JP2009543867A - 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物 - Google Patents

抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物 Download PDF

Info

Publication number
JP2009543867A
JP2009543867A JP2009520780A JP2009520780A JP2009543867A JP 2009543867 A JP2009543867 A JP 2009543867A JP 2009520780 A JP2009520780 A JP 2009520780A JP 2009520780 A JP2009520780 A JP 2009520780A JP 2009543867 A JP2009543867 A JP 2009543867A
Authority
JP
Japan
Prior art keywords
alkyl
alkylene
phenyl
substituted
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009520780A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009543867A5 (https=
Inventor
ウイリアムズ，ピーター・デイー
ベンカトラマン，シヤンカル
ラングフオード，エイチ・マリー
キム，ポーヨン
ブース，テレサ・エム
グロブラー，ジエイ・エイ
スタース，ドネツト
ルゼツク，ロウエーナ・デイー
エンブリー，マーク・ダブリユ
ウイスカウント，キヤサリン・エム
ライル，テリー・エイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2009543867A publication Critical patent/JP2009543867A/ja
Publication of JP2009543867A5 publication Critical patent/JP2009543867A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009520780A 2006-07-17 2007-07-13 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物 Withdrawn JP2009543867A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83141506P 2006-07-17 2006-07-17
PCT/US2007/016052 WO2008010964A1 (en) 2006-07-17 2007-07-13 1-hydroxy naphthyridine compounds as anti-hiv agents

Publications (2)

Publication Number Publication Date
JP2009543867A true JP2009543867A (ja) 2009-12-10
JP2009543867A5 JP2009543867A5 (https=) 2010-08-12

Family

ID=38957074

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009520780A Withdrawn JP2009543867A (ja) 2006-07-17 2007-07-13 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物

Country Status (6)

Country Link
US (1) US20100056516A1 (https=)
EP (1) EP2044068A4 (https=)
JP (1) JP2009543867A (https=)
AU (1) AU2007275816A1 (https=)
CA (1) CA2657287A1 (https=)
WO (1) WO2008010964A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013115265A1 (ja) * 2012-01-31 2013-08-08 富山化学工業株式会社 抗ｈｉｖ活性を有する複素環化合物

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
WO2011057989A1 (en) * 2009-11-11 2011-05-19 Basf Se Heterocyclic compounds having herbicidal action
WO2012058173A1 (en) * 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
FR2970967B1 (fr) 2011-01-27 2013-02-15 Pf Medicament Derives de type azaindazole ou diazaindazole comme medicament
KR20140049993A (ko) 2011-06-02 2014-04-28 메사추세츠 인스티튜트 오브 테크놀로지 메타핵 줄기 세포의 dsRNA/DNA 하이브리드 게놈 복제 중간체
WO2013049332A1 (en) * 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
WO2013165898A2 (en) * 2012-05-01 2013-11-07 The Trustees Of The University Of Pennsylvania Compositions and methods for inhibiting resolvases
EP2689778A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindoles or diazaindoles for treating pain
EP2689779A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk
JO3781B1 (ar) * 2012-12-24 2021-01-31 Cadila Healthcare Ltd مشتقات الكينولون
CN105611927A (zh) * 2013-05-16 2016-05-25 美国政府(由卫生和人类服务部的部长所代表) 用于抑制耐药性hiv-1整合酶耐药株的化合物
AU2015210833B2 (en) 2014-02-03 2019-01-03 Vitae Pharmaceuticals, Llc Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3194383B1 (en) 2014-09-19 2019-11-06 Forma Therapeutics, Inc. Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
MA53352A (fr) 2014-09-19 2021-09-15 Forma Therapeutics Inc Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase
MA53943A (fr) * 2015-11-20 2021-08-25 Vitae Pharmaceuticals Llc Modulateurs de ror-gamma
CN105418609B (zh) * 2015-12-31 2017-06-23 山东大学 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN115650976A (zh) 2017-07-24 2023-01-31 生命医药有限责任公司 RORγ的抑制剂
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
US20210196701A1 (en) 2018-05-16 2021-07-01 Forma Therapeutics, Inc. Inhibiting mutant idh-1
WO2019222551A1 (en) 2018-05-16 2019-11-21 Forma Therapeutics, Inc. Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
US11311527B2 (en) 2018-05-16 2022-04-26 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
US11013734B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation
US11013733B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
MY201239A (en) 2019-03-22 2024-02-13 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
EP4066839A4 (en) 2019-11-28 2023-12-27 Shionogi & Co., Ltd PROPHYLACTIC AND THERAPEUTIC MEDICINAL PRODUCT FOR HIV INFECTIOUS DISEASES, CHARACTERIZED BY CONTAINING THE COMBINATION OF INTEGRAS INHIBITORS AND ANTI-HIV AGENTS
PE20221569A1 (es) 2020-02-24 2022-10-06 Gilead Sciences Inc Compuestos tetraciclicos para el tratamiento de infecciones por vih
ES3064867T3 (en) 2020-09-30 2026-04-29 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv
US11613546B2 (en) 2021-01-19 2023-03-28 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
TW202446773A (zh) 2022-04-06 2024-12-01 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
JP2025534288A (ja) 2022-09-26 2025-10-15 エッジワイズ セラピューティクス， インコーポレイテッド １，４－ジヒドロキナゾリノン化合物およびその使用
WO2024206339A1 (en) * 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinolinone amide compounds and uses thereof
EP4688756A1 (en) 2023-03-27 2026-02-11 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527819A (en) * 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
US6380249B1 (en) * 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) * 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) * 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
AU5880600A (en) * 1999-06-25 2001-01-31 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
PL360944A1 (en) * 2000-10-12 2004-09-20 Merck & Co, Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
EP1326611B1 (en) * 2000-10-12 2007-06-13 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
ATE345129T1 (de) * 2000-10-12 2006-12-15 Merck & Co Inc Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
WO2002036734A2 (en) * 2000-10-12 2002-05-10 Merck & Co., Inc. Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors
ES2572030T3 (es) * 2001-08-10 2017-07-19 Shionogi & Co., Ltd. Agente antiviral
IL161337A0 (en) * 2001-10-26 2004-09-27 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
ATE355064T1 (de) * 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
EP1467970B1 (en) * 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
US7109186B2 (en) * 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
ATE404537T1 (de) * 2002-08-13 2008-08-15 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung
US7902203B2 (en) * 2002-11-01 2011-03-08 Abbott Laboratories, Inc. Anti-infective agents
US20040162285A1 (en) * 2002-11-01 2004-08-19 Pratt John K. Anti-infective agents
US7501503B2 (en) * 2002-12-31 2009-03-10 Mcgill University Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase
US7553967B2 (en) * 2004-03-12 2009-06-30 Wyeth 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections
US20050203176A1 (en) * 2004-03-12 2005-09-15 Wyeth Carbamates as HIV anti-viral agents
WO2005090316A1 (en) * 2004-03-12 2005-09-29 Wyeth HYDANTOINS HAVING RNase MODULATORY ACTIVITY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013115265A1 (ja) * 2012-01-31 2013-08-08 富山化学工業株式会社 抗ｈｉｖ活性を有する複素環化合物

