JP2009544611A - ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 - Google Patents
ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 Download PDFInfo
- Publication number
- JP2009544611A JP2009544611A JP2009520791A JP2009520791A JP2009544611A JP 2009544611 A JP2009544611 A JP 2009544611A JP 2009520791 A JP2009520791 A JP 2009520791A JP 2009520791 A JP2009520791 A JP 2009520791A JP 2009544611 A JP2009544611 A JP 2009544611A
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- JP
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- Prior art keywords
- amino
- phenyl
- thienyl
- alkyl
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C/C1=C\C(\*)=C\C(\N)=C/C=C1 Chemical compound C/C1=C\C(\*)=C\C(\N)=C/C=C1 0.000 description 12
- ARZSFEURFBPUSG-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c(cc1)ccc1C(OC)=O)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c(cc1)ccc1C(OC)=O)=O)=O ARZSFEURFBPUSG-UHFFFAOYSA-N 0.000 description 1
- GFFRKRRLEPOLGO-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c1ccc(CN)cc1)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c1ccc(CN)cc1)=O)=O GFFRKRRLEPOLGO-UHFFFAOYSA-N 0.000 description 1
- WQVWOYXFMKVDGD-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CN)cc1)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CN)cc1)=O)=O WQVWOYXFMKVDGD-UHFFFAOYSA-N 0.000 description 1
- UOJGNSZGYFSDBG-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CNC(OCc(cc2)ccc2P(C)(C)=O)=O)cc1)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CNC(OCc(cc2)ccc2P(C)(C)=O)=O)cc1)=O)=O UOJGNSZGYFSDBG-UHFFFAOYSA-N 0.000 description 1
- WYXYKRCXGGKEOH-UHFFFAOYSA-N CC(C)(CO1)CO[O]1(Cc(cc1)ccc1C(OC)=O)=O Chemical compound CC(C)(CO1)CO[O]1(Cc(cc1)ccc1C(OC)=O)=O WYXYKRCXGGKEOH-UHFFFAOYSA-N 0.000 description 1
- XXVDWWBFOIDJFP-UHFFFAOYSA-N CC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)([O](C)(OC)(OC)=O)F Chemical compound CC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)([O](C)(OC)(OC)=O)F XXVDWWBFOIDJFP-UHFFFAOYSA-N 0.000 description 1
- GWXNTPAAFSGUKO-UHFFFAOYSA-N CCOP(C)(CCC(c(cc1)ccc1Br)=O)=O Chemical compound CCOP(C)(CCC(c(cc1)ccc1Br)=O)=O GWXNTPAAFSGUKO-UHFFFAOYSA-N 0.000 description 1
- XHWFEOBQYDSLRB-UHFFFAOYSA-N CCOP(C)(CCC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O)=O Chemical compound CCOP(C)(CCC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O)=O XHWFEOBQYDSLRB-UHFFFAOYSA-N 0.000 description 1
- JSNJPRJEHUJINX-UHFFFAOYSA-N CCOP(C)(OCCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O Chemical compound CCOP(C)(OCCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O JSNJPRJEHUJINX-UHFFFAOYSA-N 0.000 description 1
- IUKCEAFVFILXRT-UHFFFAOYSA-N CCOP(C)(OCCc(cc1)ccc1C(Nc1cc(-c2ccc[s]2)ccc1N)=O)=O Chemical compound CCOP(C)(OCCc(cc1)ccc1C(Nc1cc(-c2ccc[s]2)ccc1N)=O)=O IUKCEAFVFILXRT-UHFFFAOYSA-N 0.000 description 1
- ODSMDEXNXPTKGT-UHFFFAOYSA-N CN(CC1)CCP1(c(cc1)ccc1C(O)=O)=O Chemical compound CN(CC1)CCP1(c(cc1)ccc1C(O)=O)=O ODSMDEXNXPTKGT-UHFFFAOYSA-N 0.000 description 1
- BONAGWREEDYWFC-UHFFFAOYSA-N COC[O](C(c(cc1)ccc1C(OCc1ccccc1)=O)F)(OC)=O Chemical compound COC[O](C(c(cc1)ccc1C(OCc1ccccc1)=O)F)(OC)=O BONAGWREEDYWFC-UHFFFAOYSA-N 0.000 description 1
- VBTQAKVIZKHMKY-UHFFFAOYSA-N COC[O](Nc(cc1)ccc1C(OC)=O)(OC)=O Chemical compound COC[O](Nc(cc1)ccc1C(OC)=O)(OC)=O VBTQAKVIZKHMKY-UHFFFAOYSA-N 0.000 description 1
- VSUBEANUFSZOFE-UHFFFAOYSA-N COP(COC(NCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O)(OC)=O Chemical compound COP(COC(NCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O)(OC)=O VSUBEANUFSZOFE-UHFFFAOYSA-N 0.000 description 1
- MPSZFNFRFZNTPG-UHFFFAOYSA-N CP(C)(OCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O Chemical compound CP(C)(OCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O MPSZFNFRFZNTPG-UHFFFAOYSA-N 0.000 description 1
- ZENXWFYXUDCIJW-UHFFFAOYSA-N CP(CC1)(CCN1I)=O Chemical compound CP(CC1)(CCN1I)=O ZENXWFYXUDCIJW-UHFFFAOYSA-N 0.000 description 1
- AQWBRFKCQHRFHE-UHFFFAOYSA-N CP1(OCC(CC2)(CCN2C(c(cc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)=O)CO1)=O Chemical compound CP1(OCC(CC2)(CCN2C(c(cc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)=O)CO1)=O AQWBRFKCQHRFHE-UHFFFAOYSA-N 0.000 description 1
