JP2009540018A5 - - Google Patents

Info

Publication number

JP2009540018A5

JP2009540018A5 JP2009515638A JP2009515638A JP2009540018A5 JP 2009540018 A5 JP2009540018 A5 JP 2009540018A5 JP 2009515638 A JP2009515638 A JP 2009515638A JP 2009515638 A JP2009515638 A JP 2009515638A JP 2009540018 A5 JP2009540018 A5 JP 2009540018A5

Authority

JP

Japan

Prior art keywords

seq

antibody

heavy chain

light chain

group

Prior art date

2007-06-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000539 amino acid group Chemical group 0.000 claims description 45
• 229920001184 polypeptide Polymers 0.000 claims description 40
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 40
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 40
• 239000005557 antagonist Substances 0.000 claims description 26
• 102000013691 Interleukin-17 Human genes 0.000 claims description 24
• 108050003558 Interleukin-17 Proteins 0.000 claims description 24
• 238000000034 method Methods 0.000 claims description 23
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 22
• 108010076561 Interleukin-23 Subunit p19 Proteins 0.000 claims description 17
• 102100036705 Interleukin-23 subunit alpha Human genes 0.000 claims description 17
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 13
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 13
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 7
• 108010065637 Interleukin-23 Proteins 0.000 claims description 7
• 102000013264 Interleukin-23 Human genes 0.000 claims description 7
• 201000006417 multiple sclerosis Diseases 0.000 claims description 7
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• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 3
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• 206010020751 Hypersensitivity Diseases 0.000 claims description 3
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• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 3
• 208000026935 allergic disease Diseases 0.000 claims description 3
• 230000002917 arthritic effect Effects 0.000 claims description 3
• 208000006673 asthma Diseases 0.000 claims description 3
• 230000001363 autoimmune Effects 0.000 claims description 3
• 208000037976 chronic inflammation Diseases 0.000 claims description 3
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• 210000004392 genitalia Anatomy 0.000 claims 2
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• 210000001744 T-lymphocyte Anatomy 0.000 description 2
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• 230000024949 interleukin-17 production Effects 0.000 description 1