JP2010046483A - 生検マーカー送達装置 - Google Patents
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Abstract
【課題】生検部位に生検マーカーを送達するための生検装置を提供する。
【解決手段】生検装置は、カニューレ１２の遠位端部２２に配された単一の末端部を有するマーカー配備器具を含み得る。遠位末端部は、成型された部品であり得、遠位先端部、マーカー配備ランプ２１０、およびマーカー係合要素２４０を含んでおり、このマーカー係合要素は、マーカー３００が配備されようとするまで、カニューレ１２内にマーカー３００を維持するのを助ける。
【選択図】図２
【解決手段】生検装置は、カニューレ１２の遠位端部２２に配された単一の末端部を有するマーカー配備器具を含み得る。遠位末端部は、成型された部品であり得、遠位先端部、マーカー配備ランプ２１０、およびマーカー係合要素２４０を含んでおり、このマーカー係合要素は、マーカー３００が配備されようとするまで、カニューレ１２内にマーカー３００を維持するのを助ける。
【選択図】図２
Description
〔背景〕
生検標本は、様々な医療処置において様々な仕方で、様々な装置を使用して入手されてきた。生検装置の例は、オハイオ州シンシナティのEthicon Endo-Surgery社のMAMMOTOME（登録商標）という銘柄の装置である。生検装置は、定位ガイド（stereotactic guidance）、超音波ガイド、MRIガイドなどのもとで使用されてよい。
生検標本は、様々な医療処置において様々な仕方で、様々な装置を使用して入手されてきた。生検装置の例は、オハイオ州シンシナティのEthicon Endo-Surgery社のMAMMOTOME（登録商標）という銘柄の装置である。生検装置は、定位ガイド（stereotactic guidance）、超音波ガイド、MRIガイドなどのもとで使用されてよい。
さらなる例示的な生検装置は、「Method and Apparatus for Automated Biopsy and Collection of Soft Tissue」と題する1996年6月18日発行の米国特許第5,526,822号、「Control Apparatus for an Automated Surgical Biopsy Device」と題する2000年7月11日発行の米国特許第6,086,544号、「MRI Compatible Surgical Biopsy Device」と題する2003年6月12日公開の米国特許公開第2003/0109803号、「Remote Thumbwheel for a Surgical Biopsy Device」と題する2007年5月24日公開の米国特許公開第2007/0118048号、「Biopsy System」と題する2006年12月13日出願の米国仮特許出願第60/869,736号、「Biopsy Sample Storage」と題する2006年12月13日出願の米国仮特許出願第60/874,792号、および、「Revolving Tissue Sample Holder for Biopsy Device」と題する2007年11月21日出願の米国特許出願第11/942,785号に、開示されている。上記に引用した米国特許、米国特許出願公開、米国仮特許出願、および米国特許出願の各々の開示内容は、参照によって本明細書に組み込まれる。
いくつかの状況では、生検部位の場所を、将来的な参照のために標識することが望ましい場合がある。例えば、組織標本が生検部位から採取される前、最中、または、採取された後に、１つ以上のマーカーが、生検部位に沈着されてよい。例示的なマーカー配備用具には、オハイオ州シンシナティのEthicon End-Surgery社のMAMMOMARK（登録商標）、MICROMARK（登録商標）、およびCORMARK（登録商標）という銘柄の装置が含まれる。