JP2009541461A5 - - Google Patents
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- Publication number
- JP2009541461A5 JP2009541461A5 JP2009517258A JP2009517258A JP2009541461A5 JP 2009541461 A5 JP2009541461 A5 JP 2009541461A5 JP 2009517258 A JP2009517258 A JP 2009517258A JP 2009517258 A JP2009517258 A JP 2009517258A JP 2009541461 A5 JP2009541461 A5 JP 2009541461A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- indol
- methoxy
- phenylsulfonyl
- sulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0601459 | 2006-07-03 | ||
| SE0601459-1 | 2006-07-03 | ||
| US86114606P | 2006-11-27 | 2006-11-27 | |
| US60/861,146 | 2006-11-27 | ||
| PCT/EP2007/056690 WO2008003703A1 (en) | 2006-07-03 | 2007-07-03 | Indoles as 5-ht6 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541461A JP2009541461A (ja) | 2009-11-26 |
| JP2009541461A5 true JP2009541461A5 (enExample) | 2012-07-19 |
| JP5324437B2 JP5324437B2 (ja) | 2013-10-23 |
Family
ID=38561947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517258A Expired - Fee Related JP5324437B2 (ja) | 2006-07-03 | 2007-07-03 | ５−ｈｔ６モジュレーターとしてのインドール |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7812017B2 (enExample) |
| EP (1) | EP2046741B1 (enExample) |
| JP (1) | JP5324437B2 (enExample) |
| CN (1) | CN101484420B (enExample) |
| AU (1) | AU2007271188B2 (enExample) |
| BR (1) | BRPI0712898A2 (enExample) |
| CA (1) | CA2655694C (enExample) |
| ES (1) | ES2398299T3 (enExample) |
| NZ (1) | NZ573371A (enExample) |
| RU (1) | RU2449990C2 (enExample) |
| WO (1) | WO2008003703A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010515674A (ja) * | 2007-01-08 | 2010-05-13 | スベン ライフ サイエンシズ リミティド | ５−（ヘテロシクリル）アルキル−ｎ−（アリールスルホニル）インドール化合物および５−ｈｔ６リガンドとしてのそれらの使用 |
| EP2121602B1 (en) * | 2007-01-08 | 2015-03-18 | Suven Life Sciences Limited | 4-(heterocyclyl)alkyl-n-(arylsulfonyl) indole compounds and their use as 5-ht6 ligands |
| CA2816753A1 (en) * | 2010-11-08 | 2012-05-18 | Lycera Corporation | N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of rory activity and the treatment of diseases |
| WO2013050795A1 (en) * | 2011-10-03 | 2013-04-11 | Femtonics Kft. | Use of photoactive compounds |
| WO2013138600A1 (en) * | 2012-03-16 | 2013-09-19 | Rosen Eliot M | Radioprotector compounds |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| WO2013166013A1 (en) * | 2012-04-30 | 2013-11-07 | Anderson Gaweco | Ror modulators and their uses |
| WO2013166015A1 (en) * | 2012-04-30 | 2013-11-07 | Anderson Gaweco | Ror modulators and their uses |
| ES2630079T3 (es) * | 2012-05-04 | 2017-08-17 | Novartis Ag | Moduladores de la ruta del complemento y usos de los mismos |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| WO2013169864A2 (en) | 2012-05-08 | 2013-11-14 | Lycera Corporation | TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE |
| KR20150007300A (ko) | 2012-05-08 | 2015-01-20 | 머크 샤프 앤드 돔 코포레이션 | Ror감마 활성의 억제를 위한 테트라히드로나프티리딘 및 관련 비시클릭 화합물 및 질환의 치료 |
| CA2902624C (en) | 2013-02-28 | 2021-05-18 | Takeda Pharmaceutical Company Limited | Method for producing sulfonyl chloride compound |
| EP2970269B1 (en) | 2013-03-14 | 2017-04-19 | Novartis AG | 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| EP3057422B1 (en) | 2013-10-15 | 2019-05-15 | Janssen Pharmaceutica NV | Quinolinyl modulators of ror(gamma)t |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| WO2015066241A1 (en) | 2013-10-30 | 2015-05-07 | Novartis Ag | 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof |
| US9809561B2 (en) | 2013-12-20 | 2017-11-07 | Merck Sharp & Dohme Corp. | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
