JP2009542683A - D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 - Google Patents

D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 Download PDF

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JP2009542683A
JP2009542683A JP2009518342A JP2009518342A JP2009542683A JP 2009542683 A JP2009542683 A JP 2009542683A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009542683 A JP2009542683 A JP 2009542683A
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substituted
unsubstituted
member selected
alkyl
heterocycloalkyl
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JP2009542683A5 (enExample
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ドーシー,ジェームス,エム.
ホプキンス,セス,シー.
フォグレソング,ロバート,ジェイ.
ヘファーナン,ミシェル,エル.アール.
ジョーンズ,マイケル,エル.
ペラレス,ジョー,ビー.
ファン,クン,ケビン
オグブ,シプリアン,オー.
ジョーンズ,スティーブン,ダブリュー.
ソウクリ,ムスタファ
バーニー,マーク,エー.
スペア,ケリー,エル.
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セプラコア インコーポレーテッド
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    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04Ortho-condensed systems
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
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  • Molecular Biology (AREA)
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JP2009518342A 2006-06-30 2007-07-02 D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 Pending JP2009542683A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80639106P 2006-06-30 2006-06-30
US84246506P 2006-09-05 2006-09-05
US91429307P 2007-04-26 2007-04-26
PCT/US2007/015396 WO2008005456A2 (en) 2006-06-30 2007-07-02 Fused heterocyclic inhibitors of d-amino acid oxidase

Publications (2)

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JP2009542683A true JP2009542683A (ja) 2009-12-03
JP2009542683A5 JP2009542683A5 (enExample) 2010-08-05

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EP (1) EP2057162A2 (enExample)
JP (1) JP2009542683A (enExample)
KR (1) KR20090024823A (enExample)
AU (1) AU2007269646A1 (enExample)
BR (1) BRPI0713216A2 (enExample)
CA (1) CA2659060A1 (enExample)
IL (1) IL195921A0 (enExample)
MX (1) MX2008016525A (enExample)
WO (1) WO2008005456A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522830A (ja) * 2011-07-07 2014-09-08 武田薬品工業株式会社 ピリミジノン化合物およびそれらの使用
JP2014524461A (ja) * 2011-08-22 2014-09-22 武田薬品工業株式会社 ピリダジノン化合物、及びdaao阻害剤としてのその使用
JP2016502998A (ja) * 2012-12-17 2016-02-01 武田薬品工業株式会社 Daao酵素阻害剤としてのピリダジノン
KR20220123738A (ko) * 2014-04-30 2022-09-08 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
JP2022540000A (ja) * 2019-06-28 2022-09-14 ファイザー・インク Bckdk阻害活性を有するチエノ[3,2-b]チオフェン-2-カルボン酸化合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2551952A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole daao inhibitors
WO2007081542A2 (en) 2006-01-06 2007-07-19 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
CA2636324C (en) 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
DK2013835T3 (en) 2006-03-31 2015-12-14 Sunovion Pharmaceuticals Inc Preparation of chiral amides and AMINES
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
EP2077267A4 (en) 2006-10-18 2010-04-07 Takeda Pharmaceutical CONDENSED HETEROCYCLIC COMPOUND
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
RU2470011C2 (ru) 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
AR076766A1 (es) 2009-05-14 2011-07-06 Japan Tobacco Inc Compuestos de azetidina, composiciones farmaceuticas y su uso en el tratamiento de enfermedades autoinmunes.

Citations (3)

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JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2006500394A (ja) * 2002-09-06 2006-01-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チエノピロリルおよびフラノピロリル化合物並びにヒスタミンh4受容体リガンドとしてのそれらの使用
JP2009511462A (ja) * 2005-10-06 2009-03-19 メルク シャープ エンド ドーム リミテッド D−アミノ酸酸化酵素阻害剤として神経変性および精神疾患を治療するための縮合ピロールカルボン酸の使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9803228D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
EP1391460A1 (en) * 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
CA2551952A1 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole daao inhibitors
CA2569530C (en) * 2004-07-01 2013-07-30 Daiichi Asubio Pharma Co.,Ltd. Thienopyrazole derivative having pde 7 inhibitory activity
CA2594665A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Thienopyrroles useful in the treatment of inflammation
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2006500394A (ja) * 2002-09-06 2006-01-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チエノピロリルおよびフラノピロリル化合物並びにヒスタミンh4受容体リガンドとしてのそれらの使用
JP2009511462A (ja) * 2005-10-06 2009-03-19 メルク シャープ エンド ドーム リミテッド D−アミノ酸酸化酵素阻害剤として神経変性および精神疾患を治療するための縮合ピロールカルボン酸の使用

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522830A (ja) * 2011-07-07 2014-09-08 武田薬品工業株式会社 ピリミジノン化合物およびそれらの使用
JP2014524461A (ja) * 2011-08-22 2014-09-22 武田薬品工業株式会社 ピリダジノン化合物、及びdaao阻害剤としてのその使用
JP2016502998A (ja) * 2012-12-17 2016-02-01 武田薬品工業株式会社 Daao酵素阻害剤としてのピリダジノン
US9750748B2 (en) 2012-12-17 2017-09-05 Takeda Pharmaceutical Company Limited Pyridazinones as DAAO enzyme inhibitors
KR20220123738A (ko) * 2014-04-30 2022-09-08 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
KR102537686B1 (ko) 2014-04-30 2023-05-30 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
JP2022540000A (ja) * 2019-06-28 2022-09-14 ファイザー・インク Bckdk阻害活性を有するチエノ[3,2-b]チオフェン-2-カルボン酸化合物

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Publication number Publication date
AU2007269646A1 (en) 2008-01-10
EP2057162A2 (en) 2009-05-13
IL195921A0 (en) 2009-09-01
MX2008016525A (es) 2009-03-09
WO2008005456A3 (en) 2008-07-31
CA2659060A1 (en) 2008-01-10
BRPI0713216A2 (pt) 2012-12-04
KR20090024823A (ko) 2009-03-09
WO2008005456A2 (en) 2008-01-10

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