JP2009541205A5 - - Google Patents
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- JP2009541205A5 JP2009541205A5 JP2009500513A JP2009500513A JP2009541205A5 JP 2009541205 A5 JP2009541205 A5 JP 2009541205A5 JP 2009500513 A JP2009500513 A JP 2009500513A JP 2009500513 A JP2009500513 A JP 2009500513A JP 2009541205 A5 JP2009541205 A5 JP 2009541205A5
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- JP
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- Prior art keywords
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- compound
- compound according
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 76
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 21
- -1 sulfate ester Chemical class 0.000 claims 21
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 18
- 125000002252 acyl group Chemical group 0.000 claims 18
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 125000001475 halogen functional group Chemical group 0.000 claims 16
- 208000002193 Pain Diseases 0.000 claims 15
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 208000004296 neuralgia Diseases 0.000 claims 14
- 125000000547 substituted alkyl group Chemical group 0.000 claims 11
- 150000003457 sulfones Chemical class 0.000 claims 10
- 125000004442 acylamino group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000004947 alkyl aryl amino group Chemical group 0.000 claims 9
- 125000004414 alkyl thio group Chemical group 0.000 claims 9
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 9
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims 9
- 208000037765 diseases and disorders Diseases 0.000 claims 9
- 125000004404 heteroalkyl group Chemical group 0.000 claims 9
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 9
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 9
- 150000003462 sulfoxides Chemical class 0.000 claims 9
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 9
- 150000001540 azides Chemical class 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 230000001404 mediated effect Effects 0.000 claims 8
- 208000023275 Autoimmune disease Diseases 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 7
- 208000020925 Bipolar disease Diseases 0.000 claims 6
- 206010020751 Hypersensitivity Diseases 0.000 claims 6
- 208000003251 Pruritus Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 208000023504 respiratory system disease Diseases 0.000 claims 6
- 206010029240 Neuritis Diseases 0.000 claims 5
- 125000004104 aryloxy group Chemical group 0.000 claims 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 208000021722 neuropathic pain Diseases 0.000 claims 5
- 201000008482 osteoarthritis Diseases 0.000 claims 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 206010019233 Headaches Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 4
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 206010015037 epilepsy Diseases 0.000 claims 4
- 231100000869 headache Toxicity 0.000 claims 4
- 230000007794 irritation Effects 0.000 claims 4
- 230000000155 isotopic effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 208000004371 toothache Diseases 0.000 claims 4
- 230000009529 traumatic brain injury Effects 0.000 claims 4
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 3
- 206010069632 Bladder dysfunction Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 208000006561 Cluster Headache Diseases 0.000 claims 3
- 208000030814 Eating disease Diseases 0.000 claims 3
- 208000034347 Faecal incontinence Diseases 0.000 claims 3
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 3
- 208000014540 Functional gastrointestinal disease Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 206010065390 Inflammatory pain Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010043269 Tension headache Diseases 0.000 claims 3
- 208000008548 Tension-Type Headache Diseases 0.000 claims 3
- 206010046543 Urinary incontinence Diseases 0.000 claims 3
- 208000005298 acute pain Diseases 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000004983 autoimmune atherosclerosis Diseases 0.000 claims 3
- 201000004982 autoimmune uveitis Diseases 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 208000028683 bipolar I disease Diseases 0.000 claims 3
- 230000036772 blood pressure Effects 0.000 claims 3
- 201000007637 bowel dysfunction Diseases 0.000 claims 3
- 208000018912 cluster headache syndrome Diseases 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 235000014632 disordered eating Nutrition 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 3
- 206010013990 dysuria Diseases 0.000 claims 3
- 206010014599 encephalitis Diseases 0.000 claims 3
- 230000009610 hypersensitivity Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 230000007803 itching Effects 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 125000006217 methyl sulfide group Chemical group [H]C([H])([H])S* 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 230000003959 neuroinflammation Effects 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 3
