JP2009543069A5 - - Google Patents
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- JP2009543069A5 JP2009543069A5 JP2009518574A JP2009518574A JP2009543069A5 JP 2009543069 A5 JP2009543069 A5 JP 2009543069A5 JP 2009518574 A JP2009518574 A JP 2009518574A JP 2009518574 A JP2009518574 A JP 2009518574A JP 2009543069 A5 JP2009543069 A5 JP 2009543069A5
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- Japan
- Prior art keywords
- independently
- hydrogen
- formula
- analyte
- group
- Prior art date
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- 239000003153 chemical reaction reagent Substances 0.000 claims description 295
- 238000002372 labelling Methods 0.000 claims description 282
- 150000002500 ions Chemical class 0.000 claims description 238
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 131
- 239000001257 hydrogen Substances 0.000 claims description 131
- 238000000034 method Methods 0.000 claims description 113
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- 150000003839 salts Chemical class 0.000 claims description 91
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 87
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- 125000004429 atom Chemical group 0.000 claims description 65
- 125000003118 aryl group Chemical group 0.000 claims description 63
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- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 51
- 125000001072 heteroaryl group Chemical group 0.000 claims description 48
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| US9366678B2 (en) | 2012-10-25 | 2016-06-14 | Wisconsin Alumni Research Foundation | Neutron encoded mass tags for analyte quantification |
| JP6847660B2 (ja) | 2013-06-07 | 2021-03-24 | マサチューセッツ インスティテュート オブ テクノロジー | リガンドをコードする合成バイオマーカーのアフィニティベースの検出 |
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2007
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- 2007-06-29 EP EP07812488A patent/EP2041105A2/en not_active Withdrawn
- 2007-06-29 CA CA002656295A patent/CA2656295A1/en not_active Abandoned
- 2007-06-29 AU AU2007269232A patent/AU2007269232A1/en not_active Abandoned
- 2007-06-29 WO PCT/US2007/072503 patent/WO2008005846A2/en not_active Ceased
- 2007-06-29 JP JP2009518574A patent/JP5548447B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-29 JP JP2010148351A patent/JP2010249838A/ja not_active Withdrawn
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