JP2009542683A - D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 - Google Patents

D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 Download PDF

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JP2009542683A
JP2009542683A JP2009518342A JP2009518342A JP2009542683A JP 2009542683 A JP2009542683 A JP 2009542683A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009542683 A JP2009542683 A JP 2009542683A
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substituted
unsubstituted
member selected
alkyl
heterocycloalkyl
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JP2009542683A5 (enExample
Inventor
ドーシー,ジェームス,エム.
ホプキンス,セス,シー.
フォグレソング,ロバート,ジェイ.
ヘファーナン,ミシェル,エル.アール.
ジョーンズ,マイケル,エル.
ペラレス,ジョー,ビー.
ファン,クン,ケビン
オグブ,シプリアン,オー.
ジョーンズ,スティーブン,ダブリュー.
ソウクリ,ムスタファ
バーニー,マーク,エー.
スペア,ケリー,エル.
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セプラコア インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Anesthesiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
JP2009518342A 2006-06-30 2007-07-02 D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 Pending JP2009542683A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80639106P 2006-06-30 2006-06-30
US84246506P 2006-09-05 2006-09-05
US91429307P 2007-04-26 2007-04-26
PCT/US2007/015396 WO2008005456A2 (en) 2006-06-30 2007-07-02 Fused heterocyclic inhibitors of d-amino acid oxidase

Publications (2)

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JP2009542683A true JP2009542683A (ja) 2009-12-03
JP2009542683A5 JP2009542683A5 (enExample) 2010-08-05

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EP (1) EP2057162A2 (enExample)
JP (1) JP2009542683A (enExample)
KR (1) KR20090024823A (enExample)
AU (1) AU2007269646A1 (enExample)
BR (1) BRPI0713216A2 (enExample)
CA (1) CA2659060A1 (enExample)
IL (1) IL195921A0 (enExample)
MX (1) MX2008016525A (enExample)
WO (1) WO2008005456A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522830A (ja) * 2011-07-07 2014-09-08 武田薬品工業株式会社 ピリミジノン化合物およびそれらの使用
JP2014524461A (ja) * 2011-08-22 2014-09-22 武田薬品工業株式会社 ピリダジノン化合物、及びdaao阻害剤としてのその使用
JP2016502998A (ja) * 2012-12-17 2016-02-01 武田薬品工業株式会社 Daao酵素阻害剤としてのピリダジノン
KR20220123738A (ko) * 2014-04-30 2022-09-08 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
JP2022540000A (ja) * 2019-06-28 2022-09-14 ファイザー・インク Bckdk阻害活性を有するチエノ[3,2-b]チオフェン-2-カルボン酸化合物

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ548212A (en) 2003-12-29 2010-07-30 Sepracor Inc Pyrrole and pyrazole DAAO inhibitors
US8053603B2 (en) 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
KR101294014B1 (ko) 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
EP2298772A1 (en) * 2006-10-18 2011-03-23 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
MX2009012685A (es) 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
TW201041869A (en) 2009-05-14 2010-12-01 Japan Tobacco Inc Azetidine compound and pharmaceutical use thereof
US11427600B2 (en) 2014-06-27 2022-08-30 Nogra Pharma Limited Aryl receptor modulators and methods of making and using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2006500394A (ja) * 2002-09-06 2006-01-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チエノピロリルおよびフラノピロリル化合物並びにヒスタミンh4受容体リガンドとしてのそれらの使用
JP2009511462A (ja) * 2005-10-06 2009-03-19 メルク シャープ エンド ドーム リミテッド D−アミノ酸酸化酵素阻害剤として神経変性および精神疾患を治療するための縮合ピロールカルボン酸の使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9803228D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
EP1391460A1 (en) * 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
WO2003039540A2 (en) * 2001-11-09 2003-05-15 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
NZ548212A (en) * 2003-12-29 2010-07-30 Sepracor Inc Pyrrole and pyrazole DAAO inhibitors
DK2433943T3 (da) * 2004-07-01 2013-12-16 Daiichi Sankyo Co Ltd Mellemprodukter til thienopyrazol-derivater med PDE7-inhibitorisk aktivitet
CA2594665A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Thienopyrroles useful in the treatment of inflammation
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2006500394A (ja) * 2002-09-06 2006-01-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チエノピロリルおよびフラノピロリル化合物並びにヒスタミンh4受容体リガンドとしてのそれらの使用
JP2009511462A (ja) * 2005-10-06 2009-03-19 メルク シャープ エンド ドーム リミテッド D−アミノ酸酸化酵素阻害剤として神経変性および精神疾患を治療するための縮合ピロールカルボン酸の使用

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522830A (ja) * 2011-07-07 2014-09-08 武田薬品工業株式会社 ピリミジノン化合物およびそれらの使用
JP2014524461A (ja) * 2011-08-22 2014-09-22 武田薬品工業株式会社 ピリダジノン化合物、及びdaao阻害剤としてのその使用
JP2016502998A (ja) * 2012-12-17 2016-02-01 武田薬品工業株式会社 Daao酵素阻害剤としてのピリダジノン
US9750748B2 (en) 2012-12-17 2017-09-05 Takeda Pharmaceutical Company Limited Pyridazinones as DAAO enzyme inhibitors
KR20220123738A (ko) * 2014-04-30 2022-09-08 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
KR102537686B1 (ko) 2014-04-30 2023-05-30 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
JP2022540000A (ja) * 2019-06-28 2022-09-14 ファイザー・インク Bckdk阻害活性を有するチエノ[3,2-b]チオフェン-2-カルボン酸化合物

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AU2007269646A1 (en) 2008-01-10
WO2008005456A2 (en) 2008-01-10
IL195921A0 (en) 2009-09-01
MX2008016525A (es) 2009-03-09
WO2008005456A3 (en) 2008-07-31
KR20090024823A (ko) 2009-03-09
BRPI0713216A2 (pt) 2012-12-04
CA2659060A1 (en) 2008-01-10
EP2057162A2 (en) 2009-05-13

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