- RXRHUVFUKNTLHO-UHFFFAOYSA-N CP1(OCC(CC2)(CCN2c(nc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)CO1)=O Chemical compound CP1(OCC(CC2)(CCN2c(nc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)CO1)=O RXRHUVFUKNTLHO-UHFFFAOYSA-N 0.000 description 1
- MCNALOGTMITBJE-UHFFFAOYSA-M N[AlH]NC(c1ccccc1)=O Chemical compound N[AlH]NC(c1ccccc1)=O MCNALOGTMITBJE-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5304—Acyclic saturated phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83201406P | 2006-07-20 | 2006-07-20 | |
| US92054107P | 2007-03-28 | 2007-03-28 | |
| PCT/US2007/016123 WO2008010985A2 (en) | 2006-07-20 | 2007-07-16 | Phosphorus derivatives as histone deacetylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544611A true JP2009544611A (ja) | 2009-12-17 |
| JP2009544611A5 JP2009544611A5 (US07981874-20110719-C00225.png) | 2010-08-26 |
Family
ID=38957303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520791A Withdrawn JP2009544611A (ja) | 2006-07-20 | 2007-07-16 | ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 |
Country Status (6)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010531359A (ja) * | 2007-06-27 | 2010-09-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体 |
| JP2014516989A (ja) * | 2011-05-31 | 2014-07-17 | ニューゲン セラピューティクス， インコーポレイテッド | ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 |
| JP2019069946A (ja) * | 2010-08-23 | 2019-05-09 | シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘ Ｂｉｏｓｙｓｔｅｍｓ， Ｉｎｃ． | Ｃｘｃｒ２モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
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| WO2005070020A2 (en) | 2004-01-23 | 2005-08-04 | The Regents Of The University Of Colorado | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| CA2567293C (en) | 2004-05-27 | 2017-05-16 | The Regents Of The University Of Colorado | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients |
| WO2007100657A2 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| CA2692153A1 (en) * | 2007-06-27 | 2009-01-08 | Richard W. Heidebrecht, Jr. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| AU2009285591B2 (en) | 2008-08-29 | 2015-08-27 | Treventis Corporation | Compositions and methods of treating amyloid disease |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| CA3061239A1 (en) | 2011-02-28 | 2012-09-07 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2014018913A2 (en) * | 2012-07-27 | 2014-01-30 | University Of Connecticut | Santacruzamate a compositions and analogs and methods of use |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| EP2968565A2 (en) | 2013-03-14 | 2016-01-20 | Genentech, Inc. | Methods of treating cancer and preventing cancer drug resistance |
| ES2680224T3 (es) | 2013-03-15 | 2018-09-05 | Biomarin Pharmaceutical Inc. | Inhibidores de HDAC |
| US10807944B2 (en) | 2014-04-04 | 2020-10-20 | University Of Florida Research Foundation, Inc. | HDAC inhibitor compounds and methods of treatment |
| CZ305738B6 (cs) * | 2014-12-16 | 2016-02-24 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující |
| CN104860991B (zh) * | 2015-03-24 | 2017-10-20 | 华南理工大学 | 离子型阴极缓冲层分子型材料及其制备方法和应用 |
| LT3319959T (lt) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Histono deacetilazės hetero-halogeno inhibitoriai |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| WO2017127417A1 (en) * | 2016-01-19 | 2017-07-27 | Prospero Pharmaceuticals Llc | Phosphopantothenate compounds |
| CN105859774B (zh) * | 2016-04-12 | 2018-01-19 | 盘锦格林凯默科技有限公司 | 一种膦苯类化合物的制备方法 |
| FR3050732B1 (fr) * | 2016-05-02 | 2019-06-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nouveaux derives de phosphinolactones et leurs utilisations pharmaceutiques |
| TWI770104B (zh) | 2017-01-11 | 2022-07-11 | 美商羅登醫療公司 | 組蛋白去乙醯酶雙環抑制劑 |
| MX2020001484A (es) | 2017-08-07 | 2020-08-20 | Rodin Therapeutics Inc | Inhibidores bicíclicos de la histona desacetilasa. |
| CN112538091B (zh) * | 2020-11-26 | 2022-09-09 | 湖北大学 | 一种双-（对-羧基苯氨基）苯基氧化膦阻燃剂的合成法 |
| CN114685559B (zh) * | 2022-05-16 | 2023-07-18 | 多氟多新材料股份有限公司 | 一种双三氟甲基磷酸锂的制备方法 |
| WO2024025862A1 (en) * | 2022-07-28 | 2024-02-01 | The Board Of Regents Of The University Of Oklahoma | Agonists of peroxisome proliferator-activated receptor alpha (ppara) and methods of use |
