JP4497987B2 - Medical multi-chamber container - Google Patents

Description

  The present invention comprises a plurality of storage chambers for individually storing various unstable drugs (solutions, powders, or solid agents) that change with time when mixed at the same time, and opens the sealing portion that partitions the chambers Thus, the present invention relates to a medical multi-chamber container in which medicines stored in each storage chamber can be mixed in a sterile state without generating foreign matter.

  Among drugs administered to a patient by intravenous injection, or drugs such as ocular perfusate and peritoneal dialysate, there are unstable drugs that cause undesirable changes over time when pre-mixed. For example, when an amino acid infusion solution and a glucose infusion solution are blended and stored, the mixed solution browns by a so-called Maillard reaction. In addition, if fat emulsion and electrolyte solution are blended and stored, the fat will aggregate, and if phosphoric acid-containing liquid and calcium-containing liquid are blended, calcium phosphate will precipitate and undesirable changes will occur. Wake up.

For such drugs, for example, a medical multi-chamber container as disclosed in Patent Document 1 is often used. The medical multi-chamber container includes a plastic film container main body having two storage chambers for storing medicines, and a discharge unit for discharging the medicines from the container main body. The two storage chambers are formed by a sealing portion in which the inner wall surface of the container body is heat-sealed. In use, the vicinity of the center of one of the storage chambers is pressed to increase the pressure in the storage chamber to open the sealing portion. As a result, the two storage chambers communicate with each other and the two drugs are mixed. Thereafter, the discharge part is opened, and the mixed drug is administered to the patient.
JP-A-9-327498

  By the way, the multi-chamber container as described above is often formed of a transparent film, and the sealing portion for partitioning the storage chambers is also formed by heat fusion of the film, and thus is transparent. For this reason, it is difficult to visually recognize that the container is a multi-chamber container in which the sealing portion is to be opened. Due to this, it is difficult to visually recognize which part of the container is the storage chamber, and thus it is difficult to understand which part should be pressed when the sealing part is opened.

  The present invention has been made in order to solve the above-described problem, and can provide a medical multiple chamber in which the storage chamber can be easily seen and the pressing position when the sealing portion is opened can be easily grasped. The purpose is to provide a container.

  The present invention includes a plurality of storage chambers for storing medicines, a container main body having a partition sealing portion for partitioning the storage chambers, and a discharge unit attached to the container main body and capable of discharging the medicine from the storage chambers. The partition sealing portion is a medical multi-chamber container that allows the plurality of storage chambers to communicate with each other by being opened in use, and is provided to achieve the above-described object. Is provided with a contour line extending along the peripheral edge of at least one of the storage chambers.

  According to this configuration, since the outline is provided along the peripheral edge of the storage chamber, it is possible to recognize that there are a plurality of storage chambers even if the container body is transparent or single color, and the position of the storage chamber Can be easily recognized. Thereby, since presence of a some storage chamber can be recognized, it can prevent forgetting to open a sealing part. Furthermore, the pressing position at the time of opening a sealing part can be grasped | ascertained easily, and the operativity of a container can also be improved. If the contour line is provided at the peripheral edge of at least one storage chamber, the pressing portion can be specified, but it is also possible to provide a contour line for all the storage chambers. The most easily pressed position can be selected from among the storage chambers.

  Moreover, in addition to the said outline, the display which urges opening of the sealing part for a partition can be provided in a container main body. By doing so, it is possible to make the operator strongly recognize that the container is a multi-chamber container. Therefore, forgetting to open the partition sealing portion can be prevented, and the medicine before mixing can be reliably prevented from being discharged.

  The contour line is preferably colored in a different color from other displays provided on the container body, that is, the display for prompting the opening of the sealing portion, the component display, and the like. Thereby, the position of a storage chamber can be visually recognized easily.

  The container body can be configured in various forms. For example, the container body is formed in a flat shape made of a first surface and a second surface by a plastic film, and the inner wall surfaces of the first surface and the second surface are heat-sealed. By doing so, the partition sealing portion can be formed. In this case, the contour line is provided on at least one of the first surface and the second surface. When the container body is made of a transparent film, the contour line may be provided on one surface of the container body. However, when the container body is made of a colored film, the contour line is formed on the first surface. It is preferable to provide both on the second surface.