生検部位の標識のためのさらなる例示的な装置および方法は、「Marker Device and Method of Deploying a Cavity Marker Using a Surgical Biopsy Device」と題する2005年10月13日公開の米国特許公開第2005/0228311号、「Imageable Biopsy Site Marker」と題する2006年2月7日発行の米国特許第6,996,433号、「Tissue Site Markers for In Vivo Imaging」と題する2006年1月31日発行の米国特許第6,993,375号、「Tissue Site Markers for In Vivo Imaging」と題する2006年5月16日発行の米国特許第7,047,063号、「Methods for Marking a Biopsy Site」と題する2007年6月12日発行の米国特許第7,229,417号、「Devices for Defining and Marking Tissue」と題する2006年5月16日発行の米国特許第7,044,957号、「Devices for Marking and Defining Particular Locations in Body Tissue」と題する2001年5月8日発行の米国特許第6,228,055号、および、「Subcutaneous Cavity Marking Device and Method」と題する2002年4月16日発行の米国特許第6,371,904号に、開示されている。上記に引用した米国特許および米国特許出願公開の各々の開示内容は、参照によって本明細書に組み込まれる。
カニューレタイプの配備器具から生検部位へとマーカーを配備することが望ましい場合がある。マーカーは、配備器具から不用意に外れてはならず、マーカーを配備するための力は、過剰であってはならない。
本発明は、添付の図面と合わせて考慮される、以下における、ある例の説明から、より適切に理解されるであろうと確信される。図面における同一の参照符号は、同じ要素を特定している。
〔詳細な説明〕
以下における本発明のある例の説明は、本発明の範囲を限定するために使用されるべきではない。本発明の他の例、特徴、態様、実施形態および利点が、以下の説明から、当業者には明らかとなるだろう。以下の説明は、例証としての、本発明を実施するために意図される最適な様態のうちの１つである。認識されるであろうように、本発明は、全て本発明を逸脱することなしに、他の異なる明白な態様が可能である。したがって、図面および説明は、例証的な性質のものであり、制限的なものではないとみなされるべきである。
以下における本発明のある例の説明は、本発明の範囲を限定するために使用されるべきではない。本発明の他の例、特徴、態様、実施形態および利点が、以下の説明から、当業者には明らかとなるだろう。以下の説明は、例証としての、本発明を実施するために意図される最適な様態のうちの１つである。認識されるであろうように、本発明は、全て本発明を逸脱することなしに、他の異なる明白な態様が可能である。したがって、図面および説明は、例証的な性質のものであり、制限的なものではないとみなされるべきである。
図１は、細長い外側カニューレ１２を含むマーカー送達装置１０を図示しており、この細長い外側カニューレ１２は、カニューレ１２の遠位端部の近くに形成されているもののカニューレ１２の遠位端部から近位側に離間した、側部開口１４などのマーカー出口を有する。
グリップ１６が、カニューレ１２の近位端部に提供され得る。プッシュロッド１８が提供され得、このプッシュロッド１８は、カニューレ１２内を同軸的に延び、よって、プッシュロッド１８は、カニューレ１２の内部を並進移動して側部開口１４を通して１つ以上のマーカーを転置するよう構成される（図２を参照）。ロッド１８は、マーカーをカニューレ１２の内腔から開口１４を通して押し出すために十分な圧縮剛性（rigidity in compression）を有し得るが、湾曲に関して相対的に可撓性であり得る。カニューレ１２内でロッド１８を遠位側に押しやるために、プランジャー２０がロッド１８の近位端部に提供されて、マーカーをカニューレ１２の外に配備することができる。
ユーザーは、２本の指でグリップ１６を握ってよく、同じ手の親指を使用してプランジャー２０を押してよく、よって、マーカー送達装置１０は、ユーザーの一方の手で作動され得る。バネ（不図示）または他の特徴部がロッド１８の周りに提供されて、グリップ１６およびカニューレ１２に対して近位側にロッド１８を付勢してよい。