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| BE568065A (US07981874-20110719-C00225.png) | 1957-08-07 | |||
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| DE1265896B (de) | 1962-06-19 | 1968-04-11 | Ciba Geigy | Verfahren zur Herstellung von Kuepenfarbstoffen |
| GB1491608A (en) * | 1975-05-28 | 1977-11-09 | Ici Ltd | Metal complex formazan dyestuffs and processes for their preparation |
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| US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
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| JP2787407B2 (ja) | 1992-06-19 | 1998-08-20 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| JPH11335375A (ja) | 1998-05-20 | 1999-12-07 | Mitsui Chem Inc | ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体 |
| NZ517613A (en) * | 1999-09-08 | 2004-01-30 | Sloan Kettering Inst Cancer | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
| AU1244001A (en) | 1999-10-27 | 2001-05-08 | Cor Therapeutics, Inc. | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| KR20100035666A (ko) | 1999-11-23 | 2010-04-05 | 메틸진 인크. | 히스톤 디아세틸라제의 억제제 |
| CA2432825A1 (en) | 2000-12-15 | 2002-06-20 | Emory University | Nonpeptide agonists and antagonists of vasopressin receptors |
| PT1378510E (pt) | 2001-03-19 | 2006-09-29 | Ono Pharmaceutical Co | Derivados de triazaespiro [5.5] undecano e farmacos que os contem como componentes activos |
| AR034897A1 (es) * | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| CN101851173A (zh) | 2001-09-14 | 2010-10-06 | 梅特希尔基因公司 | 组蛋白脱乙酰化酶抑制剂 |
| US7868204B2 (en) * | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| ES2306859T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonil como nuevos inhibidores de histona deacetilasa. |
| EA007272B1 (ru) | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н. В. | Новые ингибиторы гистондеацетилазы |
| JP4648628B2 (ja) | 2002-03-13 | 2011-03-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのカルボニルアミノ誘導体 |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| EP1541574A4 (en) | 2002-09-18 | 2007-06-20 | Ono Pharmaceutical Co | TRIAZASPIRO DERIVATIVES 5.5 | UNDECANS AND DRUGS CONTAINING THEM AS AN ACTIVE INGREDIENT |
| EP1738752A1 (en) | 2002-12-27 | 2007-01-03 | Schering Aktiengesellschaft | Pharmaceutical combinations comprising cis-retine acid |
| SG159388A1 (en) | 2003-01-08 | 2010-03-30 | Chiron Corp | Antibacterial agents |
| WO2005030705A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP1735319B1 (en) | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
| AU2005251816A1 (en) | 2004-06-10 | 2005-12-22 | Kalypsys, Inc. | Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease |
-
2007
- 2007-07-16 AU AU2007275743A patent/AU2007275743A1/en not_active Abandoned
- 2007-07-16 WO PCT/US2007/016123 patent/WO2008010985A2/en active Application Filing
- 2007-07-16 CA CA002657288A patent/CA2657288A1/en not_active Abandoned
- 2007-07-16 JP JP2009520791A patent/JP2009544611A/ja not_active Withdrawn
- 2007-07-16 US US12/309,459 patent/US7981874B2/en not_active Expired - Fee Related
- 2007-07-16 EP EP07810507A patent/EP2049124A4/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010531359A (ja) * | 2007-06-27 | 2010-09-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体 |
| JP2019069946A (ja) * | 2010-08-23 | 2019-05-09 | シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘ Ｂｉｏｓｙｓｔｅｍｓ， Ｉｎｃ． | Ｃｘｃｒ２モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
| USRE48547E1 (en) | 2010-08-23 | 2021-05-11 | Syntrix Biosystems Inc. | Aminopyrimidinecarboxamides as CXCR2 modulators |
| JP2014516989A (ja) * | 2011-05-31 | 2014-07-17 | ニューゲン セラピューティクス， インコーポレイテッド | ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 |
| US11248013B2 (en) | 2011-05-31 | 2022-02-15 | Rakovina Therapeutics Inc. | Tricyclic inhibitors of poly(ADP-ribose)polymerase |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008010985A3 (en) | 2008-04-03 |
| US7981874B2 (en) | 2011-07-19 |
| WO2008010985A2 (en) | 2008-01-24 |
| CA2657288A1 (en) | 2008-01-24 |
| AU2007275743A1 (en) | 2008-01-24 |
| EP2049124A4 (en) | 2010-02-10 |
| US20090270351A1 (en) | 2009-10-29 |
| EP2049124A2 (en) | 2009-04-22 |
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