JP2009544708A - ビスフラニルプロテアーゼ阻害剤 - Google Patents

ビスフラニルプロテアーゼ阻害剤 Download PDF

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Publication number
JP2009544708A
JP2009544708A JP2009521811A JP2009521811A JP2009544708A JP 2009544708 A JP2009544708 A JP 2009544708A JP 2009521811 A JP2009521811 A JP 2009521811A JP 2009521811 A JP2009521811 A JP 2009521811A JP 2009544708 A JP2009544708 A JP 2009544708A
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JP
Japan
Prior art keywords
compound
alkoxy
alkylamino
alkylthio
arylamino
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JP2009521811A
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English (en)
Japanese (ja)
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JP2009544708A5 (enExample
Inventor
マノイ シー． デサイ，
クリストファー ピー． リー，
ホンタオ リュー，
サンダラモーティ スワミナタン，
リァンホン スー，
Original Assignee
ギリアード サイエンシーズ， インコーポレイテッド
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Application filed by ギリアード サイエンシーズ， インコーポレイテッド filed Critical ギリアード サイエンシーズ， インコーポレイテッド
Publication of JP2009544708A publication Critical patent/JP2009544708A/ja
Publication of JP2009544708A5 publication Critical patent/JP2009544708A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2009521811A 2006-07-24 2007-07-24 ビスフラニルプロテアーゼ阻害剤 Pending JP2009544708A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83288206P 2006-07-24 2006-07-24
PCT/US2007/016691 WO2008013834A1 (en) 2006-07-24 2007-07-24 Bisfuranyl protease inhibitors

Publications (2)

Publication Number Publication Date
JP2009544708A true JP2009544708A (ja) 2009-12-17
JP2009544708A5 JP2009544708A5 (enExample) 2010-09-09

Family

ID=38739458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009521811A Pending JP2009544708A (ja) 2006-07-24 2007-07-24 ビスフラニルプロテアーゼ阻害剤

Country Status (6)

Country Link
US (2) US20080070910A1 (enExample)
EP (1) EP2069356A1 (enExample)
JP (1) JP2009544708A (enExample)
AU (1) AU2007277253A1 (enExample)
CA (1) CA2658545A1 (enExample)
WO (1) WO2008013834A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504393A (ja) * 2013-01-09 2016-02-12 ギリアード サイエンシーズ， インコーポレイテッド ５員ヘテロアリールおよびそれらの抗ウイルス剤としての使用
JP2017515914A (ja) * 2014-05-16 2017-06-15 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｈｉｖ−１プロテアーゼ阻害剤およびその用途
JP2023518253A (ja) * 2020-03-18 2023-04-28 パーデュー・リサーチ・ファウンデーション 三環式ｐ２リガンドを含有する強力なｈｉｖプロテアーゼ阻害剤

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
FR2941696B1 (fr) 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945531A1 (fr) 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
FR2945534B1 (fr) 2009-05-12 2012-11-16 Sanofi Aventis DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2945533B1 (fr) 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
BR112012009956A2 (pt) * 2009-10-30 2015-09-29 Lupin Ltd um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula.
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
US20170253607A1 (en) * 2014-09-11 2017-09-07 Shionogi & Co., Ltd. Long-acting hiv protease inhibitor
WO2016106050A1 (en) 2014-12-26 2016-06-30 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN104910103A (zh) * 2015-04-23 2015-09-16 上海应用技术学院 一种地瑞那韦中间体的制备方法
JP2018525404A (ja) 2015-08-17 2018-09-06 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｈｉｖ−１プロテアーゼ阻害剤およびその使用
CN105439997B (zh) * 2015-11-13 2018-03-27 新疆农垦科学院 一种克百威氨基化半抗原的合成方法及应用
CN105399711B (zh) * 2015-11-13 2018-03-27 新疆农垦科学院 一种克百威羧基化半抗原的合成方法
RU2020116571A (ru) 2017-12-07 2021-11-22 Эмори Юниверсити N4-гидроксицитидин и производные и связанные с этим противовирусные применения
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
JP2003502309A (ja) * 1999-06-11 2003-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド アスパルチルプロテアーゼのインヒビター
JP2003511383A (ja) * 1999-10-06 2003-03-25 テイボテク・フアーマシユーチカルズ・リミテツド レトロウイルスのプロテアーゼインヒビターとしてのヘキサヒドロフロ［２，３−ｂ］フラン−３−イル−ｎ−｛３［（１，３−ベンゾジオキソル−５−イルスルホニル）（イソブチル）アミノ］−１−ベンジル−２−ヒドロキシプロピル｝カルバメート
JP2005523912A (ja) * 2002-04-26 2005-08-11 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積
JP2006504621A (ja) * 2002-03-12 2006-02-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728718A (en) * 1994-12-20 1998-03-17 The United States Of America As Represented By The Department Of Health And Human Services 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
PT2336134T (pt) * 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
JP2003502309A (ja) * 1999-06-11 2003-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド アスパルチルプロテアーゼのインヒビター
JP2003511383A (ja) * 1999-10-06 2003-03-25 テイボテク・フアーマシユーチカルズ・リミテツド レトロウイルスのプロテアーゼインヒビターとしてのヘキサヒドロフロ［２，３−ｂ］フラン−３−イル−ｎ−｛３［（１，３−ベンゾジオキソル−５−イルスルホニル）（イソブチル）アミノ］−１−ベンジル−２−ヒドロキシプロピル｝カルバメート
JP2006504621A (ja) * 2002-03-12 2006-02-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル
JP2005523912A (ja) * 2002-04-26 2005-08-11 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504393A (ja) * 2013-01-09 2016-02-12 ギリアード サイエンシーズ， インコーポレイテッド ５員ヘテロアリールおよびそれらの抗ウイルス剤としての使用
JP2017515914A (ja) * 2014-05-16 2017-06-15 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｈｉｖ−１プロテアーゼ阻害剤およびその用途
JP2023518253A (ja) * 2020-03-18 2023-04-28 パーデュー・リサーチ・ファウンデーション 三環式ｐ２リガンドを含有する強力なｈｉｖプロテアーゼ阻害剤
JP7702424B2 (ja) 2020-03-18 2025-07-03 パーデュー・リサーチ・ファウンデーション 三環式ｐ２リガンドを含有する強力なｈｉｖプロテアーゼ阻害剤

Also Published As

Publication number Publication date
WO2008013834A1 (en) 2008-01-31
EP2069356A1 (en) 2009-06-17
AU2007277253A1 (en) 2008-01-31
US20080070910A1 (en) 2008-03-20
CA2658545A1 (en) 2008-01-31
US20090312318A1 (en) 2009-12-17

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