CN102202979A - Light blocking container with content viewing window and contrast background - Google Patents

Light blocking container with content viewing window and contrast background Download PDF

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Publication number
CN102202979A
CN102202979A CN2009801434170A CN200980143417A CN102202979A CN 102202979 A CN102202979 A CN 102202979A CN 2009801434170 A CN2009801434170 A CN 2009801434170A CN 200980143417 A CN200980143417 A CN 200980143417A CN 102202979 A CN102202979 A CN 102202979A
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CN
China
Prior art keywords
container
composite
observation window
wall
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801434170A
Other languages
Chinese (zh)
Inventor
R·L·伯格
M·L·图里尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN102202979A publication Critical patent/CN102202979A/en
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/54—Inspection openings or windows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0207—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by material, e.g. composition, physical features
    • B65D1/0215—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by material, e.g. composition, physical features multilayered
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/02—Linings or internal coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/08—Coverings or external coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2201/00—Means or constructions for testing or controlling the contents

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)

Abstract

Several embodiments of the invention provide a container (10) for housing a composition comprising at least one active pharmaceutical agent, the container including an interior (60) for housing the composition and a viewing window (30) allowing the user to view the interior region from the outside of the container. In some embodiments, the container is a multi-layered wall. In other aspects, the container (200) includes a main body portion (210) and a base portion (230), the base portion having a tapered bottom (235), and the main body portion having a viewing window (220) to allow viewing of the interior of the container from the outside thereof.

Description

Have the content observation window and set off by contrast the light blocking container of background
Technical field
The present invention relates to be used to accommodate the container of composite, for example comprise the container of the composite of active agents (APA) etc.
Background technology
Comprise and have active agents the some drugs product of composite (composition) of (for example liquid or powder type) can be stored in transparent, colourless container or the opaque containers.The content that the user of drug products wishes to observe internal tank to be determining surplus, and whether also surplus enough composite to distribute a dosage.A lot of active agents (APA) are accommodated in the coloured glass container, perhaps in the plastic opaque container, have certain difficulty the level of the APA compound (compound) that this holds in the user determines it.This especially becomes problem when the composite that comprises APA is light color or colourless liquid, this light color or colourless liquid can be difficult to see in being accommodated in colourless container the time.
The composite that will comprise APA is stored in light color or the colourless container and also can impacts photosensitive APA, and photosensitive APA must be maintained under certain exposure levels, to prevent degraded or undesirable reaction.Especially, some composite that contains APA can reduce effectiveness after being exposed to from the ultraviolet ray of light, increase catabolite, even completely lose effectiveness.For this composite, it is housed in that to avoid exposing with shielding APA in the container be important.
A kind of container need be provided, and it allows user effectively and observe the content of the composite that contains APA exactly, and has held this composite of protection under the situation of the phtotoactive APA of containing composite therein.
Summary of the invention
Of the present invention several aspect in, a kind of container that is used to accommodate composite is provided, described composite comprises at least a active agents, described container comprises: accommodate the described inside that comprises the composite of at least a active agents; Wall of container with inside face and outside face, wherein, described inside face and described internal communication; And extend through described wall of container to allow examining described in-to-in observation window from described container appearances; Wherein, described wall of container comprises colorant limiting background in described inside, when described background limits and observes by described observation window to the backcloth that sets off by contrast of described composite.Described composite can be light color or colourless liquid.Described composite can comprise at least a active agents, for example momestasone furoate (as momestasone furoate monohydrate or anhydrous momestasone furoate), budesonide, montelukast, oxymetazoline, azelastine, furancarboxylic acid fluticasone, FLUTICASONE PROPIONATE and combination or officinal salt.
At least a material that described outside face can comprise titanium and/or select from the group of being made up of high density polyethylene (HDPE), polypropylene, polyester, cyclic olefine copolymer and combination thereof.Described inside face can comprise the material of selecting from the group of being made of high density polyethylene (HDPE), polypropylene, polyester, cyclic olefine copolymer and combination thereof.Described window can comprise the material of selecting from the group of being made of polyethylene, cyclic olefine copolymer and combination thereof.The material that is particularly useful for window is a cyclic olefine copolymer.