図２は、本発明の一実施形態によるマーカー送達装置１０の遠位部の断面図を表す。図２は、カニューレ１２の内腔１５内に配された生検マーカー３００を示す。マーカー３００は、概して円筒形状のコラーゲン本体など、生物分解可能な、または別様に吸収可能な本体３０６、および、本体３０６の内部に配されるか、または別様に本体３０６によって保持される金属性の、概して放射線不透過性のマーカー要素３１０（透視図で示す）、を具備し得る。
カニューレ１２は、いかなる適する金属材料または非金属材料で形成することもできる。一実施形態では、カニューレ１２は、適する医療用プラスチックまたはポリマーで形成された薄壁中空チューブで形成される。適する一材料は、例えばPEBAXという商品名で知られるポリエーテルブロックアミド（PEBA）などの熱可塑性エラストマーである。カニューレ１２は、PEBAXで形成され得、可視光線およびｘ線に対して実質的に透明であり得る。
側部開口１４は、カニューレ１２の壁の一部を切り取ることによって形成され得る。側部開口１４は、カニューレの内腔１５と連絡している。側部開口１４は、図２に図示されるように、近位開口端部１４Ａから遠位開口端部１４Ｂへと、軸方向に（腔１５の軸に平行な方向に）延び得る。
カニューレ１２の遠位端部から延びる遠位先端部２２は、図２に示されるように、丸くされ得る。図２を参照すると、本発明のマーカー送達装置は、カニューレ１２の遠位端部の所定の位置に形成された単一の末端部２１によって閉じられる、カニューレ１２の遠位端部を有し得、末端部２１の一部分は、カニューレの内腔１５の中に延びている。遠位末端部２１は、成型または鋳造された部品であり得、先端部２２、ランプ面２１２を有するランプ２１０、およびマーカー係合要素２４０の一体型に形成された組み合わせを提供し得る。ランプ面２１２は、マーカー３００を内腔１５から側部開口１４を通り抜けるように方向付けるのを助ける。マーカー係合要素２４０は、ユーザーがマーカーを配備しようとするまで、マーカー３００を内腔１５内に維持するのに役立つ。
マーカー係合要素２４０は、内腔１５の内部に配され、マーカー係合要素の少なくとも一部は、側部開口１４の近位端部１４Ａの遠位側に配される。マーカー係合要素２４０は、開口１４の下のカニューレ１５の床の一部に沿って延び得、マーカー係合要素２４０は、開口１４が形成されているカニューレの一部を補強するよう位置付けられ得る。例えば、図２に示されるように、開口１４の真下にマーカー係合要素２４０を位置付けることによって、要素２４０は、カニューレ１２の壁が開口１４を形成するために切断されている領域で、カニューレ１２を強化するのに役立ち得る。
図２に示される実施形態では、マーカー係合要素２４０は、ランプ面２１２の最近位部から延び、側部開口１４の近位側には延びないが、他の実施形態では、要素２４０の一部が、開口１４の近位側に延び得る。
図２に示される実施形態では、マーカー係合要素２４０は、要素の軸方向長さに沿って、概して一定の厚さＴを有する段の形態であるが、例外として、要素は、先細状の近位端部２４２を有する。先細状の近位端部２４２は、腔１５の長さ方向軸に対して約４５°の夾角（図２の平行線に対する夾角）を形成し得、一方、ランプ面２１２は、長さ方向軸に対して約３０°の夾角を形成し得る。
厚さＴは、カニューレ１２の壁厚ｔより厚くすることができ、一実施形態では、Ｔは厚さｔの少なくとも約２倍である。一実施形態では、厚さＴは、約０．０１８インチ〜約０．０４０インチ（約０．４５７ｍｍ〜約１．０１６ｍｍ）であり得、壁厚ｔは、約０．００５インチ〜約０．００８インチ（約０．１２７ｍｍ〜約０．２０３ｍｍ）であり得る。腔１５の内径は、約０．１２０インチ（３．０４８ｍｍ）であり得る。
図２の実施形態では、マーカー係合要素２４０の上向き面２４４（開口１４に向いた面）は、遠位側に延びてランプ面２１２に接し、よって、面２４４とランプ面２１２との間には空間も間隙もない。このような配列は、マーカー３００が、マーカー係合要素を過ぎて動く際に、マーカー係合要素とランプとの間でつかえるかもしれない可能性を削減するのに有利である。
本発明の一実施形態によると、マーカー係合要素２４０、ランプ２１０、および／または先端部２２は、カニューレ１２の壁より相対的に放射線不透過性が高い材料で形成され得るか、またはそのような材料を含み得る。例えば、要素２４０、ランプ２１０、および先端部２２が、一体型の末端部２１として形成される場合、末端部２１は、硫酸バリウムなど放射線不透過性添加剤を含み得る。例えば、末端部２１は、溶融したPEBAX成型組成物に添加された硫酸バリウムを約２０重量％だけ備える、PEBAXで成型された部品であり得る。