| US9663502B2 (en) | 2013-12-20 | 2017-05-30 | Lycera Corporation | 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| EP3083588B1 (en) | 2013-12-20 | 2020-12-09 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| CN106132422A (zh) | 2014-02-27 | 2016-11-16 | 莱斯拉公司 | 使用视黄酸受体相关孤儿受体γ的激动剂的过继细胞疗法＆相关治疗方法 |
| EP3209641A4 (en) | 2014-05-05 | 2018-06-06 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease |
| JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
| EP3166924B1 (en) * | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| CN105367473B (zh) * | 2014-08-12 | 2020-02-11 | 广东东阳光药业有限公司 | 吲哚啉类衍生物及其在药物上的应用 |
| CN105367472B (zh) * | 2014-08-12 | 2020-04-21 | 广东东阳光药业有限公司 | 吲哚啉类衍生物及其在药物上的应用 |
| AU2016219183B2 (en) | 2015-02-11 | 2020-06-11 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as RORgammaT inhibitors and uses thereof |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| EP3307738B1 (en) | 2015-06-11 | 2022-04-20 | The Regents of the University of Michigan | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| AU2016344115A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Substituted indazole compounds as rorgammat inhibitors and uses thereof |
| AU2016344118A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| WO2017075178A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| CN107935905B (zh) * | 2017-11-28 | 2021-09-17 | 大理大学 | Indiacens A的合成方法 |
| CN111362859B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| WO2022092247A1 (ja) * | 2020-10-30 | 2022-05-05 | 第一三共株式会社 | ３－メチル－４－ハロ－インドール誘導体の製造方法 |
| CN114870018A (zh) * | 2022-05-12 | 2022-08-09 | 江南大学 | 炎症小体nlrp3抑制剂通过抑制神经系统炎症在制备治疗阿尔茨海默症药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2194984C (en) | 1994-07-26 | 2002-07-02 | John Eugene Macor | 4-indole derivatives as serotonin agonists and antagonists |
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| MXPA02001473A (es) * | 1999-08-12 | 2003-07-21 | Nps Allelix Corp | Azaindoles que tienen afinidad con el receptor de serotonina. |
| IL154685A0 (en) | 2000-10-20 | 2003-09-17 | Biovitrum Ab | 2-,3-,4-, or 5-substituted-n1-(benzensulfonyl) indoles and their use in therapy |
| WO2002041889A2 (en) | 2000-11-24 | 2002-05-30 | Smithkline Beecham P.L.C. | Indolsulfonyl compounds useful in the treatment of cns disorders |
| EP1401812B1 (en) | 2001-06-15 | 2006-06-28 | F. Hoffmann-La Roche Ag | 4-piperazinylindole derivatives with 5-ht6 receptor affinity |
| PL374401A1 (en) | 2002-06-05 | 2005-10-17 | F.Hoffmann-La Roche Ag | 1-sulfonyl-4-aminoalkoxy indole derivatives as 5-ht6-receptor modulators for the treatment of cns-disorders |
| ES2222828B1 (es) * | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| SE0302760D0 (sv) | 2003-10-20 | 2003-10-20 | Biovitrum Ab | New compounds |
| JP2010508344A (ja) * | 2006-10-30 | 2010-03-18 | ビオヴィトルム・アクチボラゲット（プブリクト） | ８−スルホニル−１，３，４，８−テトラヒドロ−２ｈ−［１，４］オキサゼピノ［６，７−ｅ］インドール誘導体、および５−ｈｔ６受容体リガンドとしてのその使用 |
-
2007
- 2007-07-03 EP EP07787013A patent/EP2046741B1/en active Active
- 2007-07-03 NZ NZ573371A patent/NZ573371A/en not_active IP Right Cessation
- 2007-07-03 CA CA2655694A patent/CA2655694C/en not_active Expired - Fee Related
- 2007-07-03 JP JP2009517258A patent/JP5324437B2/ja not_active Expired - Fee Related
- 2007-07-03 CN CN200780024768.0A patent/CN101484420B/zh not_active Expired - Fee Related
- 2007-07-03 US US11/824,939 patent/US7812017B2/en not_active Expired - Fee Related
- 2007-07-03 WO PCT/EP2007/056690 patent/WO2008003703A1/en not_active Ceased
- 2007-07-03 RU RU2009103313/04A patent/RU2449990C2/ru not_active IP Right Cessation
- 2007-07-03 BR BRPI0712898-3A patent/BRPI0712898A2/pt not_active IP Right Cessation
- 2007-07-03 AU AU2007271188A patent/AU2007271188B2/en not_active Ceased
- 2007-07-03 ES ES07787013T patent/ES2398299T3/es active Active
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