JP2009539786A5 - - Google Patents
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- Publication number
- JP2009539786A5 JP2009539786A5 JP2009513577A JP2009513577A JP2009539786A5 JP 2009539786 A5 JP2009539786 A5 JP 2009539786A5 JP 2009513577 A JP2009513577 A JP 2009513577A JP 2009513577 A JP2009513577 A JP 2009513577A JP 2009539786 A5 JP2009539786 A5 JP 2009539786A5
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- therapeutic system
- transdermal therapeutic
- particles
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004480 active ingredient Substances 0.000 claims description 29
- 239000002245 particle Substances 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 10
- 239000006185 dispersion Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 229920001577 copolymer Polymers 0.000 claims description 5
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000002798 polar solvent Substances 0.000 claims description 3
- -1 polybutylene Polymers 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 239000012943 hotmelt Substances 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 2
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 235000019423 pullulan Nutrition 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 229960003604 testosterone Drugs 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 14
- 239000011859 microparticle Substances 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000010419 fine particle Substances 0.000 claims 4
- 239000010410 layer Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229930003347 Atropine Natural products 0.000 claims 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims 1
- WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims 1
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000012790 adhesive layer Substances 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical group O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims 1
- 229960000396 atropine Drugs 0.000 claims 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims 1
- 229960001076 chlorpromazine Drugs 0.000 claims 1
- 229960002896 clonidine Drugs 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims 1
- 229960004976 desogestrel Drugs 0.000 claims 1
- 229960004242 dronabinol Drugs 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 229960002179 ephedrine Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229960002568 ethinylestradiol Drugs 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims 1
- 229960003727 granisetron Drugs 0.000 claims 1
- 229960003878 haloperidol Drugs 0.000 claims 1
- 229960000905 indomethacin Drugs 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229960003938 moxonidine Drugs 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920001748 polybutylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 1
- 229960003089 pramipexole Drugs 0.000 claims 1
- 229960003712 propranolol Drugs 0.000 claims 1
- 229960000744 vinpocetine Drugs 0.000 claims 1
- 210000003000 inclusion body Anatomy 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 5
- 239000007787 solid Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229920002799 BoPET Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920001938 Vegetable gum Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006026578A DE102006026578B4 (de) | 2006-06-08 | 2006-06-08 | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| DE102006026578.5 | 2006-06-08 | ||
| PCT/EP2007/004765 WO2007140909A1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009539786A JP2009539786A (ja) | 2009-11-19 |
| JP2009539786A5 true JP2009539786A5 (https=) | 2013-01-17 |
| JP5757682B2 JP5757682B2 (ja) | 2015-07-29 |
Family
ID=38520773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513577A Expired - Fee Related JP5757682B2 (ja) | 2006-06-08 | 2007-05-30 | 活性成分粒子を含み増大した活性成分流量を有する経皮治療システム |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10292942B2 (https=) |
| EP (1) | EP2029121B1 (https=) |
| JP (1) | JP5757682B2 (https=) |
| CN (1) | CN101466361B (https=) |
| AT (1) | ATE459345T1 (https=) |
| BR (1) | BRPI0712420A2 (https=) |
| CA (1) | CA2652216C (https=) |
| DE (2) | DE102006026578B4 (https=) |
| DK (1) | DK2029121T3 (https=) |
| ES (1) | ES2340732T3 (https=) |
| PL (1) | PL2029121T3 (https=) |
| PT (1) | PT2029121E (https=) |
| WO (1) | WO2007140909A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| US8369942B2 (en) * | 2008-03-20 | 2013-02-05 | The Invention Science Fund I, Llc | Subdermal material delivery device |
| CA2662499A1 (en) * | 2008-04-16 | 2009-10-16 | Nitto Denko Corporation | Transdermal drug administration device |