相対的に放射線不透過性が高いマーカー係合要素２４０、ランプ２１０、および先端部２２は、レントゲン撮影法を使用してこれらの部品の位置を識別するのに有用であり得る。また、ランプおよび／または係合要素の段が、開口１４に関連して位置付けられている場合、放射線不透過性材料の添加は、マーカー配備の前、最中、または後に、開口の位置、および開口に対するマーカー３００の位置を特定するのに役立ち得る。
図面では、腔１５に配された１つのみのマーカーが示されている。しかしながら、複数のマーカーが、端と端をつないだ構成などで、マーカー送達装置１０に配され得ることが理解されるだろう。マーカーは、同じサイズおよび形状を有するか、または代替的に、異なるサイズおよび／または形状を有し得る。
カニューレ１５は、可視光線およびｘ線に対して、概して透明であり得、末端部２１は、可視光線およびｘ線に対して、概して不透明であり得る。所望される場合、末端部２１は、液体成型組成物中の染料または他の適する着色料で着色され得る。例えば、異なる生検処置のために、異なるサイズのマーカー（例えば長さおよび／または直径）を有することが望ましい場合がある。例えば、相対的に大きな生検標本が採取される場合は大きなマーカーを、また、相対的に小さな生検標本が採取される場合は小さなマーカーを提供することが望ましい場合がある。末端部２１は、カニューレに配されるマーカーのサイズを表示するために複数の色のうちの１つを使用して着色され得る。例えば、３つのマーカーサイズが提供される場合、末端部２１は、３つの色のうちの１つで着色され得、特定のマーカー装置のカニューレにどのマーカーサイズが配されるかを特定することができる。末端部２１はまた、マーカー送達装置で使用されるべき、特定のサイズ（直径または長さ）の生検針を表示するために着色され得る。加えて、複数のマーカー送達装置が、キットの形態で梱包され得、キットには、異なるサイズのマーカーと、対応する着色された末端部とを有するマーカー送達装置が含まれる。
図３を参照すると、マーカー送達装置１０は、患者の内部の特定の場所を標識するようマーカーを配備するために使用されてよい。図３には、カニューレ生検針１０００が示されている。針１０００は、穿通先端部１００２を備えた閉じた遠位端部、および、側方組織受容孔１０１４を有して、示されている。マーカー配備器具１０は、生検針１０００を通って生検部位に導入されてよく、この生検針は、生検部位から組織標本を採集するのに使用されるものと同じ針であり得る。生検針１０００は、一回の挿入で、複数の標本を得る、真空補助生検装置（single insertion, multiple sample vacuum assisted biopsy devices）で使用されるタイプのものであり得る。いくつかのこのような生検装置は、参照されかつ参照によって本明細書に組み込まれる、様々な特許および特許出願で開示されているが、他の生検装置が使用されてもよい。
図３は、針１０００の内部に配されたマーカー配備器具１０の遠位端部を示している。針１０００は組織に位置付けられ得、生検標本が開口１０１４を通して入手され得、それによって、開口１０１４に隣接した生検空洞をもたらす。次に、組織標本が入手されて針を通して近位側に移送された後、針１０００を患者の組織から除去することなく、配備器具１０が針１０００の近位開口の中に挿入され得る。図３では、針１０００および配備器具１０は、カニューレ１２の開口１４および針１０００の開口１０１４が実質的に軸方向および円周方向に整列するように、位置付けられている。次に、配備器具および針が生検部位でそのように位置付けられた状態で、プッシュロッド１８が前進させられて、マーカーを、ランプ面２１２の上方、開口１４、次いで開口１０１４を通して、生検空洞の中に配備することができる。
図４〜図６は、マーカー送達装置１０と共に使用され得る放射線不透過性マーカー要素の説明を提供する。図４は、チタンなどの放射線不透過性材料の概して平坦なブランク（blank）３１０Ａを図示しており、この平坦なブランク３１０Ａは、第１の相対的に大きな部分３１２、第２の相対的に大きな部分３１４、ならびに、第１の部分３１２および第２の部分３１４を接続する相対的に狭い部分３１６を有するように、切断され得るか、または別様に形成され得る。ブランク３１０Ａは、第１の側部３１５および第２の側部３１７を有し得る。