- 230000008085 renal dysfunction Effects 0.000 claims 3
- 230000000241 respiratory effect Effects 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 208000019116 sleep disease Diseases 0.000 claims 3
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 2
- 208000012790 cranial neuralgia Diseases 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000036273 reactive airway disease Diseases 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 2
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- WITJHZRCLVXYCA-UHFFFAOYSA-N 3h-1,2-benzodioxepine Chemical class C1=CCOOC2=CC=CC=C21 WITJHZRCLVXYCA-UHFFFAOYSA-N 0.000 claims 1
- 206010003399 Arthropod bite Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 206010006784 Burning sensation Diseases 0.000 claims 1
- 206010008334 Cervicobrachial syndrome Diseases 0.000 claims 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 208000001375 Facial Neuralgia Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000021965 Glossopharyngeal Nerve disease Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- 206010049949 Intercostal neuralgia Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000002472 Morton Neuroma Diseases 0.000 claims 1
- 208000020059 Morton neuralgia Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 206010068106 Occipital neuralgia Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010036105 Polyneuropathy Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 claims 1
- 208000018569 Respiratory Tract disease Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 208000004078 Snake Bites Diseases 0.000 claims 1
- 208000003589 Spider Bites Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical group CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 1
- 150000005528 benzodioxoles Chemical class 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 229960002504 capsaicin Drugs 0.000 claims 1
- 235000017663 capsaicin Nutrition 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 201000005442 glossopharyngeal neuralgia Diseases 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 150000002545 isoxazoles Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000005906 menstruation Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 1
- 150000002790 naphthalenes Chemical class 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 210000003254 palate Anatomy 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- IMACFCSSMIZSPP-UHFFFAOYSA-N phenacyl chloride Chemical compound ClCC(=O)C1=CC=CC=C1 IMACFCSSMIZSPP-UHFFFAOYSA-N 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical class C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 claims 1
- 208000019629 polyneuritis Diseases 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 230000003393 splenic effect Effects 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 239000003491 tear gas Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 0 *C(NC1=C(*)**C2=C1C=CN(*)C2=O)=O Chemical compound *C(NC1=C(*)**C2=C1C=CN(*)C2=O)=O 0.000 description 6
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78312106P | 2006-03-16 | 2006-03-16 | |
| US78297306P | 2006-03-16 | 2006-03-16 | |
| US78292206P | 2006-03-16 | 2006-03-16 | |
| US78277606P | 2006-03-16 | 2006-03-16 | |
| US78359006P | 2006-03-16 | 2006-03-16 | |
| US78292306P | 2006-03-16 | 2006-03-16 | |
| US78278206P | 2006-03-16 | 2006-03-16 | |
| US78277506P | 2006-03-16 | 2006-03-16 | |
| US78374806P | 2006-03-16 | 2006-03-16 | |
| US78330406P | 2006-03-16 | 2006-03-16 | |
| US83141606P | 2006-07-17 | 2006-07-17 | |
| US84699306P | 2006-09-25 | 2006-09-25 | |
| US91812307P | 2007-03-15 | 2007-03-15 | |
| PCT/US2007/006676 WO2007109154A2 (en) | 2006-03-16 | 2007-03-16 | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009541205A JP2009541205A (ja) | 2009-11-26 |
| JP2009541205A5 true JP2009541205A5 (enExample) | 2011-03-31 |
Family
ID=39878008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500513A Withdrawn JP2009541205A (ja) | 2006-03-16 | 2007-03-16 | Ｐ２ｘ７調節因子としてのビシクロへテロアリール化合物およびその使用 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20090298825A1 (enExample) |
| EP (1) | EP1996585A4 (enExample) |
| JP (1) | JP2009541205A (enExample) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
| AU2003301443A1 (en) * | 2002-10-18 | 2004-05-04 | E.I. Du Pont De Nemours And Company | Azolecarboxamide herbicides |
| GB0312609D0 (en) * | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
-
2007
- 2007-03-16 EP EP07753312A patent/EP1996585A4/en not_active Withdrawn
- 2007-03-16 US US12/225,276 patent/US20090298825A1/en not_active Abandoned
- 2007-03-16 JP JP2009500513A patent/JP2009541205A/ja not_active Withdrawn
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