JP2009544688A5 - - Google Patents

Info

Publication number

JP2009544688A5

JP2009544688A5 JP2009521380A JP2009521380A JP2009544688A5 JP 2009544688 A5 JP2009544688 A5 JP 2009544688A5 JP 2009521380 A JP2009521380 A JP 2009521380A JP 2009521380 A JP2009521380 A JP 2009521380A JP 2009544688 A5 JP2009544688 A5 JP 2009544688A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

fusion polypeptide

phospholipase

ptd

Prior art date

2007-07-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 28
• 108090000765 processed proteins & peptides Proteins 0.000 claims 28
• 102000004196 processed proteins & peptides Human genes 0.000 claims 28
• 230000004927 fusion Effects 0.000 claims 19
• 238000000034 method Methods 0.000 claims 18
• 102000014384 Type C Phospholipases Human genes 0.000 claims 9
• 108010079194 Type C Phospholipases Proteins 0.000 claims 9
• 102000004169 proteins and genes Human genes 0.000 claims 8
• 108090000623 proteins and genes Proteins 0.000 claims 8
• 230000026683 transduction Effects 0.000 claims 8
• 238000010361 transduction Methods 0.000 claims 8
• 206010021143 Hypoxia Diseases 0.000 claims 6
• 230000007954 hypoxia Effects 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 230000010410 reperfusion Effects 0.000 claims 5
• 230000000747 cardiac effect Effects 0.000 claims 4
• 206010019280 Heart failures Diseases 0.000 claims 3
• 230000002526 effect on cardiovascular system Effects 0.000 claims 3
• 210000000056 organ Anatomy 0.000 claims 3
• 102000005701 Calcium-Binding Proteins Human genes 0.000 claims 2
• 108010045403 Calcium-Binding Proteins Proteins 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 208000021479 Cardiovascular injury Diseases 0.000 claims 2
• 102000018890 Phospholipase C delta Human genes 0.000 claims 2
• 108010013144 Phospholipase C delta Proteins 0.000 claims 2
• 230000001964 calcium overload Effects 0.000 claims 2
• 210000004413 cardiac myocyte Anatomy 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000030833 cell death Effects 0.000 claims 2
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 2
• 208000010125 myocardial infarction Diseases 0.000 claims 2
• 210000001519 tissue Anatomy 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 206010007509 Cardiac amyloidosis Diseases 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
• 208000006029 Cardiomegaly Diseases 0.000 claims 1
• 208000031229 Cardiomyopathies Diseases 0.000 claims 1
• 206010048610 Cardiotoxicity Diseases 0.000 claims 1
• 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
• 208000013875 Heart injury Diseases 0.000 claims 1
• 206010021113 Hypothermia Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000025966 Neurological disease Diseases 0.000 claims 1
• 208000030852 Parasitic disease Diseases 0.000 claims 1
• 206010063837 Reperfusion injury Diseases 0.000 claims 1
• 210000002072 atrial myocyte Anatomy 0.000 claims 1
• 230000003683 cardiac damage Effects 0.000 claims 1
• 238000007675 cardiac surgery Methods 0.000 claims 1
• 231100000259 cardiotoxicity Toxicity 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 208000028831 congenital heart disease Diseases 0.000 claims 1
• 238000002586 coronary angiography Methods 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 210000002950 fibroblast Anatomy 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 1
• 230000002631 hypothermal effect Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 208000028867 ischemia Diseases 0.000 claims 1
• 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
• 208000031225 myocardial ischemia Diseases 0.000 claims 1
• 210000004457 myocytus nodalis Anatomy 0.000 claims 1
• 210000000651 myofibroblast Anatomy 0.000 claims 1
• 231100000878 neurological injury Toxicity 0.000 claims 1
• 230000008816 organ damage Effects 0.000 claims 1
• 230000008929 regeneration Effects 0.000 claims 1
• 238000011069 regeneration method Methods 0.000 claims 1
• 210000001567 regular cardiac muscle cell of ventricle Anatomy 0.000 claims 1
• 230000001568 sexual effect Effects 0.000 claims 1
• 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
• 210000000130 stem cell Anatomy 0.000 claims 1
• 230000000451 tissue damage Effects 0.000 claims 1
• 231100000827 tissue damage Toxicity 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1
• 230000007556 vascular defect Effects 0.000 claims 1
• 210000003556 vascular endothelial cell Anatomy 0.000 claims 1