Other embodiment provide a kind of container that is used to accommodate composite, and described composite comprises at least a active agents, and described container comprises: interior zone, and it comprises main part and the bottom with tapered inner surface; And the observation window that extends to described main part top from described main part bottom, described observation window allows the user to observe described interior zone, wherein, described main part comprises colorant limiting background in described interior zone, when described background limits and observes by described observation window to the backcloth that sets off by contrast of described composite.
Another embodiment provides a kind of drug products, and it comprises: the composite that comprises at least a active agents; Accommodate the inside of described composite; Wall of container with inside face and outside face, wherein said inside face and described internal communication; And extend through described wall of container to allow examining described in-to-in observation window from described container appearances; Wherein, described wall of container comprises colorant limiting background in described inside, when described background limits and observes by described observation window to the backcloth that sets off by contrast of described composite.Described composite can be light color or colourless liquid, and it can comprise at least a photosensitive activity medicament, for example momestasone furoate (as momestasone furoate monohydrate or anhydrous momestasone furoate), budesonide, montelukast, oxymetazoline, azelastine, furancarboxylic acid fluticasone, FLUTICASONE PROPIONATE and combination or officinal salt.Described at least a photosensitive activity medicament can be momestasone furoate (as the momestasone furoate monohydrate), montelukast, oxymetazoline, azelastine, furancarboxylic acid fluticasone, FLUTICASONE PROPIONATE and combination or officinal salt.
Description of drawings
Fig. 1 is an embodiment of container formed according to the present invention.
Fig. 2 is the cutaway view of the container of Fig. 1.
Fig. 3 is the cutaway view according to the container of second embodiment of the invention formation.
Fig. 4 is the cutaway view according to the container with observation window of second embodiment of the invention formation.
Fig. 5 is the lateral plan according to the container of another embodiment of the present invention formation.
Fig. 6 is the cutaway view of the container of Fig. 5.
The specific embodiment
With reference to accompanying drawing, several embodiments of the present invention relate to container, and this container can be used for accommodating liquid, comprises chemical complex, particularly contain the composite of APA.The composite of any APA of containing can be housed in this container, and especially, the composite that contains APA can comprise the APA of liquid form.In addition, the composite that contains APA can comprise light color or dark compound, or the substantially transparent compound.The composite that contains APA can be photosensitive compound.As used herein, term " photosensitive " can comprise any composite that has light time reaction or degraded, and can comprise the compound that reacts when having ultraviolet ray especially.Term " photosensitive " is not limited to the compound that exists the light time to become entirely ineffective, but can comprise that the exposure back only reacts and/or lose the compound of validity slightly.
Said composition can be light color or colourless liquid, and it can comprise at least a active agents, for example momestasone furoate (as momestasone furoate monohydrate or anhydrous momestasone furoate), budesonide, montelukast, oxymetazoline, azelastine, furancarboxylic acid fluticasone, FLUTICASONE PROPIONATE and combination or officinal salt.The applicable various embodiment of the present invention of photosensitive compound include but not limited to, the momestasone furoate monohydrate of being sold by the Schering Corporation of Kenilworth of New Jersey under trade mark NASONEX.Another example of photosensitive compound is the oxymetazoline of being sold by the Schering Corporation of Kenilworth of New Jersey under trade mark AFRIN.Another example of photosensitive compound is the furancarboxylic acid fluticasone of being sold by GlaxoSmithKline under trade mark VERAMYST.
Container described here can be used for only storing the composite that contains APA, and perhaps it can unite use with delivery system.This delivery system comprises dropper, sparger and syringe etc.Container described here is specially adapted to unite use with the nose equipment of making up a prescription, but is appreciated that this container can be any kind or shapes of containers, includes but not limited to the nose equipment that makes up a prescription.Such nose dispenser is being known in the art.The example of this dispenser is in for example US Patent 4,274,560,4,944,429 and 5,433, and shown in 343, its whole disclosures are incorporated herein by reference.