部分３１２および３１４は、概して円形の突出部（lobe）として示されているが、正方形、長方形、三角形、楕円形など他の形状も用いられ得る。３次元マーカー要素３１０（図２に示される生物吸収可能（bioresorbable）な本体３０６内に位置付けられ得るような）を形成するために、２つの突出部３１２および３１４は、図５の矢印によって表示されるように、軸３１８の周りで反対の方向にねじられ得る。２つの突出部３１２および３１４は、それらの間の角度３１９（図６に見られるような）が、約４５°〜約１３５°となるように、ねじられ得る。結果として生じる３次元放射線不透過性マーカー要素３１０は、図６に示されるように、端部で見たときに、概してｘ形状の構成を有することになる。概して平坦な部分３１２および３１４は、互いに対して面外に（out of plane）ねじられるので、部分３１２および３１４は、ｘ線を含む様々な撮影方法において、様々な方向（例えば、上、底、横、端部）からより容易に見られることができる。図５および図６に示される３次元マーカー要素３１０は、次に、生物吸収可能な本体３０６（図２）の中に挿入されるか、または、別様に本体３０６によって保持されて、吸収可能な本体および放射線不透過性マーカー要素を有するマーカー３００を提供することができる。
図７は、カニューレ１２の遠位端部の単一の末端部２１を射出成型するために使用され得る組立体を図示している。組立体は、鋳型空洞４０２０を有する鋳型部分４０００を含み得、この鋳型空洞４０２０は、図２の丸くされた、概して半球形の先端部２１に対応する、丸くされた面４０２１を含む。カニューレ１２は、図７に示されるように、空洞４０２０内に位置付けられ得る。概して円筒形の外側面を有する成型コア部品５０００が、図７に示されるように、カニューレ１２の内腔の内部に位置付けられ得る。部品５０００は、端部面５２１２、５２４４、および５２４２を有し得、これらはそれぞれ、ランプ面２１２、段面２４４、および先細状端部面２４２に対応する。PEBAXおよび放射線不透過性添加剤を具備する溶融した組成物が、次に、空洞４０２０の中に射出され得、よって、末端部２１が、カニューレ１２の遠位開口の所定の位置に形成される。
本明細書に開示される装置の実施形態は、概して、一度使用された後、廃棄されるように設計されるが、複数回使用されるように設計されることもできる。マーカーを形成し、配備器具の中にマーカーを挿入した後、生検装置は、滅菌され得る。装置は、プラスチックバッグまたはTYVEKバッグなどのパッケージ内に設置され得る。
梱包された生検装置は、次に、γ放射線、ｘ線、または高エネルギー電子などの放射線野に設置され、装置および梱包材を滅菌してよい。装置はまた、βもしくはγ放射線、酸化エチレン、または蒸気を限定することなく含めた、当業分野で既知の他のいかなる技術を使用して滅菌されてもよい。
本発明の様々な実施形態を示し説明してきたが、本明細書で説明された方法およびシステムのさらなる改作物が、本発明の範囲を逸脱することなく、当業者により適切な改変によって達成されてよい。こうした潜在的な改変のいくつかは言及されており、他の改変が当業者には明らかであろう。例えば、上記で論じられた例、実施形態、幾何学的形状、材料、寸法、比率、ステップ、および同種のものは、例証的なものであり、必須とされるわけではない。したがって、本発明の範囲は、添付の特許請求の範囲の観点から考慮されるべきであり、明細書および図面に示され説明された詳細な構造および作動に限定されるものではないことを理解されたい。
Claims (16)
- 生検マーカー送達装置において、
カニューレであって、前記カニューレの近位端部から前記カニューレの遠位端部に延びる内腔、および、前記カニューレの前記遠位端部の近位側の、前記カニューレの側壁に形成されたマーカー出口を有する、カニューレと、
前記カニューレの前記遠位端部を閉じる遠位先端部と、
前記マーカー出口に隣接して位置付けられるランプと、
前記カニューレの前記内腔の内部に配されるマーカー係合要素であって、前記マーカー係合要素の少なくとも一部が、前記マーカー出口ポートの近位端部の遠位側に配される、マーカー係合要素と、
前記カニューレの前記内腔の内部に配される少なくとも１つのマーカーと、
を具備する、装置。 - 請求項１に記載の装置において、
前記ランプおよびマーカー係合要素は、単一の部品を構成する、装置。 - 請求項１に記載の装置において、