  According to the present invention, the storage chamber can be easily visually recognized, whereby the pressing position can be easily grasped when the sealing portion is opened. As a result, workability can be improved when using a multi-chamber container.

  Hereinafter, an embodiment of a medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 1 is a plan view of a medical multi-chamber container according to this embodiment.

  As shown in FIG. 1, this medical multi-chamber container 1 includes a container main body 5 formed into a flat bag shape by heat-sealing the peripheral edge portions 3 of two rectangular films, and the container main body 5 And a medicine discharge part 7 having a rubber plug (not shown) inside. The container body 5 has a first storage chamber 9 and a second storage chamber 11 that are arranged side by side in the longitudinal direction and in which a medicine is sealed. The two storage chambers 9 and 11 are partitioned by a partition sealing portion 13. ing. Moreover, the above-mentioned medicine discharge part 7 is connected to the end of the container body 5 on the second storage chamber 11 side. A hanging hole 17 for hanging the container 1 is formed at the end of the container body 5 opposite to the medicine discharge portion 7.

  Each of the storage chambers 9 and 11 is filled with various drugs a and b that need to be isolated in order to cause a change over time such as a Maillard reaction if mixed or dissolved in advance. For example, a solution containing an amino acid can be stored in one storage chamber, and a solution containing glucose can be stored in the other storage chamber. Moreover, an electrolyte etc. can also be enclosed in any one storage chamber as needed. Furthermore, not only a liquid agent but solid or powder medicine can also be accommodated in any one storage chamber.

  As the material of the film constituting the container body 5, various resin materials such as thermoplastic resins such as polyethylene, polypropylene, and polystyrene can be employed. However, since the partition sealing portion 13 fuses the inner wall surfaces of the container body 5 as will be described later, the film of the container body 5 is formed of a mixed resin in which resins having poor compatibility and different melting points are mixed. It is preferable. In this way, there is an advantage that the fusion strength can be easily controlled. Examples of such a resin combination include, for example, a mixed resin of polyethylene and a resin selected from a styrene resin, a methacrylate ester resin, a cyclic olefin resin, poly-4-methylpentene, polyester, polyamide, or polypropylene. be able to. Among them, a mixed resin of polyethylene and polypropylene and a mixed resin of polyethylene and cyclic olefin resin are particularly preferable because safety has been confirmed for medical use and handling in production has been established.

  Moreover, the film which forms the container main body 5 can use the film of a multilayer structure other than the single layer film which consists only of resin mentioned above. In this case, the resin layer which comprises the innermost layer of the container main body 5 should just be formed from the above resins.

  The partition sealing portion 13 is configured by heat-sealing the inner wall surfaces of the container body 5 and is opened when the internal pressure of the storage chambers 9 and 11 is increased. As such a fusion strength, for example, when one of the storage chambers is pressed with a disc having a diameter of 100 mm and a force of about 10 to 30 kg is applied, the partition sealing portion 13 is opened. Is appropriate.

  In addition, contour lines 21 a and 21 b extending along the peripheral edges of the storage chambers 9 and 11 are printed on one surface of the container body 5. The contour lines 21a and 21b are preferably formed with a width of 1 to 10 mm in order to facilitate visual recognition. Moreover, it is preferable to be colored in a color different from other indications on the surface of the container body, such as component indication (not shown). Further, a pair of partition lines 19 is printed at a position along the partition sealing portion 13 in the container body 5, and a display for prompting opening “here is opened” is printed on the partition sealing portion 13. Has been. Needless to say, a sentence other than this may be used as long as the display prompts opening.