With reference to Fig. 1, provide a kind of container 10 that is designed to accommodate the composite that contains APA within it.The composite that contains APA can be coloured or it can be colourless.In several embodiment, the composite that contains APA is light color or basic colourless liquid composite.This container 10 can be Any shape, comprises cylindricality, box-shaped, irregular or any other intended shape.Container 10 comprises wall of container 20, the zone in its formation can be contained in composite.Wall of container 20 can be made by any desired material, comprises glass or polymeric material.The suitable material that is used for wall of container 20 comprises high density polyethylene (HDPE) (HDPE), polypropylene, polyester (for example PET, PETg), COC and other similar material.Usually, need employing to provide good moisture resistance to keep acceptable penetrating level and non-friable material simultaneously.Wall of container 20 can be formed by the polymeric material of for example HDPE.
Container 10 comprises top 40 and bottom 50.Wall of container 20 can form the part that separates or can form single-piece with bottom 50.Wish container 10 be fluid not saturating with the safety of guaranteeing to be contained in APA composite wherein and effectively.The inside of hope wall of container 20 is set to coloured, is set to opaque better.Wall of container 20 can comprise that one or more colorants or opacifier are with the coloured or opaque outward appearance of the in-to-in that container 10 is set.The inside of wall of container 20 can be with its in the composite that contains APA that held form the color set off by contrast.It is to be enough to any color of distinguishing mutually with the compound that contains APA that term " sets off by contrast " inside that is interpreted as wall of container 20.For example, the composite that contains APA can be a light color or colourless, and the inside of wall of container 20 can be dark.Alternatively, the compound that contains APA can be dark, and the inside of wall of container 20 is light color or colourless.As used herein, term " dark color " needn't refer to black or similar color.Term " dark color " is meant the darker color of in-to-in color than APA composite or wall of container 20.For the APA composite of color slightly, the inside of container 10 can be any darker color, for example, is pale red or brown when needing, and vice versa.The compound that no matter contains APA is a light color or dark, and the inside of wall of container 20 and APA composite should form setting off by contrast on the color.
Wall of container 20 comprises at least one observation window 30 that extends to about top area 40 from about bottom section 50.Observation window 30 substantially transparents, and the whole thickness that extends through wall of container 20 is to allow the content from visual observation container 10.Observation window 30 can have enough length to allow to observe the top surface that is housed in the composite that contains APA in container 10 inside 60.Wall of container 20 and observation window 30 can be made or they can be made from a variety of materials by same material.For example, observation window 30 can be made by single or multiple lift cyclic olefine copolymer (COC), HDPE, COC, polypropylene or its combination.In one embodiment, observation window 30 is multi-ply constructions, and it comprises the material more than one deck.In other embodiments, observation window can be made by having the COC that coats molded pet layer.
Wall of container 20 and observation window 30 can common molded to together or the part that can be used as two separation be attached at together.In a specific embodiment, wall of container 20 can comprise shell of being made by three layers of HDPE and the observation window of being made by COC 30.In this embodiment, used material can natural combination together.In another embodiment, wall of container 20 can cover with opaque label, and described label has the opening portion that forms watch window 30.In other embodiments, wall of container 20 can comprise multi-layer H DPE, has the penetrating polypropylene strips that forms observation window 30.
As shown in Figure 2, container 10 comprises the wall of container 20 with inside face 25 and outside face 26.Container 10 comprises the interior zone 60 of accommodating the APA composite.Container 10 also comprises the observation window 30 integrally formed with wall of container 20, the whole thickness of described observation window 30 extensible wall of container 20 (that is, from inside face 25 to outside face 26).When the inside face 25 of wall of container 20 was opaque, the user still can observe the inside 60 of containers 10 by observation window 30.
