JP2009544708A - ビスフラニルプロテアーゼ阻害剤 - Google Patents

ビスフラニルプロテアーゼ阻害剤 Download PDF

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Publication number
JP2009544708A
JP2009544708A JP2009521811A JP2009521811A JP2009544708A JP 2009544708 A JP2009544708 A JP 2009544708A JP 2009521811 A JP2009521811 A JP 2009521811A JP 2009521811 A JP2009521811 A JP 2009521811A JP 2009544708 A JP2009544708 A JP 2009544708A
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JP
Japan
Prior art keywords
compound
alkoxy
alkylamino
alkylthio
arylamino
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JP2009521811A
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English (en)
Japanese (ja)
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JP2009544708A5 (cg-RX-API-DMAC7.html
Inventor
マノイ シー． デサイ，
クリストファー ピー． リー，
ホンタオ リュー，
サンダラモーティ スワミナタン，
リァンホン スー，
Original Assignee
ギリアード サイエンシーズ， インコーポレイテッド
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Application filed by ギリアード サイエンシーズ， インコーポレイテッド filed Critical ギリアード サイエンシーズ， インコーポレイテッド
Publication of JP2009544708A publication Critical patent/JP2009544708A/ja
Publication of JP2009544708A5 publication Critical patent/JP2009544708A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2009521811A 2006-07-24 2007-07-24 ビスフラニルプロテアーゼ阻害剤 Pending JP2009544708A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83288206P 2006-07-24 2006-07-24
PCT/US2007/016691 WO2008013834A1 (en) 2006-07-24 2007-07-24 Bisfuranyl protease inhibitors

Publications (2)

Publication Number Publication Date
JP2009544708A true JP2009544708A (ja) 2009-12-17
JP2009544708A5 JP2009544708A5 (cg-RX-API-DMAC7.html) 2010-09-09

Family

ID=38739458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009521811A Pending JP2009544708A (ja) 2006-07-24 2007-07-24 ビスフラニルプロテアーゼ阻害剤

Country Status (6)

Country Link
US (2) US20090312318A1 (cg-RX-API-DMAC7.html)
EP (1) EP2069356A1 (cg-RX-API-DMAC7.html)
JP (1) JP2009544708A (cg-RX-API-DMAC7.html)
AU (1) AU2007277253A1 (cg-RX-API-DMAC7.html)
CA (1) CA2658545A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008013834A1 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504393A (ja) * 2013-01-09 2016-02-12 ギリアード サイエンシーズ， インコーポレイテッド ５員ヘテロアリールおよびそれらの抗ウイルス剤としての使用
JP2017515914A (ja) * 2014-05-16 2017-06-15 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｈｉｖ−１プロテアーゼ阻害剤およびその用途
JP2023518253A (ja) * 2020-03-18 2023-04-28 パーデュー・リサーチ・ファウンデーション 三環式ｐ２リガンドを含有する強力なｈｉｖプロテアーゼ阻害剤

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
FR2941696B1 (fr) 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945531A1 (fr) 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
FR2945533B1 (fr) 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945534B1 (fr) 2009-05-12 2012-11-16 Sanofi Aventis DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
EP2493891A2 (en) * 2009-10-30 2012-09-05 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
EP3192794A4 (en) * 2014-09-11 2018-06-27 Shionogi & Co., Ltd. Sustained hiv protease inhibitor
IL296496B2 (en) 2014-12-26 2024-10-01 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN104910103A (zh) * 2015-04-23 2015-09-16 上海应用技术学院 一种地瑞那韦中间体的制备方法
DK3337567T3 (da) * 2015-08-17 2021-12-06 Purdue Research Foundation Hiv-1-proteasehæmmere og anvendelser deraf
CN105439997B (zh) * 2015-11-13 2018-03-27 新疆农垦科学院 一种克百威氨基化半抗原的合成方法及应用
CN105399711B (zh) * 2015-11-13 2018-03-27 新疆农垦科学院 一种克百威羧基化半抗原的合成方法
RS66222B1 (sr) 2017-12-07 2024-12-31 Univ Emory N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
JP2003502309A (ja) * 1999-06-11 2003-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド アスパルチルプロテアーゼのインヒビター
JP2003511383A (ja) * 1999-10-06 2003-03-25 テイボテク・フアーマシユーチカルズ・リミテツド レトロウイルスのプロテアーゼインヒビターとしてのヘキサヒドロフロ［２，３−ｂ］フラン−３−イル−ｎ−｛３［（１，３−ベンゾジオキソル−５−イルスルホニル）（イソブチル）アミノ］−１−ベンジル−２−ヒドロキシプロピル｝カルバメート
JP2005523912A (ja) * 2002-04-26 2005-08-11 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積
JP2006504621A (ja) * 2002-03-12 2006-02-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728718A (en) * 1994-12-20 1998-03-17 The United States Of America As Represented By The Department Of Health And Human Services 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
US7470506B1 (en) * 1998-06-23 2008-12-30 The United States Of America As Represented By The Department Of Health And Human Services Fitness assay and associated methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
JP2003502309A (ja) * 1999-06-11 2003-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド アスパルチルプロテアーゼのインヒビター
JP2003511383A (ja) * 1999-10-06 2003-03-25 テイボテク・フアーマシユーチカルズ・リミテツド レトロウイルスのプロテアーゼインヒビターとしてのヘキサヒドロフロ［２，３−ｂ］フラン−３−イル−ｎ−｛３［（１，３−ベンゾジオキソル−５−イルスルホニル）（イソブチル）アミノ］−１−ベンジル−２−ヒドロキシプロピル｝カルバメート
JP2006504621A (ja) * 2002-03-12 2006-02-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル
JP2005523912A (ja) * 2002-04-26 2005-08-11 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504393A (ja) * 2013-01-09 2016-02-12 ギリアード サイエンシーズ， インコーポレイテッド ５員ヘテロアリールおよびそれらの抗ウイルス剤としての使用
JP2017515914A (ja) * 2014-05-16 2017-06-15 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｈｉｖ−１プロテアーゼ阻害剤およびその用途
JP2023518253A (ja) * 2020-03-18 2023-04-28 パーデュー・リサーチ・ファウンデーション 三環式ｐ２リガンドを含有する強力なｈｉｖプロテアーゼ阻害剤
JP7702424B2 (ja) 2020-03-18 2025-07-03 パーデュー・リサーチ・ファウンデーション 三環式ｐ２リガンドを含有する強力なｈｉｖプロテアーゼ阻害剤

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Publication number Publication date
US20080070910A1 (en) 2008-03-20
AU2007277253A1 (en) 2008-01-31
EP2069356A1 (en) 2009-06-17
CA2658545A1 (en) 2008-01-31
WO2008013834A1 (en) 2008-01-31
US20090312318A1 (en) 2009-12-17

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