JP2009544718A - タンパク質の繊維性封入体または凝集体の細胞内形成に関連する疾患を処置するための接着タンパク質からのペプチドをディスプレイするファージの使用 - Google Patents

タンパク質の繊維性封入体または凝集体の細胞内形成に関連する疾患を処置するための接着タンパク質からのペプチドをディスプレイするファージの使用 Download PDF

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JP2009544718A
JP2009544718A JP2009521907A JP2009521907A JP2009544718A JP 2009544718 A JP2009544718 A JP 2009544718A JP 2009521907 A JP2009521907 A JP 2009521907A JP 2009521907 A JP2009521907 A JP 2009521907A JP 2009544718 A JP2009544718 A JP 2009544718A
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cell adhesion
sequence
filamentous bacteriophage
phage
rgd
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ジェラティ,エリン・ディー
ソロモン,ベカ
シャロン,ノア
グリンシュタイン,オーデッド
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ラモット・アット・テルアビブ・ユニバーシティ
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    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
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    • C12N2795/00011Details
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    • C12N2810/00Vectors comprising a targeting moiety
    • C12N2810/40Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C12N2810/405Vectors comprising RGD peptide

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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2009521907A 2006-07-21 2007-07-19 タンパク質の繊維性封入体または凝集体の細胞内形成に関連する疾患を処置するための接着タンパク質からのペプチドをディスプレイするファージの使用 Pending JP2009544718A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83222906P 2006-07-21 2006-07-21
PCT/US2007/073858 WO2008011503A2 (en) 2006-07-21 2007-07-19 Use of a phage displaying a peptide from an adhesion protein for treating a disease associated with intracellular formation of protein fibrillar inclusions or aggregates

Publications (2)

Publication Number Publication Date
JP2009544718A true JP2009544718A (ja) 2009-12-17
JP2009544718A5 JP2009544718A5 (https=) 2010-07-29

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JP2009521907A Pending JP2009544718A (ja) 2006-07-21 2007-07-19 タンパク質の繊維性封入体または凝集体の細胞内形成に関連する疾患を処置するための接着タンパク質からのペプチドをディスプレイするファージの使用

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Country Link
US (1) US20090324554A1 (https=)
EP (1) EP2054515B1 (https=)
JP (1) JP2009544718A (https=)
CN (1) CN101553567A (https=)
AT (1) ATE541038T1 (https=)
AU (1) AU2007275258A1 (https=)
CA (1) CA2659032A1 (https=)
WO (1) WO2008011503A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009072578A1 (ja) * 2007-12-04 2011-04-28 サッポロビール株式会社 骨吸収抑制剤
JP2015532290A (ja) * 2012-10-02 2015-11-09 ニューロファージ ファーマシューティカルズ, インコーポレイテッド アミロイド結合剤としてのバクテリオファージ融合タンパク質のp3の使用
JP2023545156A (ja) * 2020-10-07 2023-10-26 テイタム・バイオサイエンス・インコーポレイテッド がんの処置における合成バクテリオファージを分泌する生きたバイオ治療薬

Families Citing this family (13)