In this embodiment in conjunction with observation window 30, the inside face 25 of wall of container 20 can be to set off by contrast painted and/or opaque wall, and it stops that the light of real mass enters the inside 60 of container 10.As explained above, the inside face of wall of container 20 25 be housed in APA composite in inner 60 and should on color, form and set off by contrast.The inside face 25 of wall of container 20 can comprise one or more colorants or opacifier, to form setting off by contrast or opaque inside face 25 of wall of container 20.In addition, wall of container 20 can comprise that one or more UV protective agent materials hold within it the composite that contains APA with further protection.As needs, the outside face 26 of wall of container 20 can comprise mark or other marks that identifies the material that holds in it.
Produced screening effect in the inside 60 of container 10 in conjunction with setting off by contrast painted and/or opaque inside face 25, when seeing through observation window 30 and observe, described effect has increased the observability of APA composite.This permission user more clearly checks the APA composite in the inside 60 that is housed in container 10, and determines whether that more accurately enough composites to distribute a dosage, still should obtain more.Observation window 30 can have the width of essence less than wall of container 20 overall circumferences.Especially, the width of observation window 30 should be less than 5% of wall of container 20 girths.
The composite that contains APA of being accommodated in container 10 is among the embodiment of photosensitive composition, has found that just not having excessive light enters container 10 as long as observation window 30 relative containers 10 are small size and thickness.Overall dimensions of observation window 30 (width, highly, thickness) and intrinsic material thereof influence observation window 30 from the ability of transmitted light wherein.The effect that may not can significantly or nocuously reduces this photosensitive composition for the low-level exposure of photosensitive composition.
The inside face 25 of wall of container 20 and observation window 30 can contact with the composite that contains APA in the container 10.Like this, wish these parts by making, and especially should damage the pollutants of APA composite without any meeting with the material of the composite compatibility that contains APA.As needs, container 10 can comprise the inside face 25 of covering container wall 20 and/or one or more layers lining of observation window 30.
With reference to Fig. 3, show an embodiment of the container that comprises that compound wall is arranged.For example when used colorant or opacifier may pollute or otherwise damage the APA composite that holds in it, it may be useful that these many wall cloths are put.In this embodiment, container 110 is set, described container 110 has multilayer and also protects content not contaminated simultaneously with the observation that allows to strengthen the APA composite.Container 110 can have two-layer at least, or three layers.Container 110 comprises ground floor 112, the second layer 114, and optional the 3rd layer 116.Can be as needs in conjunction with more multi-layered.Ground floor 112 is positioned to the inside 118 near container 110, and the second layer 114 is positioned at from farther position, the inside 118 of container 110.Container 110 can be Any shape, comprises the shape of cylindricality, box-shaped, irregular shape or any other expectation.Container 110 comprises the interior zone 118 that is configured to accommodate the composite that contains APA.Inner 118(and accommodate within it the composite that contains APA) can adjoin with the inside face 111 of ground floor 112 and contact.Therefore, the inside face 111 of ground floor 112 should be made by the material to the composite inertia that contains APA.
In one embodiment, enough transparent the seeing through from it with permission of ground floor 112 observed, and made by the inert material that can not pollute the composite that contains APA.Embodiment is the same as previously discussed, and ground floor 112 can be made by plastics, glass or any other expectation material.The material that is suitable for ground floor 112 comprises HDPE, COC, polypropylene, PET and combination thereof.Because ground floor 112 contacts with the composite that contains APA, it does not comprise that preferably any possible potentially contaminated accommodates the material of the composite that contains APA within it.The second layer 114 can comprise anti-optical element, and can be made by plastics or other materials.Embodiment is the same as previously discussed, and the second layer 114 can be made by plastics, glass or other any desired materials.The material that is suitable for the second layer 114 comprises HDPE, COC, polypropylene, PET and combination thereof.The second layer 114 can comprise anti-luminescent material, such as colorant or UV protective agent material.In several embodiment, the second layer 114 is to set off by contrast painted layer and/or opaque layer, and it limits light substantially and enters in the inside 118 of container.As mentioned above, the term color of " setting off by contrast " composite in the inside 118 that is meant and is housed in container 110 forms the color of setting off by contrast.The second layer 114 comprises inside face 115 and outside face 117.The inside face 115 of the second layer 114 contacts with the outside face 113 of ground floor 112.