Also Published As

Publication number Publication date
EP2044068A4 (en) 2010-07-21
WO2008010964A1 (en) 2008-01-24
AU2007275816A1 (en) 2008-01-24
US20100056516A1 (en) 2010-03-04
EP2044068A1 (en) 2009-04-08
CA2657287A1 (en) 2008-01-24

Similar Documents

Publication Publication Date Title
JP2009543867A (ja) 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物
US7619086B2 (en) HIV integrase inhibitors
EP3414234B1 (en) Bruton's tyrosine kinase inhibitors
JP6215338B2 (ja) キナーゼモジュレーターとして有用な二環式ヘテロ環置換ピリジル化合物
AU2014347275B2 (en) Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses
EP2802577B1 (en) Triazolyl-substituted pyridyl compounds useful as kinase inhibitors
JP4625838B2 (ja) Ｈｉｖインテグラーゼ阻害薬
US20090099168A1 (en) HIV Integrase inhibitors
JP2006506352A (ja) Ｈｉｖインテグラーゼ阻害剤として有用なジヒドロキシピリドピラジン−１，６−ジオン化合物
JP2019508467A (ja) 癌治療用の２−シアノイソインドリン誘導体
HUP0302367A2 (hu) HIV Integráz inhibitorokként hasznos aza- és poliazanaftalenil-karboxamidok, ezeket tartalmazó gyógyszerkészítmények
JP2007519735A (ja) Ｈｉｖインテグラーゼ阻害剤として有用であるｎ−ベンジル−３，４−ジヒドロキシピリジン−２−カルボキサミド及びｎ−ベンジル−２，３−ジヒドロキシピリジン−４−カルボキサミド化合物
JP2008504367A (ja) ピロロトリアジンキナーゼ阻害剤
KR20200094168A (ko) 할로-알릴아민 ssao/vap-1 억제제 및 그의 용도
CA2607151C (en) Hiv integrase inhibitors
EP4337649A1 (en) Substituted heterocyclic compounds
CN112521386B (zh) 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途
US20170362219A1 (en) Substituted dihydro-1h-pyrrolo[3,2-c]pyridin-4(5h)-ones as ripk3 inhibitors
JP4494020B2 (ja) Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド
CN100577663C (zh) 稠合杂环型激酶抑制剂
JP2024545235A (ja) 複素芳香族化合物、その製造方法及び使用
WO2009154870A1 (en) Hiv integrase inhibitors
TWI870185B (zh) 雙環類化合物及其製備方法和應用
CA3008653C (en) Bruton's tyrosine kinase inhibitors
TW202428252A (zh) 類Cdc激酶之雜環抑制劑

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100623

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100623

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20111205