferable that characters are included in the printing because the intention indicated by the printing is easily transmitted to the user. Further, it can be clearly determined which side of the medical multi-chamber container 10A is the front side or the back side. Therefore, although it is the medical multi-chamber container 10A which printed the back side transparent film 11b from the point of the effect mentioned above, the possibility of hanging the back side forward by mistake can also be avoided. Further, shapes such as lines included in the print, especially its figure, when are those attached to a position that coincides with the liquid level L _M of the mixed drug solution as in this example, by opening the weak seal portion 12c It is preferable because it is easy to visually determine that the mixed chemical solution has been prepared. From the above points, it is preferable that printing is a mark composed of characters and graphics. The type of characters to be printed is not limited to “opened”, but may be other characters, and the type of graphics to be printed may be, for example, symbols such as ○, ×, and Δ, arrows, and these. They may be combined and are not limited to lines.
If the printed mark does not include characters and the front side transparent film and the back side transparent film cannot be distinguished, the printed side transparent film is used so as to be on the back side. It is preferable in terms of effects.

  Printing only needs to be performed on either the outer surface or the inner surface of the transparent films 11a and 11b, but it is preferable that the printing and the chemical solution do not come into direct contact from the viewpoint of suppressing contamination with the chemical solution. Therefore, it is preferable to be applied to the outer surface of the transparent film (the surface on the side in contact with the outside air but not on the chemical solution).

  In this example, the container body 12 is exemplified by a pair of opposing rectangular transparent films 11a and 11b whose peripheral portions are fused so as not to be peeled off. However, the container body 12 is formed of, for example, a cylindrical transparent film. And the thing of the form fuse | melted only the both ends of the longitudinal direction among the peripheral parts so that peeling was not possible may be sufficient, and the shape of a transparent film is not limited to a rectangle.

Further, the transparent films 11a and 11b are not limited as long as they are made of a flexible material and can be used for medical purposes, but polyolefin resins, polyamide resins, polyester resins, (meth) acrylic resins, vinyl chloride resins, A synthetic resin film made of vinylidene chloride resin, polyethersulfone, ethylene-vinyl alcohol copolymer or the like is preferable. Of these, polyolefin resins are preferred because they are excellent in transparency, flexibility, hygiene, and low cost.
Examples of the polyolefin resin include polyethylene resins such as high density polyethylene, medium density polyethylene, high pressure method low density polyethylene, linear low density polyethylene, and ethylene-vinyl acetate copolymer; ethylene-α olefin random copolymer Olefin elastomers; polypropylene resins such as polypropylene, ethylene-propylene random copolymers, α-olefin-propylene random copolymers; cyclic polyolefin resins; and mixtures thereof. Further, these resins may be partially crosslinked for the purpose of improving heat resistance.
Moreover, the transparent films 11a and 11b may be a single layer or a multilayer, and the thickness is preferably 50 to 1000 μm, more preferably 100 to 500 μm.

As a method for forming the weak seal portion 12c, for example, the inner surface side of the container body 12 is formed of a composition made of a plurality of resins having different melting points and compatibility (for example, polyethylene and polypropylene), and the melting temperature of the high melting point resin. The method of sealing is mentioned below. In addition, heat sealing is performed at a low temperature and weakly bonded in a semi-welded state, a method using a flexible material previously cross-linked with an electron beam or the like on the weak seal portion 12c formation portion, and a strong fusion portion is specified. Examples include a method using a seal bar generated at an area ratio, and a method in which an easily peelable resin tape is sandwiched between two flexible materials.
In addition, the openable partition section that divides the chemical solution storage chamber may partition the chemical solution storage chamber in a liquid-tight manner before opening, as long as it can be opened immediately before use of the medical multi-chamber container. It may be composed of a resin partition member or the like.
Moreover, the number of the chemical | medical solution storage chambers formed in the medical multi-chamber container is not limited to two as in this example, and may be three or more.

[Second Embodiment]
FIG. 5 is a perspective view of the medical multi-chamber container 10B of the second embodiment. FIGS. 6A and 6B are (a) an exploded perspective view and (b) a front view schematically showing main parts of the medical multi-chamber container 10B shown in FIG.
Also in this example, when the medical multi-chamber container 10B in which the first chemical solution and the second chemical solution are suspended so that the chemical solution discharge port 14 is located downward, before the weak seal portion 12c is opened. Is a region that is lower than the uppermost liquid level (in this example, the liquid level of the first chemical liquid) among the liquid levels of the respective chemical liquids (in this example, the first chemical liquid and the second chemical liquid), And after opening of the weak seal | sticker part 12c, the mark is printed in the area | region which becomes more than the liquid level of the prepared mixed chemical | medical solution.
Specifically, in this example, a part of the letters “opened” aligned in a horizontal line (in this example, the upper half) indicating that the weak seal portion 12c is opened is a pair of transparent films 11a and 11b. One of them (in this example, the front side transparent film 11a) is printed, and the remaining part (in this example, the lower half) is printed on the other (in this example, the back side transparent film 11b). Other points are the same as in the first embodiment.