Container can be individual layer and can be dark, to provide for holding setting off by contrast of within it composite.
At last, if desired, container 110 can comprise optional the 3rd layer 116.Can make by any desired material for optional the 3rd layer 116, and make by plastic material in one embodiment, such as HDPE, COC, polypropylene, PET and combination thereof.Optional the 3rd layer 116 comprises inside face 119 and outside face 121.The 3rd layer 116 inside face 119 contacts with the outside face 117 of the second layer 114.The 3rd layer 116 outside face 121 is exposed to outside the container 110.Although the 3rd layer 116 preferably transparent, the 3rd layer 116 also can comprise or not comprise anti-luminescent material or colorant according to user's preferences.Any layer in three layers (comprise ground floor 112, the second layer 114 and optional the 3rd layer 116) can be any color or have any opaque level.In several embodiment, at least one in 112,114,116 of layer with will accommodate within it APA composite and form and enough set off by contrast and/or opaque to form the effect of setting off by contrast described above.
Described layer (comprise ground floor 112, the second layer 114 and optional the 3rd layer 116) can form through any desired technology.In one embodiment, layer 112,114,116 is made of plastics and forms according to above-mentioned layout co-extruded.In this mode, the ground floor 112 that contacts with the composite that contains APA is avoided possible the soaking into (leach-through) with the colorant materials of the second layer 114 formation.In another embodiment, various layers can form respectively, are applied to each other then.For example, in a kind of manufacturing process, can form ground floor 112 earlier, then the second layer 114 is applied to the outside face 113 of ground floor 112.Similarly, as needs, optional the 3rd layer of 116 outside face 117 that can be applied to the second layer 114 subsequently.Can adopt any method so that apply various layers.For example, the second layer 114 can be used as the outside face 113 that paste is applied to ground floor 112, and perhaps it can be used as sticker and is applied on the outside face 113 of ground floor 112.Similarly, can be used as the outside face 117 that paste or sticker are applied to the second layer 114 for the 3rd layer 116.In this mode, again, ground floor 112 is avoided possible the soaking into of the anti-luminescent material of the second layer 114.
As described in Figure 4, multi-walled container 110 can comprise narrow observation window 120, and it extends through every layer 112,114 of container 110, at least a portion of 116, and allows the user to observe inner 118 from the outside.As mentioned above, observation window 120 allows screening effects, makes the user more clear and observe light contents in inner 118 more accurately.Observation window 120 can be integrally formed with layer 112,114,116, and perhaps observation window 120 can be the part that separates and be assembled in the container 110.Observation window 120 can be made by any material.In one embodiment, observation window 120 is made by polymeric material, such as HDPE, COC, polypropylene, PET and combination thereof.The inside face 122 of observation window 120 can contact with inner 118, thereby and can contact with the composite that contains APA that holds in it.Therefore, for avoiding polluting the composite that contains APA, observation window 120 should be made by inert material, and perhaps it should not have pollutants.
In various embodiments, observation window 120 extends through each layer of container, makes it allow the user to observe inner 118 by the outside.Observation window 120 can be Any shape or design, comprises linear, circular, box-shaped, curve, irregular shape or allows to see through any other intended shape that observation window 120 is observed.It is desirable for observation window 120 and be positioned at position, thereby the user can observe the low-level of any content of holding in the container 110 near container 110 bottoms.Observation window 120 can have enough length to allow to observe the end face of the composite that contains APA in the inside 118 that is housed in container 110.Under the situation that can observe the composite end face that contains APA, can effectively assess the amount of the composite that contains APA.Because container 110 comprises observation window 120, the user can be exposed to the content of observation container 110 under the situation of the potential objectionable constituent container 110 outside at the composite that needn't open container 110 and will contain APA.