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WO2009143470A1 (en) 2008-05-22 2009-11-26 Ramot At Tel Aviv University Ltd. Method for treating disease characterized by plaque
RU2011125971A (ru) * 2008-11-24 2012-12-27 Рамот Эт Тель-Авив Юниверсити Лтд. Способ лечения болезни паркинсона
BR112013023040A2 (pt) * 2011-03-11 2018-10-23 Univ Ramot bacteriófago filamentoso, composição farmacêutica, e, métodos para reduzir a formação de fibrilas de proteína tau ou para desagregar fibrilas pré-formadas de proteína tau em um paciente, e para tratar uma tauopatia degenerativa.
AU2012242455A1 (en) * 2011-04-15 2013-11-28 Molecular Transfer, Inc. Agents for improved delivery of nucleic acids to eukaryotic cells
WO2013016644A1 (en) 2011-07-27 2013-01-31 Neurophage Pharmaceuticals, Inc. Process for the production of filamentous bacteriophage
WO2013022717A1 (en) 2011-08-05 2013-02-14 Neurophage Pharmaceuticals, Inc. Pure filamentous bacteriophage and methods of producing same
CN114748605A (zh) 2011-11-29 2022-07-15 普罗克拉拉生物科学股份有限公司 噬菌体基因3蛋白组合物及作为淀粉样蛋白结合剂的用途
KR20160010618A (ko) 2013-05-28 2016-01-27 뉴로페이지 파마슈티컬즈, 인크. 감소된 면역원성을 갖는 개질된 박테리오파아지 g3p 아미노산 서열을 포함하는 폴리펩티드
CN104258372B (zh) * 2014-09-25 2017-01-25 中山大学 Rgd三肽在制备治疗阿尔茨海默症药物中的用途
PL3227313T3 (pl) 2014-12-03 2022-05-09 Proclara Biosciences, Inc. Polipeptydy zawierające zmodyfikowaną sekwencję aminokwasową bakteriofaga g3p pozbawioną sygnału glikozylacji
CN106800590B (zh) * 2015-11-25 2021-04-09 杭州智鹤丹谷生物医药有限公司 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用
WO2018215831A2 (en) * 2017-05-22 2018-11-29 National Hellenic Research Foundation Macrocyclic modulators of disease associated protein misfolding and aggregation
EP3684784B1 (en) * 2017-09-20 2024-03-27 Council of Scientific and Industrial Research Potent peptide inhibitors of protein aggregation

Citations (1)

* Cited by examiner, † Cited by third party
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JP2003509020A (ja) * 1999-09-03 2003-03-11 ラモット・ユニバーシティ・オーソリティ・フォー・アプライド・リサーチ・アンド・インダストリアル・ディベロップメント・リミテッド プラーク形成疾患の診断、治療、予防に有用な薬剤、組成物、その使用法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040013647A1 (en) * 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
CA2477675C (en) * 2002-03-05 2013-05-21 Ramot At Tel-Aviv University Ltd. Immunizing composition and method for inducing an immune response against the .beta.-secretase cleavage site of amyloid precursor protein
WO2006050041A2 (en) * 2004-10-28 2006-05-11 Ramot At Tel Aviv University Ltd. Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis
EP1853285B1 (en) * 2005-02-01 2011-03-16 Ramot at Tel-Aviv University Ltd. Method for treating inflammation associated with amyloid deposits and brain inflammation involving activated microglia
EP1863846B1 (en) * 2005-03-25 2009-07-22 Ramot at Tel-Aviv University Ltd. Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses

Patent Citations (1)

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JP2003509020A (ja) * 1999-09-03 2003-03-11 ラモット・ユニバーシティ・オーソリティ・フォー・アプライド・リサーチ・アンド・インダストリアル・ディベロップメント・リミテッド プラーク形成疾患の診断、治療、予防に有用な薬剤、組成物、その使用法

Non-Patent Citations (2)

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JPN6012053021; HART,S.L. et al: 'Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing pep' J Biol Chem Vol.269, No.17, 1994, p.12468-74 *
JPN6012053024; IVANENKOV,V. et al: 'Uptake and intracellular fate of phage display vectors in mammalian cells' Biochim Biophys Acta Vol.1448, No.3, 1999, p.450-62 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009072578A1 (ja) * 2007-12-04 2011-04-28 サッポロビール株式会社 骨吸収抑制剤
JP2015532290A (ja) * 2012-10-02 2015-11-09 ニューロファージ ファーマシューティカルズ, インコーポレイテッド アミロイド結合剤としてのバクテリオファージ融合タンパク質のp3の使用
JP2023545156A (ja) * 2020-10-07 2023-10-26 テイタム・バイオサイエンス・インコーポレイテッド がんの処置における合成バクテリオファージを分泌する生きたバイオ治療薬
JP7833455B2 (ja) 2020-10-07 2026-03-19 テイタム・バイオサイエンス・インコーポレイテッド がんの処置における合成バクテリオファージを分泌する生きたバイオ治療薬

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Publication number Publication date
WO2008011503A2 (en) 2008-01-24
US20090324554A1 (en) 2009-12-31
CN101553567A (zh) 2009-10-07
WO2008011503A3 (en) 2008-06-26
AU2007275258A1 (en) 2008-01-24
EP2054515B1 (en) 2012-01-11
EP2054515A2 (en) 2009-05-06
CA2659032A1 (en) 2008-01-24
ATE541038T1 (de) 2012-01-15

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