  Next, the usage method of the medical multi-chamber container comprised as mentioned above is demonstrated. In order to administer the medicine in the multi-chamber container 1 to the patient, first, either the first storage chamber 9 or the second storage chamber 11 is pressed. As the pressing position, the central portion of any of the storage chambers or the position from the central portion to the partition sealing portion 13 is most appropriate, but the positions of the storage chambers 9 and 11 are indicated by the contour lines 21a and 21b. Since it can be visually recognized easily, the pressed position can be easily grasped. Thus, when one of the storage chambers is pressed, the pressure in the storage chamber increases, the partition sealing portion 13 is opened, and the storage chambers 9 and 11 communicate with each other. As a result, the medicines in the storage chambers 9 and 11 are mixed. Subsequently, when a puncture needle (not shown) having a conduit (not shown) connected to the rubber stopper of the medicine discharge section 7 is inserted, the mixed drug solution is administered to the patient via the conduit.

  As described above, according to the present embodiment, since the contour lines 21a and 21b extending along the peripheral edges of the storage chambers 9 and 11 are printed on the surface of the container body 5, the container body 5 is transparent. However, it can be easily recognized that the container is a multi-chamber container having two storage chambers, and the positions of the storage chambers 9 and 11 can be easily visually confirmed. Thereby, an appropriate pressing position, that is, a position near the center of the storage chambers 9 and 11 and a position close to the partition sealing portion 13 can be easily grasped, and forgetting to open is prevented and operability at the time of opening is improved. be able to. Furthermore, since the partition line 19 is printed along the partition sealing portion 13, the position of the partition sealing portion 13 can be easily recognized, and an appropriate pressing position can be determined based on this. it can.

  As mentioned above, although one Embodiment of this invention was described, this invention is not limited to this, A various change is possible unless it deviates from the meaning. For example, although the storage chambers 9 and 11 are arranged in the vertical direction of the container body 5 in the above embodiment, they can be arranged in the horizontal direction as shown in FIG. In this case, the outlines 21 a and 21 b may be formed along the storage chambers 9 and 11. Further, the contour line 21 may be formed along the inner side of the peripheral edge of the storage chamber as described above, or along the outer side of the peripheral edge of the storage chamber like the contour line 21a of the first storage chamber 9 shown in FIG. It can also be formed.

  Furthermore, the contour line 21 does not necessarily have to be exactly along the periphery of the storage chambers 9 and 11, and as shown in FIG. Contour lines 21a and 21b may be formed so as to form closed regions (for example, a polygonal shape, a circular shape, an elliptical shape, etc.) at opposing positions inside the periphery. At this time, the contour line 21 does not necessarily need to be constituted by a continuous closed line, and may be a partly discontinuous line. For example, as shown in FIG. 4, in the outline 21 b of the second storage chamber 11, the part corresponding to the medicine discharge part 7 can be made discontinuous. Moreover, as shown in the figure, the partition line 19 which shows the position of the sealing part 13 for partitions can also be formed on the sealing part 13 for partitions.

  Further, as shown in FIG. 5, for example, a small container 23 filled with a vitamin preparation is stored in the first storage chamber 9, and this is fixed to the opposing inner wall surface of the container body 5 by heat fusion. It can also be left. The small container 23 has two chambers partitioned by a sealing portion 23 a having the same configuration as the partition sealing portion 13. With this configuration, the small container 23 is pulled and broken with the separation of the inner wall surfaces of the storage chamber 9 when the partition sealing portion 13 is opened, and the medicine in the small container 23 is stored in each of the storage chambers 9 and 11. Mixed with drugs. Such a multi-chamber container can be used mainly for high-calorie infusion (IVH) for central intravenous administration. In this case, if the outline 21c of the small container 19 is formed in the container main body 5 in addition to the outline 21 of the storage chambers 9 and 11, it is easy to visually recognize that the container is a multi-chamber container having small containers. Can do. In addition, although FIG. 5 showed the multi-chamber type thing comprised from several chambers as the small container 23, even if it consists of one room | chamber, it can implement similarly.

  An example of such a small container consisting of one chamber is shown in FIG. The small container 23 shown in FIG. 6 has its peripheral edge heat-sealed to form a single chamber, and its peripheral edge is heat-sealed to the opposing inner wall surface of the container body 5. And the outline 21c is formed in the outer periphery of the small container 23, and the part which cross | intersects the outline 21c of the small container 23 in the outline 21a of the 1st storage chamber 9 is made discontinuous. Moreover, the partition line 19 which shows the position of the partition sealing part 13 can be formed in the boundary part of the partition sealing part 13 and the 2nd storage chamber 11, as shown in FIG.