In this embodiment in conjunction with observation window, any layer (comprise ground floor 112, the second layer 114 and/or the 3rd layer 116) can be the dyed layer that sets off by contrast as previously discussed, and described layer stops that the light of real mass enters the inside 118 of container 110.The second layer 114 can be and sets off by contrast painted and/or opaque layer.The second layer 114 can be opaque, thereby stops that all light pass it.The second layer 114 can comprise one or more colorants or opacifier, the second layer 114 that set off by contrast with formation or opaque.In addition, the second layer 114 can comprise the composite that contains APA that one or more UV protective agent materials hold in it with further protection.
As mentioned above, set off by contrast painted or opaque layer and combining of observation window 120 and produced shade in the inside 118 of container 110, described shade has increased the composite that contains APA that holds in it observability through transparent windows 120.This allows the user to be more clearly visible the inside 118 of container 110, and determines whether more accurately whether the composite of enough colourless or light APA of containing is used for distribution, perhaps should obtain more.
Container 110 can comprise one or more UV protective agent materials on the surface that is applied in three layers 112,114,116 any layer.When the composite that contains APA of accommodating in the container 110 was photosensitive composition, the use of UV protective agent material may be useful.UV protective agent material can at any time be applied to surface 112,114,116, and can apply with any desired form, comprises sprinkling, extruding, dipping, applies or other similar approach.
Invention in this explanation can also comprise access openings and/or delivery system.This embodiment both can be used in the single wall design of above explanation, also can be used in many wall designs of above explanation.Just to illustrative purposes,, also can be used for above-described one-wall vessel 10 but should understand embodiment described here with reference to multi-walled container 110.Container 110 can comprise access openings, and it is provided to the visit of the inside 118 of inner casing 110.Access openings normally is covered, unless make the user physically handle container 110 removing the composite that contains APA, otherwise can not remove the composite that contains APA.
At an embodiment, as above explanation make up a prescription (for example, nose dispenser) thereby or instillation mechanism can be fixed to container 110 via access openings visit inner 118.In this structure, may there be the nose dispenser that is communicated with the inside 118 of container 110.This dispenser can be configured to and will contain dosage 118 nasal cavities of releasing the access customer of going forward side by side internally of the composite of APA.Dispenser and container 110 are defined for jointly liquid dosages are dispensed into equipment in user's nasal cavity.In other embodiments, container 110 can comprise that lid or other mechanisms seal (for example, sealing access openings) to allow the user with the inside 118 of container 110.
In certain embodiments, container 110 can use in conjunction with two component systems.For example, system can comprise a plurality of shells, and wherein, container 110 of the present invention forms inner casing, thereby accommodates the composite that contains APA, and has the shell of separation around inner casing.
In another embodiment, container has the bottom of convergent to reduce the amount of APA surplus.Describe as Fig. 5 and Fig. 6, a kind of container 200 is provided, it has and is designed for the inside 215 of accommodating the composite 240 that contains APA.The composite 240 that contains APA can be a liquid form, is such as other such forms of powder but also can conceive.Container 200 comprises main part 210 and base portion 230.Main part 210 can be made maybe and can be made from a variety of materials with base portion 230 by same material, its can comprise can with any material of the composite that contains APA 240 compatibilities of accommodating in it.Main part 210 can be made by polymeric material with base portion 230, such as HDPE, and COC, PET, polypropylene and combination thereof.Main part 210 can be painted with base portion 230 or they can be colourless.In one embodiment, main part 210 and base portion 230 be with its in the composite color of accommodating form the color of setting off by contrast, and can be opaque.The same with container described above, container 200 can comprise the mark of expression content of accommodating in it on its main body.