In such a medical multi-chamber container 10B, the characters “opened” are divided and printed on the front transparent film 11a and the back transparent film 11b, and before the weak seal portion 12c is opened, This printing is located below the liquid surface of the first chemical liquid. Therefore, before the opening of the weak seal part 12c, a 1st chemical | medical solution exists between the front side transparent film 11a and the back side transparent film 11b in the part of the divided printing. Therefore, even if the user sees this print, it is difficult to recognize that the character is “open”. However, when the weak seal portion 12c is opened, the first chemical liquid and the second chemical liquid are mixed to prepare a mixed chemical liquid, and the liquid level is lower than the liquid level of the first chemical liquid before opening. Therefore, no chemical is present between the front side transparent film 11a and the back side transparent film 11b in the printed part, and at the same time, the front side transparent film 11a and the back side transparent film 11b are in close contact with each other in the printed part. To come. As a result, the upper half and the lower half of the character appear to be combined, and the user can clearly recognize the print as “open”.
Therefore, according to the medical multi-chamber container 10B, the user can recognize that the weak seal portion 12c is opened only by visual observation. Therefore, although the weak seal portion 12c is not opened and the first chemical liquid and the second chemical liquid are not mixed, the chemical liquid before mixing from the chemical liquid discharge port 14 (in this case, only the second chemical liquid) is erroneous. It can be prevented from being administered. The medical multi-chamber container 10B can also be manufactured without requiring complicated processes and difficult techniques, and can be used in a normal handling method, so that the handling property is also good.
Further, in this case, it is preferable that the first chemical liquid is colored because it becomes more difficult for the user to recognize that the printing is “opened” before opening the weak seal portion 12c. .

In addition, such printing should just be performed to either one of the outer surface or inner surface of the front side transparent film 11a and the back side transparent film 11b, but the direction where printing and a chemical | medical solution do not contact directly is to a chemical | medical solution. Since it is preferable from the viewpoint of contamination, it is preferably applied to the outer surface.
In this example, the characters “opened” are divided into an upper half and a lower half, the upper half is printed on the front transparent film 11a, and the remaining half is printed on the rear transparent film 11b. The upper half may be printed on the back side transparent film 11b. In addition, it is preferable that printing of characters is divided into an upper half and a lower half as in this example, because the characters are not easily recognized as characters before the weak seal portion 12c is opened. However, depending on circumstances, the right half of the characters may be printed on one of the transparent films 11a and 11b, and the left half may be printed on the other, or a plurality of characters may alternately be printed on the front transparent film 11a and the back surface. It may be printed on the side transparent film 11b.
Furthermore, the type of characters to be printed is not limited to “opened”, but may be other characters. Further, printing is not limited to characters, and may be a graphic indicating that the weak seal portion 12c is opened or a combination of characters and graphics.

It is a perspective view of the medical multi-chamber container of the first embodiment. (A) The front view of the medical multi-chamber container of FIG. 1, (b) The back view of the medical multi-chamber container of FIG. 1 shows (a) before opening of the weak seal portion and (b) after opening of the weak seal portion of the medical multi-chamber container of FIG. FIG. 2 is a longitudinal sectional view showing the medical multi-chamber container of FIG. 1 before the opening of the weak seal portion, and (b) a longitudinal sectional view showing the state after opening of the weak seal portion. It is a perspective view of the medical multiple-chamber container of 2nd Embodiment. It is the (a) exploded perspective view which showed typically the principal part of the medical multiple-chamber container of FIG. 5, and (b) front view.

Explanation of symbols

10A, 10B: medical multi-chamber container 11a: transparent film (front side transparent film)
11b: Transparent film (back side transparent film)
12a: 1st chemical | medical solution storage chamber 12b: 2nd chemical | medical solution storage chamber 12c: Weak seal part (partition part)
13: Hanging hole 14: Chemical solution outlet

Claims (4)

A container body formed of a pair of opposing transparent films and having a plurality of chemical solution storage chambers defined by openable partitions, and a chemical solution provided in communication with one of the plurality of chemical solution storage chambers A medical multi-chamber container having a discharge port,
When the medical multi-chamber container is suspended so that the chemical solution discharge port is downward, before opening the partition portion, the uppermost of the liquid levels of the chemical solutions in the plurality of chemical solution storage chambers At least one of the pair of transparent films is printed on a region that is below the liquid level and is located above the liquid level of the mixed chemical mixed with each chemical after the partition is opened. A medical multi-chamber container characterized by having The pair of transparent films are a front side transparent film and a back side transparent film,
The medical multi-chamber container according to claim 1, wherein characters are included in the printing, and the printing is performed at least on the back side transparent film.   The medical multi-chamber container according to claim 2, wherein the printing is performed only on the back side transparent film. The pair of transparent films are a front side transparent film and a back side transparent film,
2. The medical multi-chamber container according to claim 1, wherein a part of the printing is applied to the front transparent film and the remaining part is applied to the rear transparent film.

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