  Furthermore, as shown in FIG. 7, a discharge restricting sealing portion 25 can be provided between the second storage chamber 11 and the discharge portion 7. Similar to the partition sealing portion 13, the discharge regulation sealing portion 25 is obtained by heat-sealing the inner wall surfaces of the container body 5, and partitions the second storage chamber 11 and the discharge portion 7. . The following effects can be obtained by the discharge restricting sealing portion 25. That is, before opening the partition sealing part 13, even if an attempt is made to take out the medicine from the discharge part 7, the second storage chamber 11 and the discharge part 7 are blocked by the discharge restriction sealing part 25. Therefore, discharge of the medicine can be prevented. Therefore, it is possible to reliably prevent the medicine before mixing from being discharged. When such a discharge restricting sealing portion 25 is provided, the partition line 27 can be printed or a display for prompting the opening of the discharge restricting sealing portion 25 can be provided in the same manner as the partition sealing portion 13. . Thereby, it can be visually recognized more reliably that the discharge restricting sealing portion 25 is formed.

  In the present invention, the line type of the contour line 21 is not particularly limited, and may be various line types such as a continuous line, a wavy line, a wavy line, and a one-dot chain line. Also, the color may be composed of one color or a combination of two or more colors. Furthermore, in the said embodiment, although the outline 21 is formed by printing, it can also form by sticking a seal | sticker to the container main body 5. FIG. Moreover, the outline 21 may be provided in the peripheral part of all the storage chambers as mentioned above, and can also be provided with respect to any one storage chamber. However, it is advantageous to provide contour lines in all the storage chambers because the pressing position can be appropriately selected.

  In the said embodiment, since the container main body 5 is comprised with the transparent film, even if it prints the outline 21 on one side of the container main body 5, the outline 21 can be visually recognized from both surfaces, For example, when the container main body 5 is comprised with the colored film, it is preferable to provide an outline on both surfaces.

  Moreover, although the said embodiment demonstrated the container main body which made the number of the storage chambers two, it is not limited to this, Three or more storage chambers can also be provided.

It is a top view which shows one Embodiment of the medical multiple chamber container which concerns on this invention. It is a top view which shows the other example of the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of the medical multi-chamber container which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 5 Container main body 9,11 Storage chamber 13 Partition sealing part 19 Partition line 21 Contour line

Claims (8)

A container body having a plurality of storage chambers for storing medicines and a partition sealing portion for partitioning the storage chambers; and a discharge portion attached to the container body and capable of discharging the medicines from the storage chamber. A medical multi-chamber container in which the plurality of storage chambers communicate with each other by opening a stopper when used,
A medical multi-chamber container, wherein the container body is provided with a contour line that extends along an inner periphery of at least one of the storage chambers and is colored by printing . The medical multi-chamber container according to claim 1, wherein the contour line is provided so as to form a closed region including a partially discontinuous portion or a continuous closed region. The medical container according to claim 1 or 2, wherein the container body further includes a pair of partition lines printed along both sides of the partition sealing portion. The medical multi-chamber container according to any one of claims 1 to 3, wherein the container body is provided with the contour line for all the storage chambers. The medical multi-chamber container according to any one of claims 1 to 4, wherein the container main body is provided with a display for prompting opening of the partition sealing portion. The medical multi-chamber container according to any one of claims 1 to 5 , wherein the contour line is colored in a color different from other indications provided on the container body. A small container disposed in at least one of the storage chambers and storing a medicine;
The medical multi-chamber container according to any one of claims 1 to 6, wherein a contour line surrounding a periphery of the small container is formed in the container body. The container body is formed into a flat shape composed of a first surface and a second surface by a plastic film,
The partition sealing portion is configured by heat-sealing inner wall surfaces of the first surface and the second surface,
The medical multi-chamber container according to any one of claims 1 to 7 , wherein the contour line is provided on at least one of the first surface and the second surface.

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