Main part 210 and base portion 230 can be used as the one-piece molded unit and are formed together, or the moulded parts that they can be used as separation forms and is assembled together.As the skilled person will appreciate, consider the parts of every part of container 200, main part 210 is formed as the part that separates with base portion 230 can provide tangible manufacturing advantage.Main part 210 can be attached to by any means known with base portion 230, comprises by ultrasonic welding, mechanical attachment, bonding or other expectation means.When being assembled together, main part 210 forms one bonded assembly containers 200 with base portion 230, described container 200 be fluid not saturating securely and effectively to accommodate the composite that contains APA 240 of accommodating in it.
Main part 210 comprises visible observation window 220, and it allows user to observe content in the inside 215 of container 200.Observation window 220 can be the form of vertical bar, but also can conceive other geometric construction, comprises avette, piece shape and other expectation figure.Observation window 220 can be positioned on the either side of main part 210, comprises forward and backward or the side.As needs, can there be observation window 220 to be positioned on the main part 210 more than one.It is desirable for observation window 220 is thin relatively sizes, to allow to observe the content in the container 200, allows main part 210 to form the major part of container 200 bodies simultaneously.In one embodiment, the rugosity of observation window 220 is less than about 5% of the girth of container 200 bodies.Observation window 220 can have any desired length, and in one embodiment, and observation window begins in position that base portion 230 combines with main part 210 or near this position.Observation window 220 can have sufficient length, its extend in main part 210 the top or near.In one embodiment, container 200 bodies comprise label or the sticker that is applied to outside face, and this label is enough opaque or set off by contrast paintedly, and comprises the part of observation window 220 as label.
In a specific embodiment, as can be as can be seen from Figure 6, base portion 230 comprises convergent bottom 235.Convergent bottom 235 can be extended to the greatest extent towards inner 215 requiredly.Convergent bottom 235 can roughly extend to the zone of base portion 230 and main part 210 combinations.The composite 240 that contains APA is housed in the inside 215 of container 200, and further is accommodated in by in 235 zones that form, the convergent of base portion 230 bottom.
After the user had believed container 200 skies, the composite 240 that the convergent of base portion 230 bottom 235 contains APA in minimizing may be stayed aspect the excess quantity in the container 200 useful.This being configured in when the delivery system (not shown) is attached to container 200 is particularly useful, and particularly useful when delivery system comprises the sprinkling annex.In representative type spray bottle structure, delivery system comprises the flexible pipe that extends in the container.This flexible pipe can not remove the composite of staying the container bottommost usually effectively.Under the situation of typical construction, this bottom is flat, and it stays bulk zone so that stay for excessive composite.In some instances, found in this representative type container that the remaining not remaining set compound of usefulness is enough distributed nearly 8-10 agent.
On the contrary, under the situation of convergent of the present invention bottom 235, base area 230 provides the zone of much less in the inside 215 of container 200, therefore reduces the remaining amount that contains the composite 240 of APA in the container 200 of back of using significantly.In fact, determined in the container 200 that the remaining set compound 240 of usefulness does not provide enough about 2-4 agent usually.Here the wastage that therefore invention that provides will contain the composite 240 of APA reduces to about 25% of prior art equipment.In addition, observation window 220 can be configured to only to extend to the top of convergent bottom 235, so the user do not know a small amount of composite 240 that is left, and therefore can not attempt to provide medicament when the level of composite 240 is not high enough to arrive delivery system.
Provided explanation in order to explain to the embodiment of the invention with illustrative purposes.They are not intended to is exhaustive or limits the invention to disclosed exact form, considers that above-mentioned instruction obviously has many modifications and variations.

Claims (22)

1. container that is used to accommodate composite, described composite comprises at least a active agents, described container comprises:
A. accommodate the described inside that comprises the composite of at least a active agents;
B. the wall of container that has inside face and outside face, wherein, described inside face and described internal communication; And
C. extend through described wall of container to allow examining described in-to-in observation window from described container appearances;
Wherein, described wall of container comprises colorant limiting background in described inside, when described background limits and observes by described observation window to the backcloth that sets off by contrast of described composite.
