JP2009543867A - 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物 - Google Patents

抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物 Download PDF

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Publication number
JP2009543867A
JP2009543867A JP2009520780A JP2009520780A JP2009543867A JP 2009543867 A JP2009543867 A JP 2009543867A JP 2009520780 A JP2009520780 A JP 2009520780A JP 2009520780 A JP2009520780 A JP 2009520780A JP 2009543867 A JP2009543867 A JP 2009543867A
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JP
Japan
Prior art keywords
alkyl
alkylene
phenyl
substituted
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2009520780A
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English (en)
Japanese (ja)
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JP2009543867A5 (https=
Inventor
ウイリアムズ，ピーター・デイー
ベンカトラマン，シヤンカル
ラングフオード，エイチ・マリー
キム，ポーヨン
ブース，テレサ・エム
グロブラー，ジエイ・エイ
スタース，ドネツト
ルゼツク，ロウエーナ・デイー
エンブリー，マーク・ダブリユ
ウイスカウント，キヤサリン・エム
ライル，テリー・エイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
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Merck and Co Inc
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Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2009543867A publication Critical patent/JP2009543867A/ja
Publication of JP2009543867A5 publication Critical patent/JP2009543867A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009520780A 2006-07-17 2007-07-13 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物 Withdrawn JP2009543867A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83141506P 2006-07-17 2006-07-17
PCT/US2007/016052 WO2008010964A1 (en) 2006-07-17 2007-07-13 1-hydroxy naphthyridine compounds as anti-hiv agents

Publications (2)

Publication Number Publication Date
JP2009543867A true JP2009543867A (ja) 2009-12-10
JP2009543867A5 JP2009543867A5 (https=) 2010-08-12

Family

ID=38957074

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009520780A Withdrawn JP2009543867A (ja) 2006-07-17 2007-07-13 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物

Country Status (6)

Country Link
US (1) US20100056516A1 (https=)
EP (1) EP2044068A4 (https=)
JP (1) JP2009543867A (https=)
AU (1) AU2007275816A1 (https=)
CA (1) CA2657287A1 (https=)
WO (1) WO2008010964A1 (https=)

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WO2013115265A1 (ja) * 2012-01-31 2013-08-08 富山化学工業株式会社 抗ｈｉｖ活性を有する複素環化合物

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EP2632454A1 (en) * 2010-10-29 2013-09-04 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
FR2970967B1 (fr) 2011-01-27 2013-02-15 Pf Medicament Derives de type azaindazole ou diazaindazole comme medicament
US20140369934A1 (en) 2011-06-02 2014-12-18 Massachusetts Institute Of Technology dsRNA/DNA Hybrid Genome Replication Intermediate Of Metakaryotic Stem Cells
WO2013049332A1 (en) * 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
WO2013165898A2 (en) * 2012-05-01 2013-11-07 The Trustees Of The University Of Pennsylvania Compositions and methods for inhibiting resolvases
EP2689779A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk
EP2689778A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindoles or diazaindoles for treating pain
WO2014102818A1 (en) * 2012-12-24 2014-07-03 Cadila Healthcare Limited Novel quinolone derivatives
JP2016524607A (ja) * 2013-05-16 2016-08-18 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｈｉｖ−１インテグラーゼの薬物耐性株を阻害するための化合物
EP3102576B8 (en) 2014-02-03 2019-06-19 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma
ES2768694T3 (es) 2014-09-19 2020-06-23 Forma Therapeutics Inc Composiciones de quinolinona pirimidinas como inhibidores de isocitrato dehidrogenasa mutante
WO2016044789A1 (en) 2014-09-19 2016-03-24 Forma Therapeutics, Inc. Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
US11008340B2 (en) 2015-11-20 2021-05-18 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
CN105418609B (zh) * 2015-12-31 2017-06-23 山东大学 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020528904A (ja) 2017-07-24 2020-10-01 ヴァイティー ファーマシューティカルズ，エルエルシー ＲＯＲγの阻害剤
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
US11013734B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation
US11013733B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
US10532047B2 (en) 2018-05-16 2020-01-14 Forma Therapeutics, Inc. Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
US11311527B2 (en) 2018-05-16 2022-04-26 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
WO2019222553A1 (en) 2018-05-16 2019-11-21 Forma Therapeutics, Inc. Inhibiting mutant idh-1
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
TWI902729B (zh) 2019-11-28 2025-11-01 日商鹽野義製藥股份有限公司 以組合整合酶阻礙劑及抗ｈｉｖ藥為特徵之ｈｉｖ感染症的預防及治療用醫藥
IL295677B1 (en) 2020-02-24 2026-04-01 Gilead Sciences Inc Tetracyclic compounds for the treatment of HIV infection
CA3192145A1 (en) 2020-09-30 2022-04-07 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
FI4196479T3 (fi) 2021-01-19 2024-01-17 Gilead Sciences Inc Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
KR20250128292A (ko) 2022-09-26 2025-08-27 엣지와이즈 테라퓨틱스, 인크. 1,4-디하이드로퀴나졸리논 화합물 및 이의 용도
WO2024206345A1 (en) 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
CN121194963A (zh) * 2023-03-27 2025-12-23 艾知怀斯治疗学公司 喹啉酮酰胺类化合物及其用途

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JP2004517860A (ja) * 2000-10-12 2004-06-17 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
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US7109186B2 (en) * 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013115265A1 (ja) * 2012-01-31 2013-08-08 富山化学工業株式会社 抗ｈｉｖ活性を有する複素環化合物

Also Published As

Publication number Publication date
EP2044068A4 (en) 2010-07-21
EP2044068A1 (en) 2009-04-08
CA2657287A1 (en) 2008-01-24
AU2007275816A1 (en) 2008-01-24
US20100056516A1 (en) 2010-03-04
WO2008010964A1 (en) 2008-01-24

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