前記ランプおよびマーカー係合要素は、前記遠位先端部と一体化している、装置。 - 請求項１に記載の装置において、
前記遠位先端部、ランプ、およびマーカー係合要素は、単一の部品を構成する、装置。 - 請求項１に記載の装置において、
前記遠位先端部、ランプ、およびマーカー係合要素は、単一の成型された部品を構成する、装置。 - 請求項１に記載の装置において、
前記カニューレは、相対的に可撓性の薄壁チューブを具備し、
前記マーカー係合要素は、前記内腔の内部に配される相対的に強固な部材を具備する、装置。 - 請求項１に記載の装置において、
前記カニューレは、壁厚ｔを有し、
前記マーカー係合要素の厚さは、ｔより厚い、装置。 - 請求項１に記載の装置において、
前記マーカー係合要素は、軸方向長さの少なくとも一部に沿って、概して一定の厚さを有する段を具備する、装置。 - 請求項８に記載の装置において、
前記マーカー係合要素は、先細状の近位端部を具備する、装置。 - 請求項１に記載の装置において、
前記遠位先端部は、相対的に前記カニューレより放射線不透過性が高い、装置。 - 請求項１０に記載の装置において、
前記遠位先端部、ランプ、および前記マーカー係合要素は、相対的に前記カニューレより放射線不透過性が高い、装置。 - 請求項１１に記載の装置において、
前記遠位先端部、ランプ、およびマーカー係合要素は、放射線不透過性材料を具備する、装置。 - 請求項１２に記載の装置において、
前記遠位先端部、ランプ、およびマーカー係合要素は、硫酸バリウムを具備する単一の成型された部品である、装置。 - 請求項１に記載の装置において、
前記マーカー係合要素は、前記マーカー出口の概しての反対側の前記内腔の床に沿って延びる、装置。 - 請求項１に記載の装置において、
前記マーカー係合要素は、前記カニューレを補強するために前記カニューレに配される、装置。 - 生検マーカー送達装置において、
カニューレであって、近位端部、遠位端部、前記近位端部から前記遠位端部に延びる内腔、および、前記カニューレの側壁に形成されたマーカー出口を有する、カニューレと、
前記カニューレの前記遠位端部に配される単一の末端部であって、
遠位先端部、
前記遠位先端部の近位側に配されるランプであって、前記マーカー出口の遠位端部から延びるランプ面を有する、ランプ、
前記ランプから近位側に延びるマーカー係合要素、
を含む、単一の末端部と、
前記カニューレの前記内腔の内部に配される少なくとも１つの生検マーカーと、
を具備する、装置。
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| US8251916B2 (en) | 2006-12-13 | 2012-08-28 | Devicor Medical Products, Inc. | Revolving tissue sample holder for biopsy device |
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2008
- 2008-08-22 US US12/196,301 patent/US8532747B2/en active Active
-
2009
- 2009-07-31 AU AU2009203189A patent/AU2009203189B2/en not_active Ceased
- 2009-08-20 CA CA2676035A patent/CA2676035C/en active Active
- 2009-08-21 PL PL09252037T patent/PL2156807T3/pl unknown
- 2009-08-21 CN CN200910167431.6A patent/CN101653382B/zh active Active
- 2009-08-21 CN CN201310699470.7A patent/CN103637846B/zh active Active
- 2009-08-21 JP JP2009191710A patent/JP5451251B2/ja active Active
- 2009-08-21 EP EP09252037.8A patent/EP2156807B1/en active Active
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2013