| US20110033545A1 (en) * | 2009-08-06 | 2011-02-10 | Absize, Inc. | Topical pharmaceutical preparations having both a nanoparticle solution and a nanoparticle suspension and methods for the treatment of acute and chronic pain therewith |
| DE102011100619A1 (de) | 2010-05-05 | 2012-01-05 | Amw Gmbh | Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum |
| CN103052380B (zh) | 2010-08-23 | 2015-11-25 | 塔科达有限责任公司 | 包含治疗活性物质的湿润颗粒 |
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| WO2014195352A1 (en) * | 2013-06-04 | 2014-12-11 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system |
| EP3209389B1 (en) | 2014-10-21 | 2019-10-02 | The Procter and Gamble Company | Kit for improving skin appearance |
| CN104758181A (zh) * | 2015-04-09 | 2015-07-08 | 史祎 | 一种无溶剂贴敷剂制备工艺 |
| CN108348788B (zh) | 2015-10-22 | 2021-11-05 | 宝洁公司 | 发泡膜的阻隔贴片和改善皮肤外观的方法 |
| CN108136230B (zh) | 2015-10-22 | 2022-05-13 | 宝洁公司 | 发泡膜的阻隔贴片和改善皮肤外观的方法 |
| EP3565641B1 (en) * | 2017-01-09 | 2021-06-23 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US10751265B2 (en) * | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
| US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| EP3641952B1 (en) * | 2017-06-22 | 2023-08-02 | The Procter & Gamble Company | Beauty care films including a water-soluble layer and a vapor-deposited coating |
| KR102524880B1 (ko) * | 2017-12-21 | 2023-04-21 | 한양대학교 산학협력단 | 하이드로콜로이드 조성물 및 이를 포함하는 바이오 패치 |
| US10751266B2 (en) | 2018-03-19 | 2020-08-25 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
| US12491166B2 (en) | 2020-08-31 | 2025-12-09 | Wacker Chemie Ag | Method of delivering an active compound and delivery device for use in the same |
| US12201733B2 (en) * | 2021-03-08 | 2025-01-21 | Nikita Patel | Transdermal delivery system |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3965482A (en) * | 1974-11-12 | 1976-06-22 | Rca Corporation | Velocity correction circuit for video discs |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4687481A (en) | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
| ATE95430T1 (de) * | 1984-12-22 | 1993-10-15 | Sanol Arznei Schwarz Gmbh | Wirkstoffpflaster. |
| GB8629640D0 (en) | 1986-12-11 | 1987-01-21 | Beecham Group Plc | Composition & method |
| US5059189A (en) | 1987-09-08 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Method of preparing adhesive dressings containing a pharmaceutically active ingredient |
| IT1230566B (it) | 1988-10-17 | 1991-10-28 | Vectorpharma Int | Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione |
| DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
| US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
| IT1243745B (it) * | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
| DE4332093C2 (de) | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| US6238700B1 (en) | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| DE19652196A1 (de) | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
| EP1021241B1 (de) * | 1997-10-06 | 2001-08-29 | Adalbert-Raps-Stiftung | Verfahren zur herstellung eines pulverförmigen produktes aus einem flüssigen stoff oder stoffgemisch |
| DE19844079A1 (de) * | 1998-05-22 | 1999-11-25 | Novosis Pharma Ag | Biphasische Transdermalsysteme |
| DE19906152B4 (de) | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| FI20010115A0 (fi) * | 2001-01-18 | 2001-01-18 | Orion Corp | Menetelmä nanopartikkelien valmistamiseksi |
| DE10136784A1 (de) * | 2001-07-27 | 2003-02-20 | Lohmann Therapie Syst Lts | Darreichungsformen mit wirkstoffhaltigen Partikeln, zur Anwendung auf der Haut oder Schleimhaut |
| DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
-
2006
- 2006-06-08 DE DE102006026578A patent/DE102006026578B4/de not_active Expired - Fee Related
-
2007
- 2007-05-30 AT AT07725656T patent/ATE459345T1/de active
- 2007-05-30 BR BRPI0712420-1A patent/BRPI0712420A2/pt not_active IP Right Cessation
- 2007-05-30 US US12/302,065 patent/US10292942B2/en active Active
- 2007-05-30 DE DE502007003020T patent/DE502007003020D1/de active Active
- 2007-05-30 ES ES07725656T patent/ES2340732T3/es active Active
- 2007-05-30 EP EP07725656A patent/EP2029121B1/de not_active Revoked
- 2007-05-30 JP JP2009513577A patent/JP5757682B2/ja not_active Expired - Fee Related
- 2007-05-30 WO PCT/EP2007/004765 patent/WO2007140909A1/de not_active Ceased
- 2007-05-30 PT PT07725656T patent/PT2029121E/pt unknown
- 2007-05-30 DK DK07725656.8T patent/DK2029121T3/da active
- 2007-05-30 CN CN200780021134XA patent/CN101466361B/zh not_active Expired - Fee Related
- 2007-05-30 PL PL07725656T patent/PL2029121T3/pl unknown
- 2007-05-30 CA CA2652216A patent/CA2652216C/en active Active
-
2019
- 2019-04-10 US US16/380,069 patent/US10596126B2/en active Active
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