JP2009544758A5 - - Google Patents
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- Publication number
- JP2009544758A5 JP2009544758A5 JP2009522956A JP2009522956A JP2009544758A5 JP 2009544758 A5 JP2009544758 A5 JP 2009544758A5 JP 2009522956 A JP2009522956 A JP 2009522956A JP 2009522956 A JP2009522956 A JP 2009522956A JP 2009544758 A5 JP2009544758 A5 JP 2009544758A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- disease
- salt
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CCOC([C@](CC(CC1)N(C)C(C)C)C1N(CC[C@@]1*)C1=O)=O Chemical compound CCOC([C@](CC(CC1)N(C)C(C)C)C1N(CC[C@@]1*)C1=O)=O 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83423506P | 2006-07-28 | 2006-07-28 | |
| US89602607P | 2007-03-21 | 2007-03-21 | |
| US11/782,704 US7671062B2 (en) | 2006-07-28 | 2007-07-25 | Modulators of chemokine receptor activity, crystalline forms and process |
| PCT/US2007/074438 WO2008014381A2 (en) | 2006-07-28 | 2007-07-26 | Modulators of chemokine receptor activity, crystalline forms and process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544758A JP2009544758A (ja) | 2009-12-17 |
| JP2009544758A5 true JP2009544758A5 (https=) | 2010-08-12 |
Family
ID=38823540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522956A Withdrawn JP2009544758A (ja) | 2006-07-28 | 2007-07-26 | ケモカイン受容体活性のモジュレーター、結晶形および方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7671062B2 (https=) |
| EP (2) | EP2049477B1 (https=) |
| JP (1) | JP2009544758A (https=) |
| KR (1) | KR20090035036A (https=) |
| CN (1) | CN101511822A (https=) |
| AR (1) | AR062114A1 (https=) |
| AT (1) | ATE471928T1 (https=) |
| AU (1) | AU2007279256A1 (https=) |
| BR (1) | BRPI0715066A2 (https=) |
| CA (1) | CA2659259A1 (https=) |
| CL (3) | CL2007002195A1 (https=) |
| CO (1) | CO6190527A2 (https=) |
| CY (1) | CY1110785T1 (https=) |
| DE (1) | DE602007007335D1 (https=) |
| DK (1) | DK2049477T3 (https=) |
| EA (1) | EA014960B1 (https=) |
| ES (1) | ES2346591T3 (https=) |
| HR (1) | HRP20100371T1 (https=) |
| IL (1) | IL196518A0 (https=) |
| MX (1) | MX2009000803A (https=) |
| NO (1) | NO20090256L (https=) |
| NZ (1) | NZ574656A (https=) |
| PE (1) | PE20080838A1 (https=) |
| PL (1) | PL2049477T3 (https=) |
| PT (1) | PT2049477E (https=) |
| SG (1) | SG158925A1 (https=) |
| SI (1) | SI2049477T1 (https=) |
| TW (1) | TW200823203A (https=) |
| WO (1) | WO2008014381A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687508B2 (en) * | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US8383812B2 (en) * | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| DK3297438T3 (da) * | 2015-05-21 | 2022-01-17 | Chemocentryx Inc | Ccr2-modulatorer |
| DK3655395T3 (da) * | 2017-07-20 | 2022-03-07 | Bristol Myers Squibb Co | Fremgangsmåde til fremstilling af n-((1r,2s,sr)-5-(tert-butylamino)-2-((s)-3-(7- tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1- yl)cyclohexyl)acetamid |
| CA3293051A1 (en) | 2017-09-25 | 2026-03-02 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
| CN112105353B (zh) | 2018-01-08 | 2024-04-19 | 凯莫森特里克斯股份有限公司 | Ccr2拮抗剂治疗实体瘤的方法 |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN115494184B (zh) * | 2022-05-09 | 2023-07-28 | 浙江海正药业股份有限公司 | 一种同时检测药物中异丙苯磺酸甲酯、异丙苯磺酸乙酯的方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6383082A (ja) | 1986-09-26 | 1988-04-13 | Takeda Chem Ind Ltd | テトラヒドロフランカルボン酸誘導体の製造法 |
| CA2084800A1 (en) | 1991-12-16 | 1993-06-17 | Joseph P. Vacca | Hiv protease inhibitors with an internal lactam ring |
| GB9515411D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | N-(4-substituted-benzyl)-2-aminolactam derivatives |
| US5827875A (en) | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| UA51716C2 (uk) | 1996-07-08 | 2002-12-16 | Авентіс Фармасьютікалз Продактс Інк. | Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування |
| US6054579A (en) | 1997-06-26 | 2000-04-25 | Leukosite, Inc. | Synthesis of substituted lactams |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| TR200002182T2 (tr) | 1998-01-27 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | İkame edilmiş aksozaherosayklil faktör xa inhibitörleri |
| US6492553B1 (en) | 1998-01-29 | 2002-12-10 | Aventis Pharamaceuticals Inc. | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds |
| DE69940191D1 (de) | 1998-01-29 | 2009-02-12 | Aventis Pharma Inc | VERFAHREN ZUR HERSTELLUNG EINER N-i(ALIPHATHISCH ODER AROMATISCH)CARBONYL -2-AMINOACETAMID-VERBINDUNG UND EINER CYCLISCHEN VERBINDUNG |
| GB9803228D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| US6541208B1 (en) | 1998-03-17 | 2003-04-01 | University Of Maryland Biotechnology Institute | Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia |
| AU7354900A (en) | 1999-09-09 | 2001-04-10 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6620823B2 (en) | 2000-07-11 | 2003-09-16 | Bristol-Myers Squibb Pharme Company | Lactam metalloprotease inhibitors |
| US6706712B2 (en) | 2000-12-20 | 2004-03-16 | Bristol-Myers Squibb Pharma Company | Cyclic derivatives as modulators of chemokine receptor activity |
| WO2002050019A2 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Co. | Diamines as modulators of chemokine receptor activity |
| DE60209471D1 (de) | 2001-03-29 | 2006-04-27 | Topo Target As Copenhagen Koeb | Succinimid- und maleimidderivate und ihre verwendung als katalytische inhibitoren der topoisomerase ii |
| GB0114867D0 (en) | 2001-06-18 | 2001-08-08 | Merck Sharp & Dohme | Therapeutic agents |
| DE10135043A1 (de) | 2001-07-11 | 2003-01-30 | Bayer Cropscience Gmbh | Substituierte 3-Heteroaryl(amino- oder oxy)-pyrrolidin-2-one, Verfahren zu deren Herstellung und Verwendung als Herbizide oder als Pflanzenwachstumsregulatoren |
| WO2003075853A2 (en) | 2002-03-08 | 2003-09-18 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| WO2004022536A1 (en) | 2002-09-04 | 2004-03-18 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| US7338975B2 (en) | 2003-02-12 | 2008-03-04 | Bristol-Myers Squibb Co. | Lactams as modulators of chemokine receptor activity |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| WO2004110376A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Ccr-2 antagonists for treatment of neuropathic pain |
| US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7863317B2 (en) | 2003-08-21 | 2011-01-04 | Bristol-Myers Squibb Company | Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity |
| US7317019B2 (en) | 2003-08-21 | 2008-01-08 | Bristol Myers Squibb Co. | N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity |
| US20050043392A1 (en) | 2003-08-21 | 2005-02-24 | Carter Percy H. | Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| MX2007001204A (es) | 2004-07-30 | 2007-03-23 | Pfizer Prod Inc | Procedimientos para tratar las enfermedades o trastornos mediados por ccr2. |
| CN101065374A (zh) | 2004-09-28 | 2007-10-31 | 詹森药业有限公司 | 取代的二哌啶化学引诱物细胞因子受体2拮抗剂 |
-
2007
- 2007-07-25 US US11/782,704 patent/US7671062B2/en active Active
- 2007-07-26 PT PT07799831T patent/PT2049477E/pt unknown
- 2007-07-26 CN CNA2007800327628A patent/CN101511822A/zh active Pending
- 2007-07-26 EP EP07799831A patent/EP2049477B1/en not_active Not-in-force
- 2007-07-26 MX MX2009000803A patent/MX2009000803A/es active IP Right Grant
- 2007-07-26 CL CL200702195A patent/CL2007002195A1/es unknown
- 2007-07-26 WO PCT/US2007/074438 patent/WO2008014381A2/en not_active Ceased
- 2007-07-26 ES ES07799831T patent/ES2346591T3/es active Active
- 2007-07-26 SG SG201000704-5A patent/SG158925A1/en unknown
- 2007-07-26 HR HR20100371T patent/HRP20100371T1/hr unknown
- 2007-07-26 SI SI200730305T patent/SI2049477T1/sl unknown
- 2007-07-26 PE PE2007000968A patent/PE20080838A1/es not_active Application Discontinuation
- 2007-07-26 TW TW096127306A patent/TW200823203A/zh unknown
- 2007-07-26 DE DE602007007335T patent/DE602007007335D1/de active Active
- 2007-07-26 EA EA200900244A patent/EA014960B1/ru not_active IP Right Cessation
- 2007-07-26 CL CL200702194A patent/CL2007002194A1/es unknown
- 2007-07-26 DK DK07799831.8T patent/DK2049477T3/da active
- 2007-07-26 EP EP10001344A patent/EP2184283A1/en not_active Withdrawn
- 2007-07-26 NZ NZ574656A patent/NZ574656A/en not_active IP Right Cessation
- 2007-07-26 CL CL200702196A patent/CL2007002196A1/es unknown
- 2007-07-26 AR ARP070103321A patent/AR062114A1/es not_active Application Discontinuation
- 2007-07-26 JP JP2009522956A patent/JP2009544758A/ja not_active Withdrawn
- 2007-07-26 PL PL07799831T patent/PL2049477T3/pl unknown
- 2007-07-26 BR BRPI0715066-0A patent/BRPI0715066A2/pt not_active IP Right Cessation
- 2007-07-26 KR KR1020097004327A patent/KR20090035036A/ko not_active Withdrawn
- 2007-07-26 AU AU2007279256A patent/AU2007279256A1/en not_active Abandoned
- 2007-07-26 AT AT07799831T patent/ATE471928T1/de active
- 2007-07-26 CA CA002659259A patent/CA2659259A1/en not_active Abandoned
-
2009
- 2009-01-15 IL IL196518A patent/IL196518A0/en unknown
- 2009-01-16 NO NO20090256A patent/NO20090256L/no not_active Application Discontinuation
- 2009-01-27 CO CO09007271A patent/CO6190527A2/es not_active Application Discontinuation
-
2010
- 2010-09-22 CY CY20101100852T patent/CY1110785T1/el unknown
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