- 2013-12-25 JP JP2013266775A patent/JP2014138842A/ja active Pending
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2014
- 2014-05-14 HK HK14104533.0A patent/HK1191207A1/zh not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007069105A2 (en) * | 2005-12-16 | 2007-06-21 | Suros Surgical Systems, Inc. | Biopsy site marker deployment device |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014519950A (ja) * | 2011-06-23 | 2014-08-21 | デビコー・メディカル・プロダクツ・インコーポレイテッド | 生検装置のための導入器 |
| JP2016518871A (ja) * | 2013-03-15 | 2016-06-30 | デビコー・メディカル・プロダクツ・インコーポレイテッドＤｅｖｉｃｏｒ Ｍｅｄｉｃａｌ Ｐｒｏｄｕｃｔｓ， Ｉｎｃ． | 生検部位マーカーアプライヤー |
| US10874841B2 (en) | 2013-03-15 | 2020-12-29 | Devicor Medical Products, Inc. | Biopsy site marker applier |
| JP2017534370A (ja) * | 2014-10-08 | 2017-11-24 | デヴィコア メディカル プロダクツ, インク.Devicor Medical Products, Inc. | 生検マーカー及び生検マーカー製造方法 |
| US10492884B2 (en) | 2014-10-08 | 2019-12-03 | Devicor Medical Products, Inc. | Biopsy marker |
| US11123151B2 (en) | 2014-10-08 | 2021-09-21 | Devicor Medical Products, Inc. | Biopsy marker |
| JP2017538564A (ja) * | 2014-11-06 | 2017-12-28 | ディヴァコア メディカル プロダクツ， インコーポレイテッドＤｅｖｉｃｏｒ Ｍｅｄｉｃａｌ Ｐｒｏｄｕｃｔｓ， Ｉｎｃ． | スプリング射出バイオマーカー |
Also Published As
| Publication number | Publication date |
|---|---|
| US8532747B2 (en) | 2013-09-10 |
| AU2009203189A1 (en) | 2010-03-11 |
| EP2156807A3 (en) | 2012-01-04 |
| JP2014138842A (ja) | 2014-07-31 |
| CN103637846A (zh) | 2014-03-19 |
| HK1191207A1 (zh) | 2014-07-25 |
| CN101653382A (zh) | 2010-02-24 |
| US20100049084A1 (en) | 2010-02-25 |
| EP2156807B1 (en) | 2017-01-04 |
| PL2156807T3 (pl) | 2017-07-31 |
| CA2676035C (en) | 2017-07-18 |
| CN103637846B (zh) | 2016-08-17 |
| JP5451251B2 (ja) | 2014-03-26 |
| CN101653382B (zh) | 2014-01-22 |
| CA2676035A1 (en) | 2010-02-22 |
| AU2009203189B2 (en) | 2015-07-02 |
| EP2156807A2 (en) | 2010-02-24 |
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