2. container as claimed in claim 1, wherein, described container comprises plastic material.
3. container as claimed in claim 1, wherein, described wall of container is opaque.
4. container as claimed in claim 1, wherein, described colorant is dark.
5. container as claimed in claim 1, wherein, described colorant is an opacifier.
6. container as claimed in claim 1 also comprises UV protective agent material.
7. container as claimed in claim 1 comprises being attached to described container and the spraying mechanism that described in-to-in is visited being provided.
8. container as claimed in claim 1, wherein, described wall of container comprises ground floor that forms described inside face and the second layer that forms described second surface.
9. container as claimed in claim 8, wherein, the described second layer comprises described colorant.
10. container as claimed in claim 8 also comprises the 3rd layer, described the 3rd layer of outside face that is applied to the described second layer.
11. container as claimed in claim 1, wherein, described observation window does not have colorant substantially.
12. container as claimed in claim 1, wherein, described outside face comprises titanium.
13. container as claimed in claim 1, wherein, described outside face comprises at least a material of selecting from the group of being made up of high density polyethylene (HDPE), polypropylene, polyester, cyclic olefine copolymer and combination thereof.
14. container as claimed in claim 1, wherein, described inside face comprises the material of selecting from the group of being made up of high density polyethylene (HDPE), polypropylene, polyester, cyclic olefine copolymer and combination thereof.
15. container as claimed in claim 1, wherein, described window comprises the material of selecting from the group of being made up of polyethylene, cyclic olefine copolymer and combination thereof.
16. container as claimed in claim 1, wherein, described window is a cyclic olefine copolymer.
17. a container that is used to accommodate composite, described composite comprises at least a active agents, and described container comprises:
A. interior zone, it comprises:
I. main part; With
Ii. the bottom that has tapered inner surface; And
B. extend to the observation window at the top of described main part from the bottom of described main part, described observation window allows the user to observe described interior zone,
Wherein, described main part comprises colorant limiting background in described interior zone, when described background limits and observes by described observation window to the backcloth that sets off by contrast of described composite.
18. container as claimed in claim 17 comprises being attached to described container and the spraying mechanism that described in-to-in is visited being provided.
19. a drug products comprises:
A. the composite that comprises at least a active agents;
B. accommodate the inside of described composite;
C. the wall of container that has inside face and outside face, wherein, described inside face and described internal communication; And
D. extend through described wall of container to allow examining described in-to-in observation window from described container appearances;
Wherein, described wall of container comprises colorant limiting background in described inside, when described background limits and observes by described observation window to the backcloth that sets off by contrast of described composite.
20. drug products as claimed in claim 19, wherein, described composite is light color or colourless liquid.
21. drug products as claimed in claim 19, wherein, described composite comprises at least a photosensitive activity medicament.
22. drug products as claimed in claim 19, wherein, described at least a photosensitive medicament is selected from the group of being made up of momestasone furoate monohydrate, oxymetazoline, azelastine, furancarboxylic acid fluticasone, FLUTICASONE PROPIONATE and combination thereof.
CN2009801434170A 2008-11-03 2009-11-03 Light blocking container with content viewing window and contrast background Pending CN102202979A (en)

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US11089908P 2008-11-03 2008-11-03
US61/110899 2008-11-03
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AU (1) AU2009319963A1 (en)
CA (1) CA2741364A1 (en)
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WO2016058124A1 (en) * 2014-10-14 2016-04-21 The Procter & Gamble Company Dispensing article having piston with indicium

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JP2012510931A (en) 2012-05-17
CA2741364A1 (en) 2010-06-03
AU2009319963A1 (en) 2010-06-03
EP2352678A1 (en) 2011-08-10
US20120024742A1 (en) 2012-02-02
AR074266A1 (en) 2011-01-05
WO2010062741A8 (en) 2011-01-06
WO2010062741A1 (en) 2010-06-03
TW201032793A (en) 2010-09-16

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Application publication date: 20110928